D S Greene
Affiliation: Bristol-Myers Squibb
- Clinical pharmacokinetics of nefazodoneD S Greene
Metabolism and Pharmacokinetics Department, Bristol Myers Squibb, Princeton, New Jersey, USA
Clin Pharmacokinet 33:260-75. 1997..No clinically significant interaction was observed when nefazodone was administered with lorazepam, lithium, alcohol, cimetidine, warfarin, theophylline or propranolol...
- Assessment of effect of food, gender, and intra-subject variability in the pharmacokinetics of avitriptanP H Marathe
Department of Metabolism and Pharmacokinetics, Bristol Myers Squibb Company, Princeton, NJ, USA
Biopharm Drug Dispos 19:153-7. 1998..The intra- and inter-subject variability (%CV) in the Cmax and AUC of avitriptan in the fasted and fed conditions ranged from 10 to 60% in male and female subjects...
- Evaluation of the effect of food on the pharmacokinetics of avitriptanP H Marathe
Department of Metabolism and Pharmacokinetics and Biostatistics and Data Management, Bristol Myers Squibb Company, Pharmaceutical Research Institute, Princeton, NJ 08543, USA
Biopharm Drug Dispos 19:381-94. 1998..Thus, it appears that avitriptan absorption and bioavailability are highly sensitive to presence of food in the stomach and any food-related changes in gastric emptying time and gastrointestinal motility...
- Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humansR C Dockens
Department of Metabolism and Pharmacokinetics, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, USA
Drug Metab Dispos 28:973-80. 2000..Approximately 40 to 50% of the radioactivity in rat and dog plasma was accounted for by parent drug whereas, in humans, approximately 60% of the plasma radioactivity was accounted for by ifetroban acylglucuronide...
- Effect of altered gastric emptying and gastrointestinal motility on metformin absorptionP H Marathe
Department of Metabolism and Pharmacokinetics, Bristol Myers Squibb Company, Princeton, NJ 08543, USA
Br J Clin Pharmacol 50:325-32. 2000..The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects...