J Thompson

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit
    J Thompson
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 98:9002-7. 2001
  2. pmc Testing the conservation of the translational machinery over evolution in diverse environments: assaying Thermus thermophilus ribosomes and initiation factors in a coupled transcription-translation system from Escherichia coli
    Jill Thompson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Nucleic Acids Res 32:5954-61. 2004
  3. pmc Effects of a number of classes of 50S inhibitors on stop codon readthrough during protein synthesis
    Jill Thompson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA
    Antimicrob Agents Chemother 48:4889-91. 2004
  4. pmc Staphylococcus aureus domain V functions in Escherichia coli ribosomes provided a conserved interaction with domain IV is restored
    J Thompson
    Department of Molecular and Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    RNA 7:1076-83. 2001
  5. ncbi request reprint The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo
    Jill Thompson
    Department of Molecular and Cellular Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    J Mol Biol 322:273-9. 2002
  6. ncbi request reprint Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome
    Dale M Cameron
    School of Microbiology and Immunology, University of New South Wales, Sydney, NSW 2052, Australia
    J Mol Biol 319:27-35. 2002
  7. pmc Thiostrepton-resistant mutants of Thermus thermophilus
    Dale M Cameron
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Nucleic Acids Res 32:3220-7. 2004
  8. pmc Thermus thermophilus L11 methyltransferase, PrmA, is dispensable for growth and preferentially modifies free ribosomal protein L11 prior to ribosome assembly
    Dale M Cameron
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    J Bacteriol 186:5819-25. 2004
  9. pmc The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal RNA is responsible for pH sensitivity of the peptidyltransferase active site conformation
    Mark A Bayfield
    Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Nucleic Acids Res 32:5512-8. 2004
  10. ncbi request reprint Pharmacologically regulated production of targeted retrovirus from T cells for systemic antitumor gene therapy
    Marka Crittenden
    Department of Immunology and Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 63:3173-80. 2003

Collaborators

  • MICHAEL O'CONNOR
  • Dale M Cameron
  • Albert E Dahlberg
  • Marka Crittenden
  • Steven T Gregory
  • Mark A Bayfield
  • Michael Gough
  • Paul E March
  • Kevin Harrington
  • Patrick A Limbach
  • Moo Jin Suh
  • John Chester
  • Richard G Vile
  • Tim Kottke
  • Richard Vile
  • Anja Ruchatz
  • Francois Luic Cosset
  • Luis Alvarez Vallina
  • Ken Olivier
  • Tim Clackson
  • Heung Chong
  • Rosa Maria Diaz

Detail Information

Publications11

  1. pmc Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit
    J Thompson
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 98:9002-7. 2001
    ..The significant levels of peptidyltransferase activity of ribosomes with mutations at A2451 and G2447 need to be reconciled with the roles proposed for these residues in catalysis...
  2. pmc Testing the conservation of the translational machinery over evolution in diverse environments: assaying Thermus thermophilus ribosomes and initiation factors in a coupled transcription-translation system from Escherichia coli
    Jill Thompson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Nucleic Acids Res 32:5954-61. 2004
    ..This functional compatibility is remarkable given the extreme and highly divergent environments to which these species have adapted...
  3. pmc Effects of a number of classes of 50S inhibitors on stop codon readthrough during protein synthesis
    Jill Thompson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA
    Antimicrob Agents Chemother 48:4889-91. 2004
    ..Inhibitors which bind close to the entrance of the peptide exit tunnel on the 50S ribosomal subunit promote substantial levels of readthrough, presumably by disrupting the mechanism of peptide release...
  4. pmc Staphylococcus aureus domain V functions in Escherichia coli ribosomes provided a conserved interaction with domain IV is restored
    J Thompson
    Department of Molecular and Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    RNA 7:1076-83. 2001
    ..Additionally, although the single-site mutations U1782C and U2586C in E. coli are viable, the double mutant is lethal...
  5. ncbi request reprint The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo
    Jill Thompson
    Department of Molecular and Cellular Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    J Mol Biol 322:273-9. 2002
    ..We conclude that effects on translational fidelity may play a significant role in the mechanism of action of the oxazolidinones...
  6. ncbi request reprint Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome
    Dale M Cameron
    School of Microbiology and Immunology, University of New South Wales, Sydney, NSW 2052, Australia
    J Mol Biol 319:27-35. 2002
    ..Micrococcin stimulates GTP hydrolysis by both factors. We show directly that these drugs act by destabilizing the interaction of EF-G with the ribosome, and provide evidence that they have similar effects on IF2...
  7. pmc Thiostrepton-resistant mutants of Thermus thermophilus
    Dale M Cameron
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Nucleic Acids Res 32:3220-7. 2004
    ..These data suggest that increased flexibility of the factor binding site results in resistance to thiostrepton by counteracting the conformation-stabilizing effect of the antibiotic...
  8. pmc Thermus thermophilus L11 methyltransferase, PrmA, is dispensable for growth and preferentially modifies free ribosomal protein L11 prior to ribosome assembly
    Dale M Cameron
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    J Bacteriol 186:5819-25. 2004
    ....
  9. pmc The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal RNA is responsible for pH sensitivity of the peptidyltransferase active site conformation
    Mark A Bayfield
    Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Nucleic Acids Res 32:5512-8. 2004
    ..coli peptidyltransferase center, its lack of conservation makes it, and consequently its near-neutral pK(a), unlikely to contribute to function during peptide bond formation...
  10. ncbi request reprint Pharmacologically regulated production of targeted retrovirus from T cells for systemic antitumor gene therapy
    Marka Crittenden
    Department of Immunology and Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 63:3173-80. 2003
    ..We hypothesize that this enhanced targeting to tumor sites is responsible for the efficiency of T cell-mediated retroviral gene transfer and that this principle can be used to enhance systemic therapies using immune-cell carriers...
  11. ncbi request reprint Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity
    Marka Crittenden
    Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 63:5505-12. 2003
    ..Finally, coexpression of HSVtk with either CCL3 or CCL20 was able to significantly increase protection against subsequent tumor rechallenge...