Anna M van Heeckeren
Affiliation: Case Western Reserve University
- Murine models of chronic Pseudomonas aeruginosa lung infectionAnna M van Heeckeren
Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
Lab Anim 36:291-312. 2002..aeruginosa-laden agarose beads, since the histopathological features were similar, though further characterization is needed to evaluate its utility as an adequate model of cystic fibrosis...
- Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in miceAnna M van Heeckeren
Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4948, USA
Am J Physiol Lung Cell Mol Physiol 287:L944-52. 2004..Therefore, it appears that any functional defect in CFTR produces comparable inflammatory responses to lung infections with P. aeruginosa...
- Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis miceAnna M van Heeckeren
Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
Am J Respir Crit Care Med 173:288-96. 2006....
- Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infectionAnna M van Heeckeren
Case Western Reserve Univ School of Medicine, Biomedical Research Bldg 827, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
Am J Physiol Lung Cell Mol Physiol 286:L717-26. 2004..In conclusion, the observed survival advantage of adenoviral delivery of CFTR to the CF lung may be due either to CFTR expression or possibly to proinflammatory effects of the adenoviral vector, or both...
- Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in miceAnna M van Heeckeren
Case Western Reserve University School of Medicine, Cleveland, Ohio Hospital San Rafael, La Coruna, Spain
Infect Immun 72:1479-86. 2004..In conclusion, diet and docosahexaenoic acid imbalances alone are unlikely to explain the differences in the host response to lung infections with mucoid P. aeruginosa between mice with cystic fibrosis and their wild-type counterparts...
- Peroxisome proliferator-activated receptor-gamma in cystic fibrosis lung epitheliumAura Perez
Deptartment of Pediatrics, School of Medicine, Case Western Reserve University, BRB Bldg R829, 10900 Euclid Ave, Cleveland, OH 44106 4948, USA
Am J Physiol Lung Cell Mol Physiol 295:L303-13. 2008..aeruginosa in CF, but not wild-type, mice. In summary, PPARgamma inhibits the inflammatory response in CF, at least in part by interaction with NF-kappaB in airway epithelial cells. PPARgamma agonists may be therapeutic in CF...
- Monitoring infection and inflammation in murine models of cystic fibrosis with magnetic resonance imagingVipul R Sheth
Case Center for Imaging Research and Department of Biomedical Engineering, Case Western Reserve University Cystic Fibrosis Core Center Animal Core, Cleveland, Ohio 44106 7207, USA
J Magn Reson Imaging 28:527-32. 2008..To evaluate magnetic resonance imaging (MRI) in assessing lung inflammation longitudinally in genetic mouse models of cystic fibrosis (CF). MRI is used to view soft tissues noninvasively, but the lung is challenging to image...
- SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosisBarbara R Grubb
Cystic Fibrosis Pulmonary Research and Treatment Center, 7011 Thurston Bowles Bldg, CB 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
Am J Respir Cell Mol Biol 34:355-63. 2006....
- Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosisVolker Teichgräber
Department of Molecular Biology, Hufelandstrasse 55, University of Duisburg Essen, 45122 Essen, Germany
Nat Med 14:382-91. 2008..These data suggest inhibition of Asm as a new treatment strategy for cystic fibrosis...
- Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infectionBrian J Day
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Infect Immun 72:2045-51. 2004..Individuals with lung diseases associated with altered antioxidant transport, such as cystic fibrosis, might lack the ability to adapt to the infection and present with a more severe inflammatory response...
- Tissue inhibitor of metalloproteinase 1 regulates resistance to infectionMarie Mei Lee
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Infect Immun 73:661-5. 2005..Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance...
- P. aeruginosa lung disease in CFAnna Van Heeckeren; Fiscal Year: 2006..These studies will direct future studies to more fully understand the pathophysiology of CF so novel treatments can be evaluated for use in CF patients. ..