Bertrand L Jaber

Summary

Affiliation: Caritas St. Elizabeth's Medical Center
Country: USA

Publications

  1. doi request reprint Scope and design of the Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements (FREEDOM) Study
    Bertrand L Jaber
    Tufts University School of Medicine, Boston, MA, USA
    Am J Kidney Dis 53:310-20. 2009
  2. pmc Impact of short daily hemodialysis on restless legs symptoms and sleep disturbances
    Bertrand L Jaber
    St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Clin J Am Soc Nephrol 6:1049-56. 2011
  3. pmc Hospital-acquired acute kidney injury: an analysis of nadir-to-peak serum creatinine increments stratified by baseline estimated GFR
    Jose Calvo Broce
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 6:1556-65. 2011
  4. doi request reprint Effect of daily hemodialysis on depressive symptoms and postdialysis recovery time: interim report from the FREEDOM (Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements) Study
    Bertrand L Jaber
    Tufts University School of Medicine, St Elizabeth s Medical Center, Tufts Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 56:531-9. 2010
  5. ncbi request reprint Plasma interleukin-6 predicts cardiovascular mortality in hemodialysis patients
    Madhumathi Rao
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 45:324-33. 2005
  6. ncbi request reprint Cytokine gene polymorphisms in hemodialysis patients: association with comorbidity, functionality, and serum albumin
    Vaidyanathapuram S Balakrishnan
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 65:1449-60. 2004
  7. ncbi request reprint Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    J Am Soc Nephrol 18:904-12. 2007
  8. pmc Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Biomarkers 14:423-31. 2009
  9. pmc Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes
    Mary C Perianayagam
    Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Kidney Int 82:909-19. 2012
  10. ncbi request reprint Reprocessed (high-flux) Polyflux dialyzers resist trans-membrane endotoxin passage and attenuate inflammatory markers
    Geoffrey S Teehan
    Dialysis Research Laboratory, Division of Nephrology, Tufts New England Medical Center, Boston, Mass, USA
    Blood Purif 22:329-37. 2004

Research Grants

Detail Information

Publications79

  1. doi request reprint Scope and design of the Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements (FREEDOM) Study
    Bertrand L Jaber
    Tufts University School of Medicine, Boston, MA, USA
    Am J Kidney Dis 53:310-20. 2009
    ..The objectives of the Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements Study are to evaluate outcomes of DHD (6 times/wk) with the NxStage System One (NxStage Medical Inc, Lawrence, MA) device...
  2. pmc Impact of short daily hemodialysis on restless legs symptoms and sleep disturbances
    Bertrand L Jaber
    St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Clin J Am Soc Nephrol 6:1049-56. 2011
    ..Restless legs syndrome (RLS) and sleep disturbances are common among in-center hemodialysis patients and are associated with increased morbidity/mortality...
  3. pmc Hospital-acquired acute kidney injury: an analysis of nadir-to-peak serum creatinine increments stratified by baseline estimated GFR
    Jose Calvo Broce
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 6:1556-65. 2011
    ..The objective of this study was to establish whether baseline estimated GFR (eGFR) provides additional risk stratification to sCr-based increments for defining AKI...
  4. doi request reprint Effect of daily hemodialysis on depressive symptoms and postdialysis recovery time: interim report from the FREEDOM (Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements) Study
    Bertrand L Jaber
    Tufts University School of Medicine, St Elizabeth s Medical Center, Tufts Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 56:531-9. 2010
    ..Clinical depression and postdialysis fatigue are important concerns for patients with kidney failure and can have a negative impact on quality of life and survival...
  5. ncbi request reprint Plasma interleukin-6 predicts cardiovascular mortality in hemodialysis patients
    Madhumathi Rao
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 45:324-33. 2005
    ....
  6. ncbi request reprint Cytokine gene polymorphisms in hemodialysis patients: association with comorbidity, functionality, and serum albumin
    Vaidyanathapuram S Balakrishnan
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 65:1449-60. 2004
    ....
  7. ncbi request reprint Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    J Am Soc Nephrol 18:904-12. 2007
    ..78 (95% CI 0.71 to 0.84) in predicting the composite outcome. Urinary markers of kidney injury such as NAG and KIM-1 can predict adverse clinical outcomes in patients with ARF...
  8. pmc Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Biomarkers 14:423-31. 2009
    ..006). In this small pilot cohort, KIM-1 performed best as an early biomarker for AKI. Larger studies are needed to explore further the role of biomarkers for early detection of AKI following cardiac surgery...
  9. pmc Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes
    Mary C Perianayagam
    Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Kidney Int 82:909-19. 2012
    ..In summary, our two-step genetic association study identified several polymorphisms spanning the entire MPO gene locus and a common haplotype marker for patients at risk for acute kidney injury...
  10. ncbi request reprint Reprocessed (high-flux) Polyflux dialyzers resist trans-membrane endotoxin passage and attenuate inflammatory markers
    Geoffrey S Teehan
    Dialysis Research Laboratory, Division of Nephrology, Tufts New England Medical Center, Boston, Mass, USA
    Blood Purif 22:329-37. 2004
    ..Clinical correlation with pre-dialysis levels of systemic markers of inflammation, and clearance of middle molecules was also assessed in vivo...
  11. ncbi request reprint NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure
    Mary C Perianayagam
    Division of Nephrology, Kidney and Dialysis Research Laboratory, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    J Am Soc Nephrol 18:255-63. 2007
    ..02). The polymorphism in the gene that encodes the NADPH oxidase p22phox subunit at position +242 is associated with dialysis requirement or hospital death among patients with ARF. Larger studies are needed to confirm these relationships...
  12. pmc A genetic variant of hypoxia-inducible factor-1alpha is associated with adverse outcomes in acute kidney injury
    Alexey Y Kolyada
    Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Kidney Int 75:1322-9. 2009
    ..Despite the limited cohort size, our study found this particular HIF-1alpha genetic variant to be associated with disease severity and adverse outcomes in AKI. Larger studies are needed to confirm these relationships...
  13. pmc Plasma adiponectin levels and clinical outcomes among haemodialysis patients
    Madhumathi Rao
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center Hospitals, Box 391, 750 Washington Street, Boston, MA 02111, USA
    Nephrol Dial Transplant 23:2619-28. 2008
    ..Adiponectin (ADPN) levels are consistently elevated among patients with advanced chronic kidney disease, but its relationship with cardiovascular outcomes in this population remains controversial...
  14. pmc Tumor necrosis factor alpha promoter polymorphism and severity of acute kidney injury
    Paweena Susantitaphong
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Nephron Clin Pract 123:67-73. 2013
    ..Tumor necrosis factor-alpha is a proinflammatory cytokine that has been implicated in the pathobiology of acute kidney injury (AKI)...
  15. ncbi request reprint Factors associated with urea reduction ratio in acute renal failure
    Orfeas Liangos
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA 02135, USA
    Artif Organs 28:1076-81. 2004
    ....
  16. pmc Interleukin-8 and acute kidney injury following cardiopulmonary bypass: a prospective cohort study
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Nephron Clin Pract 113:c148-54. 2009
    ..We hypothesized that acute kidney injury (AKI) following CPB might be mediated by IL-8 and examined the association of perioperative plasma IL-8 levels with AKI in a prospective cohort...
  17. doi request reprint Serum cystatin C for prediction of dialysis requirement or death in acute kidney injury: a comparative study
    Mary C Perianayagam
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 54:1025-33. 2009
    ..However, its utility and performance in patients with acute kidney injury (AKI), particularly for the prediction of dialysis requirement, is not well known...
  18. ncbi request reprint Cytokine gene promoter polymorphisms and mortality in acute renal failure
    Bertrand L Jaber
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Cytokine 25:212-9. 2004
    ..Although cytokines play a pivotal role in the inflammatory responses that mediate the severity of acute renal failure (ARF), the importance of pro- and anti-inflammatory cytokine gene promoter polymorphisms has been unexplored...
  19. ncbi request reprint Dialyzer membrane type and reuse practice influence polymorphonuclear leukocyte function in hemodialysis patients
    Madhumathi Rao
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 65:682-91. 2004
    ..Polymorphonuclear leukocyte (PMNL) production of reactive oxygen species (ROS) has been linked to hemodialysis (HD) associated morbidity. The effect of dialyzer membrane type and reuse on PMNL function has not been clearly defined...
  20. ncbi request reprint Daily hemofiltration for end-stage renal disease: a feasibility and efficacy trial
    Bertrand L Jaber
    Division of Nephrology, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Blood Purif 22:481-9. 2004
    ..The aim of this feasibility study was to validate and assess the efficacy of DHF (6 times/week) as an alternative to CHD (3 times/week) in patients with ESRD...
  21. pmc Association of functional kallikrein-1 promoter polymorphisms and acute kidney injury: a case-control and longitudinal cohort study
    Paweena Susantitaphong
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, Mass, USA
    Nephron Clin Pract 122:107-13. 2012
    ..Kallikrein-1 (KLK1) is a highly conserved serine protease that is expressed in the kidney and involved in blood pressure regulation. The activity of this enzyme is diminished in acute kidney injury (AKI)...
  22. ncbi request reprint Protective effect of erythropoietin against radiocontrast-induced renal tubular epithelial cell injury
    Alexey Y Kolyada
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, Caritas St Elizabeth s Medical Center, Boston, Mass 02135, USA
    Am J Nephrol 28:203-9. 2008
    ..Recombinant human erythropoietin (rhEpo) has been shown to reduce tissue injury following ischemia-reperfusion. We examined whether rhEpo protects in vitro renal tubular epithelial cells against radiocontrast media-induced injury...
  23. doi request reprint Sevelamer hydrochloride use and circulating endotoxin in hemodialysis patients: a pilot cross-sectional study
    Phyllis P Sun
    Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Ren Nutr 19:432-8. 2009
    ..This study explores the hypothesis that sevelamer hydrochloride binds bacterial endotoxin in the intestinal tract, leading to lower circulating endotoxin levels, and offering a novel anti-inflammatory mechanism...
  24. ncbi request reprint A systematic review of the effect of the Excebrane dialyser on biomarkers of lipid peroxidation
    Marie Anne Sosa
    Department of Medicine, Tufts University School of Medicine, Boston, MA 02135, USA
    Nephrol Dial Transplant 21:2825-33. 2006
    ..We conducted a systematic review and meta-analysis to examine the effect of Excebrane, a vitamin E-coated cellulose-based dialyser, on circulating biomarkers of lipid peroxidation, as surrogate markers of oxidative stress...
  25. pmc Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study
    Orfeas Liangos
    Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Biomarkers 15:436-45. 2010
    ..Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality...
  26. ncbi request reprint Cytokine single nucleotide polymorphism. Role in acute renal failure
    Orfeas Liangos
    Dialysis Research Laboratory, Division of Nephrology, Tufts New England Medical Center, Boston, Mass, USA
    Contrib Nephrol 144:63-75. 2004
    ..4). Ultimately, cytokine-modulating therapies could be employed on the basis of genotypic risk stratification with the goal to prevent kidney injury or minimize its deleterious effects on patient outcome...
  27. ncbi request reprint Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients
    Madhumathi Rao
    Division of Nephrology and Division of Biostatistics and Clinical Care Research, Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 66:419-27. 2004
    ....
  28. doi request reprint Urinary α- and π-glutathione s-transferases for early detection of acute kidney injury following cardiopulmonary bypass
    Paweena Susantitaphong
    Kidney and Dialysis Research Laboratory, Department of Medicine, Division of Nephrology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Biomarkers 18:331-7. 2013
    ..Urinary α-GST and π-GST are renal tubular leakage markers...
  29. doi request reprint Effect of ultrapure dialysate on markers of inflammation, oxidative stress, nutrition and anemia parameters: a meta-analysis
    Paweena Susantitaphong
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 28:438-46. 2013
    ..We conducted a meta-analysis that examined the effect of ultrapure versus standard dialysate on markers of inflammation, oxidative stress, nutrition and anemia parameters...
  30. pmc GFR at initiation of dialysis and mortality in CKD: a meta-analysis
    Paweena Susantitaphong
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 59:829-40. 2012
    ..Recent data suggest that higher GFR may be associated with increased mortality...
  31. ncbi request reprint Effect of methyl derivatives of dopamine on tumor necrosis factor alpha and lipid peroxidation
    Mary C Perianayagam
    Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge St, Boston, MA 01235, USA
    Ann N Y Acad Sci 1122:253-9. 2007
    ..Our results indicated that the inhibitory effect of NAS, NAD, NMD, or 4-O-MD on LPS-induced TNF-alpha production and FeCl(2)-stimulated lipid peroxidation is robust and dose dependent...
  32. ncbi request reprint Inflammatory biomarkers and cardiovascular risk: association or cause and effect?
    Madhumathi Rao
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Semin Dial 19:129-35. 2006
    ..This review discusses the available evidence that argues for and against a causal role for inflammatory biomarkers, with specific reference to CRP, in the atherosclerotic process...
  33. ncbi request reprint Polymorphism of host response genes: implications in the pathogenesis and treatment of acute renal failure
    Bertrand L Jaber
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Kidney Int 67:14-33. 2005
    ..Conclusions are drawn on the application of genetic epidemiology to the field of ARF and the rationale for further research on the role of genetic markers in ARF...
  34. ncbi request reprint Genomic medicine, gene polymorphisms, and human biological diversity
    Vaidyanathapuram S Balakrishnan
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Semin Dial 18:37-40. 2005
    ..This review provides a broad overview of recent developments in this field, basic information and terminology in common use, and explores the impact of genetic variations or polymorphisms on human biological diversity...
  35. pmc Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury
    Ahsan Alam
    Division of Nephrology, Tufts Medical Center, Boston, Mass, USA
    Nephron Clin Pract 114:c253-9. 2010
    ..We studied single nucleotide polymorphisms (SNPs) of phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholaminergic pathway, and their association with adverse outcomes in AKI...
  36. ncbi request reprint Immune-modulating effects of melatonin, N-acetylserotonin, and N-acetyldopamine
    Mary C Perianayagam
    Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, Massachusetts 02135, USA
    Ann N Y Acad Sci 1053:386-93. 2005
    ..These compounds are equally effective in attenuating the generation of oxidant radicals, although to a lesser degree...
  37. pmc Efficacy and safety of combined vs. single renin-angiotensin-aldosterone system blockade in chronic kidney disease: a meta-analysis
    Paweena Susantitaphong
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA, USA
    Am J Hypertens 26:424-41. 2013
    ..We conducted a meta-analysis of all randomized controlled trials comparing the efficacy and safety of combined vs. single RAAS blockade therapy in chronic kidney disease (CKD)...
  38. pmc Dose of erythropoiesis-stimulating agents and adverse outcomes in CKD: a metaregression analysis
    Ioannis Koulouridis
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 61:44-56. 2013
    ..Targeting higher hemoglobin levels with erythropoiesis-stimulating agents (ESAs) to treat the anemia of chronic kidney disease (CKD) is associated with increased cardiovascular risk...
  39. ncbi request reprint Gene polymorphism association studies in dialysis: cardiovascular disease
    Madhumathi Rao
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Semin Dial 18:217-25. 2005
    ....
  40. pmc Mitochondrial DNA injury and mortality in hemodialysis patients
    Madhumathi Rao
    Tufts New England Medical Center, 35 Kneeland Street, Boston, MA 02111, USA
    J Am Soc Nephrol 20:189-96. 2009
    ..Although further exploration of these associations is needed, evaluation of mitochondrial DNA copy number and somatic mtDNA mutations may provide simple genomic biomarkers to predict clinical outcomes among patients with ESRD...
  41. ncbi request reprint Polymorphism of immunomodulatory cytokine genes: implications in acute renal failure
    Bertrand L Jaber
    Dialysis Research Laboratory, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood Purif 22:101-11. 2004
    ..Conclusions are drawn on the application of genetic epidemiology to the field of ARF and the rationale for further research on the role of genetic markers in ARF...
  42. ncbi request reprint Model for gene-environment interaction: the case for dialysis
    Orfeas Liangos
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Semin Dial 18:41-6. 2005
    ..Methodologic limitations of the existing published data, the need for large prospective cohort studies, and potential future risks for the use of genomic information in resource allocation are also highlighted...
  43. doi request reprint Acute oxalate nephropathy associated with Clostridium difficile colitis
    Abraham Cohen-Bucay
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA Electronic address
    Am J Kidney Dis 63:113-8. 2014
    ..We discuss potential mechanisms, including increased colonic permeability to oxalate. We conclude that C difficile-associated diarrhea is a potential cause of acute oxalate nephropathy. ..
  44. doi request reprint Urinary α-GST and π-GST for prediction of dialysis requirement or in-hospital death in established acute kidney injury
    Victor F Seabra
    Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA, USA
    Biomarkers 16:709-17. 2011
    ..Urinary α-glutathione S-transferase (α-GST) and π-glutathione S-transferase (π-GST) are promising proximal and distal tubular leakage markers for early detection of acute kidney injury (AKI)...
  45. doi request reprint Multiple organ dysfunction syndrome in children with sepsis: role of genetic factors
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center and Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA
    Semin Nephrol 28:499-509. 2008
    ..The current pertinent literature is comprehensively reviewed and limitations and future directions are discussed...
  46. ncbi request reprint Insulin therapy and acute kidney injury in critically ill patients a systematic review
    George Thomas
    Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    Nephrol Dial Transplant 22:2849-55. 2007
    ..We performed a systematic review and meta-analysis to ascertain the effect of intensive insulin therapy on the incidence of acute kidney injury (AKI) in adult critically ill patients...
  47. pmc Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized controlled trials
    Victor F Seabra
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Clin J Am Soc Nephrol 5:1734-44. 2010
    ..This meta-analysis compares these two surgical techniques with respect to causing acute kidney injury (AKI)...
  48. ncbi request reprint Relationship of urine output to dialysis initiation and mortality in acute renal failure
    Orfeas Liangos
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
    Nephron Clin Pract 99:c56-60. 2005
    ..The present study explores the relationship between urine volume and the start of dialysis and hospital mortality in patients with ARF...
  49. pmc Short- and long-term effects of alkali therapy in chronic kidney disease: a systematic review
    Paweena Susantitaphong
    Division of Nephrology, Kidney and Dialysis Research Laboratory, Department of Medicine, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Nephrol 35:540-7. 2012
    ..We systematically reviewed the effect of sodium bicarbonate on benefits and harms in patients with CKD...
  50. pmc Effect of frequent or extended hemodialysis on cardiovascular parameters: a meta-analysis
    Paweena Susantitaphong
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 59:689-99. 2012
    ..Increased left ventricular (LV) mass is a risk factor for cardiovascular mortality in patients with chronic kidney failure. More frequent or extended hemodialysis (HD) has been hypothesized to have a beneficial effect on LV mass...
  51. ncbi request reprint Progression of chronic kidney disease: can it be prevented or arrested?
    Bertrand L Jaber
    Department of Medicine, Tufts University School of Medicine, Caritas St Elizabeth s Medical Center, Boston, Mass 02135, USA
    Am J Med 118:1323-30. 2005
    ..Such a concerted, multifaceted approach to management might indeed prevent or arrest progression of chronic kidney disease, or even achieve regression of chronic kidney disease...
  52. pmc Effect of intra-dialytic, low-intensity strength training on functional capacity in adult haemodialysis patients: a randomized pilot trial
    Joline L T Chen
    The Renal Section, Boston University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 25:1936-43. 2010
    ..However, the effect of low-intensity strength training has not been well documented, thus representing the objective of this pilot study...
  53. ncbi request reprint Update on dialytic management of acute renal failure
    Geoffrey S Teehan
    Division of Nephrology, Tupper Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Intensive Care Med 18:130-8. 2003
    ..However, dosing strategies during CRRT are promising. Finally, the application of cell therapy to the successful substitution of renal function shows promise for the future...
  54. ncbi request reprint Iron storage indices: novel predictors of bacteremia in hemodialysis patients initiating intravenous iron therapy
    Geoffrey S Teehan
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 38:1090-4. 2004
    ..2) were also at increased risk. Modest iron storage levels may increase the risk of bacteremia among HD patients initiating intravenous iron therapy. Additional studies are needed to confirm these relationships...
  55. pmc Short-term efficacy and safety of vasopressin receptor antagonists for treatment of hyponatremia
    Bertrand L Jaber
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Med 124:977.e1-9. 2011
    ..We performed a meta-analysis to systematically measure efficacy and safety of vasopressin receptor antagonists (VRAs) tested in randomized controlled trials for treatment of hyponatremia...
  56. ncbi request reprint Long-term management of the tunneled venous catheter
    Orfeas Liangos
    Department of Medicine, Tufts University School of Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Semin Dial 19:158-64. 2006
    ..However, these measures should not detract from the goal of avoiding or limiting the long-term use of catheters, thereby optimizing vascular access management by ensuring the timely availability of functioning arteriovenous fistulas...
  57. ncbi request reprint Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey
    Orfeas Liangos
    Division of Nephrology, Tufts New England Medical Center, Boston, MA, USA
    Clin J Am Soc Nephrol 1:43-51. 2006
    ..These findings suggest that in the United States, ARF is associated with increased in-hospital and post-hospitalization resource utilization...
  58. doi request reprint Endotoxin-binding affinity of sevelamer hydrochloride
    Mary C Perianayagam
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Am J Nephrol 28:802-7. 2008
    ..We hypothesize that sevelamer hydrochloride binds bacterial endotoxin (ET) resulting in a decrease in ET levels and cytokine production...
  59. ncbi request reprint Defective interleukin-10 synthesis by peripheral blood mononuclear cells among hemodialysis patients
    Mary C Perianayagam
    Division of Nephrology, Department of Medicine, New England Medical Center Hospitals, 750 Washington Street, Boston, MA 02111, USA
    Blood Purif 20:543-50. 2002
    ..We hypothesized that defective synthesis of IL-10 could contribute to the inflammatory state in hemodialysis (HD) patients due to impaired feedback inhibition of proinflammatory cytokine production...
  60. ncbi request reprint Effect of a novel adsorbent on cytokine responsiveness to uremic plasma
    Marion D Morena
    Department of Medicine, Tupper Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 63:1150-4. 2003
    ..We assessed the effect of this column on the bioreactivity of uremic plasma, as measured by cytokine responsiveness...
  61. doi request reprint KDOQI US commentary on the KDIGO clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in CKD
    Craig E Gordon
    Tufts Center for Guideline Development and Implementation, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 52:811-25. 2008
    ..Research recommendations that are of particular interest to the United States are then summarized to highlight future areas of inquiry that would enable updating of the guidelines...
  62. ncbi request reprint Validity of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for Acute Renal Failure
    Sushrut S Waikar
    Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1688-94. 2006
    ..The excellent performance characteristics of ICD-9-CM codes for ARF-D suggest that administrative data sets may be particularly well suited for research endeavors that involve patients with ARF-D...
  63. ncbi request reprint Antioxidant and oxidative stress indices in dialysis-dependent acute renal failure
    Vaidyanathapuram S Balakrishnan
    Division of Nephrology, Department of Medicine, Tupper Research Institute, Tufts New England Medical Center, Boston, Mass, USA
    Blood Purif 21:213-9. 2003
    ..Little is known of the effects of hemodialysis and other clinical variables on antioxidant defenses and oxidative stress among patients with ARF...
  64. doi request reprint Epidemiology of hyponatremia
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA
    Semin Nephrol 29:227-38. 2009
    ....
  65. pmc CYBA Gene Polymorphisms and Adverse Outcomes in Acute Kidney Injury: A Prospective Cohort Study
    Mary C Perianayagam
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, Mass
    Nephron Extra 1:112-23. 2011
    ..NADPH oxidase is an important enzyme involved in the generation of reactive oxygen species in acute kidney injury (AKI). Its key subunit, p22(phox), is encoded by the highly polymorphic CYBA gene...
  66. ncbi request reprint Single-use versus reusable dialyzers: the known unknowns
    Ashish Upadhyay
    Department of Medicine, Tufts University School of Medicine, Boston, MA, USA
    Clin J Am Soc Nephrol 2:1079-86. 2007
    ..The dialysis community has a responsibility to explore ways to mitigate environmental consequences before single-use and a more frequent dialysis regimen becomes a standard practice in the United States...
  67. ncbi request reprint Acute renal failure after endovascular vs open repair of abdominal aortic aneurysm
    Ron Wald
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Vasc Surg 43:460-466; discussion 466. 2006
    ..The effect of EVAR on postprocedure acute renal failure has not been determined. We hypothesized that EVAR would be associated with a lower risk of acute renal failure and acute renal failure requiring hemodialysis...
  68. doi request reprint Molecular adsorbent recirculating system as artificial support therapy for liver failure: a meta-analysis
    Arjun Vaid
    Department of Medicine, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    ASAIO J 58:51-9. 2012
    ..Large studies are required to assess the merit of this promising therapy on patient-centered outcomes...
  69. ncbi request reprint Rationale and experience with short daily hemofiltration
    Bertrand L Jaber
    Division of Nephrology, Tufts New England Medical Center, Boston, MA, USA
    Semin Dial 17:146-50. 2004
    ..The preliminary results suggest that improvements in blood pressure, beta2-microglobulin (beta2M) levels, and quality of life are possible...
  70. ncbi request reprint C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway
    Mary C Perianayagam
    Division of Nephrology, Department of Medicine, Tupper Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 61:456-63. 2002
    ..In the present study, we explored whether complement fragment C5a has a modulatory effect on neutrophil apoptosis through this signaling pathway...
  71. ncbi request reprint Dialysis-related amyloidosis: late finding or hidden epidemic?
    Laura M Dember
    Renal Section, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Semin Dial 19:105-9. 2006
    ....
  72. ncbi request reprint Anemia in acute renal failure: role for erythropoiesis-stimulating proteins?
    Orfeas Liangos
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Artif Organs 27:786-91. 2003
    ....
  73. ncbi request reprint Bacterial infections in hemodialysis patients: pathogenesis and prevention
    Bertrand L Jaber
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 67:2508-19. 2005
  74. ncbi request reprint Incidence and prevalence of hyponatremia
    Ashish Upadhyay
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Med 119:S30-5. 2006
    ..Beyond the phenomenologic value, advances in the epidemiology of hyponatremia should also provide insights in the prognostic implications as well as the preventive and management strategies of the disorder in various clinical settings...
  75. ncbi request reprint Hemodialysis-associated methemoglobinemia in acute renal failure
    Juan P de Torres
    Division of Pulmonary Critical Care Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Am J Kidney Dis 39:1307-9. 2002
    ..Causes, treatment, and prevention of chloramine toxicity in patients receiving dialysis in the intensive care unit are discussed...
  76. ncbi request reprint Prevention of radiocontrast nephropathy with N-acetylcysteine in patients with chronic kidney disease: a meta-analysis of randomized, controlled trials
    Alvaro Alonso
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 43:1-9. 2004
    ..We performed a meta-analysis of group data extracted from previously published studies to assess the effect of NAC on the prevention of RCN in patients with pre-existing chronic kidney disease (CKD)...
  77. ncbi request reprint The serotonin syndrome complicating co-prescription of paroxetine and clarithromycin
    Bertrand L Jaber
    Caritas St Elizabeth s Medical Center, Boston, Massachusetts, USA
    Am J Med 119:e3. 2006
  78. pmc Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation
    Orfeas Liangos
    The Kidney and Dialysis Research Laboratory, Division of Nephrology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13658. 2010
    ..To identify the molecular mechanisms underlying CS/CPB-induced pathophysiology we employed an integrative systems biology approach using the whole blood transcriptome as the sentinel organ...
  79. ncbi request reprint Correlates of urea kinetic modeling during hemodialysis in patients with acute renal failure
    Bertrand L Jaber
    Division of Nephrology, Department of Medicine, New England Medical Center, Boston, Mass 02111, USA
    Blood Purif 20:154-60. 2002
    ....

Research Grants1

  1. Cytokine Gene Polymorphisms in Acute Renal Failure
    Bertrand Jaber; Fiscal Year: 2007
    ..The proposed training program and research project will prepare him for a career as an independent investigator. ..