Adil A Khan

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. pmc Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo
    Adil A Khan
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 104:19114-9. 2007
  2. pmc Regulation of hypoxic neuronal death signaling by neuroglobin
    Adil A Khan
    The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    FASEB J 22:1737-47. 2008
  3. pmc A neuroglobin-overexpressing transgenic mouse
    Adil A Khan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Gene 398:172-6. 2007
  4. pmc Neuroglobin protects against nitric oxide toxicity
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Neurosci Lett 430:135-7. 2008
  5. pmc Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia
    Adil A Khan
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:17944-8. 2006
  6. pmc Neuroglobin: an endogenous neuroprotectant
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94549, USA
    Curr Opin Pharmacol 8:20-4. 2008

Detail Information

Publications6

  1. pmc Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo
    Adil A Khan
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 104:19114-9. 2007
    ....
  2. pmc Regulation of hypoxic neuronal death signaling by neuroglobin
    Adil A Khan
    The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    FASEB J 22:1737-47. 2008
    ..We link the protective actions of Ngb to inhibition of Pak1 kinase activity and Rac1-GDP-dissociation inhibitor disassociation, and inhibition of actin assembly and death-signaling module polarization...
  3. pmc A neuroglobin-overexpressing transgenic mouse
    Adil A Khan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Gene 398:172-6. 2007
    ..We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken beta-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo...
  4. pmc Neuroglobin protects against nitric oxide toxicity
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Neurosci Lett 430:135-7. 2008
    ..The results suggest that the ability of Ngb to neutralize the neurotoxic effects of reactive nitrogen species may be an important contributor to its neuroprotective properties...
  5. pmc Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia
    Adil A Khan
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:17944-8. 2006
    ..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms...
  6. pmc Neuroglobin: an endogenous neuroprotectant
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94549, USA
    Curr Opin Pharmacol 8:20-4. 2008
    ..However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear...