Thomas D Harris

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi request reprint Structure-activity relationships of 111In- and 99mTc-labeled quinolin-4-one peptidomimetics as ligands for the vitronectin receptor: potential tumor imaging agents
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, N Billerica, Massachusetts 01862, USA
    Bioconjug Chem 17:1294-313. 2006
  2. ncbi request reprint Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, North Billerica, MA 01862, USA
    Cancer Biother Radiopharm 18:627-41. 2003
  3. ncbi request reprint Radiolabeled divalent peptidomimetic vitronectin receptor antagonists as potential tumor radiotherapeutic and imaging agents
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, North, Billerica, Massachusetts 01862, USA
    Bioconjug Chem 18:1266-79. 2007
  4. ncbi request reprint 90Y and 111In complexes of a DOTA-conjugated integrin alpha v beta 3 receptor antagonist: different but biologically equivalent
    David C Onthank
    Discovery R and D, Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA
    Bioconjug Chem 15:235-41. 2004
  5. ncbi request reprint Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci
    Matthias Broekema
    Bristol Myers Squibb Medical Imaging, North Billerica, Massachusetts 01862, USA
    J Med Chem 48:6442-53. 2005
  6. ncbi request reprint Anaerobic 90Y- and 177Lu-labeling of a DOTA-conjugated nonpeptide vitronectin receptor antagonist
    Shuang Liu
    Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA
    Bioconjug Chem 14:1030-7. 2003
  7. pmc Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction
    David F Meoli
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    J Clin Invest 113:1684-91. 2004
  8. ncbi request reprint Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 110:84-90. 2004
  9. ncbi request reprint Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis
    Patrick M Winter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 26:2103-9. 2006
  10. ncbi request reprint MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles
    Tillmann Cyrus
    Division of Cardiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Cardiovasc Magn Reson 8:535-41. 2006

Collaborators

  • Shuang Liu
  • Simon P Robinson
  • Otto C Boerman
  • Rob M J Liskamp
  • Samuel A Wickline
  • W J G Oyen
  • Patrick Winter
  • Joel Lazewatsky
  • Peter Laverman
  • J R Lindner
  • H J Rennen
  • Julliette E M van Eerd
  • D Scott Edwards
  • Frans H M Corstens
  • Mehran M Sadeghi
  • Matthias Broekema
  • Jiasheng Zhang
  • Svetlana Krassilnikova
  • Albert J Sinusas
  • Barry L Zaret
  • Tillmann Cyrus
  • Shelton D Caruthers
  • Gregory M Lanza
  • Anne H Schmieder
  • Amir A Gharaei
  • Jeffrey R Bender
  • Hooman Rastegar Fassaei
  • Leila Esmailzadeh
  • David C Onthank
  • David F Meoli
  • Charles E Ellars
  • Laurent M Riou
  • John A M Ramshaw
  • Jerome A Werkmeister
  • Veronica Glattauer
  • Dana R Abendschein
  • Huiying Zhang
  • Grace Hu
  • Todd A Williams
  • John S Allen
  • Michael J Scott
  • J David Robertson
  • George Tellides
  • Abolfazl Asadi
  • Michael Azure
  • Elizabeth K Lacy
  • JulliĆ«tte J E M van Eerd
  • Brian N Bourke
  • Frank J Giordano
  • Haili Su
  • Donald P Dione
  • John A Barrett
  • Scott Edwards
  • Ali Kooshkabadi
  • Paula J Silva
  • Joseph A Madri
  • Padmaja Yalamanchili
  • Gail W Sullivan
  • Mirta Ruiz
  • David K Glover
  • Howard Leong-Poi
  • Joel Linden
  • George A Beller

Detail Information

Publications19

  1. ncbi request reprint Structure-activity relationships of 111In- and 99mTc-labeled quinolin-4-one peptidomimetics as ligands for the vitronectin receptor: potential tumor imaging agents
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, N Billerica, Massachusetts 01862, USA
    Bioconjug Chem 17:1294-313. 2006
    ..A scintigraphic imaging study with (111)In-TA138 showed a clear delineation of the tumors and rapid clearance of activity from nontarget tissues...
  2. ncbi request reprint Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, North Billerica, MA 01862, USA
    Cancer Biother Radiopharm 18:627-41. 2003
    ..Tumors are visible as early as 0.5 hours PI. Radiotherapy studies in the c-neu Oncomouse model demonstrated a slowing of tumor growth at a dose of 15 mCi/m(2), and a regression of tumors at a dose of 90 mCi/m(2)...
  3. ncbi request reprint Radiolabeled divalent peptidomimetic vitronectin receptor antagonists as potential tumor radiotherapeutic and imaging agents
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, North, Billerica, Massachusetts 01862, USA
    Bioconjug Chem 18:1266-79. 2007
    ..A comparison of therapeutic indices for 90Y-TA138 and 177Lu-15 indicate an improved therapeutic index for the divalent agent. The implications for radiotherapeutic applications and the mechanism of this multivalent effect are discussed...
  4. ncbi request reprint 90Y and 111In complexes of a DOTA-conjugated integrin alpha v beta 3 receptor antagonist: different but biologically equivalent
    David C Onthank
    Discovery R and D, Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA
    Bioconjug Chem 15:235-41. 2004
    ..Therefore, (111)In-TA138 is useful as an imaging surrogate for (90)Y-TA138 and should be able to predict the radiation dosimetry of (90)Y-TA138, a therapeutic radiopharmaceutical for treatment of rapidly growing tumors...
  5. ncbi request reprint Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci
    Matthias Broekema
    Bristol Myers Squibb Medical Imaging, North Billerica, Massachusetts 01862, USA
    J Med Chem 48:6442-53. 2005
    ..The best scintigraphic images were obtained with monovalent HYNIC conjugate 15 using tricine and isonicotinic acid as coligands with HYNIC for coordination with (99m)Tc...
  6. ncbi request reprint Anaerobic 90Y- and 177Lu-labeling of a DOTA-conjugated nonpeptide vitronectin receptor antagonist
    Shuang Liu
    Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA
    Bioconjug Chem 14:1030-7. 2003
    ..The anaerobic formulation described in this study is particularly useful for (90)Y- and (177)Lu-labeling of DOTA-conjugated small biomolecules, which are sensitive to the radiolytic degradation during radiolabeling...
  7. pmc Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction
    David F Meoli
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    J Clin Invest 113:1684-91. 2004
    ..This approach may also have significant clinical utility for noninvasively tracking therapeutic myocardial angiogenesis...
  8. ncbi request reprint Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 110:84-90. 2004
    ..We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo...
  9. ncbi request reprint Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis
    Patrick M Winter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 26:2103-9. 2006
    ..Alpha(v)beta3 integrin-targeted paramagnetic nanoparticles were prepared for noninvasive assessment of angiogenesis in early atherosclerosis, for site-specific delivery of antiangiogenic drug, and for quantitative follow-up of response...
  10. ncbi request reprint MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles
    Tillmann Cyrus
    Division of Cardiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Cardiovasc Magn Reson 8:535-41. 2006
    ..In conclusion, MR molecular imaging with alphavbeta3-integrin or collagen Ill-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography...
  11. ncbi request reprint Imaging of infection and inflammation with an improved 99mTc-labeled LTB4 antagonist
    Julliette E M van Eerd
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 46:1546-51. 2005
    ..In this study, 2 new hydrazinonicotinamide (HYNIC)-conjugated compounds that are structurally related to DPC11870 were studied to further improve image quality...
  12. ncbi request reprint Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study
    Jiasheng Zhang
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    FASEB J 19:1857-9. 2005
    ..In conclusion, alphavbeta3 integrin is transiently up-regulated (and activated) in GA and may be targeted by RP748 for detection of the proliferative process in early GA...
  13. ncbi request reprint Scintigraphic imaging of infectious foci with an 111In-LTB4 antagonist is based on in vivo labeling of granulocytes
    Julliette E M van Eerd
    Department of Nuclear Medicine, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Nucl Med 46:786-93. 2005
    ....
  14. ncbi request reprint Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles
    Anne H Schmieder
    Department of Biomedical Engineering, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Magn Reson Med 53:621-7. 2005
    ..This technique may be employed to noninvasively detect very small regions of angiogenesis associated with nascent melanoma tumors, and to phenotype and stage early melanoma in a clinical setting...
  15. ncbi request reprint Scintigraphic detection of pulmonary aspergillosis in rabbits with a radiolabeled leukotriene b4 antagonist
    Julliette E M van Eerd
    Department of Nuclear Medicine, University Medical Centre Nijmegen, The Netherlands
    J Nucl Med 45:1747-53. 2004
    ..The imaging characteristics of 111In-DPC11870 were compared with those of 67Ga-citrate, a radiopharmaceutical commonly used to detect pulmonary infections in patients...
  16. ncbi request reprint Imaging of experimental colitis with a radiolabeled leukotriene B4 antagonist
    Julliette E M van Eerd
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Nucl Med 45:89-93. 2004
    ..Imaging characteristics of the (111)In-labeled LTB(4) antagonist (DPC11870) were compared with those of (18)F-FDG and (99m)Tc-HMPAO-granulocytes in a rabbit model of experimental colitis...
  17. ncbi request reprint Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5838-43. 2003
    ....
  18. ncbi request reprint A bivalent leukotriene B(4) antagonist for scintigraphic imaging of infectious foci
    Julliette E M van Eerd
    Department of Nuclear Medicine, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Nucl Med 44:1087-91. 2003
    ..In this study, we investigated the in vivo and in vitro characteristics of a new hydrophilic (111)In-labeled LTB(4) antagonist...
  19. ncbi request reprint Assessment of myocardial inflammation produced by experimental coronary occlusion and reperfusion with 99mTc-RP517, a new leukotriene B4 receptor antagonist that preferentially labels neutrophils in vivo
    Laurent M Riou
    University of Virginia Health System, Charlottesville, VA 22908 0500, USA
    Circulation 106:592-8. 2002
    ....