Genomes and Genes
GEORGE T O'CONNOR
Affiliation: Boston University
- Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung functionBrian J Reardon
Division of Nutritional Sciences, Cornell University, 209 Savage Hall, Ithaca, NY 14853, USA
BMC Med Genet 14:122. 2013..This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants...
- Characterization of regulatory T cells in urban newbornsNgoc P Ly
Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
Clin Mol Allergy 7:8. 2009..The objective of this study was to compare Treg phenotype and function in cord blood (CB) of newborns to those in peripheral blood (PB) of a subset of participating mothers...
- The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study populationJames E Gern
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
BMC Pulm Med 9:17. 2009..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
- Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health StudyGEORGE T O'CONNOR
Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
Am J Respir Crit Care Med 179:1159-64. 2009..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
- Allergen avoidance in asthma: what do we do now?GEORGE T O'CONNOR
Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
J Allergy Clin Immunol 116:26-30. 2005..The role of allergen avoidance in infancy in the primary prevention of asthma is a subject of active investigation, but data remain too preliminary to make public health recommendations in this regard...
- Acute respiratory health effects of air pollution on children with asthma in US inner citiesGEORGE T O'CONNOR
Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Allergy Clin Immunol 121:1133-1139.e1. 2008..Children with asthma in inner-city communities may be particularly vulnerable to adverse effects of air pollution because of their airways disease and exposure to relatively high levels of motor vehicle emissions...
- Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma StudyGEORGE T O'CONNOR
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
J Allergy Clin Immunol 114:599-606. 2004..Despite growing evidence of the importance of exposure to fungi as an environmental risk factor for asthma, few data have been reported on the exposure to airborne fungi of asthmatic children living in US inner cities...
- Framingham Heart Study genome-wide association: results for pulmonary function measuresJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 8:S8. 2007..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study...
- A genome-wide association study of pulmonary function measures in the Framingham Heart StudyJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
PLoS Genet 5:e1000429. 2009..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation...
- Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health studyDaniel J Gottlieb
VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
Circulation 122:352-60. 2010..The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women...
- Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areasAntonella Zanobetti
Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415, PO Box 15698, Boston, MA 02215, USA
Am J Respir Crit Care Med 182:819-25. 2010..S. adults, and may be more prevalent in poor urban environments. SDB and air pollution have been linked to increased cardiovascular diseases and mortality, but the association between pollution and SDB is poorly understood...
- Genome-wide association of sleep and circadian phenotypesDaniel J Gottlieb
The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S9. 2007..More than 700 participants were genotyped using the Affymetrix 100K SNP GeneChip, providing a unique opportunity to assess genetic linkage and association of these traits...
- Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsivenessNancy T Mendonça
Department of Biomedical Engineering, 44 Cummington St, Boston University, Boston, MA 02215, USA
Respir Res 12:96. 2011..The goal of this study was to test the hypothesis that the minimal airway resistance achievable during a maximal inspiration (R(min)) is abnormally elevated in subjects with airway hyperresponsiveness...
- Obesity in relation to lung cancer incidence in African American womenTraci N Bethea
Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA, 02215, USA
Cancer Causes Control 24:1695-703. 2013..Although a number of studies have found an inverse association between body mass index (BMI) and risk of lung cancer, there is little information on this relation in African Americans, who experience a higher incidence of lung cancer...
- A genome-wide association study of plasma total IgE concentrations in the Framingham Heart StudyMark Granada
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
J Allergy Clin Immunol 129:840-845.e21. 2012..Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation...
- Asthma-susceptibility variants identified using probands in case-control and family-based analysesBlanca E Himes
Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
BMC Med Genet 11:122. 2010..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
- Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathingHassan A Chami
Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
Vasc Med 14:351-60. 2009..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation...
- A comparison of visual and quantitative methods to identify interstitial lung abnormalitiesCORRINE R KLIMENT
From the Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Pulm Med 15:134. 2015..To investigate this relationship, we created lung density metrics and compared these to visual assessments of ILA...
- Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smokingTetsuro Araki
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, 02215, USA
Eur Radiol 26:15-24. 2016..To investigate CT appearance and size of the thymus in association with participant characteristics...
- Abuse during childhood and adolescence and risk of adult-onset asthma in African American womenPatricia F Coogan
Slone Epidemiology Center, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA 02215, USA
J Allergy Clin Immunol 131:1058-63. 2013..Experiences of violence contribute to the occurrence of childhood asthma, but there is little information on the effect of early-life abuse on adult-onset asthma...
- Eosinophil and T cell markers predict functional decline in COPD patientsJEANINE M D'ARMIENTO
Department of Medicine, Columbia University, New York, NY, USA
Respir Res 10:113. 2009..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
- Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health studySusan Redline
Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
Am J Respir Crit Care Med 182:269-77. 2010....
- Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance?Tetsuro Araki
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Thorax 70:1156-62. 2015..To investigate the prevalence and natural course of pulmonary cysts in a population-based cohort and to describe the CT image characteristics in association with participant demographics and pulmonary functions...
- Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical TrialAugusto A Litonjua
Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts
JAMA 315:362-70. 2016..Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring...
- MUC5B promoter polymorphism and interstitial lung abnormalitiesGary M Hunninghake
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
N Engl J Med 368:2192-200. 2013..It is not known whether this polymorphism is associated with interstitial lung disease in the general population...
- Vascular inflammation and sleep disordered breathing in a community-based cohortHassan A Chami
Department of Medicine, American University of Beirut, Beirut, Lebanon
Sleep 36:763-768C. 2013..The pathophysiologic mechanisms remain unclear, but enhanced vascular inflammation is implicated. We sought to evaluate the association of sleep disordered breathing with biomarkers of inflammation...
- A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairmentKatrina Steiling
Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA
Am J Respir Crit Care Med 187:933-42. 2013..Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function...
- Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging StudyAugusto A Litonjua
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Allergy Asthma Immunol 90:422-8. 2003..To confirm these findings, we tested the hypothesis that serum cytokines are associated with longitudinal lung function decline...
- Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung AbnormalitiesJennifer E Ho
1 Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Am J Respir Crit Care Med 194:77-83. 2016..Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis in experimental studies, and Gal-3 levels have been found to be elevated in small studies of human pulmonary fibrosis...
- Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthmaSupinda Bunyavanich
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Mol Allergy 9:1. 2011..Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied...
- Replication and fine mapping of asthma-associated loci in individuals of African ancestryDavid B Kantor
Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
Hum Genet 132:1039-47. 2013..These results improve the understanding of asthma genetics and further demonstrate the utility of genetic studies in populations other than those of largely European ancestry. ..
- Network-guided sparse regression modeling for detection of gene-by-gene interactionsChen Lu
Department of Biostatistics, Boston University School of Public Health, Pulmonary Center, Department of Medicine and Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Bioinformatics 29:1241-9. 2013..We propose a novel approach to detect such interactions that uses penalized regression and sparse estimation principles, and incorporates outside biological knowledge through a network-based penalty...
- Systemic inflammation and COPD: the Framingham Heart StudyRobert E Walter
Section of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Chest 133:19-25. 2008..We examined the hypothesis that systemic inflammatory biomarkers are associated with impaired lung function, particularly among those with extensive cigarette smoking...
- The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reportsL Adrienne Cupples
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S1. 2007....
- Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart StudyJemma B Wilk
Neurology Department, Boston University School of Medicine, Boston, MA 02118, USA
Hum Mol Genet 12:2745-51. 2003..This study supports the presence of a gene influencing pulmonary function on the q-terminus of chromosome 6 in the region of 184 cM (D6S503) to 190 cM (D6S281)...
- Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responsesDiane R Gold
Channing Laboratory, Brigham and Women s Hospital, Boston, Mass, USA
J Allergy Clin Immunol 124:1078-87. 2009....
- Body mass index and asthma incidence in the Black Women's Health StudyPatricia F Coogan
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
J Allergy Clin Immunol 123:89-95. 2009..There are few data on this topic in black women, among whom the prevalence of obesity and asthma is high...
- Variation in symptoms of sleep-disordered breathing with race and ethnicity: the Sleep Heart Health StudyGEORGE T O'CONNOR
Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
Sleep 26:74-9. 2003..To examine the relation of sleep-related symptoms to race and ethnicity in a diverse sample of middle-aged and older men and women...
- Genome-wide association analysis identifies PDE4D as an asthma-susceptibility geneBlanca E Himes
Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
Am J Hum Genet 84:581-93. 2009..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
- Meta-Analysis for Penalized Regression Methods with Multi-Cohort Genome-Wide Association StudiesChen Lu
Department of Biostatistics, Boston University School of Public Health, Boston, Mass, USA
Hum Hered 81:142-149. 2016..While meta-analysis is often conducted to increase power and protect patients' confidentiality, methods for meta-analyzing results of penalized regression in multi-cohort setting are still under development...
- Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomesSusan Cheng
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
Eur Heart J 35:2980-7. 2014....
- Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstructionJemma B Wilk
Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
Am J Respir Crit Care Med 186:622-32. 2012..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...
- Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPDNadia N Hansel
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Hum Genet 132:79-90. 2013..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility...
- Association of asthma with a functional promoter polymorphism in the IL16 geneKristin M Burkart
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Allergy Clin Immunol 117:86-91. 2006..A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described...
- Predictors of heartburn during sleep in a large prospective cohort studyRonnie Fass
Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
Chest 127:1658-66. 2005..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study...
- Severity of Kyphosis and Decline in Lung Function: The Framingham StudyAmanda L Lorbergs
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts Department of Medicine, Harvard Medical School, Boston, Massachusetts Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
J Gerontol A Biol Sci Med Sci . 2016..We conducted a longitudinal study to quantify the impact of kyphosis severity on decline in pulmonary function over 16 years in women and men...
- The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in childrenAugusto A Litonjua
Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, United States Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, United States Harvard Medical School, Boston, MA, United States Electronic address
Contemp Clin Trials 38:37-50. 2014..Ancillary studies will investigate neonatal T-regulatory cell function, maternal vaginal flora, and maternal and child intestinal flora...
- Similarities and differences between smoking-related gene expression in nasal and bronchial epitheliumXiaoling Zhang
Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
Physiol Genomics 41:1-8. 2010..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
- Effect of medical conditions on improvement in self-reported and observed functional performance of eldersRam R Miller
Geriatrics Section, Boston University School of Medicine, Boston, Massachusetts, USA
J Am Geriatr Soc 52:217-23. 2004..To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders...
- Association between glycemic state and lung function: the Framingham Heart StudyRobert E Walter
The Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Am J Respir Crit Care Med 167:911-6. 2003..The adverse effect of diabetes and glycemic level on pulmonary function was stronger among ever smokers than never smokers, suggesting an interaction between the level of fasting glycemia and tobacco smoking...
- Analysis of lipids, inflammation, and pulmonary functionGEORGE O CONNOR; Fiscal Year: 2003..abstract_text> ..
- SLEEP HEART HEALTH STUDYGEORGE O CONNOR; Fiscal Year: 2007..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..