Andres S Hernandez

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. doi request reprint Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues
    Andres S Hernandez
    Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 18:2067-72. 2008
  2. ncbi request reprint Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues
    Andres S Hernandez
    Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 17:5928-33. 2007
  3. doi request reprint Tetrazole based amides as growth hormone secretagogues
    James J Li
    Discovery Chemistry, Bristol Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543 5400, USA
    Bioorg Med Chem Lett 18:2536-9. 2008
  4. ncbi request reprint Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)
    Jun Li
    Department of Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, P O Box 5400, Princeton, NJ 08543, USA
    J Med Chem 50:5890-3. 2007
  5. doi request reprint Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)
    Jun Li
    Metabolic Diseases Chemistry, Bristol Myers Squibb, Building 13, P O Box 5400, Princeton, New Jersey 08543 5400, USA
    J Med Chem 53:2854-64. 2010
  6. ncbi request reprint Comparison of conventional spin-echo and fast spin-echo magnetic resonance imaging in the canine brain
    Jaime E Sage
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210, USA
    Vet Radiol Ultrasound 47:249-53. 2006
  7. ncbi request reprint Evaluation of engineered meniscal cartilage constructs based on different scaffold geometries using magnetic resonance imaging and spectroscopy
    Andre A Neves
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Tissue Eng 12:53-62. 2006
  8. ncbi request reprint 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups
    Klaus Klumpp
    Roche Palo Alto LLC, Palo Alto, California 94304, USA
    J Biol Chem 283:2167-75. 2008
  9. ncbi request reprint Characterization of a novel polymorphic form of celecoxib
    Guang Wei Lu
    Global Research and Development, Michigan laboratory, Pfizer Inc, Ann Arbor, 48105, USA
    J Pharm Sci 95:305-17. 2006
  10. ncbi request reprint Towards the creation of an international toxicology information centre
    Philip N Judson
    Lhasa Ltd, 22 23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD, UK
    Toxicology 213:117-28. 2005

Collaborators

Detail Information

Publications12

  1. doi request reprint Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues
    Andres S Hernandez
    Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 18:2067-72. 2008
    ..An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed...
  2. ncbi request reprint Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues
    Andres S Hernandez
    Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 17:5928-33. 2007
    ..The tetrazole 9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10 mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed...
  3. doi request reprint Tetrazole based amides as growth hormone secretagogues
    James J Li
    Discovery Chemistry, Bristol Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543 5400, USA
    Bioorg Med Chem Lett 18:2536-9. 2008
    ..Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model...
  4. ncbi request reprint Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)
    Jun Li
    Department of Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, P O Box 5400, Princeton, NJ 08543, USA
    J Med Chem 50:5890-3. 2007
    ..Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development...
  5. doi request reprint Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)
    Jun Li
    Metabolic Diseases Chemistry, Bristol Myers Squibb, Building 13, P O Box 5400, Princeton, New Jersey 08543 5400, USA
    J Med Chem 53:2854-64. 2010
    ..The role of the crystal structure of compound 12 with PPARalpha in the development of the SAR that ultimately resulted in the discovery of compound 2 is discussed...
  6. ncbi request reprint Comparison of conventional spin-echo and fast spin-echo magnetic resonance imaging in the canine brain
    Jaime E Sage
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210, USA
    Vet Radiol Ultrasound 47:249-53. 2006
    ..Fast spin echo offers increased resolution in a comparable time to conventional spin echo by increased number of excitations and finer matrix size, thus improving the signal-to-noise ratio and spatial resolution, respectively...
  7. ncbi request reprint Evaluation of engineered meniscal cartilage constructs based on different scaffold geometries using magnetic resonance imaging and spectroscopy
    Andre A Neves
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Tissue Eng 12:53-62. 2006
    ..MRI and MRS are powerful techniques that can be used to optimize the design of engineered meniscal cartilage and that could be used subsequently to evaluate clinical outcome postimplantation...
  8. ncbi request reprint 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups
    Klaus Klumpp
    Roche Palo Alto LLC, Palo Alto, California 94304, USA
    J Biol Chem 283:2167-75. 2008
    ..Therefore, 2'-alpha-deoxy-4'-azido nucleosides are a new class of antiviral nucleosides with promising preclinical properties as potential medicines for the treatment of HCV infection...
  9. ncbi request reprint Characterization of a novel polymorphic form of celecoxib
    Guang Wei Lu
    Global Research and Development, Michigan laboratory, Pfizer Inc, Ann Arbor, 48105, USA
    J Pharm Sci 95:305-17. 2006
    ..There were no measurable changes in the solid state of Form IV either in dried solids or in the suspension for at least 6 months at 40 degrees C and 16 months at 25 degrees C...
  10. ncbi request reprint Towards the creation of an international toxicology information centre
    Philip N Judson
    Lhasa Ltd, 22 23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD, UK
    Toxicology 213:117-28. 2005
    ..Successful completion of the pilot has led to an ongoing project to develop and expand the system...
  11. doi request reprint Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase
    Zachary K Sweeney
    Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 18:4348-51. 2008
    ..Pharmacokinetic studies indicated that inhibitor 7e has good bioavailability in rats. Several fragments of inhibitor 7c were prepared, and the binding of these compounds to HIV-RT was analyzed by surface plasmon resonance spectroscopy...
  12. ncbi request reprint The liver sieve and gene therapy
    Robin Fraser
    Blood 101:3338; author reply 3338-9. 2003