H W Kim

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Active myogenic tone: a requisite for hemoglobin mediated vascular contraction?
    H W Kim
    Brown University School of Medicine and The Miriam Hospital Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 32:339-51. 2004
  2. ncbi request reprint Hemoglobin mediated contraction of the isolated rat thoracic aorta: why is precontraction necessary?
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 33:27-36. 2005
  3. ncbi request reprint Temporal effect of hemoglobin resuscitation on sepsis survival
    H W Kim
    Brown University School of Medicine The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 32:401-11. 2004
  4. ncbi request reprint Artificial oxygen carriers as red blood cell substitutes: a selected review and current status
    Hae won Kim
    Department of Surgery, Brown University Medical School, The Miriam Hospital, Providence, RI 02906, USA
    Artif Organs 28:813-28. 2004
  5. ncbi request reprint Contraction coupled endothelial nitric oxide release: a new paradigm for local vascular control?
    H W Kim
    Department of Surgery, Brown University The Miriam Hospital, 164 Summit Avenue, Providence, Rhode Island 02906, USA
    J Surg Res 100:93-8. 2001
  6. ncbi request reprint Nitric oxide scavenging modulates an experimental vasoplesia in-vitro
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 29:263-74. 2001
  7. ncbi request reprint Alpha adrenergic activation and hemoglobin mediated contraction in the isolated rat thoracic aorta
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 29:367-80. 2001
  8. doi request reprint Relative roles of heme-irons and globin-thiols in the genesis of acellular hemoglobin mediated vasoconstriction
    Hae won Kim
    Department of Molecular Pharmacology, Physiology and Biotechnology Brown University, 171 Meeting Street, Providence, RI 02912, USA
    Artif Cells Blood Substit Immobil Biotechnol 38:5-12. 2010
  9. ncbi request reprint Civilian uses of hemoglobin-based oxygen carriers
    A Gerson Greenburg
    Department of Surgery, Brown University Medical School, The Miriam Hospital, Providence, RI 02906, USA
    Artif Organs 28:795-9. 2004
  10. pmc Differential sensitivities of pulmonary and coronary arteries to hemoglobin-based oxygen carriers and nitrovasodilators: study in a bovine ex vivo model of vascular strips
    Vera Fonseca
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, USA
    Vascul Pharmacol 52:215-23. 2010

Collaborators

  • Chi Ming Hai
  • A Gerson Greenburg
  • Daniel Freilich
  • Enrico Bucci
  • Hye Kyung Lee
  • Vera Fonseca
  • Timothy Estep
  • Young Hoon Kim
  • Young Joo Seo
  • Jessica Avizinis
  • Paula Moon-Massat
  • Ken Olsen
  • Phyllis Mitchell
  • C Robert Valeri
  • Harvey Klein
  • Gerson Greenburg
  • John Harrington
  • Martha Farmer
  • Andre Palmer
  • Robert Winslow
  • George Nemo
  • Eui Sic Cho
  • Seung Whan Kim
  • Se Mi Bok
  • Eun Mi Lee
  • Mi Young Lim
  • Jun Whee Lee
  • Eun Hee Lee

Detail Information

Publications15

  1. ncbi request reprint Active myogenic tone: a requisite for hemoglobin mediated vascular contraction?
    H W Kim
    Brown University School of Medicine and The Miriam Hospital Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 32:339-51. 2004
    ..In these vessel rings, exogenous 8-Br-cGMP, a membrane permeable cGMP analog, did not elicit relaxation. In conclusion, in the isolated rat thoracic aorta, Hb mediated contraction may be contingent upon the state of myogenic tone...
  2. ncbi request reprint Hemoglobin mediated contraction of the isolated rat thoracic aorta: why is precontraction necessary?
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 33:27-36. 2005
    ..This may explain why the Hb mediated additional contraction occurs only after an agonist induced precontraction...
  3. ncbi request reprint Temporal effect of hemoglobin resuscitation on sepsis survival
    H W Kim
    Brown University School of Medicine The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 32:401-11. 2004
    ..In conclusion, HS resuscitation does not appear to enhance postresuscitation sepsis mortality. Rather, when conducted concomitantly or prior to sepsis, HS resuscitation appears to improve survival from a subsequent sepsis challenge...
  4. ncbi request reprint Artificial oxygen carriers as red blood cell substitutes: a selected review and current status
    Hae won Kim
    Department of Surgery, Brown University Medical School, The Miriam Hospital, Providence, RI 02906, USA
    Artif Organs 28:813-28. 2004
    ..This article provides a short review of the basic principles, approaches, and current status of RCS development. Results of preclinical and clinical studies including recent Phase II/III clinical studies are discussed...
  5. ncbi request reprint Contraction coupled endothelial nitric oxide release: a new paradigm for local vascular control?
    H W Kim
    Department of Surgery, Brown University The Miriam Hospital, 164 Summit Avenue, Providence, Rhode Island 02906, USA
    J Surg Res 100:93-8. 2001
    ..In isolated rat thoracic aorta, however, hemoglobin (Hb), a nitric oxide scavenger, elicited contraction only when the vessels were precontracted with an alpha adrenergic agonist. Does vascular contraction induce endothelial NO release?..
  6. ncbi request reprint Nitric oxide scavenging modulates an experimental vasoplesia in-vitro
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 29:263-74. 2001
    ..In conclusion, NO scavenging, alone or in combination with a moderate NOS inhibition, may render an alternative therapeutic approach to NOS synthesis inhibition in modulating the vasoplesia in septic shock...
  7. ncbi request reprint Alpha adrenergic activation and hemoglobin mediated contraction in the isolated rat thoracic aorta
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 29:367-80. 2001
    ..The mechanism how prior tone enhancement allows Hb mediated contraction remains unclear but results from this study suggest a factor that controls cytosolic Ca++ levels may be involved...
  8. doi request reprint Relative roles of heme-irons and globin-thiols in the genesis of acellular hemoglobin mediated vasoconstriction
    Hae won Kim
    Department of Molecular Pharmacology, Physiology and Biotechnology Brown University, 171 Meeting Street, Providence, RI 02912, USA
    Artif Cells Blood Substit Immobil Biotechnol 38:5-12. 2010
    ..These results indicate that reactive globin-thiols do not appear to play a prominent role relative to heme-irons in Hb-mediated vasoconstriction...
  9. ncbi request reprint Civilian uses of hemoglobin-based oxygen carriers
    A Gerson Greenburg
    Department of Surgery, Brown University Medical School, The Miriam Hospital, Providence, RI 02906, USA
    Artif Organs 28:795-9. 2004
    ..Some general parametric values of HBOCs are presented. These values are by no means considered optimal for all HBOCs and are subject to exploration, fine tuning, correction, or even rejection...
  10. pmc Differential sensitivities of pulmonary and coronary arteries to hemoglobin-based oxygen carriers and nitrovasodilators: study in a bovine ex vivo model of vascular strips
    Vera Fonseca
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, USA
    Vascul Pharmacol 52:215-23. 2010
    ..Among the three nitrovasodilators investigated, nitroglycerin appears to be the most promising candidate for attenuating HBOC-induced pulmonary hypertension in older HBOCs...
  11. pmc Hemoglobin-based oxygen carriers
    A Gerson Greenburg
    Brown University School of Medicine, Providence, Rhode Island, USA
    Crit Care 8:S61-4. 2004
    ..An update on clinical trial status is provided, and the potential utility of hemoglobin-based oxygen carriers in surgery combined with intraoperative autologous donation is discussed...
  12. ncbi request reprint Toward 21st century blood component replacement therapeutics: artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and others
    Hae won Kim
    Brown University Medical School and The Miriam Hospital, Providence, Rhode Island, USA
    Artif Cells Blood Substit Immobil Biotechnol 34:537-50. 2006
    ..In addition, some future approaches and prospects of blood component replacement therapeutics are discussed...
  13. ncbi request reprint Role of glutathione in the adaptive tolerance to H2O2
    Young Joo Seo
    Department of Pharmacology, University of Ulsan College of Medicine, Seoul 138 736, South Korea
    Free Radic Biol Med 37:1272-81. 2004
    ....
  14. ncbi request reprint Age differences in cholinergic airway responsiveness in relation with muscarinic receptor subtypes
    Hye Kyung Lee
    Department of Pharmacology, University of Ulsan College of Medicine, Songpagu, Seoul, South Korea
    Life Sci 81:204-9. 2007
    ....
  15. doi request reprint Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006
    Timothy Estep
    Chart Biotech Consulting, LLC, Erie, Colorado, USA
    Transfusion 48:776-82. 2008
    ..This communication summarizes the opinion of workshop participants on these issues and concludes with a list of specific recommended areas of research that could positively impact the development of blood substitutes...