K A Augustine-Rauch

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi request reprint Predictive teratology: teratogenic risk-hazard identification partnered in the discovery process
    K A Augustine-Rauch
    Bristol Myers Squibb, Hopewell, NJ 08534, USA
    Curr Drug Metab 9:971-7. 2008
  2. ncbi request reprint A study of vehicles for dosing rodent whole embryo culture with non aqueous soluble compounds
    Karen A Augustine-Rauch
    Department of Reproductive Toxicology, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA
    Reprod Toxicol 18:391-8. 2004
  3. ncbi request reprint Alternative experimental approaches for interpreting skeletal findings in safety studies
    Karen Augustine-Rauch
    Reproductive Toxicology, Bristol Myers Squibb Research Institute, Hopewell, New Jersey 08534, USA
    Birth Defects Res B Dev Reprod Toxicol 80:497-504. 2007
  4. ncbi request reprint Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation
    Karen A Augustine-Rauch
    Department of Reproductive Toxicology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 70:789-807. 2004
  5. ncbi request reprint SB-236057: Critical window of sensitivity study and embryopathy of a potent musculoskeletal teratogen
    Karen A Augustine-Rauch
    GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 70:773-88. 2004
  6. ncbi request reprint Selection of normalizer genes in conducting relative gene expression analysis of embryos
    Qin J Zhang
    Department of Reproductive Toxicology, Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 67:533-44. 2003

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Predictive teratology: teratogenic risk-hazard identification partnered in the discovery process
    K A Augustine-Rauch
    Bristol Myers Squibb, Hopewell, NJ 08534, USA
    Curr Drug Metab 9:971-7. 2008
    ..This review discusses approaches that can be applied for proactive assessment of compounds for teratogenic liability...
  2. ncbi request reprint A study of vehicles for dosing rodent whole embryo culture with non aqueous soluble compounds
    Karen A Augustine-Rauch
    Department of Reproductive Toxicology, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA
    Reprod Toxicol 18:391-8. 2004
    ..Both solutions delivered RA to the cultured rat embryos at higher doses. In summary, all four solvents/solutions may have utility as vehicles dependent upon the chemical properties of the compound to be solubilized...
  3. ncbi request reprint Alternative experimental approaches for interpreting skeletal findings in safety studies
    Karen Augustine-Rauch
    Reproductive Toxicology, Bristol Myers Squibb Research Institute, Hopewell, New Jersey 08534, USA
    Birth Defects Res B Dev Reprod Toxicol 80:497-504. 2007
    ....
  4. ncbi request reprint Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation
    Karen A Augustine-Rauch
    Department of Reproductive Toxicology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 70:789-807. 2004
    ..SB-236057 is a potent skeletal teratogen in rodents and rabbits, producing axial and posterior somite malformations in cultured rat embryos. The compound shares some structural similarity to cyclopamine...
  5. ncbi request reprint SB-236057: Critical window of sensitivity study and embryopathy of a potent musculoskeletal teratogen
    Karen A Augustine-Rauch
    GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 70:773-88. 2004
    ..SB-236057 is a potent skeletal teratogen in rodents and rabbits. The study objective was to identify the critical developmental window of compound sensitivity and to characterize the early onset of SB-236057 embryopathy...
  6. ncbi request reprint Selection of normalizer genes in conducting relative gene expression analysis of embryos
    Qin J Zhang
    Department of Reproductive Toxicology, Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 67:533-44. 2003
    ..Since some developmental toxicants secondarily cause general growth retardation and/or other general biological changes, commonly used housekeeping genes may not serve as accurate normalizers...