Dermot P B McGovern

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
  2. pmc MAGI2 genetic variation and inflammatory bowel disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 15:75-83. 2009
  3. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
  4. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
  5. pmc IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
    Kathrin S Michelsen
    Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    PLoS ONE 4:e4719. 2009
  6. doi request reprint Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway
    Manreet Kaur
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas Division of Hematology and Oncology, Department of Medicine and Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California and Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 22:862-9. 2016
  7. pmc Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease
    Andrew Ippoliti
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Inflamm Bowel Dis 16:1279-85. 2010
  8. pmc Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
    Marla C Dubinsky
    Departments of Pediatrics, Pediatric Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:1662-70. 2013
  9. pmc Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
  10. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010

Detail Information

Publications22

  1. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
    ..Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls...
  2. pmc MAGI2 genetic variation and inflammatory bowel disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 15:75-83. 2009
    ..Our aim was to test MAGI2 variants for association with IBD and also their role in determining intermediate hereditary phenotypes defined by antibody production to microbial antigens...
  3. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  4. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
    ..001). These findings strongly implicate this locus in CD susceptibility and highlight the role of the mucus layer in the development of CD...
  5. pmc IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
    Kathrin S Michelsen
    Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    PLoS ONE 4:e4719. 2009
    ..TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD). TL1A gene haplotypes increase CD susceptibility in Japanese, European, and US cohorts...
  6. doi request reprint Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway
    Manreet Kaur
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas Division of Hematology and Oncology, Department of Medicine and Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California and Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 22:862-9. 2016
    ..Previous studies investigating the etiology of pCD have been limited in the numbers of subjects and the intensity of genotyping. The aim of this study was to identify clinical, serological, and genetic factors associated with pCD...
  7. pmc Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease
    Andrew Ippoliti
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Inflamm Bowel Dis 16:1279-85. 2010
    ....
  8. pmc Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
    Marla C Dubinsky
    Departments of Pediatrics, Pediatric Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:1662-70. 2013
    ....
  9. pmc Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
    ..A numeric rating scale (NRS) is a quick, inexpensive, and convenient patient-reported outcome that can capture the patient's overall perception of health...
  10. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010
    ..The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC...
  11. pmc Variants in ZNF365 isoform D are associated with Crohn's disease
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 60:1060-7. 2011
    ..Genome-wide association studies have identified multiple Crohn's disease (CD) susceptibility loci, including association with non-coding intergenic single-nucleotide polymorphisms (SNPs) at 10q21...
  12. doi request reprint Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease
    Seper Dezfoli
    Division of Gastroenterology, Department of Medicine, F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 21:1754-60. 2015
    ..The impact of immunosuppressive regimens for inflammatory bowel disease (IBD) on vaccine responses to the Tdap vaccine is not known...
  13. doi request reprint Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study
    Adam V Weizman
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CAWomen s College Hospital, Division of Gastroenterology, University of Toronto, Toronto, ONDepartment of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CAMedical Genetics Research Institute, Cedars Sinai Medical AU2 Center, Los Angeles, CA
    J Cutan Med Surg 19:125-31. 2015
    ..Pyoderma gangrenosum (PG) is a severe extraintestinal manifestation of inflammatory bowel disease (IBD)...
  14. pmc Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens
    Rivkah Gonsky
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 17:171-8. 2011
    ..This study evaluated the relationship between IFNG methylation and serologic and clinical profiles in peripheral T cells from IBD patients...
  15. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
    ....
  16. doi request reprint Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits
    Sasha Taleban
    Department of Medicine, Division of Gastroenterology, University of Arizona College of Medicine, Tucson, AZ, USA F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Crohns Colitis 10:43-9. 2016
    ..This study identified clinical, serological, and genetic factors associated with ocular EIMs [O-EIMs] in IBD...
  17. pmc Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients
    Adam Weizman
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California and Medical Genetics Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 20:525-33. 2014
    ..Pyoderma gangrenosum (PG) and erythema nodosum (EN) are the most common cutaneous manifestations of inflammatory bowel disease (IBD) but little is known regarding their etiopathogenesis...
  18. pmc Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism
    Maomeng Tong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    ISME J 8:2193-206. 2014
    ..Therefore, the colonic microbiota of non-secretors is altered at both the compositional and functional levels, affecting the host mucosal state and potentially explaining the association of FUT2 genotype and CD susceptibility. ..
  19. pmc Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function
    Lin Lin
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095
    J Immunol 193:940-9. 2014
    ....
  20. pmc Genetics of Inflammatory Bowel Diseases
    Dermot P B McGovern
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Medical Genetics Research Institute, Cedars Sinai Medical Center, Los Angeles, California
    Gastroenterology 149:1163-1176.e2. 2015
    ..Highly collaborative studies across research centers and across subspecialties and disciplines will be required to fully realize the promise of genetic discovery in IBD. ..
  21. pmc Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans
    Suk Kyun Yang
    1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 2Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea 3Human Genetics Group, Genome Institute of Singapore, Singapore, Singapore 4The F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California 5Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 6Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea 7Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 8Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea 9Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea 10Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Ansan, Korea 11Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, Seoul, Korea 12Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea 13Department of Life Science
    Inflamm Bowel Dis 21:1-7. 2015
    ..As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population...
  22. pmc A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease
    Maomeng Tong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e80702. 2013
    ..Microbial modules thus provide an integrative view of microbial ecology relevant to IBD. ..