Genomes and Genes
Stephen M Maricich
Affiliation: Case Western Reserve University
- Factors in the genetic background suppress the engrailed-1 cerebellar phenotypeNatalie A Bilovocky
Alzheimer Research Laboratory, University Hospitals Research Institute, Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 23:5105-12. 2003..In support of this, C57BL/6-En1-/- embryos that are also En2+/- lack a cerebellum and caudal midbrain: a phenotype identical to 129/Sv-En1-/- mice...
- Rodents rely on Merkel cells for texture discrimination tasksStephen M Maricich
Department of Pediatrics and Departments of Dermatology, Neurosciences, and Otolaryngology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 32:3296-300. 2012..These findings suggest that Merkel cell/neurite complexes are essential for texture discrimination tasks involving glabrous skin but not whiskers...
- Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nucleiStephen M Maricich
Department of Pediatrics and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 29:11123-33. 2009..These new mouse models of predominantly central deafness illuminate the importance of the CN for support of a subset of peripheral and central auditory neurons...
- Mammalian Merkel cells are descended from the epidermal lineageKristin M Morrison
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
Dev Biol 336:76-83. 2009..Thus, mammalian Merkel cells are derived from the skin lineage...
- Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological PhenotypesErin G Reed-Geaghan
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106
J Neurosci 36:4362-76. 2016..We conclude that BDNF produced by Merkel cells during a precise embryonic period guides SAI neuron development, providing the first direct evidence that the skin instructs sensory neuron molecular and functional maturation...
- Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermisStephen M Ostrowski
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA
Development 142:2533-44. 2015....
- Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid bodyWalid Jalabi
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom, Department of Neurobiology and Anatomy, University of Rochester, Rochester, New York 14642, and Richard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15224
J Neurosci 33:15044-9. 2013..These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought. ..
- Peripheral somatosensation: a touch of geneticsErin G Reed-Geaghan
Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, United States
Curr Opin Genet Dev 21:240-8. 2011..Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch...
- Pontocerebellar hypoplasia: review of classification and genetics, and exclusion of several genes known to be important for cerebellar developmentStephen M Maricich
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA
J Child Neurol 26:288-94. 2011..We conclude that classification based on clinical, imaging, and neuropathological findings does not differentiate between pontocerebellar hypoplasia subtypes with different genetic causes...