R Gong

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Multi-target anti-inflammatory action of hepatocyte growth factor
    Rujun Gong
    Brown University School of Medicine, Department of Medicine, Providence, RI 02903, USA
    Curr Opin Investig Drugs 9:1163-70. 2008
  2. pmc Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanisms
    Jin Si
    Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
    Kidney Int 83:635-46. 2013
  3. pmc Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury
    Hao Bao
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Kidney Int 81:662-73. 2012
  4. pmc Leveraging melanocortin pathways to treat glomerular diseases
    Rujun Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, RI Electronic address
    Adv Chronic Kidney Dis 21:134-51. 2014
  5. ncbi request reprint Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity
    Andrew S Brem
    Div of Kidney Diseases and Hypertension, Rhode Island Hospital, Providence, RI 02903, USA
    Am J Physiol Renal Physiol 298:F1178-87. 2010
  6. pmc Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells
    Rujun Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Provindence, Rhode Island 02903, USA
    J Biol Chem 283:7401-10. 2008
  7. ncbi request reprint Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endothelium
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
    J Am Soc Nephrol 17:2464-73. 2006
  8. ncbi request reprint Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin
    R Gong
    Department of Medicine, Division of Renal Diseases, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Kidney Int 69:1166-74. 2006
  9. pmc The renaissance of corticotropin therapy in proteinuric nephropathies
    Rujun Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Nat Rev Nephrol 8:122-8. 2012
  10. ncbi request reprint Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Am Soc Nephrol 15:2868-81. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Multi-target anti-inflammatory action of hepatocyte growth factor
    Rujun Gong
    Brown University School of Medicine, Department of Medicine, Providence, RI 02903, USA
    Curr Opin Investig Drugs 9:1163-70. 2008
    ..Thus, HGF might represent a novel integrated multiple-target approach to suppress inflammation and to lower the risk of complications from inflammatory injury...
  2. pmc Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanisms
    Jin Si
    Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
    Kidney Int 83:635-46. 2013
    ..Thus, ACTH has additive renoprotective actions achieved by both steroid-dependent mechanisms and MC1R-directed anti-apoptosis. ACTH may represent a novel therapeutic strategy to prevent or treat AKI...
  3. pmc Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury
    Hao Bao
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Kidney Int 81:662-73. 2012
    ..Hence, inhibition of GSK3β ameliorates NSAID-induced acute kidney injury by induction of renal cortical COX-2 and direct inhibition of the mitochondrial permeability transition...
  4. pmc Leveraging melanocortin pathways to treat glomerular diseases
    Rujun Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, RI Electronic address
    Adv Chronic Kidney Dis 21:134-51. 2014
    ....
  5. ncbi request reprint Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity
    Andrew S Brem
    Div of Kidney Diseases and Hypertension, Rhode Island Hospital, Providence, RI 02903, USA
    Am J Physiol Renal Physiol 298:F1178-87. 2010
    ..Thus, extended Aldo exposure produces fibrotic changes in cells containing MR and in normal kidneys. MR antagonists and the end products of 11β-HSD attenuate these fibrogenic effects...
  6. pmc Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells
    Rujun Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Provindence, Rhode Island 02903, USA
    J Biol Chem 283:7401-10. 2008
    ....
  7. ncbi request reprint Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endothelium
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
    J Am Soc Nephrol 17:2464-73. 2006
    ..These findings suggest that HGF has potent and direct anti-inflammatory effects on the basis of suppression of NF-kappaB activation and downstream endothelial inflammation...
  8. ncbi request reprint Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin
    R Gong
    Department of Medicine, Division of Renal Diseases, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Kidney Int 69:1166-74. 2006
    ..These findings suggest that HGF ameliorates acute renal inflammation in part by downregulating E-selectin mediated macrophage adhesion to the inflamed endothelium...
  9. pmc The renaissance of corticotropin therapy in proteinuric nephropathies
    Rujun Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Nat Rev Nephrol 8:122-8. 2012
    ....
  10. ncbi request reprint Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Am Soc Nephrol 15:2868-81. 2004
    ..These findings suggest that the beneficial effect of HGF in chronic renal disease is attributable, at least in part, to a direct anti-inflammatory action, likely via NF-kappaB, on tubular epithelial cells...
  11. ncbi request reprint Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft disease
    R Gong
    Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Providence, RI, USA
    Am J Transplant 8:1852-63. 2008
    ..Collectively, GSK3beta plays an important role in mediating proinflammatory NF-kappaB activation and renal inflammation. Suppression of GSK3beta activity might represent a novel therapeutic strategy to treat CRAD...
  12. ncbi request reprint Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade
    Shan Chen
    Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Kidney Int 74:1128-38. 2008
    ..There was, however, a dose-dependent improvement of renal redox homeostasis. Our study suggests that candesartan suppresses redox-sensitive NFkappaB-mediated renal inflammation by a direct antioxidant effect independent of AT1R blockade...
  13. ncbi request reprint Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Brown University Medical School, Providence, RI 02903, USA
    Biochem Biophys Res Commun 330:27-33. 2005
    ..These findings suggest that PI3K-Akt activation and subsequent inhibitory phosphorylation of GSK3beta are required for HGF-induced suppression of RANTES in HKC...
  14. pmc Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways
    Murugavel Ponnusamy
    Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA
    Am J Physiol Renal Physiol 297:F1361-70. 2009
    ..Therefore, we have identified TGase-1 as a novel survival factor in renal epithelial cells and it contributes to cell survival through activation of the AKT and STAT3 signaling pathways following oxidant injury...
  15. ncbi request reprint Long-term, high-dosage candesartan suppresses inflammation and injury in chronic kidney disease: nonhemodynamic renal protection
    Chen Yu
    Division of Renal Disease, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    J Am Soc Nephrol 18:750-9. 2007
    ..Renal protection with high-dosage therapy may depend on these nonhemodynamic effects...
  16. ncbi request reprint Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury
    Lance D Dworkin
    Brown Medical School, and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Kidney Int 65:409-19. 2004
    ..Hepatocyte growth factor (HGF) has been reported to prevent injury in several models of renal disease; however, whether HGF can also retard progression of established renal disease is not known...
  17. ncbi request reprint Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease
    Jin Si
    Department of Medicine, Brown University School of Medicine, Providence, RI, USA
    Lab Invest 90:448-58. 2010
    ....
  18. ncbi request reprint Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate
    Purba Biswas
    Diivsion of Renal Diseases, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Renal Physiol 288:F8-15. 2005
    ..This finding was consistent with the observation in vivo of a decrease in ET-1 production in renal parenchyma of rats chronically treated with HGF. Our data suggest both a hemodynamic and biological role for HGF-mediated ET-1 regulation...
  19. ncbi request reprint Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells
    Rujun Gong
    Rhode Island Hospital, Division of Kidney Diseases and Hypertension, Brown Medical School, Providence, RI 02903, United States
    Steroids 73:1187-96. 2008
    ..Changes in 11beta-HSD1 with growth and during repair occurred at the transcription level. Thus, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth...
  20. pmc Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3
    Zhu Zhang
    Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA
    J Biol Chem 284:3345-53. 2009
    ..These results demonstrate that TGase-1 plays an important role in regulation of renal epithelial cell proliferation through the JAK2-Stat-3 signaling pathway...
  21. ncbi request reprint Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosis
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, and Department of Pathology, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Am Soc Nephrol 14:3047-60. 2003
    ..Collectively, these findings demonstrate that HGF ameliorates renal fibrosis by enhancing extracellular matrix catabolism via both MMP and the PA/plasmin proteolytic pathways...
  22. ncbi request reprint Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2
    Rujun Gong
    Rhode Island Hospital Division of Kidney Diseases and Hypertension, Brown Medical School, Providence, R I, United States
    Life Sci 82:631-7. 2008
    ..Thus, normal human kidney contains active 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 co-localizes with COX-2 in proximal tubule cells...