James F Chmiel

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    Treat Respir Med 4:255-73. 2005
  2. pmc Antibiotic and anti-inflammatory therapies for cystic fibrosis
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106
    Cold Spring Harb Perspect Med 3:a009779. 2013
  3. doi request reprint Anti-inflammatory therapies for cystic fibrosis-related lung disease
    David P Nichols
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Clin Rev Allergy Immunol 35:135-53. 2008
  4. pmc Sputum biomarkers of inflammation in cystic fibrosis lung disease
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA
    Proc Am Thorac Soc 4:406-17. 2007
  5. ncbi request reprint The role of inflammation in the pathophysiology of CF lung disease
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine, Division of Pediatric Pulmonology, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Clin Rev Allergy Immunol 23:5-27. 2002
  6. ncbi request reprint Inflammation and anti-inflammatory therapies for cystic fibrosis
    James F Chmiel
    Division of Pediatric Pulmonology, Department of Pediatrics, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Clin Chest Med 28:331-46. 2007
  7. pmc The role of inhaled corticosteroids in the management of cystic fibrosis
    Kristie R Ross
    Department of Pediatrics, Division of Pulmonology, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    Paediatr Drugs 11:101-13. 2009
  8. ncbi request reprint Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice
    James F Chmiel
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 165:1176-81. 2002
  9. doi request reprint Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis
    James F Chmiel
    Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA Electronic address
    J Cyst Fibros 14:720-6. 2015
  10. pmc Clinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders
    Samuel M Moskowitz
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195 7740, USA
    Genet Med 10:851-68. 2008

Detail Information

Publications14

  1. ncbi request reprint Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    Treat Respir Med 4:255-73. 2005
    ..Until those therapies aimed at repairing the basic defect are realized, limiting the effects of the inflammatory process will be important in slowing the decline in lung function and thus prolonging survival in patients with CF...
  2. pmc Antibiotic and anti-inflammatory therapies for cystic fibrosis
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106
    Cold Spring Harb Perspect Med 3:a009779. 2013
    ..It is likely that antibiotics and anti-inflammatory drugs will remain an important part of the maintenance regimen for CF in the foreseeable future. Current and future antibiotic and anti-inflammatory therapies for CF are reviewed. ..
  3. doi request reprint Anti-inflammatory therapies for cystic fibrosis-related lung disease
    David P Nichols
    Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Clin Rev Allergy Immunol 35:135-53. 2008
    ..Available data from studies commenced over the last two decades, which have generated both encouraging and disappointing results, are reviewed below...
  4. pmc Sputum biomarkers of inflammation in cystic fibrosis lung disease
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA
    Proc Am Thorac Soc 4:406-17. 2007
    ..In the future, pulmonary biomarkers will likely be useful in predicting disease progression, indicating the onset and resolution of a pulmonary exacerbation, and assessing response to current therapies or candidate therapeutics...
  5. ncbi request reprint The role of inflammation in the pathophysiology of CF lung disease
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine, Division of Pediatric Pulmonology, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Clin Rev Allergy Immunol 23:5-27. 2002
    ....
  6. ncbi request reprint Inflammation and anti-inflammatory therapies for cystic fibrosis
    James F Chmiel
    Division of Pediatric Pulmonology, Department of Pediatrics, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Clin Chest Med 28:331-46. 2007
    ..This article reviews the current state of the art of anti-inflammatory therapy in cystic fibrosis and introduces clinical trials that are underway...
  7. pmc The role of inhaled corticosteroids in the management of cystic fibrosis
    Kristie R Ross
    Department of Pediatrics, Division of Pulmonology, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    Paediatr Drugs 11:101-13. 2009
    ..This review provides an overview of the inflammatory response in CF, the mechanisms of action of corticosteroids, the safety of ICS, and the literature relevant to the use of ICS in CF...
  8. ncbi request reprint Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice
    James F Chmiel
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 165:1176-81. 2002
    ..These data suggest that IL-10 deficiency contributes to prolonged inflammatory responses early in CF, when infection may be transient...
  9. doi request reprint Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis
    James F Chmiel
    Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA Electronic address
    J Cyst Fibros 14:720-6. 2015
    ..High-dose ibuprofen (HDI) is a clinically beneficial anti-inflammatory regimen that may be a useful reagent to study induced sputum inflammatory marker changes over short study periods appropriate for early-phase CF clinical trials...
  10. pmc Clinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders
    Samuel M Moskowitz
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195 7740, USA
    Genet Med 10:851-68. 2008
    ..Widespread implementation of newborn screening programs among populations with significant cystic fibrosis mutation carrier frequencies is expected to result in increasing demands on genetic counseling resources...
  11. ncbi request reprint Murine models of CF airway infection and inflammation
    James F Chmiel
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Methods Mol Med 70:495-515. 2002
  12. ncbi request reprint Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosis
    Claudia L Ordonez
    Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA
    Am J Respir Crit Care Med 168:1471-5. 2003
    ..Seven of 127 (6%) sputum induction procedures showed a decrease in FEV1 of 20% or more. We conclude that markers in induced sputum may be useful, noninvasive outcome measures to assess response to therapies in cystic fibrosis studies...
  13. pmc Preliminary comparison of normalized T1 and non-contrast perfusion MRI assessments of regional lung disease in cystic fibrosis patients
    Shannon B Donnola
    Department of Radiology, Case Western Reserve University, Cleveland, OH, USA
    J Cyst Fibros . 2015
    ..In this study, we compare the sensitivity of normalized T1 (nT1) and non-contrast perfusion MRI techniques to detect regional lung disease in CF patients...
  14. pmc State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?
    James F Chmiel
    Department of Pediatrics, Case Western Reserve University School of Medicine at Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Respir Res 4:8. 2003
    ..Until a cure is discovered, further investigations into therapies that relieve obstruction, control infection, and attenuate inflammation offer the best hope of limiting damage to host tissues and prolonging survival...