California Institute of Technology

Summary

Organization: California Institute of Technology
Country: USA

Top Publications

  1. doi Large-scale, long-term nonadiabatic electron molecular dynamics for describing material properties and phenomena in extreme environments
    Andres Jaramillo-Botero
    Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125, USA
    J Comput Chem 32:497-512. 2011
  2. ncbi Nucleation of membrane adhesions
    Cheng Zhong Zhang
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 77:021906. 2008
  3. pmc Postnatal tuning of cutaneous inhibitory receptive fields in the rat
    Lindsay R Bremner
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Physiol 586:1529-37. 2008
  4. ncbi Quantum dot photon statistics measured by three-dimensional particle tracking
    Kevin McHale
    Physical Measurement and Control 266 33, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 7:3535-9. 2007
  5. ncbi In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors
    Daniel Procissi
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 13:3738-47. 2007
  6. ncbi Digital three-dimensional atlas of quail development using high-resolution MRI
    Seth W Ruffins
    California Institute of Technology, Division of Biology, Biological Imaging Center, Beckman Institute, Pasadena, CA, USA
    ScientificWorldJournal 7:592-604. 2007
  7. ncbi Using extracellular action potential recordings to constrain compartmental models
    Carl Gold
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA, USA
    J Comput Neurosci 23:39-58. 2007
  8. ncbi Cerebrocerebellar circuits for the perceptual cancellation of eye-movement-induced retinal image motion
    Axel Lindner
    Hertie Institut für Clinical Brain Research, Department of Cognitive Neurology, Tubingen, Germany
    J Cogn Neurosci 18:1899-912. 2006
  9. ncbi Abnormal use of facial information in high-functioning autism
    Michael L Spezio
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Caltech, Pasadena, CA 91125, USA
    J Autism Dev Disord 37:929-39. 2007
  10. ncbi Free-flight responses of Drosophila melanogaster to attractive odors
    Seth A Budick
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 209:3001-17. 2006

Research Grants

Detail Information

Publications62

  1. doi Large-scale, long-term nonadiabatic electron molecular dynamics for describing material properties and phenomena in extreme environments
    Andres Jaramillo-Botero
    Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125, USA
    J Comput Chem 32:497-512. 2011
    ..As an absolute reference, an NVT run with 2 million particle lithium bulk system (0.5 M nuclei and 1.5 M electrons) on Lobo takes ∼0.44 s/timestep on 1024 processors (∼1 day/ps using an integration timestep of 0.005 fs)...
  2. ncbi Nucleation of membrane adhesions
    Cheng Zhong Zhang
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 77:021906. 2008
    ..These results are verified by numerical calculations...
  3. pmc Postnatal tuning of cutaneous inhibitory receptive fields in the rat
    Lindsay R Bremner
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Physiol 586:1529-37. 2008
    ....
  4. ncbi Quantum dot photon statistics measured by three-dimensional particle tracking
    Kevin McHale
    Physical Measurement and Control 266 33, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 7:3535-9. 2007
    ..In addition, we show that 2-mercaptoethanol suppresses short time-scale intermittency (1 ms to 1 s) in quantum dot fluorescence by reducing time spent in the off-state...
  5. ncbi In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors
    Daniel Procissi
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 13:3738-47. 2007
    ....
  6. ncbi Digital three-dimensional atlas of quail development using high-resolution MRI
    Seth W Ruffins
    California Institute of Technology, Division of Biology, Biological Imaging Center, Beckman Institute, Pasadena, CA, USA
    ScientificWorldJournal 7:592-604. 2007
    ..This provides a method for the analysis and examination of the spatial relationships among the different types of information within the context of the entire embryo...
  7. ncbi Using extracellular action potential recordings to constrain compartmental models
    Carl Gold
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA, USA
    J Comput Neurosci 23:39-58. 2007
    ..Based on these results, we conclude that EAP recordings are an excellent source of data for the purpose of constraining compartmental models...
  8. ncbi Cerebrocerebellar circuits for the perceptual cancellation of eye-movement-induced retinal image motion
    Axel Lindner
    Hertie Institut für Clinical Brain Research, Department of Cognitive Neurology, Tubingen, Germany
    J Cogn Neurosci 18:1899-912. 2006
    ....
  9. ncbi Abnormal use of facial information in high-functioning autism
    Michael L Spezio
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Caltech, Pasadena, CA 91125, USA
    J Autism Dev Disord 37:929-39. 2007
    ..These findings provide a novel quantitative assessment of how people with autism utilize information in faces when making social judgments...
  10. ncbi Free-flight responses of Drosophila melanogaster to attractive odors
    Seth A Budick
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 209:3001-17. 2006
    ..These results indicate both similarities and differences between the behavior of D. melanogaster and the responses of male moths to pheromone plumes, suggesting possible differences in underlying neural mechanisms...
  11. ncbi A nonparametric quantification of neural response field structures
    Marina Brozovic
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuroreport 17:963-7. 2006
    ..This finding reflects the fact that the response fields were generated by the same neural network and encode the same underlying process...
  12. pmc The effect of genome length on ejection forces in bacteriophage lambda
    Paul Grayson
    Department of Physics, California Institute of Technology, Pasadena, 91125, USA
    Virology 348:430-6. 2006
    ....
  13. pmc Transposable elements have contributed to thousands of human proteins
    Roy Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 103:1798-803. 2006
    ..This report of observable relationships leaves to the future the functional implications as well as the detection of the events of TE insertion...
  14. ncbi Mitochondrial dynamics in cell life and death
    D Chan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell Death Differ 13:680-4. 2006
  15. doi On the trail of the 'new head' in Les Treilles
    Marianne Bronner-Fraser
    Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Development 135:2995-9. 2008
    ....
  16. pmc Textpresso for neuroscience: searching the full text of thousands of neuroscience research papers
    Hans Michael Muller
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA
    Neuroinformatics 6:195-204. 2008
    ..This web service is used by the NIF interface to access Textpresso. The standalone website of Textpresso for Neuroscience can be accessed at http://www.textpresso.org/neuroscience/...
  17. pmc Properties of developmental gene regulatory networks
    Eric H Davidson
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:20063-6. 2008
    ....
  18. doi Fine-scale staging of T cell lineage commitment in adult mouse thymus
    Mary A Yui
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 185:284-93. 2010
    ..Instead, the downregulation of select stem cell and non-T lineage genes appears to be key to the extinction of alternative lineage choices...
  19. ncbi Fluctuation in electrolyte solutions: the self energy
    Zhen Gang Wang
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 81:021501. 2010
    ..We illustrate the phenomenon of charge separation by considering cations and anions of difference sizes and valencies in a periodic dielectric medium...
  20. pmc A hormone-activated central pattern generator for courtship
    Daniel A Wagenaar
    Broad Fellows Program and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 20:487-95. 2010
    ..The neural basis of this behavior is presently unknown and currently impossible to study directly because electrophysiological recording techniques disrupt the behavior...
  21. ncbi Dehydrogenation of amine-boranes with a frustrated Lewis pair
    Alexander J M Miller
    Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Pasadena, CA, USA
    Chem Commun (Camb) 46:1709-11. 2010
    ..Bulky tertiary phosphine/borane Lewis pairs P(t)Bu(3)/B(C(6)F(5))(3) react with amine-boranes to afford dehydrocoupling products and phosphonium borohydride salts...
  22. pmc Biophysics of magnetic orientation: strengthening the interface between theory and experimental design
    Joseph L Kirschvink
    Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    J R Soc Interface 7:S179-91. 2010
    ....
  23. doi Characterization of acceptance angles of small circular apertures
    Ying Min Wang
    Department of Bioengineering MC138 78, California Institute of Technology, Pasadena, CA 91125, USA
    Opt Express 17:23903-13. 2009
    ..This work in understanding of the behavior of light transmission through subwavelength apertures will guide the design of better aperture based imaging devices where apertures are used as light collection units...
  24. pmc Coordination of tolerogenic immune responses by the commensal microbiota
    June L Round
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Pasadena, CA, USA
    J Autoimmun 34:J220-5. 2010
    ....
  25. doi Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Adv Drug Deliv Rev 61:1189-92. 2009
    ..IT-101 is currently being investigated in human clinical trials. Here, the design and development of IT-101 is described with emphasis on features distinguishing it from other polymer-containing therapeutics...
  26. doi Tunable color filters based on metal-insulator-metal resonators
    Kenneth Diest
    Thomas J Watson Laboratory of Applied Physics, California Institute of Technology, Pasadena, California, 91125, USA
    Nano Lett 9:2579-83. 2009
    ..Simulations using lithium niobate as the dielectric layer and the top and bottom Ag layers as electrodes, indicate that the output color can be tuned over the visible spectrum with an applied field...
  27. doi Hippocampal theta oscillations are travelling waves
    Evgueniy V Lubenov
    Division of Biology, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California 91125, USA
    Nature 459:534-9. 2009
    ..The presence of travelling waves indicates that the instantaneous output of the hippocampus is topographically organized and represents a segment, rather than a point, of physical space...
  28. pmc Neural activity in the visual thalamus reflects perceptual suppression
    Melanie Wilke
    Unit on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:9465-70. 2009
    ..Our findings demonstrate that visual responses of pulvinar neurons reflect the perceptual awareness of a stimulus, while those of LGN neurons do not...
  29. doi Genomic control of patterning
    Isabelle S Peter
    California Institute of Technology, Pasadena, 91125, USA
    Int J Dev Biol 53:707-16. 2009
    ....
  30. doi Choosing the road less traveled by: a ligand-receptor system that controls target recognition by Drosophila motor axons
    Kai Zinn
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Genes Dev 23:1042-5. 2009
    ..Siebert and colleagues now show that Beat and Side are cell surface proteins that physically interact with each other, and that Beat-expressing motor axon growth cones reach their targets via recognition of Side-expressing pathways...
  31. ncbi Effects of soluble ferri-hydroxide complexes on microbial neutralization of acid mine drainage
    A Azra Bilgin
    Department of Civil, Environmental, and Architectural Engineering, University of Colorado, Boulder, Colorado 80309, USA
    Environ Sci Technol 39:7826-32. 2005
    ..Results suggest that initiation of bacterial iron reduction may result in neutralization of acid mine drainage. However, this effect is extremely sensitive to iron speciation within a relatively small and critical pH range...
  32. pmc Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening
    Angie S Mah
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Biochem 6:22. 2005
    ..The components of MEN that act upstream of Dbf2-Mob1 have been characterized, but physiological substrates for Dbf2-Mob1 have yet to be identified...
  33. ncbi A photochemical model of the martian atmosphere
    H Nair
    Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena 91125, USA
    Icarus 111:124-50. 1994
    ..We feel that there is no need at this time to invoke heterogeneous processes to reconcile models and observations...
  34. ncbi Compression of space in visual memory
    B R Sheth
    California Institute of Technology, 139 74 Caltech, Pasadena, CA 91125, USA
    Vision Res 41:329-41. 2001
    ....
  35. ncbi Subthreshold voltage noise due to channel fluctuations in active neuronal membranes
    P N Steinmetz
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    J Comput Neurosci 9:133-48. 2000
    ..For all subthreshold voltage ranges, the quasi-active linearized approximation is accurate within 8% and may thus be used in large-scale simulations of realistic neuronal geometries...
  36. ncbi Nitrogenase: standing at the crossroads
    D C Rees
    Howard Hughes Medical Institute, Division of Chemistry and Chemical Engineering, 147 75CH, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Opin Chem Biol 4:559-66. 2000
    ....
  37. ncbi Effects of biased feedback on learning and deciding in a vernier discrimination task
    M H Herzog
    Center for Cognitive Science, University of Bremen, Germany
    Vision Res 39:4232-43. 1999
    ..If the external feedback is switched off instead of being corrected, the rebound is less vigorous. The findings contradict predictions of supervised neural network models...
  38. ncbi Analysis of light noise sources in a recycled Michelson interferometer with Fabry-Perot arms
    J B Camp
    LIGO Project, California Institute of Technology, Pasadena 91125, USA
    J Opt Soc Am A Opt Image Sci Vis 17:120-8. 2000
    ..We find that noise on the radio frequency sidebands generally limits the detector's sensitivity...
  39. ncbi Plants, animals and the logic of development
    E M Meyerowitz
    Division of Biology 156 29, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA
    Trends Cell Biol 9:M65-8. 1999
    ..Comparison of the genes used to serve similar functions shows how organisms can use different genes for similar ends and thereby reveals the principles of development...
  40. ncbi Sequence-specific DNA recognition by polyamides
    P B Dervan
    Department of Chemistry, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Opin Chem Biol 3:688-93. 1999
    ..Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture...
  41. ncbi Visual structure and the integration of form and color information
    B Khurana
    Department of Psychology, University of California, Berkeley, USA
    J Exp Psychol Hum Percept Perform 24:1766-85. 1998
    ..Together, these results offer a new tool for the study of the binding problem in vision...
  42. ncbi The electric organ discharges of the gymnotiform fishes: II. Eigenmannia
    C Assad
    Department of Electrical Engineering, Caltech, Pasadena, CA 91125, USA
    J Comp Physiol A 183:419-32. 1998
    ..Electric organ discharge maps and animations resulting from this series of studies are available via the Internet (http:@www.bbb.caltech.edu/ElectricFish, or www.fiu.edu/ approximately stoddard/electricfish.html)...
  43. ncbi Effects of interaural decorrelation on neural and behavioral detection of spatial cues
    K Saberi
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 21:789-98. 1998
    ....
  44. ncbi Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite
    C Marcelle
    Division of Biology and Beckman Institute, California Institute of Technology, Pasadena 91125, USA
    Development 124:3955-63. 1997
    ....
  45. ncbi Genetic probes: new ways to watch cells in action
    M S Siegel
    California Institute of Technology, Computation and Neural Systems Pasadena, California 06520, USA
    Curr Biol 7:R556-7. 1997
    ..Progress towards this goal is being made with the development of new types of protein sensor that can be targeted within cells and organisms...
  46. ncbi Extracellular potentials in low-density dissociated neuronal cultures
    Enric Claverol-Tinture
    Department of Physics, Mathematics and Astronomy, California Institute of Technology, 326 Kerchoff MC 156 29, 1200 East California Blvd, Pasadena, CA 91125, USA
    J Neurosci Methods 117:13-21. 2002
    ....
  47. ncbi From postsynaptic potentials to spikes in the genesis of auditory spatial receptive fields
    Jose Luis Pena
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 22:5652-8. 2002
    ....
  48. ncbi Computer simulation of flagellar movement VIII: coordination of dynein by local curvature control can generate helical bending waves
    Charles J Brokaw
    Division of Biology, California Institute of Technology, Pasadena, USA
    Cell Motil Cytoskeleton 53:103-24. 2002
    ..However, experimental observations indicate that this "hard-wired" solution is not appropriate for real flagella...
  49. ncbi New tools for visualization and analysis of morphogenesis in spherical embryos
    J Michael Tyszka
    Biological Imaging Center, Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Dev Dyn 234:974-83. 2005
    ..These methods for quantitative analysis and visualization of early development in spherical embryos are introduced by using them for the quantitative analysis of 2D and 3D images of gastrula stage Xenopus laevis...
  50. ncbi On the estimation of swimming and flying forces from wake measurements
    John O Dabiri
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 208:3519-32. 2005
    ....
  51. ncbi Origins of lymphocyte developmental programs: transcription factor evidence
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Semin Immunol 16:227-38. 2004
    ..We consider the functions of these factors in animals without lymphocytes in terms of discrete program components, which could have been assembled in a new way to create the lymphocyte developmental program approximately 500 My ago...
  52. ncbi Information coding and oscillatory activity in synfire neural networks with and without inhibitory coupling
    Farshad Moradi
    School of Intelligent Systems, Institute for Studies in Theoretical Physics and Mathematics, Tehran, Iran
    Biol Cybern 91:283-94. 2004
    ..The quasiperiodic dynamics is validated with simulation with leaky integrate-and-fire neurons. The networks demonstrate different modes of quasiperiodic activity as the inhibition or excitation parameters of the network are varied...
  53. ncbi A doctor on the front line: Enrico Pajes (1912-1993)
    Judith Goodstein
    California Institute of Technology, USA
    J Med Biogr 12:172-82. 2004
    ..How did a Jew of Polish origin end up practising medicine in Italy for over 40 years? This oral history is the story of Enrico Pajes's life...
  54. ncbi Qualia
    Christof Koch
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 14:R496. 2004
  55. ncbi A mathematical model for top-shelf vertigo: the role of sedimenting otoconia in BPPV
    Todd M Squires
    Departments of Applied and Computational Mathematics and Physics, California Institute of Technology, Pasadena, CA 91125, USA
    J Biomech 37:1137-46. 2004
    ..Larger cupular volume displacement and nystagmus could result from larger and/or multiple otoconia...
  56. ncbi Rationale for dopamine agonist use as monotherapy in Parkinson's disease
    Johannes Schwarz
    Department of Neurology, University of Leipzig, Germany
    Curr Opin Neurol 16:S27-33. 2003
    ..Dopamine agonists also appear to reduce the loss of functional dopamine transporters when used early in the disease course, and these factors combine to build a case for the use of dopamine agonists in early-stage Parkinson's disease...
  57. ncbi Signaling contours by neuromorphic wave propagation
    Christoph Rasche
    Department of Psychology, University of California Santa Barbara, Santa Barbara CA, USA
    Biol Cybern 90:272-9. 2004
    ..Following that, the signaled edge (or contour) actively propagates across the retinal map. The retinal signal can be used for a contour-integration or a contour-propagation approach...
  58. pmc The scaling of frontal cortex in primates and carnivores
    Eliot C Bush
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 101:3962-6. 2004
    ..94 (95% confidence interval, 0.82-1.07). This finding supports the idea that there are substantial differences in frontal cortex structure and development between the two groups...
  59. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling...
  60. ncbi Identification of birch pollen respirable particles
    Philip E Taylor
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Chest 123:433S. 2003
  61. pmc CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex
    Joel L Pomerantz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 21:5184-94. 2002
    ..These results implicate CARD11 in factor- specific activation of NF-kappaB by the TCR complex and establish a role for a MAGUK family member in antigen receptor signaling...
  62. ncbi Fluorescence signaling of ligand binding and assembly in metal-chelating lipid membranes
    K Maloney
    Division of Chemistry and Chemical Engineering 210 41, California Institute of Technology, Pasadena, CA 91125, USA
    Chem Biol 3:185-92. 1996
    ..We set out to examine whether lipids of this kind would produce a signal in response to ligand binding...

Research Grants62

  1. CIS-REGULATORY ANALYSIS OF PU.1 BY IN VITRO ES CELL DIFFERENTIATION
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..This should permit faster and cheaper experiments to reveal how powerful regulatory genes are themselves controlled. ..
  2. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression. ..
  3. Application for a Fluorescence-Activated Cell Sorter
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..new, high-performance fluorescence-activated cell sorter to serve a diverse group of clients at the California Institute of Technology Flow Cytometry/Cell Sorting Facility...
  4. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2004
    ....
  5. Reverse engineering genetic network architecture of stem-cell/lymphocyte transiti
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..Through a dialogue between computational modeling and experimental analysis, we will explain the regulatory network that makes T-cell development robust, providing new insights into mechanisms that can prevent disease. ..
  6. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression ..
  7. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2005
    ..1 itself. ..
  8. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2006
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression. ..
  9. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2009
    ..The mechanisms studied here imply that mixed-lineage thymic lymphomas may also result from primary defects of a natural T/myeloid lineage choice. ..
  10. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    Ellen V Rothenberg; Fiscal Year: 2010
    ..The mechanisms studied here imply that mixed-lineage thymic lymphomas may also result from primary defects of a natural T/myeloid lineage choice. ..
  11. LINEAGE ANALYSIS OF FUNC IN THYMOCYTE DIFF.
    ELLEN ROTHENBERG; Fiscal Year: 1999
    ..Specific aim 3: To test the fidelity of T-cell lineage-restricted lL-2 expression by analysis of lL-2/Cre-dependent marking of non-T lineage cells in vivo. ..
  12. Design of Gene Delivery System to Target Hepatocytes
    Mark Davis; Fiscal Year: 2007
    ..The long-term objective of our proposal is to design and engineer a generalized, synthetic system for ultimately delivering nucleic acid-based therapeutics to hepatocytes in humans. ..
  13. A Novel Method of Nanoparticle Delivery to Brain by Targeting Ec-gp96
    Mark E Davis; Fiscal Year: 2010
    ....
  14. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2007
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
  15. EMOTIONAL MODULATION OF MEMORY BY THE HUMAN AMYGDALA
    Ralph Adolphs; Fiscal Year: 2007
    ..abstract_text> ..
  16. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2006
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  17. NEUROANATOMICAL SUBSTRATES OF EMOTIONAL MEMORY IN HUMANS
    Ralph Adolphs; Fiscal Year: 2002
    ....
  18. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 2003
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  19. COMPUTATIONAL MODEL OF GENE REGULATORY PROGRAM
    Eric Davidson; Fiscal Year: 2003
    ..The model will ultimately constitute a quantitative computational analysis of a genomic regulatory network, defined at the DNA sequence level, the function of which is to organize a complex, major process in animal development. ..
  20. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2004
    ..abstract_text> ..