Genomes and Genes
Affiliation: Boston University
- Zcchc11-dependent uridylation of microRNA directs cytokine expressionMatthew R Jones
The Pulmonary Center, Boston University School of Medicine, MA 102118, USA
Nat Cell Biol 11:1157-63. 2009..Thus, Zcchc11 fine tunes IL-6 production by uridylating miR-26a, which we propose is an enzymatic modification of the terminal nucleotide sequence of mature miRNA as a means to regulate gene expression...
- Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survivalMatthew R Jones
Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
PLoS Genet 8:e1003105. 2012..We propose that the miRNA 3' terminus is a regulatory node upon which multiple enzymes converge to direct silencing activity and tune gene expression...
- Respiratory infection and the impact of pulmonary immunity on lung health and diseaseJoseph P Mizgerd
Boston University School of Medicine, The Pulmonary Center, 72 East Concord Street, Boston, MA 02118, USA
Am J Respir Crit Care Med 186:824-9. 2012..Further advances in pulmonary immunity and elucidation of the cellular and molecular responses to microbes in the lung are needed to develop novel approaches to predicting, preventing, and curing respiratory disease...
- Earliest innate immune responses require macrophage RelA during pneumococcal pneumoniaLynnelle A Pittet
Pulmonary Center, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
Am J Respir Cell Mol Biol 45:573-81. 2011..Thus, during pneumococcal pneumonia, only the earliest induction of the cytokines measured depended on transcription by RelA in myeloid cells, and this transcriptional activity contributed to effective immunity...