Brookhaven National Laboratory

Summary

Organization: Brookhaven National Laboratory
Country: USA

Top Publications

  1. pmc Development of diamond-based X-ray detection for high-flux beamline diagnostics
    Jen Bohon
    Center for Synchrotron Biosciences, Case Western Reserve University, Upton, NY 11973, USA
    J Synchrotron Radiat 17:711-8. 2010
  2. pmc Propagation of large concentration changes in reversible protein-binding networks
    Sergei Maslov
    Department of Condensed Matter Physics and Materials Science, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 104:13655-60. 2007
  3. ncbi In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 61:577-86. 2007
  4. ncbi Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Exp Hematol 35:69-77. 2007
  5. ncbi Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York, New York 11973, USA
    J Nucl Med 48:277-87. 2007
  6. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
  7. ncbi An atomistic MD simulation and pair-distribution-function study of disorder and reactivity of alpha-AlF3 nanoparticles
    Santanu Chaudhuri
    Department of Chemistry, SUNY Stony Brook, NY 11794 3400, USA
    Phys Chem Chem Phys 8:5045-55. 2006
  8. ncbi Increased C availability at elevated carbon dioxide concentration improves N assimilation in a legume
    Alistair Rogers
    Department of Environmental Sciences, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Plant Cell Environ 29:1651-8. 2006
  9. pmc Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential
    F Avraham Dilmanian
    Medical Department, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:9709-14. 2006
  10. pmc X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1)
    Babu A Manjasetty
    Protein Structure Factory, c o BESSY GmbH, Albert Einstein Str 15, 12489 Berlin, Germany
    BMC Struct Biol 5:21. 2005

Detail Information

Publications62

  1. pmc Development of diamond-based X-ray detection for high-flux beamline diagnostics
    Jen Bohon
    Center for Synchrotron Biosciences, Case Western Reserve University, Upton, NY 11973, USA
    J Synchrotron Radiat 17:711-8. 2010
    ..Prototype single-crystal quadrant detectors have provided the ability to simultaneously resolve the X-ray beam position and obtain a quantitative measurement of the flux...
  2. pmc Propagation of large concentration changes in reversible protein-binding networks
    Sergei Maslov
    Department of Condensed Matter Physics and Materials Science, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 104:13655-60. 2007
    ..Such "action-at-a-distance" requires high concentrations of heterodimers along the path as well as low free (unbound) concentration of intermediate proteins...
  3. ncbi In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 61:577-86. 2007
    ..Thus, CNS-5161 binds preferentially to the activated state of the NMDA receptor channel in vitro and in vivo. The high affinity and fast kinetics make it compatible with PET imaging of a carbon-11 labeled CNS-5161...
  4. ncbi Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Exp Hematol 35:69-77. 2007
    ..The repairs apparently involve the microvasculature and the glial system. We evaluate a hypothesis on the involvement of bystander effects in these repairs...
  5. ncbi Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York, New York 11973, USA
    J Nucl Med 48:277-87. 2007
    ....
  6. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
    ....
  7. ncbi An atomistic MD simulation and pair-distribution-function study of disorder and reactivity of alpha-AlF3 nanoparticles
    Santanu Chaudhuri
    Department of Chemistry, SUNY Stony Brook, NY 11794 3400, USA
    Phys Chem Chem Phys 8:5045-55. 2006
    ....
  8. ncbi Increased C availability at elevated carbon dioxide concentration improves N assimilation in a legume
    Alistair Rogers
    Department of Environmental Sciences, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Plant Cell Environ 29:1651-8. 2006
    ..One possible explanation for these findings is that N fixation had increased, and that these plants had acclimated to the increased N demand at elevated [CO2]...
  9. pmc Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential
    F Avraham Dilmanian
    Medical Department, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:9709-14. 2006
    ..These findings strongly suggest potential application of interlaced microbeams to treat tumors or to ablate nontumorous abnormalities with minimal damage to surrounding normal tissue...
  10. pmc X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1)
    Babu A Manjasetty
    Protein Structure Factory, c o BESSY GmbH, Albert Einstein Str 15, 12489 Berlin, Germany
    BMC Struct Biol 5:21. 2005
    ..Human Aortic Preferentially Expressed Protein-1 (APEG-1) is a novel specific smooth muscle differentiation marker thought to play a role in the growth and differentiation of arterial smooth muscle cells (SMCs)...
  11. ncbi Formation of protein-birnessite complex: XRD, FTIR, and AFM analysis
    A Naidja
    Department of Soil Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan, S7N 5A8, Canada
    J Colloid Interface Sci 251:46-56. 2002
    ..The information obtained in this study is of fundamental significance for understanding birnessite as an adsorbent of biopolymers and the catalytic role of the enzyme-birnessite complex...
  12. ncbi Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs...
  13. ncbi My early days in photobiology with Philip Hanawalt
    Richard B Setlow
    Biology Department, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973, USA
    Mutat Res 577:4-8. 2005
    ..That communication was essential in elucidating some of the important steps in nucleotide excision repair-a field in which Phil is a pre-eminent scholar and investigator...
  14. ncbi Recent advances in the neuroimaging of multiple sclerosis
    William D Rooney
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Curr Neurol Neurosci Rep 5:217-24. 2005
    ..Specific disease measures such as endothelial activation, microglial activation, and cell trafficking are accessible to neuroimaging and offer significant promise for improved characterization of central nervous system involvement in MS...
  15. pmc Widespread disruption in brain activation patterns to a working memory task during cocaine abstinence
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Brain Res 1171:83-92. 2007
    ..This widespread neurofunctional disruption is likely to underlie the cognitive deficits during early cocaine abstinence and to reflect involvement of dopamine as well as other neurotransmitters...
  16. pmc X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family
    Rajiv Tyagi
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    BMC Struct Biol 7:62. 2007
    ..Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs)...
  17. ncbi Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography
    Panayotis K Thanos
    Behavioral Neuropharmacology Laboratory, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 62:50-61. 2008
    ..Here we assess DA D2 receptors (D2R) in a genetic rodent obesity model characterized by leptin-receptor deficiency and assess the influence of food restriction on these receptors...
  18. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  19. doi Yields of clustered DNA damage induced by charged-particle radiations of similar kinetic energy per nucleon: LET dependence in different DNA microenvironments
    Deborah J Keszenman
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Radiat Res 174:238-50. 2010
    ..The yields of DSBs and non-DSB clusters as well as the damage spectra varied with LET and DNA milieu, suggesting the involvement of more than one mechanism in the formation of the different types of clustered damages...
  20. pmc Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, New York, USA
    PLoS ONE 5:e11067. 2010
    ....
  21. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  22. ncbi Scanning moiré fringe imaging by scanning transmission electron microscopy
    Dong Su
    Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA
    Ultramicroscopy 110:229-33. 2010
    ..Application of the technique to reveal the Burgers vector of misfit dislocations at the interface of epitaxial films is demonstrated and its potential for studying strain fields is discussed...
  23. pmc Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Dept of Health and Human Services, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 94:374-9. 2010
    ....
  24. pmc The neurocircuitry of impaired insight in drug addiction
    Rita Z Goldstein
    Center for Translational Neuroimaging, Medical Research, Brookhaven National Laboratory, 30 Bell Ave Bldg 490, Upton, NY 11973 5000, USA
    Trends Cogn Sci 13:372-80. 2009
    ..We discuss implications for clinical treatment including the design of interventions to improve insight into illness severity in addiction...
  25. pmc Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
    ..Our results suggest that protecting salvinorin A derivatives from metabolism will prolong duration of action, but only when administered by routes giving slow absorption...
  26. pmc Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
    Proc Natl Acad Sci U S A 106:1249-54. 2009
    ..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity...
  27. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  28. doi Biodistribution of radiolabeled ethanol in rodents
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NNew York 11973, USA
    Drug Metab Dispos 36:1853-8. 2008
    ..It is thus tempting to speculate that the well documented high incidence of pancreatic disease observed in human chronic alcoholism may be related to a propensity of this organ to accumulate ethanol and/or reactive ethanol metabolites...
  29. ncbi Reductive dissolution of Pu(IV) by Clostridium sp. under anaerobic conditions
    Arokiasamy J Francis
    Environmental Sciences Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Environ Sci Technol 42:2355-60. 2008
    ....
  30. doi Activation of natural Hf and Ta in relation to the production of 177Lu
    Dmitri G Medvedev
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Appl Radiat Isot 66:1300-6. 2008
    ..The results are in good agreement with theoretical data calculated using computer codes MCNPX and ORIGEN2S. Production of relevant medical isotopes such as (167)Tm and (169)Yb from the above targets is discussed as well...
  31. ncbi 241Am, 137Cs, Sr and Pb uptake by tobacco as influenced by application of Fe chelators to soil
    Mark Fuhrmann
    Environmental Sciences Department, Brookhaven National Laboratory, Building 830, P O Box 5000, Upton, NY 11973, USA
    J Environ Radioact 82:33-50. 2005
    ..SXRF maps indicate differences in behavior between Fe and Pb that are consistent with the bulk plant observations and provide insight into changes in metal content of the roots in the presence of EDTA...
  32. ncbi Comparison of a digital and an analog signal processing system for neutron inelastic gamma-ray spectrometry
    S Mitra
    Department of Environmental Sciences, Earth Systems Science Division, Brookhaven National Laboratory, Upton, NY 11973, USA
    Appl Radiat Isot 61:1463-8. 2004
    ..43 MeV, and O, 6.13 MeV, gamma-rays. In separate experiments, the digital and the analog systems were also compared using an intense 10.3 mCi 137Cs source to vary the ICR, and the 1.17 MeV peak area of 60Co was used as the reference...
  33. ncbi Biodistribution of copper carboranyltetraphenylporphyrins in rodents bearing an isogeneic or human neoplasm
    M Miura
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Neurooncol 52:111-7. 2001
    ....
  34. ncbi A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it
    W F Mangel
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Curr Med Chem 8:933-9. 2001
    ..It contains an active site and two cofactor binding sites; the functions of the active site are dependent upon the cofactors interacting with their binding sites. We describe how to obtain drugs against the three different sites...
  35. ncbi Resting brain metabolic activity in a 4 tesla magnetic field
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Magn Reson Med 44:701-5. 2000
    ..We conclude that a static magnetic field of 4 T does not in itself affect this fairly sensitive measure of brain activity...
  36. pmc Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York, NY 11973, USA
    Br J Pharmacol 131:645-50. 2000
    ..The SR 141716A-induced enhancement of ACh release can similarly be observed in hippocampal synaptosomes and is probably due to an inverse agonist action at constitutively active receptors...
  37. ncbi Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain
    N D Volkow
    Medical Department, Upton, NY 11973, USA
    Life Sci 67:1507-15. 2000
    ..The faster time course for the subjective effects for smoked than intravenous and for intravenous than for intranasal cocaine highlights the importance of the speed of cocaine's delivery into the brain on its reinforcing effects...
  38. ncbi PURR-TURBO: a novel pulse sequence for longitudinal relaxographic imaging
    J H Lee
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Magn Reson Med 43:773-7. 2000
    ..Here, we demonstrate that a single slice human brain (1)H(2)O T(1) map with a nominal in-plane resolution of less than (1 mm)2can be obtained at 4 T in about 4 min. Published 2000 Wiley-Liss, Inc...
  39. ncbi Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:75-80. 2000
    ..This study investigates the relationship between measures of brain dopamine D(2) receptors (molecules that transmit dopamine signals) and regional brain glucose metabolism (a marker of brain function) in healthy individuals...
  40. ncbi Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  41. ncbi Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:344-9. 1998
    ..This study assessed the relation between measures of brain dopamine activity and indexes of motor and cognitive function in healthy individuals...
  42. ncbi Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: a PET study
    N D Volkow
    Medical Department, Brookhaven National Laboratory, NY 11973, USA
    Am J Psychiatry 155:200-6. 1998
    ..Because cocaine enhances dopamine brain activity and dopamine signals are transferred through gamma-aminobutyric acid pathways, the authors hypothesized GABA-ergic disruption in cocaine-abusing subjects. This study tests this hypothesis...
  43. ncbi Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 61:PL 191-7. 1997
    ..However, the binding site domains which interact with AM251 and CP 55,940 may not be identical, since IC50 values for cannabinoid receptor ligands depended on whether [123I]AM251 or [3H]CP 55,940 was used as radioligand...
  44. ncbi Evidence for an uncommon microsatellite instability on mouse chromosomes 2 and 4 and its possible role in radiation leukemogenesis
    K N Rithidech
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Blood Cells Mol Dis 23:99-109. 1997
    ....
  45. ncbi Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
    ..The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity...
  46. ncbi Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  47. ncbi Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  48. ncbi Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications
    Nora D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 43:181-7. 2002
    ....
  49. ncbi Small-gap insertion-device development at the National Synchrotron Light Source--performance of the new X13 mini-gap undulator
    J M Ablett
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Synchrotron Radiat 11:129-31. 2004
    ..3 mm within the NSLS X13 straight section, is reported. It is the brightest source of hard X-rays in the energy range approximately 3.7-16 keV at the NSLS, and replaces an in-vacuum undulator which had a more limited tunability...
  50. ncbi Uptake and release of cesium-137 by five plant species as influenced by soil amendments in field experiments
    Mark Fuhrmann
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    J Environ Qual 32:2272-9. 2003
    ....
  51. ncbi Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    Wynne K Schiffer
    SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
    Neuropsychopharmacology 28:2192-8. 2003
    ..5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA...
  52. ncbi Evidence linking the Pseudomonas oleovorans alkane omega-hydroxylase, an integral membrane diiron enzyme, and the fatty acid desaturase family
    John Shanklin
    Department of Biology, Brookhaven National Laboratory, Building 463, 50 Bell Ave, Upton, NY 11973, USA
    FEBS Lett 545:188-92. 2003
    ....
  53. ncbi Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Radiat Res 43:S149-52. 2002
    ..Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation...
  54. ncbi Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
  55. ncbi Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Antivir Ther 8:17-26. 2003
    ..We aimed to evaluate whether brain abnormalities will improve 3 months after HAART...
  56. ncbi Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Radiat Res 159:632-41. 2003
    ..02), but severe leg dysfunction was also lower (P < 0.003). These findings suggest that single-fraction microbeams can ablate tumors at high rates with relatively little normal-tissue toxicity...
  57. ncbi Evaluation of number average length analysis in quantifying double strand breaks in genomic DNAs
    Betsy M Sutherland
    Department of Biology, Brookhaven National Laboratory, Building 463, 50 Bell Avenue, Upton, New York 11973 5000, USA
    Biochemistry 42:3375-84. 2003
    ..The use of this approach in quantifying DNA damages is illustrated for double strand breaks and damage clusters (e.g., OxyPurine clusters recognized by Escherichia coli Fpg protein) induced in T7 DNA by ionizing radiation...
  58. ncbi Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies
    Nora D Volkow
    Medical Department Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur Neuropsychopharmacol 12:557-66. 2002
    ..Moreover, abuse of methylphenidate is constrained by its long half-life, which we postulate limits the frequency at which it can be administered...
  59. ncbi Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    T Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurology 59:1343-9. 2002
    ..The current study aims to determine whether patients who are HIV-1 positive and have normal cognitive function also show increased brain activation on fMRI...
  60. pmc Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
    Am J Psychiatry 159:1642-52. 2002
    ..Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction...
  61. ncbi Sulfur polymer solidification/stabilization of elemental mercury waste
    M Fuhrmann
    Environmental Research and Technology Division, Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Waste Manag 22:327-33. 2002
    ..Values for the effective diffusion coefficient averaged 7.6x10(-18) cm2/s. Concentrations of mercury vapor from treated waste in equilibrium static headspace tests averaged 0.6 mg/m3...
  62. ncbi Brain glucose metabolism in violent psychiatric patients: a preliminary study
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 61:243-53. 1995
    ..These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior...

Research Grants62

  1. PET STUDIES IN COCAINE ABUSE
    Nora Volkow; Fiscal Year: 1992
    ..We also hypothesize that the actions of cocaethylene on the dopamine transporter act as a positive reinforcement that promotes the combined use of alcohol and cocaine...
  2. STUDIES IN COCAINE ABUSERS
    Nora Volkow; Fiscal Year: 2001
    ..abstract_text> ..
  3. PHARMACOKINETICS OF PSYCHOSTIMULANTS AND REINFORCEMENT
    Nora Volkow; Fiscal Year: 2002
    ....
  4. Addiction and the Brain: Are We Hard Wired to Abuse Drugs
    Joanna Fowler; Fiscal Year: 2007
    ....
  5. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2004
    ....
  6. Role of Genotype and Maternal Smoking on Brain MAO A
    Joanna Fowler; Fiscal Year: 2007
    ..abstract_text> ..
  7. RADIOTRACER RANDD IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2000
    ....
  8. The prefrontal cortex in salience and control in cocaine addiction: phFMRI study
    Rita Z Goldstein; Fiscal Year: 2010
    ..Thus, using the pharmacological functional activation and behavioral results in our study, we may be able to highlight the intervention approaches that may be most beneficial. ..
  9. The prefrontal cortex in salience and control in cocaine addiction: phFMRI study
    Rita Goldstein; Fiscal Year: 2009
    ..Thus, using the pharmacological functional activation and behavioral results in our study, we may be able to highlight the intervention approaches that may be most beneficial. ..
  10. Behavioral correlates of fMRI response in cocaine users
    Rita Goldstein; Fiscal Year: 2006
    ..b>Brookhaven National Laboratory (BNL) provides an ideal training environment: 1) BNL is home to state-of-the-art functional ..
  11. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..
  12. Neurochemistry of Nicotine Dependence in Schizophrenia
    Wynne Schiffer; Fiscal Year: 2004
    ..Or increase inhibitory activity with the GABA agonist, gamma-vinyl GABA, prior to the nicotine challenge. We hope to guide the development of novel therapies for dual-diagnosis schizophrenia. ..
  13. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2006
    ..abstract_text> ..
  14. DNA Damage Clusters: Repair in Mammalian Cells
    Betsy Sutherland; Fiscal Year: 2004
    ..Further, knowledge of conditions affecting formation of clustered damages, and cellular paths for dealing with them could allow the design of more effective radiation therapies. ..
  15. PET Investigations of Abused Inhalants
    Madina Gerasimov; Fiscal Year: 2002
    ..More importantly, these studies will provide the strategy and tools to identify characteristics of inhalants that are associated with their abuse liability. ..
  16. Metals and Protein Structure in Protein-Folding Diseases
    Lisa Miller; Fiscal Year: 2007
    ..Finally, we use the local structure and homogeneity of the in situ metal-protein complex to develop a possible mechanism for the complex formation and toxicity. ..
  17. Synchrotron-Based Infrared Microscope for Chemical Imaging of Disease
    Lisa Miller; Fiscal Year: 2007
    ..This instrument will be unique worldwide. ..
  18. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2003
    ..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
  19. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..Furthermore, these experiments will give information on the mode of action of cannabinoid antagonists and could suggest novel therapeutic uses for this new class of compounds. ..
  20. PET Studies of Alcohol Distribution and Metabolism
    Andrew Gifford; Fiscal Year: 2005
    ..abstract_text> ..
  21. Animal model for inhalant abuse
    Andrew Gifford; Fiscal Year: 2004
    ..Additionally, an animal model for inhalant abuse will aid further exploration of the factors contributing to the predisposition, development and potential treatment of inhalant abuse. ..
  22. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  23. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2009
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  24. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2007
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  25. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia Klein; Fiscal Year: 2010
    ..Therefore, understanding the basic genetic, neurochemical and neuroanatomical processes associated with aggression is a public health concern. ..
  26. Antiviral agents directed to novel targets in the adenovirus proteinase
    Walter F Mangel; Fiscal Year: 2010
    ..We are studying virus-coded proteinases as targets for antiviral agents. Several novel classes of drug targets have been uncovered, and we are now identifying compounds that bind to them and act as anti-viral agents. ..