Brian K Kennedy

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. pmc Geroscience: linking aging to chronic disease
    Brian K Kennedy
    Buck Institute for Research on Aging, Novato, CA USA Electronic address
    Cell 159:709-13. 2014
  2. pmc Drugs that modulate aging: the promising yet difficult path ahead
    Brian K Kennedy
    Buck Institute for Research on Aging, Novato, Calif Electronic address
    Transl Res 163:456-65. 2014
  3. pmc Rho signaling participates in membrane fluidity homeostasis
    Daniel Lockshon
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e45049. 2012
  4. pmc Vacuolar dynamics and replicative aging
    Scott Tsuchiyama
    Buck Institute for Research on Aging Novato, CA USA
    Cell Cycle 11:2778. 2012
  5. pmc Genome-scale studies of aging: challenges and opportunities
    Mark A McCormick
    Buck Institute for Research on Aging, Novato, CA, USA
    Curr Genomics 13:500-7. 2012
  6. pmc The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1
    Monique N O'Leary
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 9:e1003708. 2013
  7. pmc Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice
    Richard L Frock
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e42918. 2012
  8. pmc Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1
    Steven C Chen
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e19780. 2011
  9. doi request reprint RB and lamins in cell cycle regulation and aging
    Brian K Kennedy
    The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA
    Adv Exp Med Biol 773:127-42. 2014
  10. doi request reprint Asymmetric segregation: the shape of things to come?
    Brian K Kennedy
    Buck Institute for Research on Aging, Novato, CA 94945, USA
    Curr Biol 21:R149-51. 2011

Research Grants

  1. Genome-wide Analysis of Aging in Yeast
    Brian K Kennedy; Fiscal Year: 2010

Collaborators

Detail Information

Publications69

  1. pmc Geroscience: linking aging to chronic disease
    Brian K Kennedy
    Buck Institute for Research on Aging, Novato, CA USA Electronic address
    Cell 159:709-13. 2014
    ....
  2. pmc Drugs that modulate aging: the promising yet difficult path ahead
    Brian K Kennedy
    Buck Institute for Research on Aging, Novato, Calif Electronic address
    Transl Res 163:456-65. 2014
    ..Here, we discuss the strategies to translate discoveries from aging research into drugs. Will aging research lead to novel therapies toward chronic disease, prevention of disease or be targeted directly at extending lifespan? ..
  3. pmc Rho signaling participates in membrane fluidity homeostasis
    Daniel Lockshon
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e45049. 2012
    ..This work provides the first evidence for the existence of a signaling pathway that enables eukaryotic cells to control membrane fluidity, a requirement for division, differentiation and environmental adaptation...
  4. pmc Vacuolar dynamics and replicative aging
    Scott Tsuchiyama
    Buck Institute for Research on Aging Novato, CA USA
    Cell Cycle 11:2778. 2012
    ..Comment on: Gebre S, et al. Cell Cycle 2012; 11:2176-88...
  5. pmc Genome-scale studies of aging: challenges and opportunities
    Mark A McCormick
    Buck Institute for Research on Aging, Novato, CA, USA
    Curr Genomics 13:500-7. 2012
    ..In this context, we also discuss recent technological advances and some of the likely future directions that they portend...
  6. pmc The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1
    Monique N O'Leary
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 9:e1003708. 2013
    ..We propose that ribosome specificity may exist in mammals, providing evidence that one ribosomal protein can influence composition of the ribosome by regulating its own paralog. ..
  7. pmc Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice
    Richard L Frock
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e42918. 2012
    ..The expression of lamin A is sufficient to rescue certain cellular defects associated with loss of A-type lamins in cardiomyocytes in a cell-autonomous fashion...
  8. pmc Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1
    Steven C Chen
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e19780. 2011
    ..We propose that depressed myoblast proliferation may contribute to the pathology of mice overexpressing FRG1 and may play a part in FSHD...
  9. doi request reprint RB and lamins in cell cycle regulation and aging
    Brian K Kennedy
    The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA
    Adv Exp Med Biol 773:127-42. 2014
    ..Here we describe the current state of knowledge and speculate that lamins may be intimately involved in the regulation of cell proliferation, acting at the interface between cancer and aging. ..
  10. doi request reprint Asymmetric segregation: the shape of things to come?
    Brian K Kennedy
    Buck Institute for Research on Aging, Novato, CA 94945, USA
    Curr Biol 21:R149-51. 2011
    ..Two new studies indicate that retention of ERCs in mother cells occurs not by tethering to the nuclear periphery but rather by the simple rules of diffusion in a time-limited and complex landscape...
  11. ncbi request reprint Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
    Mitsuhiro Tsuchiya
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Aging Cell 5:505-14. 2006
    ..Thus, we propose that lifespan extension by CR is independent of sirtuins and that nicotinamide has sirtuin-independent effects on lifespan extension by CR...
  12. pmc Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 133:292-302. 2008
    ..Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms...
  13. pmc Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging
    Joe R Delaney
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 12:156-66. 2013
    ..These data demonstrate an unexpected link between a mitochondrial protease, cytoplasmic mRNA translation, and aging...
  14. ncbi request reprint Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 312:1312; author reply 1312. 2006
    ..Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1...
  15. pmc Extension of chronological life span in yeast by decreased TOR pathway signaling
    R Wilson Powers
    Department of Genome Sciences and Medicine, The Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 20:174-84. 2006
    ..We propose that up-regulation of a highly conserved response to starvation-induced stress is important for life span extension by decreased TOR signaling in yeast and higher eukaryotes...
  16. pmc Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53
    Brian A Kudlow
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Mol Biol Cell 19:5238-48. 2008
    ....
  17. pmc Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation
    Richard L Frock
    Department of Biochemistry, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 20:486-500. 2006
    ..The delayed differentiation kinetics and decreased differentiation potential of lamin A/C-deficient and emerin-deficient myoblasts may in part underlie the dystrophic phenotypes observed in patients with EDMD...
  18. ncbi request reprint Genes determining yeast replicative life span in a long-lived genetic background
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:491-504. 2005
    ..These results define a limited number of genes likely to regulate replicative life span in a strain-independent manner, and create a basis for future epistasis analysis to determine genetic pathways of aging...
  19. pmc Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genome Res 18:564-70. 2008
    ..Together, these findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging...
  20. pmc A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan
    Elizabeth X Kwan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003329. 2013
    ....
  21. pmc Increased life span due to calorie restriction in respiratory-deficient yeast
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 1:e69. 2005
    ....
  22. pmc Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2
    Ryan T Nitta
    Department of Biochemistry, University of Washington, Seattle, Washington, USA
    PLoS ONE 2:e963. 2007
    ..p14(arf) expression was also insufficient to stabilize pRB or confer cell cycle arrest, suggesting that MDM2 also does not mediate pRB degradation in Lmna-/- cells...
  23. pmc Sir2 deletion prevents lifespan extension in 32 long-lived mutants
    Joe R Delaney
    Department of Pathology, University of Washington, Seattle, WA, USA
    Aging Cell 10:1089-91. 2011
    ..They also demonstrate that failure to observe lifespan extension in a short-lived background, such as cells or animals lacking sirtuins, should be interpreted with caution...
  24. pmc Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genetics 191:107-18. 2012
    ....
  25. pmc Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival
    Fresnida J Ramos
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Sci Transl Med 4:144ra103. 2012
    ....
  26. pmc A genomic analysis of chronological longevity factors in budding yeast
    Christopher R Burtner
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    Cell Cycle 10:1385-96. 2011
    ....
  27. pmc Elevated MTORC1 signaling and impaired autophagy
    Fresnida J Ramos
    Department of Pathology, University of Washington, Seattle, WA, USA
    Autophagy 9:108-9. 2013
    ..These findings elaborate a potential treatment option for dilated cardiomyopathy and muscular dystrophy associated with LMNA mutation and supplement growing evidence linking impaired autophagy to human disease...
  28. pmc A molecular mechanism of chronological aging in yeast
    Christopher R Burtner
    Department of Biochemistry, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Cell Cycle 8:1256-70. 2009
    ..We conclude that acetic acid induced mortality is the primary mechanism of chronological aging in yeast under standard conditions...
  29. pmc Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
    Erica D Smith
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Dev Biol 8:49. 2008
    ..Dietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood...
  30. ncbi request reprint Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    Matt Kaeberlein
    Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195, USA
    Science 310:1193-6. 2005
    ..We propose that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast...
  31. pmc Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    Katherine A Steinkraus
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 7:394-404. 2008
    ..These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1...
  32. ncbi request reprint Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases
    Brian A Kudlow
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Nat Rev Mol Cell Biol 8:394-404. 2007
    ....
  33. pmc The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function
    Daniel Lockshon
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genetics 175:77-91. 2007
    ..We propose that yeast deficient in peroxisomal and other functions are sensitive to oleate perhaps because of an inability to effectively control the fatty acid composition of membrane phospholipids...
  34. ncbi request reprint Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
    ..Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction...
  35. ncbi request reprint A method for high-throughput quantitative analysis of yeast chronological life span
    Christopher J Murakami
    Department of Pathology, University of Washington, Box 357470, Seattle, WA 98195 7470, USA
    J Gerontol A Biol Sci Med Sci 63:113-21. 2008
    ..We also report that life-span extension from dietary restriction does not require any of the five yeast sirtuins (Sir2, Hst1, Hst2, Hst3, or Hst4) either alone or in combination...
  36. pmc Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae
    Undine Kruegel
    Department of Biochemistry, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS Genet 7:e1002253. 2011
    ....
  37. pmc Molecular mechanisms underlying genotype-dependent responses to dietary restriction
    Jennifer Schleit
    Department of Pathology, University of Washington, Seattle, WA, USA
    Aging Cell 12:1050-61. 2013
    ..These observations define conserved molecular processes that underlie genotype-dependent effects of DR that may be important modulators of DR in higher organisms. ..
  38. pmc Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1
    Ling Cai
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Cell Rep 4:1063-71. 2013
    ..However, instead of modulating overall rates of RP gene transcription or cell growth, the nutrient-responsive phosphorylation of Ifh1p plays a more prominent role in the regulation of cellular replicative lifespan. ..
  39. ncbi request reprint Single-gene deletions that restore mating competence to diploid yeast
    Tom Schmidlin
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    FEMS Yeast Res 8:276-86. 2008
    ..In summary, this study underscores and elaborates upon predicted pathways by which mutations restore mating function to yeast diploids and identifies new mutants warranting further study...
  40. ncbi request reprint The enigmatic role of Sir2 in aging
    Brian K Kennedy
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Cell 123:548-50. 2005
    ..In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction...
  41. pmc Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest
    Ryan T Nitta
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Mol Cell Biol 26:5360-72. 2006
    ..These findings do link lamin A/C to the functional activation of a critical tumor suppressor pathway and further the possibility that somatic mutations in LMNA contribute to tumor progression...
  42. pmc Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects
    Steven C Chen
    Fred Hutchinson Cancer Research Center FHCRC, Public Health Sciences Division, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Exp Cell Res 319:888-96. 2013
    ..7-fold increased levels by immunoblot. We conclude that increased pS279/282 Cx43 in the Lmna(-/-) background results in decreased cell communication and may contribute to the arrhythmic pathology in vivo...
  43. pmc End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging
    Joe R Delaney
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    FEMS Yeast Res 13:267-76. 2013
    ..These observations suggest that randomly occurring damage may contribute to stochasticity during replicative aging by causing a subset of the population to terminally arrest prematurely in the S or G2 phase of the cell cycle...
  44. doi request reprint Translate this ... during dietary restriction
    Brian K Kennedy
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell Metab 10:247-8. 2009
    ..Recently, Zid et al. (Zid et al., 2009) linked the benefits of dietary restriction in flies to increased levels of the downstream TOR target 4E-BP1 and corresponding changes in the relative translation rates of classes of mRNAs...
  45. ncbi request reprint Protein translation, 2007
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Aging Cell 6:731-4. 2007
    ..This Hot Topic article discusses papers published in the last year related to the importance of translation and its regulation by signaling through the target of rapamycin kinase, in modulating aging and age-associated diseases...
  46. pmc Recent developments in yeast aging
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e84. 2007
    ..Here we briefly outline aging in yeast and describe recent findings that continue to keep this "simple" eukaryote at the forefront of aging research...
  47. pmc A-type nuclear lamins act as transcriptional repressors when targeted to promoters
    Damian C Lee
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Exp Cell Res 315:996-1007. 2009
    ..These findings indicate that A-type lamins can promote transcriptional repression when in proximity of a promoter...
  48. pmc Late-life rapamycin treatment reverses age-related heart dysfunction
    James M Flynn
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA
    Aging Cell 12:851-62. 2013
    ....
  49. ncbi request reprint Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005
    ..In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined...
  50. pmc Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast
    Joe R Delaney
    Department of Pathology, University of Washington, Seattle, WA, USA
    Cell Cycle 10:156-65. 2011
    ....
  51. doi request reprint Progeria syndromes and ageing: what is the connection?
    Christopher R Burtner
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Mol Cell Biol 11:567-78. 2010
    ..These observations, coupled with genetic studies of longevity, lead to a hypothesis whereby progeria syndromes accelerate a subset of the pathological changes that together drive the normal ageing process...
  52. ncbi request reprint Aging: progeria and the lamin connection
    Brian A Kudlow
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Curr Biol 16:R652-4. 2006
    ..A recent study finds that LMNA, a gene targeted for mutation in Hutchinson Gilford Progeria Syndrome, may control the onset of aging-associated decline in normal fibroblasts...
  53. ncbi request reprint Genome-wide identification of conserved longevity genes in yeast and worms
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 128:106-11. 2007
    ..Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms...
  54. ncbi request reprint A-type nuclear lamins, progerias and other degenerative disorders
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:447-60. 2005
    ..Here, we compare and contrast the LMNA mutations leading to laminopathies with emphasis on progerias, and discuss possible functional roles for A-type lamins in the maintenance of healthy tissues...
  55. pmc Hot topics in aging research: protein translation and TOR signaling, 2010
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 10:185-90. 2011
    ....
  56. pmc Will the real aging Sirtuin please stand up?
    Chen Yu Liao
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    Cell Res 22:1215-7. 2012
    ..Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting plot twist - the lesser known SIRT6 is the longevity factor...
  57. pmc Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice
    J Scott Hale
    Department of Immunology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e10127. 2010
    ..Lmna(-/-) mice also display smaller spleens and thymuses. In this study, we investigated whether altered lymphoid organ sizes are correlated with specific defects in lymphocyte development...
  58. ncbi request reprint Large-scale identification in yeast of conserved ageing genes
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:17-21. 2005
    ....
  59. doi request reprint Protein translation, 2008
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Aging Cell 7:777-82. 2008
    ..Importantly, studies published this year also began to provide insights into specific mechanisms by which altered mRNA translation does (and in some cases does not) slow aging in invertebrate model organisms...
  60. pmc Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A
    Linda C Enns
    Department of Comparative Medicine, University of Washington, Seattle, WA, 98915, USA
    J Gerontol A Biol Sci Med Sci 64:1221-31. 2009
    ..These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance...
  61. pmc Hot topics in aging research: protein translation, 2009
    Brian K Kennedy
    Departments of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Aging Cell 8:617-23. 2009
    ..Other significant findings have connected translation control with other known longevity pathways and provided fodder for mechanistic hypotheses. Here, we summarize advances in this emerging field and raise questions for future studies...
  62. pmc TOR and ageing: a complex pathway for a complex process
    Mark A McCormick
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Philos Trans R Soc Lond B Biol Sci 366:17-27. 2011
    ..We also briefly cover other ageing genes identified by comparing worms and yeast, addressing the likelihood that their mammalian counterparts will affect longevity...
  63. ncbi request reprint LMNA mutations in progeroid syndromes
    Shurong Huang
    Department of Pathology, University of Washington, Box 357470, Seattle, WA 98195, USA
    Novartis Found Symp 264:197-202; discussion 202-7, 227-30. 2005
    ..When compared to WRN-mutant WS, LMNA-mutant atypical WS patients appear to show earlier onset and possibly more severe ageing-related symptoms...
  64. ncbi request reprint HIV protease inhibitors block adipocyte differentiation independently of lamin A/C
    Brian A Kudlow
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    AIDS 19:1565-73. 2005
    ..To determine the importance of lamin A/C for fat cell differentiation in vitro and for the anti-adipogenic activity of HIV protease inhibitors such as indinavir...
  65. pmc The TOR pathway comes of age
    Monique N Stanfel
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Biochim Biophys Acta 1790:1067-74. 2009
    ..Longevity studies in mammals are not published to date. Instead, we highlight studies in mouse models, which indicate that dampening the TOR pathway leads to widespread protection from an array of age-related diseases...
  66. pmc The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction
    Mark A McCormick
    Buck Institute for Research on Aging, Novato, CA 94945, USA Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell Rep 8:477-86. 2014
    ....
  67. pmc A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging
    Mark A McCormick
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 22:895-906. 2015
    ..Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging. ..
  68. doi request reprint Sirtuins in yeast: phenotypes and tools
    Scott Tsuchiyama
    Buck Institute for Research on Aging, Novato, CA, USA
    Methods Mol Biol 1077:11-37. 2013
    ..Here we describe phenotypes associated with yeast Sirtuins and assays used to monitor Sirtuin function in yeast, including the replicative aging assay. ..

Research Grants1

  1. Genome-wide Analysis of Aging in Yeast
    Brian K Kennedy; Fiscal Year: 2010
    ..When completed, this study will dramatically improve our understanding of aging in yeast and lead to models of caloric restriction that can be tested in mammalian systems. ..