William P Milberg

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Alterations in the dynamics of semantic activation in Alzheimer's disease: evidence for the Gain/Decay hypothesis of a disorder of semantic memory
    W Milberg
    Geriatric Neuropsychology Laboratory, Brockton West Roxbury Department of Veterans Affairs Medical Center, Boston, MA 02132, USA
    J Int Neuropsychol Soc 5:641-58. 1999
  2. ncbi request reprint Summation priming in aphasia: evidence for alterations in semantic integration and activation
    William Milberg
    Geriatric Neuropsychology Laboratory, Geriatric, Research, Education and Clinical Center, Brockton West Roxbury Department of Veterans Affairs Medical Center, Boston, MA, USA
    Brain Cogn 51:31-47. 2003
  3. ncbi request reprint Taking the thumbs off the multidimensional scales in the debate on semantic memory and Alzheimer's disease: a comment on Storms et al. (2003)
    William Milberg
    Geriatric Neuropsychology Laboratory, New England Geriatric, Research, Education and Clinical Center, Veterans Affairs Boston Healthcare Medical Center, Massachusetts 02130, USA
    Neuropsychology 17:312-4; discussion 323-9. 2003
  4. pmc Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults
    David H Salat
    Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA
    Neuroimage 59:181-92. 2012
  5. pmc Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning
    Nikki H Stricker
    Psychology Service, VA Boston Healthcare System, Boston, MA, USA
    J Int Neuropsychol Soc 19:925-37. 2013
  6. pmc Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults
    Victoria J Williams
    Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Massachusetts, USA
    Hum Brain Mapp 34:1826-41. 2013
  7. pmc Widespread effects of alcohol on white matter microstructure
    Catherine B Fortier
    Geriatric Research, Education and Clinical Center GRECC, Translational Research Center for TBI and Stress Disorders TRACTS, VA Boston Healthcare System, Boston, Massachusetts Neuroimaging Research Center for Veterans, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Alcohol Clin Exp Res 38:2925-33. 2014
  8. pmc Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults
    Jessica M Foley
    1Psychology Service, VA Boston Healthcare System, Boston, MA, USA
    Am J Alzheimers Dis Other Demen 29:222-35. 2014
  9. pmc Glucose Dysregulation Interacts With APOE-∊4 to Potentiate Temporoparietal Cortical Thinning
    Jessica M Foley
    Department of Psychiatry, VA Boston Healthcare System, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    Am J Alzheimers Dis Other Demen 31:76-86. 2016
  10. pmc Associations between T1 white matter lesion volume and regional white matter microstructure in aging
    Elizabeth C Leritz
    Geriatric Research, Education and Clinical Center GRECC and Neuroimaging Research for Veterans Center NeRVe, VA Boston Healthcare System, Boston, Massachusetts Division of Aging, Brigham and Women s Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts
    Hum Brain Mapp 35:1085-100. 2014

Research Grants

  1. COGNITIVE PROCESSING IN HEMISPATIAL NEGLECT
    William Milberg; Fiscal Year: 2004

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Alterations in the dynamics of semantic activation in Alzheimer's disease: evidence for the Gain/Decay hypothesis of a disorder of semantic memory
    W Milberg
    Geriatric Neuropsychology Laboratory, Brockton West Roxbury Department of Veterans Affairs Medical Center, Boston, MA 02132, USA
    J Int Neuropsychol Soc 5:641-58. 1999
    ..The implications of this hypothesis for a range of experimental and clinical phenomena are discussed, as are possible biological correlates of the hypothesized alterations in the modulation of activation...
  2. ncbi request reprint Summation priming in aphasia: evidence for alterations in semantic integration and activation
    William Milberg
    Geriatric Neuropsychology Laboratory, Geriatric, Research, Education and Clinical Center, Brockton West Roxbury Department of Veterans Affairs Medical Center, Boston, MA, USA
    Brain Cogn 51:31-47. 2003
    ..These results suggest that aphasics differ from normals in their ability to integrate the activation derived from multiple linguistic associations and may provide an account of some of the clinical phenomenology of these patients...
  3. ncbi request reprint Taking the thumbs off the multidimensional scales in the debate on semantic memory and Alzheimer's disease: a comment on Storms et al. (2003)
    William Milberg
    Geriatric Neuropsychology Laboratory, New England Geriatric, Research, Education and Clinical Center, Veterans Affairs Boston Healthcare Medical Center, Massachusetts 02130, USA
    Neuropsychology 17:312-4; discussion 323-9. 2003
    ..Critically, their analysis suggests that the T. Shallice and E. K. Warrington (1979) criteria widely used to operationalize the semantic memory deficit in AD be carefully scrutinized and reevaluated...
  4. pmc Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults
    David H Salat
    Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA
    Neuroimage 59:181-92. 2012
    ....
  5. pmc Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning
    Nikki H Stricker
    Psychology Service, VA Boston Healthcare System, Boston, MA, USA
    J Int Neuropsychol Soc 19:925-37. 2013
    ..These results provide further support for the potential role of white matter integrity as an early biomarker for individuals at risk for AD and highlight that changes in white matter may be independent of gray matter changes...
  6. pmc Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults
    Victoria J Williams
    Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Massachusetts, USA
    Hum Brain Mapp 34:1826-41. 2013
    ....
  7. pmc Widespread effects of alcohol on white matter microstructure
    Catherine B Fortier
    Geriatric Research, Education and Clinical Center GRECC, Translational Research Center for TBI and Stress Disorders TRACTS, VA Boston Healthcare System, Boston, Massachusetts Neuroimaging Research Center for Veterans, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Alcohol Clin Exp Res 38:2925-33. 2014
    ..Evidence suggests that chronic misuse of alcohol may preferentially affect the integrity of frontal white matter (WM) tracts, which can impact executive functions important to achieve and maintain abstinence...
  8. pmc Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults
    Jessica M Foley
    1Psychology Service, VA Boston Healthcare System, Boston, MA, USA
    Am J Alzheimers Dis Other Demen 29:222-35. 2014
    ..Results suggest interactive effects of APOE4 and diabetes risk on later myelinating WM regions, which supports preclinical detection of AD among this particularly susceptible subgroup...
  9. pmc Glucose Dysregulation Interacts With APOE-∊4 to Potentiate Temporoparietal Cortical Thinning
    Jessica M Foley
    Department of Psychiatry, VA Boston Healthcare System, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    Am J Alzheimers Dis Other Demen 31:76-86. 2016
    ..This study supports aggressive management of cerebrovascular factors and earlier preclinical detection of AD among individuals presenting with genetic and metabolic risks. ..
  10. pmc Associations between T1 white matter lesion volume and regional white matter microstructure in aging
    Elizabeth C Leritz
    Geriatric Research, Education and Clinical Center GRECC and Neuroimaging Research for Veterans Center NeRVe, VA Boston Healthcare System, Boston, Massachusetts Division of Aging, Brigham and Women s Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts
    Hum Brain Mapp 35:1085-100. 2014
    ..In addition, our results suggest that overt lesions may not account for the association of increasing age with decreased white matter tissue integrity...
  11. pmc Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults
    Elizabeth C Leritz
    Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, MA 02130, USA
    Neuroimage 54:2659-71. 2011
    ....
  12. pmc Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum
    Nikki H Stricker
    Psychology Service, VA Boston Healthcare System, Boston, MA, USA Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Am J Alzheimers Dis Other Demen 31:68-75. 2016
    ..Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC. ..
  13. doi request reprint Intrinsic functional connectivity predicts individual differences in distractibility
    Victoria N Poole
    Translational Research Center for TBI and Stress Disorders TRACTS, VA RR and D TBI Center of Excellence, VA Boston Healthcare System, Boston, MA, USA Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA Harvard Medical School, Boston, MA, USA Neuroimaging Research for Veterans NeRVe Center, VA Boston Healthcare System, Boston, MA, USA Boston Attention and Learning Lab BAL LAB, VA Boston Healthcare System, Boston, MA, USA Electronic address
    Neuropsychologia 86:176-82. 2016
    ....
  14. doi request reprint Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease
    Jasmeet P Hayes
    National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA
    Brain . 2017
    ..These results underscore the importance of documenting head injuries even within the mild range as they may interact with genetic risk to produce negative long-term health consequences such as neurodegenerative disease...
  15. pmc Neurobiological indicators of disinhibition in posttraumatic stress disorder
    Naomi Sadeh
    National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA
    Hum Brain Mapp 36:3076-86. 2015
    ..Furthermore, aberrant coupling between frontal regions and networks involved in selective attention, memory/learning, and response preparation suggest disruptions in functional connectivity may also play a role...
  16. doi request reprint Combat exposure is associated with cortical thickness in Veterans with a history of chronic pain
    Vincent Corbo
    Translational Research Center for TBI and Stress Disorders TRACTS Geriatric Research Education and Clinical Centers GRECC, VA Boston Healthcare System, Boston, MA, USA Boston University School of Medicine, Boston, MA, USA Electronic address
    Psychiatry Res 249:38-44. 2016
    ..These findings suggest that CP may alter the relationship between cortical thickness and exposure to the stress of combat. ..
  17. pmc Reduced cortical thickness in veterans exposed to early life trauma
    Vincent Corbo
    Translational Research Center for TBI and Stress Disorders TRACTS Geriatric Research Education and Clinical Centers GRECC, VA Boston Healthcare System, Jamaica Plain, MA, USA Boston University School of Medicine, Boston, MA, USA Neuroimaging Research for Veterans NeRVe Center, VA Boston Healthcare, Jamaica Plain, MA, USA Electronic address
    Psychiatry Res 223:53-60. 2014
    ..Changes in neural morphometry may provide information about the emergence and maintenance of symptoms in individuals with PTSD. ..
  18. pmc Distinct functional networks within the cerebellum and their relation to cortical systems assessed with independent component analysis
    Vitaly I Dobromyslin
    Neuroimaging Research Center for Veterans, VA Boston Healthcare System, Boston, MA, USA
    Neuroimage 60:2073-85. 2012
    ..Such information may prove crucial for understanding the cognitive and behavioral importance of the cerebellum in health and disease...
  19. pmc Aging memory for pictures: using high-density event-related potentials to understand the effect of aging on the picture superiority effect
    Brandon A Ally
    Center for Translational Cognitive Neuroscience, Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA 01730, United States
    Neuropsychologia 46:679-89. 2008
    ..The findings of this study suggest that pictures allow older adults to compensate for their impaired memorial processes, and may allow these memorial components to function more effectively in older adults...
  20. ncbi request reprint Elevated rates of memory impairment in military service-members and veterans with posttraumatic stress disorder
    Nikki H Stricker
    a VA Boston Healthcare System, Boston, MA, USA
    J Clin Exp Neuropsychol . 2016
    ....
  21. pmc The Clock-in-the-Box, a brief cognitive screen, is associated with failure to return home in an elderly hospitalized sample
    Colleen E Jackson
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs VA Boston Healthcare System, Boston, MA Translational Research Center for TBI and Stress Disorders, Department of Veterans Affairs VA Boston Healthcare System, Boston, MA Department of Psychiatry, Boston University School of Medicine, Boston, MA
    Clin Interv Aging 11:1715-1721. 2016
    ..The purpose of this study is to demonstrate the predictive validity of the CIB for discharge location among a sample of older medical inpatients...
  22. doi request reprint Early life trauma is associated with altered white matter integrity and affective control
    Vincent Corbo
    Translational Research Center for TBI and Stress Disorders Geriatric Research Education and Clinical Centers GRECC, VA Boston Healthcare System, Boston, MA, USA Boston University School of Medicine, Boston, MA, USA Electronic address
    J Psychiatr Res 79:70-7. 2016
    ..This suggests that ELT may be associated with a distinct brain-behavior relationship that could be related to other determinants of FA than those present in healthy adults. ..
  23. pmc Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory
    Elizabeth C Leritz
    Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, MA, USA
    Metab Brain Dis 31:465-73. 2016
    ..Our findings demonstrate the importance of consideration of vascular risk factors, such as cholesterol, in studies of cognitive aging. ..
  24. doi request reprint Identification of pseudobulbar affect symptoms in Veterans with possible traumatic brain injury
    Jennifer R Fonda
    Translational Research Center for Traumatic Brain Injury and Stress Disorders, and Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Boston Healthcare System, Boston, MA
    J Rehabil Res Dev 52:839-49. 2015
    ..PBA symptoms were common in this Veteran cohort, were detected using simple screening tools, and often co-occurred with other psychiatric disorders common in Veterans. ..
  25. doi request reprint Sleep Quality and Reexperiencing Symptoms of PTSD Are Associated With Current Pain in U.S. OEF/OIF/OND Veterans With and Without mTBIs
    Margaret A Powell
    Translational Research Center for TBI and Stress Disorders TRACTS and Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Trauma Stress 28:322-9. 2015
    ..These data support the hypothesis that PTSD symptoms influence pain, but suggest that problems with sleep and alcohol use may exacerbate the relationship...
  26. pmc Military blast exposure, ageing and white matter integrity
    Benjamin B Trotter
    1 VA Boston Healthcare System, Translational Research Center for Traumatic Brain Injury and Stress Disorders, RR and D TBI Center of Excellence, Boston, Massachusetts USA and Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, Massachusetts, USA 2 VA Boston Healthcare System Neuroimaging Research for Veterans Center, Boston, Massachusetts, USA
    Brain 138:2278-92. 2015
    ..Additional work examining longitudinal changes in brain tissue integrity in individuals exposed to military blast forces will be an important future direction to the initial findings presented here. ..
  27. pmc Correspondence of the Boston Assessment of Traumatic Brain Injury-Lifetime (BAT-L) clinical interview and the VA TBI screen
    Catherine Brawn Fortier
    Translational Research Center for TBI and Stress Disorders TRACTS, VA Boston Healthcare System, Boston, Massachusetts Drs Fortier, Amick, Kenna, Milberg, and McGlinchey Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, Massachusetts Drs Fortier, Milberg, and McGlinchey Department of Psychiatry, Harvard Medical School, Boston, Massachusetts Drs Fortier, Milberg, and McGlinchey and Department of Psychiatry, Boston University Medical School, Boston, Massachusetts Dr Amick
    J Head Trauma Rehabil 30:E1-7. 2015
    ..Mild traumatic brain injury is the signature injury of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND), yet its identification and diagnosis is controversial and fraught with challenges...
  28. pmc Implicit memory in Korsakoff's syndrome: a review of procedural learning and priming studies
    Scott M Hayes
    Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA
    Neuropsychol Rev 22:132-53. 2012
    ....
  29. pmc Detecting cognitive impairment in individuals at risk for cardiovascular disease: the "Clock-in-the-Box" screening test
    Laura J Grande
    Geriatric Research Education and Clinical Center, Boston VA Healthcare System, Boston, MA, USA
    Int J Geriatr Psychiatry 26:969-75. 2011
    ..The purpose of this study was to evaluate the performance on the Clock-in-the-Box (CIB), a screening measure for cognitive function, relative to neuropsychological testing in an older population with cardiovascular risk...
  30. ncbi request reprint Measuring attention in very old adults using the Test of Everyday Attention
    Guusje van der Leeuw
    a College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn . 2016
    ..These results demonstrate the challenges and potential value of the Test of Everyday Attention in studies of very old populations...
  31. doi request reprint Close-range blast exposure is associated with altered functional connectivity in Veterans independent of concussion symptoms at time of exposure
    Meghan E Robinson
    Neuroimaging Research for Veterans Center NeRVe, VA Boston Healthcare System, Boston, Massachusetts Translational Research Center for TBI and Stress Disorders TRACTS, VA Boston Healthcare System, Boston, Massachusetts
    Hum Brain Mapp 36:911-22. 2015
    ..It further offers a clinical guideline for determining which blasts (namely, those within 10 meters) are likely to lead to long-term health concerns and may be more accurate than using concussion symptoms alone...
  32. doi request reprint Poor performance validity predicts clinical characteristics and cognitive test performance of OEF/OIF/OND Veterans in a research setting
    Alexandra L Clark
    a Translational Research Center for TBI and Stress Disorders TRACTS and Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, MA, USA
    Clin Neuropsychol 28:802-25. 2014
    ....
  33. pmc Effects of OEF/OIF-related physical and emotional co-morbidities on associative learning: concurrent delay and trace eyeblink classical conditioning
    Regina E McGlinchey
    Geriatric Research Education and Clinical Center GRECC and the Translational Research Center for TBI and Stress related Disorders TRACTS, Boston, MA 02130, USA
    Int J Environ Res Public Health 11:3046-73. 2014
    ....
  34. pmc PTSD modifies performance on a task of affective executive control among deployed OEF/OIF veterans with mild traumatic brain injury
    Melissa M Amick
    Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, MA 02130, USA
    J Int Neuropsychol Soc 19:792-801. 2013
    ..This association was not observed in the mTBI- group. This study underscores the importance of considering the impact of a military-related mTBI and PTSD severity upon affective executive control...
  35. pmc Cerebral blood flow regulation during cognitive tasks: effects of healthy aging
    Farzaneh A Sorond
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02115, USA
    Cortex 44:179-84. 2008
    ..Our data suggest that there is differential blood flow increase in the ACA and PCA in young versus elderly subjects during cognitive tasks...
  36. pmc Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study
    Farzaneh A Sorond
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Women s Hospital, Boston, MA 02115, USA
    Ann Neurol 70:213-20. 2011
    ..Our study examines the association between neurovascular coupling in the middle cerebral artery and gait speed in elderly individuals with impaired cerebral vasoreactivity...
  37. pmc Using lexical familiarity judgments to assess verbally mediated intelligence in aphasia
    Elizabeth C Leritz
    Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, Massachusetts 02130, USA
    Neuropsychology 22:687-96. 2008
    ....
  38. doi request reprint Comment on Shomstein, Kimchi, Hammer, and Behrmann (2010): a case study in methodological anosagnosia?
    William P Milberg
    VA Boston Healthcare System, Boston, Massachusetts, USA
    Atten Percept Psychophys 72:619-21; discussion 622-7. 2010
    ..We caution that Shomstein et al.'s article does not present convincing evidence of grouping without attentional selection because they do not directly assess attentional selection in their experimental task...
  39. pmc Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision
    Richard N Jones
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
    J Clin Exp Neuropsychol 32:1041-9. 2010
    ..82). The developed measure provided a reliable, continuous measure (reliability > .90) across a broad range of performance (-1.5 SDs to +1.0 SDs) with minimal ceiling and floor effects...
  40. ncbi request reprint The role of homocysteine in multisystem age-related problems: a systematic review
    Hsu Ko Kuo
    Hebrew Rehabilitation Center for Aged, 1200 Centre Street, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 60:1190-201. 2005
    ..More research is needed to investigate whether lifelong homocysteine lowering can prevent the development of late-life morbidity...
  41. ncbi request reprint Hemispheric asymmetries for selective attention apparent only with increased task demands in healthy participants
    Denise L Evert
    Department of Psychology and Neuroscience Program, Skidmore College, Saratoga Springs, NY 12866, USA
    Brain Cogn 53:34-41. 2003
    ..These results are interpreted as RH specialization in light of evidence suggesting that the RH can direct attention to a larger portion of the visual field...
  42. pmc Impaired executive function is associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA
    J Am Geriatr Soc 54:937-41. 2006
    ..To determine the extent to which preoperative performance on tests of executive function and memory was associated with delirium after coronary artery bypass graft (CABG) surgery...
  43. pmc Selective impairment of frontal-executive cognitive function in african americans with cardiovascular risk factors
    Kenneth G Pugh
    Beth Israel Deaconess Medical Center, Department of Medicine, Gerontology Division, Boston, Massachusetts, USA
    J Am Geriatr Soc 51:1439-44. 2003
    ..To determine whether a summary cardiovascular risk score is associated with an increased risk of frontal-executive cognitive impairment...

Research Grants1

  1. COGNITIVE PROCESSING IN HEMISPATIAL NEGLECT
    William Milberg; Fiscal Year: 2004
    ..The data should also have relevance to understanding normal operations of these processes. ..