Genomes and Genes
GEORGE T O'CONNOR
Affiliation: Boston University
- The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reportsL Adrienne Cupples
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S1. 2007....
- Genome-wide association of sleep and circadian phenotypesDaniel J Gottlieb
The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S9. 2007..More than 700 participants were genotyped using the Affymetrix 100K SNP GeneChip, providing a unique opportunity to assess genetic linkage and association of these traits...
- Framingham Heart Study genome-wide association: results for pulmonary function measuresJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 8:S8. 2007..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study...
- Variation in symptoms of sleep-disordered breathing with race and ethnicity: the Sleep Heart Health StudyGEORGE T O'CONNOR
Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
Sleep 26:74-9. 2003..To examine the relation of sleep-related symptoms to race and ethnicity in a diverse sample of middle-aged and older men and women...
- Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health studyDaniel J Gottlieb
VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
Circulation 122:352-60. 2010..The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women...
- Obesity in relation to lung cancer incidence in African American womenTraci N Bethea
Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA, 02215, USA
Cancer Causes Control 24:1695-703. 2013..Although a number of studies have found an inverse association between body mass index (BMI) and risk of lung cancer, there is little information on this relation in African Americans, who experience a higher incidence of lung cancer...
- A comparison of visual and quantitative methods to identify interstitial lung abnormalitiesCORRINE R KLIMENT
From the Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Pulm Med 15:134. 2015..To investigate this relationship, we created lung density metrics and compared these to visual assessments of ILA...
- Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smokingTetsuro Araki
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, 02215, USA
Eur Radiol 26:15-24. 2016..To investigate CT appearance and size of the thymus in association with participant characteristics...
- Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areasAntonella Zanobetti
Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415, PO Box 15698, Boston, MA 02215, USA
Am J Respir Crit Care Med 182:819-25. 2010..S. adults, and may be more prevalent in poor urban environments. SDB and air pollution have been linked to increased cardiovascular diseases and mortality, but the association between pollution and SDB is poorly understood...
- Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance?Tetsuro Araki
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Thorax 70:1156-62. 2015..To investigate the prevalence and natural course of pulmonary cysts in a population-based cohort and to describe the CT image characteristics in association with participant demographics and pulmonary functions...
- A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairmentKatrina Steiling
Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA
Am J Respir Crit Care Med 187:933-42. 2013..Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function...
- Abuse during childhood and adolescence and risk of adult-onset asthma in African American womenPatricia F Coogan
Slone Epidemiology Center, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA 02215, USA
J Allergy Clin Immunol 131:1058-63. 2013..Experiences of violence contribute to the occurrence of childhood asthma, but there is little information on the effect of early-life abuse on adult-onset asthma...
- Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health studySusan Redline
Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
Am J Respir Crit Care Med 182:269-77. 2010....
- Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsivenessNancy T Mendonça
Department of Biomedical Engineering, 44 Cummington St, Boston University, Boston, MA 02215, USA
Respir Res 12:96. 2011..The goal of this study was to test the hypothesis that the minimal airway resistance achievable during a maximal inspiration (R(min)) is abnormally elevated in subjects with airway hyperresponsiveness...
- Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung AbnormalitiesJennifer E Ho
1 Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Am J Respir Crit Care Med 194:77-83. 2016..Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis in experimental studies, and Gal-3 levels have been found to be elevated in small studies of human pulmonary fibrosis...
- Replication and fine mapping of asthma-associated loci in individuals of African ancestryDavid B Kantor
Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
Hum Genet 132:1039-47. 2013..These results improve the understanding of asthma genetics and further demonstrate the utility of genetic studies in populations other than those of largely European ancestry. ..
- MUC5B promoter polymorphism and interstitial lung abnormalitiesGary M Hunninghake
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
N Engl J Med 368:2192-200. 2013..It is not known whether this polymorphism is associated with interstitial lung disease in the general population...
- Vascular inflammation and sleep disordered breathing in a community-based cohortHassan A Chami
Department of Medicine, American University of Beirut, Beirut, Lebanon
Sleep 36:763-768C. 2013..The pathophysiologic mechanisms remain unclear, but enhanced vascular inflammation is implicated. We sought to evaluate the association of sleep disordered breathing with biomarkers of inflammation...
- A genome-wide association study of plasma total IgE concentrations in the Framingham Heart StudyMark Granada
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
J Allergy Clin Immunol 129:840-845.e21. 2012..Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation...
- A genome-wide association study of pulmonary function measures in the Framingham Heart StudyJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
PLoS Genet 5:e1000429. 2009..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation...
- Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathingHassan A Chami
Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
Vasc Med 14:351-60. 2009..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation...
- Meta-Analysis for Penalized Regression Methods with Multi-Cohort Genome-Wide Association StudiesChen Lu
Department of Biostatistics, Boston University School of Public Health, Boston, Mass, USA
Hum Hered 81:142-149. 2016..While meta-analysis is often conducted to increase power and protect patients' confidentiality, methods for meta-analyzing results of penalized regression in multi-cohort setting are still under development...
- Network-guided sparse regression modeling for detection of gene-by-gene interactionsChen Lu
Department of Biostatistics, Boston University School of Public Health, Pulmonary Center, Department of Medicine and Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Bioinformatics 29:1241-9. 2013..We propose a novel approach to detect such interactions that uses penalized regression and sparse estimation principles, and incorporates outside biological knowledge through a network-based penalty...
- Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstructionJemma B Wilk
Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
Am J Respir Crit Care Med 186:622-32. 2012..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...
- Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health StudyGEORGE T O'CONNOR
Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
Am J Respir Crit Care Med 179:1159-64. 2009..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
- Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthmaSupinda Bunyavanich
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Mol Allergy 9:1. 2011..Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied...
- Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomesSusan Cheng
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
Eur Heart J 35:2980-7. 2014....
- Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPDNadia N Hansel
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Hum Genet 132:79-90. 2013..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility...
- Body mass index and asthma incidence in the Black Women's Health StudyPatricia F Coogan
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
J Allergy Clin Immunol 123:89-95. 2009..There are few data on this topic in black women, among whom the prevalence of obesity and asthma is high...
- Eosinophil and T cell markers predict functional decline in COPD patientsJEANINE M D'ARMIENTO
Department of Medicine, Columbia University, New York, NY, USA
Respir Res 10:113. 2009..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
- Similarities and differences between smoking-related gene expression in nasal and bronchial epitheliumXiaoling Zhang
Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
Physiol Genomics 41:1-8. 2010..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
- Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responsesDiane R Gold
Channing Laboratory, Brigham and Women s Hospital, Boston, Mass, USA
J Allergy Clin Immunol 124:1078-87. 2009....