Dhruv Sareen

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy
    Dhruv Sareen
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    PLoS ONE 7:e39113. 2012
  2. pmc HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
    Virginia B Mattis
    The Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA
    Hum Mol Genet 24:3257-71. 2015
  3. pmc Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium
    Dhruv Sareen
    Regenerative Medicine Institute, Eye Program, and Departments of Biomedical Sciences, Neurosurgery, Genomics Core, and Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA Norris Comprehensive Cancer Center Bioinformatics Core and Division of Hematology, University of Southern California, Los Angeles, California, USA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Stem Cells Transl Med 3:1002-12. 2014
  4. pmc A simple alkaline method for decellularizing human amniotic membrane for cell culture
    Mehrnoosh Saghizadeh
    Eye Program, Cedars Sinai Medical Center, Los Angeles, California, United States of America Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America Departments of Biomedical Sciences, Surgery, and Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 8:e79632. 2013
  5. pmc Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines
    Robert Barrett
    Regenerative Medicine Institute, F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells Transl Med 3:1429-34. 2014
  6. pmc Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord
    Dhruv Sareen
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048 Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, 90048
    J Comp Neurol 522:2707-28. 2014
  7. pmc Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1
    Biagio Saitta
    1 Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California
    Stem Cells Dev 23:1464-78. 2014
  8. doi request reprint Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model
    Yuchun Tsai
    Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells 33:2537-49. 2015
  9. pmc Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells
    Seigo Hatada
    Board of Governors, Regenerative Medicine Institute, Department of Biomedical Sciences, iPSC Core, The David and Janet Polak Foundation Stem Cell Core Laboratory, Genomics Core Facility, Department of Surgery, and Department of Neurology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells Transl Med 4:998-1010. 2015
  10. pmc Neonatal immune-tolerance in mice does not prevent xenograft rejection
    Virginia B Mattis
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Exp Neurol 254:90-8. 2014

Collaborators

  • Robert H Baloh
  • Amber L Southwell
  • Christopher A Ross
  • John Ravits
  • Deborah Krakow
  • David L Rimoin
  • Allison D Ebert
  • Daniel H Cohn
  • Clive N Svendsen
  • Anais Sahabian
  • Loren Ornelas
  • Virginia B Mattis
  • Berhan Mandefro
  • Seigo Hatada
  • Yuchun Tsai
  • Colton Tom
  • Lindsay Lenaeus
  • Robert Barrett
  • Biagio Saitta
  • Mehrnoosh Saghizadeh
  • Aparna Subramanian
  • Michael R Hayden
  • Michael E Østergaard
  • Songyang Ren
  • Benjamin Bakondi
  • Jamshid Arjomand
  • Ho Won Kim
  • Vaithilingaraja Arumugaswami
  • Crystal N Doty
  • Shaomei Wang
  • Jie Tang
  • Sergey Girman
  • Vincent Funari
  • Sergey Akimov
  • Bin Lu
  • Jasmine Saeedian
  • Dustin R Wakeman
  • Nicole Yeager
  • Leslie M Thompson
  • Stephan R Targan
  • Hemraj B Dodiya
  • Jeffrey H Kordower
  • Shilpa Argade
  • Andrew H Tran
  • Sylvia Y Yeung
  • JACK REIDLING
  • Jenna Passarini
  • Ksenija Bernau
  • Yaron S Rabinowitz
  • Chantelle A Ghiam
  • William J Brunken
  • Katerina Jirsova
  • Homayon Ghiasi
  • Andrei A Kramerov
  • Slobodan D Dimitrijevich
  • Michael A Winkler
  • Ezra Maguen
  • Alexander V Ljubimov
  • David M Hemmati

Detail Information

Publications11

  1. pmc Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy
    Dhruv Sareen
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    PLoS ONE 7:e39113. 2012
    ..Together, these data further validate this human stem cell model of SMA, suggesting that specific inhibitors of apoptotic pathways may be beneficial for patients...
  2. pmc HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
    Virginia B Mattis
    The Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA
    Hum Mol Genet 24:3257-71. 2015
    ..Together, these results provide important insight into HD mechanisms at early developmental time points, which may suggest novel approaches to HD therapeutics. ..
  3. pmc Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium
    Dhruv Sareen
    Regenerative Medicine Institute, Eye Program, and Departments of Biomedical Sciences, Neurosurgery, Genomics Core, and Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA Norris Comprehensive Cancer Center Bioinformatics Core and Division of Hematology, University of Southern California, Los Angeles, California, USA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Stem Cells Transl Med 3:1002-12. 2014
    ..These data emphasize the importance of the natural niche and limbal tissue of origin in generating iPSCs as a LESC source with translational potential for LSCD treatment. ..
  4. pmc A simple alkaline method for decellularizing human amniotic membrane for cell culture
    Mehrnoosh Saghizadeh
    Eye Program, Cedars Sinai Medical Center, Los Angeles, California, United States of America Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America Departments of Biomedical Sciences, Surgery, and Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 8:e79632. 2013
    ..This simple, fast and reliable method can be used to standardize decellularized amniotic membrane preparations for expansion of limbal stem cells in vitro before transplantation to patients. ..
  5. pmc Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines
    Robert Barrett
    Regenerative Medicine Institute, F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells Transl Med 3:1429-34. 2014
    ....
  6. pmc Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord
    Dhruv Sareen
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048 Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, 90048
    J Comp Neurol 522:2707-28. 2014
    ..These results suggest that human iNPCs behave like fNPCs and could thus be a valuable alternative for cellular regenerative therapies of neurological diseases...
  7. pmc Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1
    Biagio Saitta
    1 Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California
    Stem Cells Dev 23:1464-78. 2014
    ....
  8. doi request reprint Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model
    Yuchun Tsai
    Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells 33:2537-49. 2015
    ..The results described here support the therapeutic utility of iNPCs as autologous grafts for early-stage of AMD...
  9. pmc Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells
    Seigo Hatada
    Board of Governors, Regenerative Medicine Institute, Department of Biomedical Sciences, iPSC Core, The David and Janet Polak Foundation Stem Cell Core Laboratory, Genomics Core Facility, Department of Surgery, and Department of Neurology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells Transl Med 4:998-1010. 2015
    ..This simple method allows higher throughput of new, targeted hPSC lines that are crucial to expand the use of disease modeling and to develop novel avenues of cell therapy...
  10. pmc Neonatal immune-tolerance in mice does not prevent xenograft rejection
    Virginia B Mattis
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Exp Neurol 254:90-8. 2014
    ..We also address specific challenges associated with the generation of humanized mouse models of disease. ..
  11. pmc Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
    Dhruv Sareen
    Regenerative Medicine Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Sci Transl Med 5:208ra149. 2013
    ..These data show that patient-derived motor neurons can be used to delineate pathogenic events in ALS. ..