Danny Manor

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70)
    Krista P Kauppinen
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:21638-44. 2005
  2. doi request reprint Vitamin E trafficking in neurologic health and disease
    Lynn Ulatowski
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Annu Rev Nutr 33:87-103. 2013
  3. pmc Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation
    Elena Kamynina
    Case School of Medicine, WG 48, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 27:1809-22. 2007
  4. pmc Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases
    Meghana Gupta
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 288:14522-30. 2013
  5. doi request reprint Adenovirus modulates Toll-like receptor 4 signaling by reprogramming ORP1L-VAP protein contacts for cholesterol transport from endosomes to the endoplasmic reticulum
    Nicholas L Cianciola
    Departments of Molecular Biology and Microbiology and Nutrition and the Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    J Virol . 2017
  6. pmc Tyrosine phosphorylation of Dbl regulates GTPase signaling
    Meghana Gupta
    From the Departments of Pharmacology, and Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    J Biol Chem 289:17195-202. 2014
  7. pmc Hepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation
    Varsha Thakur
    Department of Nutrition, School of Medicine
    Biochemistry 49:9339-44. 2010

Collaborators

  • Hong Wang
  • Meghana Gupta
  • Varsha Thakur
  • Elena Kamynina
  • Nicholas L Cianciola
  • Stacey Chung
  • Lynn Ulatowski
  • Samantha Morley
  • Nora Muakkassa
  • Faping Duan
  • Krista P Kauppinen
  • Cathleen R Carlin
  • Xiaojun Qi
  • Shayna Brathwaite
  • Gaurav Sharma
  • Krista Kauppinen
  • Jared I Wels

Detail Information

Publications7

  1. ncbi request reprint Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70)
    Krista P Kauppinen
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:21638-44. 2005
    ..We propose that Hsc70 attenuates Dbl activity by maintaining an inactive conformation in which the amino terminus is "folded over" the catalytic DH-PH domain...
  2. doi request reprint Vitamin E trafficking in neurologic health and disease
    Lynn Ulatowski
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Annu Rev Nutr 33:87-103. 2013
    ..The critical roles of this protein and its ligand are underscored by the debilitating pathologies that characterize human carriers of mutations in the TTPA gene. ..
  3. pmc Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation
    Elena Kamynina
    Case School of Medicine, WG 48, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 27:1809-22. 2007
    ..Onco-Dbl, lacking the spectrin homology domain, cannot bind these regulators and therefore accumulates in cells at high levels, leading to persistent stimulation of its downstream signaling pathways...
  4. pmc Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases
    Meghana Gupta
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 288:14522-30. 2013
    ..These findings indicate that Plekhg4 is an aggregation-prone member of the Dbl family GEFs and that regulation of GTPase signaling is critical for proper cerebellar function...
  5. doi request reprint Adenovirus modulates Toll-like receptor 4 signaling by reprogramming ORP1L-VAP protein contacts for cholesterol transport from endosomes to the endoplasmic reticulum
    Nicholas L Cianciola
    Departments of Molecular Biology and Microbiology and Nutrition and the Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    J Virol . 2017
    ..Collectively these data show that RIDα utilizes ORP1L in a way that is distinct from its normal function in uninfected cells to fine-tune lipid raft cholesterol that regulates innate immunity to adenovirus in endosomes...
  6. pmc Tyrosine phosphorylation of Dbl regulates GTPase signaling
    Meghana Gupta
    From the Departments of Pharmacology, and Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    J Biol Chem 289:17195-202. 2014
    ..These findings uncover a novel layer of complexity in the physiological regulation of this protein. ..
  7. pmc Hepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation
    Varsha Thakur
    Department of Nutrition, School of Medicine
    Biochemistry 49:9339-44. 2010
    ..These findings suggest that vitamin E imparts a distinct conformation on TTP that is associated with localization to a specific cellular compartment, where the protein is less susceptible to proteasomal degradation...