Pamela B Davis

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Inflammatory mediators in CF patients
    Jay B Hilliard
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Methods Mol Med 70:409-31. 2002
  2. ncbi request reprint Cystic fibrosis since 1938
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine at Rainbow Babies and Children s Hospital, Cleveland OH 44106, USA
    Am J Respir Crit Care Med 173:475-82. 2006
  3. ncbi request reprint Some like it hot: curcumin and CFTR
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, BRB 8th floor, 2109 Adelbert Road, Cleveland, OH 44106, USA
    Trends Mol Med 10:473-5. 2004
  4. pmc Vectors for airway gene delivery
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    AAPS J 9:E11-7. 2007
  5. ncbi request reprint Relation of sweat chloride concentration to severity of lung disease in cystic fibrosis
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Pediatr Pulmonol 38:204-9. 2004
  6. ncbi request reprint Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution
    Michael W Konstan
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Gene Ther 15:1255-69. 2004
  7. ncbi request reprint Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice
    Anna M van Heeckeren
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 287:L944-52. 2004
  8. pmc The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease
    David P Nichols
    Department of Pediatrics, National Jewish Health K1026, 1400 Jackson St, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 297:L828-36. 2009
  9. pmc Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid
    Xuguang Chen
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Ther 19:93-102. 2011
  10. pmc Peroxisome proliferator-activated receptor-gamma in cystic fibrosis lung epithelium
    Aura Perez
    Deptartment of Pediatrics, School of Medicine, Case Western Reserve University, BRB Bldg R829, 10900 Euclid Ave, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 295:L303-13. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Inflammatory mediators in CF patients
    Jay B Hilliard
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Methods Mol Med 70:409-31. 2002
  2. ncbi request reprint Cystic fibrosis since 1938
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine at Rainbow Babies and Children s Hospital, Cleveland OH 44106, USA
    Am J Respir Crit Care Med 173:475-82. 2006
    ..In the future, treatments directed at the basic defect can be expected, with concomitant improvements in morbidity and mortality...
  3. ncbi request reprint Some like it hot: curcumin and CFTR
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, BRB 8th floor, 2109 Adelbert Road, Cleveland, OH 44106, USA
    Trends Mol Med 10:473-5. 2004
    ..Although other laboratories have not been able to confirm the initial observations, activating DeltaF508 CFTR could have such important therapeutic implications that a thorough investigation of the potential of curcumin is warranted...
  4. pmc Vectors for airway gene delivery
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    AAPS J 9:E11-7. 2007
    ..Considerable advances in the understanding of the cellular uptake and expression of these agents and in their practical utility have occurred in the last few years; these advances are reviewed here...
  5. ncbi request reprint Relation of sweat chloride concentration to severity of lung disease in cystic fibrosis
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Pediatr Pulmonol 38:204-9. 2004
    ..These data suggest that, by itself, sweat chloride concentration does not necessarily predict a milder pulmonary course in patients with cystic fibrosis...
  6. ncbi request reprint Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution
    Michael W Konstan
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Gene Ther 15:1255-69. 2004
    ..In conclusion, compacted DNA nanoparticles can be safely administered to the nares of CF subjects, with evidence of vector gene transfer and partial NPD correction...
  7. ncbi request reprint Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice
    Anna M van Heeckeren
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 287:L944-52. 2004
    ..Therefore, it appears that any functional defect in CFTR produces comparable inflammatory responses to lung infections with P. aeruginosa...
  8. pmc The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease
    David P Nichols
    Department of Pediatrics, National Jewish Health K1026, 1400 Jackson St, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 297:L828-36. 2009
    ..As these two signaling pathways appear to be pivotal in regulating the net inflammatory response in the CF airway, these compounds are a promising potential anti-inflammatory therapy for CF lung disease...
  9. pmc Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid
    Xuguang Chen
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Ther 19:93-102. 2011
    ..Taken together, our findings shed light on important determinants of DNP trafficking in cells and support the notion that nucleolin is a good target for nonviral gene delivery...
  10. pmc Peroxisome proliferator-activated receptor-gamma in cystic fibrosis lung epithelium
    Aura Perez
    Deptartment of Pediatrics, School of Medicine, Case Western Reserve University, BRB Bldg R829, 10900 Euclid Ave, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 295:L303-13. 2008
    ..aeruginosa in CF, but not wild-type, mice. In summary, PPARgamma inhibits the inflammatory response in CF, at least in part by interaction with NF-kappaB in airway epithelial cells. PPARgamma agonists may be therapeutic in CF...
  11. pmc Non-covalent ligand conjugation to biotinylated DNA nanoparticles using TAT peptide genetically fused to monovalent streptavidin
    Wenchao Sun
    Department of Biochemistry, Case Western Reserve University Schoolof Medicine, Cleveland, Ohio 44106, USA
    J Drug Target 20:678-90. 2012
    ..In vivo studies showed that TAT modified DNA NPs mediated equal level of gene transfer to the mouse airways via the luminal route compared to unmodified DNA NPs...
  12. ncbi request reprint Cell surface nucleolin serves as receptor for DNA nanoparticles composed of pegylated polylysine and DNA
    Xuguang Chen
    Department of Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Mol Ther 16:333-42. 2008
    ..Therefore, the data strongly suggest that cell surface nucleolin serves as a receptor for DNA nanoparticles, and that nucleolin is essential for internalization and/or transport of the nanoparticles from cell surface to the nucleus...
  13. pmc Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice
    Anna M van Heeckeren
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Am J Respir Crit Care Med 173:288-96. 2006
    ....
  14. doi request reprint Methods for evaluating inflammation in cystic fibrosis
    Assem G Ziady
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 742:51-76. 2011
    ..Our discussion will describe the character of pulmonary inflammation in CF and present potential therapeutic approaches that can ameliorate excessive responses and improve disease prognosis...
  15. ncbi request reprint Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator
    Sanhita Gupta
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 6006, USA
    Am J Respir Cell Mol Biol 30:242-8. 2004
    ..Particularly, the last 22 a.a. residues (838-859) of R are essential for this binding. R-R interaction possibly plays a role in channel gating...
  16. ncbi request reprint Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung
    Assem Galal Ziady
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106 6006, USA
    Mol Ther 8:948-56. 2003
    ..This favorable toxicity profile encourages development of stabilized compacted DNA for airway administration...
  17. pmc Reducible DNA nanoparticles enhance in vitro gene transfer via an extracellular mechanism
    Wenchao Sun
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Control Release 146:118-27. 2010
    ..These results provided further insight into the mechanisms of in vitro gene transfer enhancement by introducing reducible linkages, contributing to the rational design of more efficient non-viral gene delivery systems...
  18. ncbi request reprint CFTR inhibition mimics the cystic fibrosis inflammatory profile
    Aura Perez
    Department of Pediatrics, School of Medicine, Case Western Reserve University, BRB Bldg R829, 10900 Euclid Ave, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 292:L383-95. 2007
    ..Our results support the hypothesis that lack of CFTR activity is responsible for the onset of the inflammatory cascade in the CF lung...
  19. pmc Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis
    Michael W Konstan
    Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Am J Respir Crit Care Med 176:1084-9. 2007
    ..High-dose ibuprofen in a 4-year controlled trial slowed FEV(1) decline in young subjects with cystic fibrosis, but the effectiveness of ibuprofen has not been assessed in a large group of patients treated clinically with this therapy...
  20. pmc Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice
    Anna M van Heeckeren
    Case Western Reserve University School of Medicine, Cleveland, Ohio Hospital San Rafael, La Coruna, Spain
    Infect Immun 72:1479-86. 2004
    ..In conclusion, diet and docosahexaenoic acid imbalances alone are unlikely to explain the differences in the host response to lung infections with mucoid P. aeruginosa between mice with cystic fibrosis and their wild-type counterparts...
  21. ncbi request reprint Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Case Western Reserve Univ School of Medicine, Biomedical Research Bldg 827, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 286:L717-26. 2004
    ..In conclusion, the observed survival advantage of adenoviral delivery of CFTR to the CF lung may be due either to CFTR expression or possibly to proinflammatory effects of the adenoviral vector, or both...
  22. pmc S163 is critical for FXYD5 modulation of wound healing in airway epithelial cells
    Timothy J Miller
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Wound Repair Regen 16:791-9. 2008
    ..0001). We conclude that negative charge at S163 regulates FXYD5/Na,K-ATPase interaction and that this interaction modulates cell migration across a wound in airway epithelial cells...
  23. ncbi request reprint Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor
    Assem Galal Ziady
    Department of Pediatrics at Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Mol Ther 5:413-9. 2002
    ..Molecular conjugates targeting the serpin-enzyme complex receptor, used to compact plasmid DNA, hold promise for gene therapy of cystic fibrosis...
  24. ncbi request reprint Current prospects for gene therapy of cystic fibrosis
    Assem G Ziady
    Department of Pediatrics, Case Western Reserve University, School of Medicine, BRB 826, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Curr Opin Pharmacol 6:515-21. 2006
    ..Improvements of viral and non-viral vectors continue to advance the construction of stable, safe and efficacious vectors that can be re-administered...
  25. pmc Antibodies to the polymeric immunoglobulin receptor with different binding and trafficking patterns
    Sanhita Gupta
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Am J Respir Cell Mol Biol 33:363-70. 2005
    ..Different binding sites probably account for the different trafficking of these Mabs and may predict differential therapeutic utility...
  26. ncbi request reprint Gene profile changes after Pseudomonas aeruginosa exposure in immortalized airway epithelial cells
    Aura Perez
    Department of Pediatrics, Case Western Reserve University at Rainbow Babies and Children s Hospital, Cleveland, OH 44106 4948, USA
    J Struct Funct Genomics 5:179-94. 2004
    ..However, there were substantial quantitative differences in gene expression. Thus, the difference between CF and normal resides in the magnitude, not the pattern, of the changes...
  27. ncbi request reprint Non-viral gene transfer therapy for cystic fibrosis
    Assem G Ziady
    Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Expert Opin Biol Ther 3:449-58. 2003
    ..modifying the plasmid DNA to reduce inflammatory CpG sequences and enhance intensity, duration and tissue specificity of expression, and iv). modification of the complexes to improve nuclear access...
  28. ncbi request reprint Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects
    Michael W Konstan
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    J Pharmacol Exp Ther 306:1086-91. 2003
    ....
  29. pmc Genetic variation and clinical heterogeneity in cystic fibrosis
    Mitchell L Drumm
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Annu Rev Pathol 7:267-82. 2012
    ..Such studies are providing new insights into the disease, such as altered apoptotic responses, oxidative stress dysregulation, and neuronal involvement, all of which may open new therapeutic avenues to exploration...
  30. pmc Relation of exaggerated cytokine responses of CF airway epithelial cells to PAO1 adherence
    Dianne M Kube
    Department of Pediatrics, Case Western Reserve University School of Medicine, BRB 8th floor, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Respir Res 6:69. 2005
    ....
  31. ncbi request reprint Jointly modelling the relationship between survival and pulmonary function in cystic fibrosis patients
    Mark D Schluchter
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH, USA
    Stat Med 21:1271-87. 2002
    ..s.a...
  32. ncbi request reprint Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts
    Thomas Ferkol
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Respir Crit Care Med 167:1374-9. 2003
    ....
  33. ncbi request reprint Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivo
    Assem Galal Ziady
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Ther 8:936-47. 2003
    ..Stable compacted DNA nanoparticles transfer exogenous genes to airway epithelium and show promise for lung gene therapy...
  34. ncbi request reprint Receptor-directed molecular conjugates for gene transfer
    Assem G Ziady
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
    Methods Mol Med 69:25-48. 2002
  35. ncbi request reprint A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification
    Junxia Xie
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 277:23019-27. 2002
    ..We speculate that the NEG2 region interacts with other cytosolic domains of CFTR to control opening and closing transitions of the chloride channel...
  36. doi request reprint FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia
    Timothy J Miller
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Physiol Lung Cell Mol Physiol 294:L654-64. 2008
    ..001), which was abrogated by an inhibitor of NF-kappaB. Thus FXYD5 is upregulated in CF epithelia, and this change may exacerbate the Na(+) hyperabsorption and surface liquid dehydration observed in CF airway epithelia...
  37. ncbi request reprint Cystic fibrosis: a review of epidemiology and pathobiology
    Steven D Strausbaugh
    Division of Pediatric Pulmonology, Rainbow Babies and Children s Hospital and University Hospitals at Case, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 6006, USA
    Clin Chest Med 28:279-88. 2007
    ..This article reviews some of the key epidemiologic and pathobiologic factors discovered thus far...
  38. ncbi request reprint Pharmacological approaches for the discovery and development of new anti-inflammatory agents for the treatment of cystic fibrosis
    Michael W Konstan
    Department of Pediatrics, Case Western Reserve University School of Medicine and Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Adv Drug Deliv Rev 54:1409-23. 2002
    ....
  39. pmc State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine at Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Respir Res 4:8. 2003
    ..Until a cure is discovered, further investigations into therapies that relieve obstruction, control infection, and attenuate inflammation offer the best hope of limiting damage to host tissues and prolonging survival...
  40. ncbi request reprint Pacing the marathon: rate of decline of pulmonary function in cystic fibrosis
    Pamela B Davis
    J Pediatr 151:111-3. 2007