David C Schultz

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
    David C Schultz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:919-32. 2002
  2. ncbi Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    Yael Ziv
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 8:870-6. 2006
  3. ncbi Assessment of sera for chromatin-immunoprecipitation
    Juliette Nguyen
    Centre National de la Recherche Scientifique, Paris, France
    Biotechniques 44:66, 68. 2008
  4. pmc PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
    Alexey V Ivanov
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell 28:823-37. 2007
  5. pmc Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
    Kasirajan Ayyanathan
    The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
    Genes Dev 17:1855-69. 2003
  6. ncbi The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
    Mark S Lechner
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 331:929-37. 2005
  7. pmc Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae
    Kristin Ingvarsdottir
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:7856-64. 2007
  8. pmc Identification and characterization of small molecule human papillomavirus E6 inhibitors
    Kimberly A Malecka
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    ACS Chem Biol 9:1603-12. 2014
  9. pmc Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance
    Mark Mason
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Structure 21:109-20. 2013
  10. pmc Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex
    Yong Tang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    Biochemistry 51:2366-77. 2012

Collaborators

  • Peter D Adams
  • Ronen Marmorstein
  • Emmanuel Skordalakes
  • Maureen E Murphy
  • Ming Ming Zhou
  • Ali Shilatifard
  • Shelley L Berger
  • Y Shiloh
  • Yael Ziv
  • Mark S Lechner
  • Moshe Sadofsky
  • Jiri Bartek
  • Pierre Antoine Defossez
  • M Daniel Ricketts
  • Yong Tang
  • Daniela Fera
  • MELVIN REICHMAN
  • Frank J Rauscher
  • Kimberly A Malecka
  • Nadezhda Tikhmyanova
  • Taranjit Singh Rai
  • Santosh Hodawadekar
  • Mark Mason
  • Christopher Bryan
  • Paul M Lieberman
  • Hestia S Mellert
  • Scott Thompson
  • Juliette Nguyen
  • Kristin Ingvarsdottir
  • Xu Li
  • Alexey V Ivanov
  • Smitha P Sripathy
  • Meghan E Pennini
  • Gerd G Maul
  • Kasirajan Ayyanathan
  • Brian Frederick
  • Maria Grazia Vizioli
  • Henry Hoff
  • Theresa Lee
  • Joseph M Salvino
  • Preston S Donover
  • David W Speicher
  • Jennifer J Wanat
  • Cory Rice
  • Michael Harkisheimer
  • Sandy Harper
  • F Brad Johnson
  • Aastha Puri
  • Joseph L Kissil
  • Scott Troutman
  • Preston Scott Donover
  • Jason Melvin
  • Jason Hoffmann
  • Donna M Huryn
  • Elise Hoi
  • Timothy J Stanek
  • Stephen M Sykes
  • Steven B McMahon
  • Troy Messick
  • Daisuke Yamada
  • David K Ann
  • Dmitri G Negorev
  • Yun Yen
  • Jen Chong Jeng
  • Kyoko L Yap
  • Jung Shin Lee
  • Vyacheslav Yurchenko
  • Ramin Shiekhattar
  • David E White
  • Hsiu Ming Shih
  • William J Fredericks
  • Yung Kang Lee
  • Hongzhuang Peng
  • Chris Edwards
  • Min Gyu Lee
  • Elyse Psulkowski
  • Clifford V Harding
  • Jessica Stevens
  • Rish K Pai
  • W Henry Boom
  • Kiyoyuki Torigoe
  • Kazuhiro Tanaka
  • Peter Bell
  • Yoshihiko Yamada

Detail Information

Publications19

  1. pmc SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
    David C Schultz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:919-32. 2002
    ..Thus, KAP-1 is a molecular scaffold that is targeted by KRAB-ZFPs to specific loci and coordinates both histone methylation and the deposition of HP1 proteins to silence gene expression...
  2. ncbi Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    Yael Ziv
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 8:870-6. 2006
    ..These results suggest that chromatin relaxation is a fundamental pathway in the DNA-damage response and identify its primary mediators...
  3. ncbi Assessment of sera for chromatin-immunoprecipitation
    Juliette Nguyen
    Centre National de la Recherche Scientifique, Paris, France
    Biotechniques 44:66, 68. 2008
    ..This approach is useful as a first step toward ChIP-on-chip or ChIP-sequencing, especially in the case of recently identified proteins for which no binding sites are yet known...
  4. pmc PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
    Alexey V Ivanov
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell 28:823-37. 2007
    ..These data provide a mechanistic explanation for the cooperation of PHD and bromodomains in gene regulation and describe a function of the PHD domain as an intramolecular E3 SUMO ligase...
  5. pmc Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
    Kasirajan Ayyanathan
    The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
    Genes Dev 17:1855-69. 2003
    ..Thus, like variegation in Drosophila, recruitment of mammalian HP1 to a euchromatic promoter can establish a silenced state that is epigenetically heritable...
  6. ncbi The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
    Mark S Lechner
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 331:929-37. 2005
    ..Thus, this spectrum of direct binding partners suggests an expanded role for HP1 as factor participating in promoter-enhancer communication, chromatin remodeling/assembly, and sub-nuclear compartmentalization...
  7. pmc Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae
    Kristin Ingvarsdottir
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:7856-64. 2007
    ..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes...
  8. pmc Identification and characterization of small molecule human papillomavirus E6 inhibitors
    Kimberly A Malecka
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    ACS Chem Biol 9:1603-12. 2014
    ..The compounds identified here constitute attractive starting points for further medicinal chemistry efforts and development into beneficial therapeutics. ..
  9. pmc Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance
    Mark Mason
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Structure 21:109-20. 2013
    ..We therefore propose that dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping...
  10. pmc Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex
    Yong Tang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    Biochemistry 51:2366-77. 2012
    ..Together, these studies implicate the NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex...
  11. pmc Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex
    M Daniel Ricketts
    1 Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 2 Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 6:7711. 2015
    ..3 G90, although the mechanism for H3.3 G90 recognition appears to be distinct. This study points to UBN1 as the determinant of H3.3-specific binding and deposition by the HIRA complex. ..
  12. pmc Structure of the human telomeric Stn1-Ten1 capping complex
    Christopher Bryan
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e66756. 2013
    ..Cell based assays indicate that hTen1 is critical for the telomeric function of hCST, both in telomere protection and downregulation of telomerase function. ..
  13. pmc Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins
    Daniela Fera
    Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA 19104, USA
    Chem Biol 19:518-28. 2012
    ..These inhibitors provide a promising scaffold for the development of therapies to treat HPV-mediated pathologies...
  14. pmc Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1
    Scott Thompson
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Biomol Screen 15:1107-15. 2010
    ..Further screening in conjunction with medicinal chemistry optimization may provide a selective inhibitor of EBNA1 and EBV latent infection...
  15. pmc Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr Virus
    Nadezhda Tikhmyanova
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    ACS Chem Biol 9:785-95. 2014
    ..We conclude that we have identified a class of small molecule compounds that are highly effective at reactivating latent EBV infection in a variety of cell types and show promise for lytic therapy in combination with GCV. ..
  16. pmc Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis
    Hestia S Mellert
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:4264-70. 2011
    ..This knowledge may impact the rational application of deacetylase inhibitors in the treatment of human cancer...
  17. ncbi Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
    Xu Li
    Department of Molecular and Clinical Pharmacology, City of Hope, Duarte, California 91010, USA
    J Biol Chem 282:36177-89. 2007
    ....
  18. pmc The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression
    Smitha P Sripathy
    Case Western Reserve University, Department of Pharmacology and Case Comprehensive Cancer Center, Cleveland, Ohio 44106 4965, USA
    Mol Cell Biol 26:8623-38. 2006
    ....
  19. ncbi Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling
    Meghan E Pennini
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 176:4323-30. 2006
    ..Chromatin remodeling at MHC2TA is a novel target of inhibition by Mtb. These mechanisms may diminish class II MHC expression by infected macrophages, contributing to immune evasion by Mtb...