Kumar Sinniah

Summary

Affiliation: Calvin College
Country: USA

Publications

  1. ncbi request reprint Investigating live and fixed epithelial and fibroblast cells by atomic force microscopy
    Kumar Sinniah
    Department of Chemistry, Calvin College, Grand Rapids, MI 49546, USA
    Curr Eye Res 24:188-95. 2002
  2. ncbi request reprint Investigating live and fixed epithelial and fibroblast cells by atomic force microscopy
    Kumar Sinniah
    Departments of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA
    Curr Eye Res 25:61-8. 2002
  3. pmc Estimating kinetic and thermodynamic parameters from single molecule enzyme-inhibitor interactions
    Laura Porter-Peden
    Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, Michigan 49546, USA
    Langmuir 24:11556-61. 2008
  4. doi request reprint An isothermal titration and differential scanning calorimetry study of the G-quadruplex DNA-insulin interaction
    Christine M Timmer
    Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street Southeast, Grand Rapids, Michigan 49546, United States
    J Phys Chem B 118:1784-90. 2014
  5. pmc Atomic force microscopy probing of receptor-nanoparticle interactions for riboflavin receptor targeted gold-dendrimer nanocomposites
    Amanda B Witte
    Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street SE, Grand Rapids, Michigan 49546, United States
    J Phys Chem B 118:2872-82. 2014
  6. pmc Biophysical characterization of a riboflavin-conjugated dendrimer platform for targeted drug delivery
    Amanda B Witte
    Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street South East, Grand Rapids, Michigan 49546, United States
    Biomacromolecules 13:507-16. 2012
  7. ncbi request reprint Effects of contact force and salt concentration on the unbinding of a DNA duplex by force spectroscopy
    Mark Vander Wal
    Department of Chemistry and Biochemistry, Calvin College, 1726 Knollcrest Circle SE, Grand Rapids, Michigan 49546, USA
    Langmuir 22:882-6. 2006
  8. ncbi request reprint Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single-molecule force spectroscopy
    Sarah G Kamper
    Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA
    Langmuir 23:12561-5. 2007

Research Grants

Collaborators

  • Seok Ki Choi
  • Dejian Zhou
  • John Ubels
  • Chris Abell
  • Amanda B Witte
  • Christine M Timmer
  • Laura Porter-Peden
  • Sarah G Kamper
  • Mark Vander Wal
  • Ronald Blankespoor
  • Pamela T Wong
  • Abigail N Leistra
  • Phillip Smith
  • Sophia Bharathi
  • Nicole L Michmerhuizen
  • Kevin Refior
  • Ola Kaso
  • Margaret Van Winkle
  • Bradford G Orr
  • Jeremy J Gam
  • Mark M Banaszak Holl
  • James R Baker
  • Trevor Rayment
  • Jennifer Headley
  • Sarah Kamper

Detail Information

Publications8

  1. ncbi request reprint Investigating live and fixed epithelial and fibroblast cells by atomic force microscopy
    Kumar Sinniah
    Department of Chemistry, Calvin College, Grand Rapids, MI 49546, USA
    Curr Eye Res 24:188-95. 2002
    ..Rabbit corneal fibroblasts, Chang conjunctival cells, and transformed human corneal epithelial cells were chosen so that AFM parameters could be set for future use in toxicologic and pharmacologic studies of ocular cells...
  2. ncbi request reprint Investigating live and fixed epithelial and fibroblast cells by atomic force microscopy
    Kumar Sinniah
    Departments of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA
    Curr Eye Res 25:61-8. 2002
    ..Rabbit corneal fibroblasts, Chang conjunctival cells, and transformed human corneal epithelial cells were chosen so that AFM parameters could be set for future use in toxicologic and pharmacologic studies of ocular cells...
  3. pmc Estimating kinetic and thermodynamic parameters from single molecule enzyme-inhibitor interactions
    Laura Porter-Peden
    Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, Michigan 49546, USA
    Langmuir 24:11556-61. 2008
    ..We also report that linkers that are attached to the enzyme and inhibitor show appreciable effects on the apparent kinetic and thermodynamic parameters...
  4. doi request reprint An isothermal titration and differential scanning calorimetry study of the G-quadruplex DNA-insulin interaction
    Christine M Timmer
    Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street Southeast, Grand Rapids, Michigan 49546, United States
    J Phys Chem B 118:1784-90. 2014
    ..Additionally, the large negative change in heat capacity for this interaction may be associated with the dominant hydrophobicity of the amino acid sequence of insulin's β subunit, which is known to bind to the ILPR G-quadruplex DNA...
  5. pmc Atomic force microscopy probing of receptor-nanoparticle interactions for riboflavin receptor targeted gold-dendrimer nanocomposites
    Amanda B Witte
    Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street SE, Grand Rapids, Michigan 49546, United States
    J Phys Chem B 118:2872-82. 2014
    ..In summary, physical determination of size distribution by AFM imaging can serve as a quantitative approach to monitor and characterize the nanoscale interaction between a dendrimer-covered AuNP and target protein molecules in vitro. ..
  6. pmc Biophysical characterization of a riboflavin-conjugated dendrimer platform for targeted drug delivery
    Amanda B Witte
    Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street South East, Grand Rapids, Michigan 49546, United States
    Biomacromolecules 13:507-16. 2012
    ..Notably, the affinity is inversely correlated with ligand valency. These findings are also corroborated by DSC, where greater protein-conjugate stability is achieved with the N-3 series and at lower ligand valency...
  7. ncbi request reprint Effects of contact force and salt concentration on the unbinding of a DNA duplex by force spectroscopy
    Mark Vander Wal
    Department of Chemistry and Biochemistry, Calvin College, 1726 Knollcrest Circle SE, Grand Rapids, Michigan 49546, USA
    Langmuir 22:882-6. 2006
    ..Furthermore, this study demonstrates the importance of reporting contact forces in force spectroscopy measurements for quantitative comparisons between different biomolecular systems, especially for noncovalent-type interactions...
  8. ncbi request reprint Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single-molecule force spectroscopy
    Sarah G Kamper
    Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA
    Langmuir 23:12561-5. 2007
    ..The dissociation rate for the enzyme-inhibitor complex was found to be significantly faster (~35 times) than the natural spontaneous dissociation rate...

Research Grants1

  1. Biophysical Analysis of Enzyme Inhibitor Interactions
    Kumar Sinniah; Fiscal Year: 2005
    ..This will provide a method for obtaining inhibitor constants which can be compared to other techniques. ..