Gordon Lithgow

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. ncbi request reprint Stress resistance as a determinate of C. elegans lifespan
    Gordon J Lithgow
    Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Mech Ageing Dev 123:765-71. 2002
  2. ncbi request reprint Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant
    Yi Ting Lin
    Department of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA 92834, USA
    Free Radic Biol Med 40:1185-93. 2006
  3. ncbi request reprint Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments
    Anders Olsen
    The Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Biogerontology 7:221-30. 2006
  4. doi request reprint Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans
    Suzanne Angeli
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    Metallomics 6:1816-23. 2014
  5. pmc Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans
    Kathryn E Page
    The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    Metallomics 4:512-22. 2012
  6. ncbi request reprint Why aging isn't regulated: a lamentation on the use of language in aging literature
    Gordon J Lithgow
    The Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Exp Gerontol 41:890-3. 2006
  7. ncbi request reprint Does anti-aging equal anti-microbial?
    Gordon J Lithgow
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2003:PE16. 2003
  8. ncbi request reprint DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid
    Jason M Held
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 5:283-91. 2006
  9. pmc Compounds that confer thermal stress resistance and extended lifespan
    Michael G Benedetti
    The Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Exp Gerontol 43:882-91. 2008
  10. pmc Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
    Gawain McColl
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Biol Chem 283:350-7. 2008

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Stress resistance as a determinate of C. elegans lifespan
    Gordon J Lithgow
    Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Mech Ageing Dev 123:765-71. 2002
    ..As with most other biological problems, the most important experimental developments are coming from studying simple organisms in a reductionist fashion...
  2. ncbi request reprint Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant
    Yi Ting Lin
    Department of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA 92834, USA
    Free Radic Biol Med 40:1185-93. 2006
    ..elegans, the mode of action remains unclear. Manganese may work directly as a free radical scavenger, as it has been postulated to do so in unicellular organisms, or may work indirectly by up regulating several protective factors...
  3. ncbi request reprint Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments
    Anders Olsen
    The Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Biogerontology 7:221-30. 2006
    ..The levels of the heat shock proteins HSP-4 and HSP-16 correlate well with the effects on lifespan by the hormetic treatments...
  4. doi request reprint Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans
    Suzanne Angeli
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    Metallomics 6:1816-23. 2014
    ..elegans can provide a useful platform for identifying therapeutic interventions for ER stress, proteotoxicity, and age-dependent susceptibilities, key pathological features of PD and other related neurodegenerative diseases. ..
  5. pmc Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans
    Kathryn E Page
    The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    Metallomics 4:512-22. 2012
    ..Similar changes in Al have been noted in association with Al toxicity in humans and other mammals, suggesting that C. elegans may be of use as a model for understanding the mechanisms of Al toxicity in mammalian systems...
  6. ncbi request reprint Why aging isn't regulated: a lamentation on the use of language in aging literature
    Gordon J Lithgow
    The Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Exp Gerontol 41:890-3. 2006
    ..Rather than a scholarly review of this important issue, this article is intended to prompt debate. Consequently, "the gloves are off"...
  7. ncbi request reprint Does anti-aging equal anti-microbial?
    Gordon J Lithgow
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2003:PE16. 2003
    ..Perhaps enhanced innate immunity is a feature of genetically determined longevity...
  8. ncbi request reprint DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid
    Jason M Held
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 5:283-91. 2006
    ..These data suggest that carboxylated sterols may be key determinants of life history...
  9. pmc Compounds that confer thermal stress resistance and extended lifespan
    Michael G Benedetti
    The Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Exp Gerontol 43:882-91. 2008
    ..Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging...
  10. pmc Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
    Gawain McColl
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Biol Chem 283:350-7. 2008
    ..2), a histone demethylase; knockdown by RNA interference of T08D10.2 is sufficient to extend longevity ( approximately 25% median increase), suggesting Li(+) regulates survival by modulating histone methylation and chromatin structure...
  11. ncbi request reprint Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
    Glenda A Walker
    The Buck Institute, 8001 Redwood Blvd, Novato, CA 94945, USA
    Aging Cell 2:131-9. 2003
    ..The DAF-16 transcription factor is essential for maximal hsp-16 expression and for lifespan extension conferred by hsp-16. This demonstrates that lifespan is determined in part by insulin-like regulation of molecular chaperones...
  12. pmc Fitness cost of extended lifespan in Caenorhabditis elegans
    Nicole L Jenkins
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Biol Sci 271:2523-6. 2004
    ..Despite long-lived mutants appearing healthy, they exhibit a heavy fitness cost consistent with an evolutionary theory of aging...
  13. ncbi request reprint An automated high-throughput assay for survival of the nematode Caenorhabditis elegans
    Matthew S Gill
    Buck Institute, Novato, CA 94945, USA
    Free Radic Biol Med 35:558-65. 2003
    ..We propose that this novel method of survival analysis will accelerate the discovery of new pharmacological interventions in aging and oxidative stress...
  14. pmc Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
    Kally Z Pan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Aging Cell 6:111-9. 2007
    ..Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans...
  15. ncbi request reprint Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics
    James N Sampayo
    The Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 2:319-26. 2003
    ..Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed...
  16. ncbi request reprint S.W.A.T.--SOD weapons and tactics
    James N Sampayo
    The Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:pe27. 2004
    ..This mechanism highlights the importance of rapid responses in the fight against oxidative stress...
  17. ncbi request reprint Using Caenorhabditis elegans as a model for aging and age-related diseases
    Anders Olsen
    The Buck Institute, Novato, CA 94945, USA
    Ann N Y Acad Sci 1067:120-8. 2006
    ..This review will focus on the most recent developments in C. elegans aging research with the aim of illustrating the diversity of the field...
  18. ncbi request reprint Lipophilic regulator of a developmental switch in Caenorhabditis elegans
    Matthew S Gill
    Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 3:413-21. 2004
    ..We propose that the dauer rescuing activity is a hormone synthesized by DAF-9 that acts through DAF-12...
  19. pmc The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span
    Gawain McColl
    Buck Institute for Age Research, Novato, California 94945, USA
    FASEB J 19:1716-8. 2005
    ..These observations support the view that organismal stress resistance determines life span and Ku70 modulates these effects...
  20. pmc Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans
    Anders Olsen
    Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Science 312:1381-5. 2006
    ..elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells...
  21. pmc Science fact and the SENS agenda. What can we reasonably expect from ageing research?
    Huber Warner
    Buck Institute for Age Research, Novato, CA, USA
    EMBO Rep 6:1006-8. 2005
  22. pmc MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
    Dipa Bhaumik
    Buck Institute for Age Research, Novato, CA 94945, USA
    Aging (Albany NY) 1:402-11. 2009
    ....
  23. ncbi request reprint Physiology: Cost-free longevity in mice?
    Gordon J Lithgow
    Nature 421:125-6. 2003
  24. pmc The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia
    Alfred L Fisher
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 283:9127-35. 2008
    ..We also use our model to identify genes that suppress the damage produced by K10C2.4 RNAi in a pilot genetic screen. Our results establish worms as a model for the study of type I tyrosinemia...
  25. ncbi request reprint M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape
    Joaquin M Muriel
    Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611, USA
    Dev Biol 260:339-51. 2003
    ..M142.2 therefore plays a major role in the assembly of the alae and the morphology of the dauer cuticle; because of its similarity to the other cut genes of the cuticle, we have named the gene cut-6...
  26. ncbi request reprint The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms
    Alfred L Fisher
    Division of Geriatrics, Department of Medicine, University of California, San Francisco, 94121, USA
    Aging Cell 5:127-38. 2006
    ..Our results point to daf-12 modulating aging and stress responses in part through the repression of specific genes, and emphasize the role that the repression of genes that curtail maximal lifespan plays in lifespan determination...

Research Grants4

  1. Gordon Research Conference, Biology of Aging, 2004
    Gordon Lithgow; Fiscal Year: 2004
    ..abstract_text> ..
  2. Comparative Biology of p53, Checkpoint and Longevity
    Gordon Lithgow; Fiscal Year: 2007
    ..As these factors appear to affect aging in both simple invertebrates and mammals, we expect to define broad mechanisms by which cellular and organismal aging are co-regulated. ..
  3. C. elegans, Aging and High Throughput Screening (RMI)
    Gordon Lithgow; Fiscal Year: 2004
    ..elegans for HTS. Our longer term goal is to undertake HTS for compounds that protect against oxidative stress, extend lifespan and translate into mammalian models of age-related diseases such as Alzheimer's and Parkinson's. ..
  4. Lifespan determination and stress response in C. elegans
    Gordon Lithgow; Fiscal Year: 2006
    ..Thirdly, we will identify and manipulate the levels of endocrine signals that act downstream of the insulin/IGF signaling pathway to limit lifespan. ..