Marc E Lenburg
Affiliation: Boston University
- Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expressionJennifer Beane
Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
Genome Biol 8:R201. 2007..The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk...
- Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epitheliumSriram Sridhar
Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
BMC Genomics 9:259. 2008..In this study, we explored relationships in whole-genome gene expression between extrathorcic (buccal and nasal) and intrathoracic (bronchial) epithelium in healthy current and never smokers...
- Discovering biological connections between experimental conditions based on common patterns of differential gene expressionAdam C Gower
Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
BMC Bioinformatics 12:381. 2011..The second query, which used a signature of silencing of the transcription factor p63 (a key regulator of epidermal differentiation), identified datasets related to stratified squamous epithelia or epidermal diseases such as melanoma...
- Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray dataMarc E Lenburg
Department of Genetics and Genomics, Boston University School of Medicine 715 Albany Street, E613 Boston, Massachusetts 02118, USA
BMC Cancer 3:31. 2003..To better understand this lack of agreement we profiled renal cell tumor gene expression using genome-wide microarrays (45,000 probe sets) and compare our analysis to previous microarray studies...
- Similarities and differences between smoking-related gene expression in nasal and bronchial epitheliumXiaoling Zhang
Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
Physiol Genomics 41:1-8. 2010..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
- Airway PI3K pathway activation is an early and reversible event in lung cancer developmentAdam M Gustafson
Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
Sci Transl Med 2:26ra25. 2010..Our work further suggests that additional lung cancer chemoprevention trials either targeting the PI3K pathway or measuring airway PI3K activation as an intermediate endpoint are warranted...
- Reliability and reproducibility of gene expression measurements using amplified RNA from laser-microdissected primary breast tissue with oligonucleotide arraysChialin King
Division of Graduate Medical Sciences, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
J Mol Diagn 7:57-64. 2005..Future studies of in vivo gene expression using this approach will identify functionally important differences within or between specimens...
- Gene expression abnormalities in histologically normal breast epithelium of breast cancer patientsAnusri Tripathi
Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
Int J Cancer 122:1557-66. 2008..Thus, cancer-related pathways may be perturbed in normal epithelium. These abnormalities could be markers of disease risk, occult disease, or the tissue's response to an existing tumor...
- Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecinJonathan P Carson
Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA
Cancer Res 64:2096-104. 2004....
- Airway gene expression in chronic obstructive pulmonary diseaseKatrina Steiling
The Pulmonary Center, Boston University Medical Center, 72 East Concord Street R 304, Boston, MA 02118
Proc Am Thorac Soc 6:697-700. 2009....
- Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokersKatrina Steiling
The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts, United States of America
PLoS ONE 4:e5043. 2009....
- MicroRNAs as modulators of smoking-induced gene expression changes in human airway epitheliumFrank Schembri
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 106:2319-24. 2009..These data indicate that mir-218 levels modulate the airway epithelial gene expression response to cigarette smoke and support a role for miRNAs in regulating host response to environmental toxins...
- A prediction model for lung cancer diagnosis that integrates genomic and clinical featuresJennifer Beane
The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
Cancer Prev Res (Phila) 1:56-64. 2008..These findings suggest that use of the clinicogenomic model may expedite more invasive testing and definitive therapy for smokers with lung cancer and reduce invasive diagnostic procedures for individuals without lung cancer...
- Clinical impact of high-throughput gene expression studies in lung cancerJennifer Beane
Bioinformatics Program, Boston University School of Engineering, Boston, Massachusetts, USA
J Thorac Oncol 4:109-18. 2009....
- Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arraysXiaoling Zhang
Boston University, Boston, Massachusetts 02215, USA
Genome Inform 18:247-57. 2007..These findings suggest that the all-Exon array is a more robust platform for measuring airway epithelial gene expression and can serve as an effective tool for exploring host response to and damage from cigarette smoke...
- Transcriptomic studies of the airway field of injury associated with smoking-related lung diseaseAdam C Gower
Boston University School of Medicine, Boston, MA 02118, USA
Proc Am Thorac Soc 8:173-9. 2011....
- Applying gene expression microarrays to pulmonary diseaseJoshua D Campbell
Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston University, Boston, Massachusetts 02118, USA
Respirology 16:407-18. 2011....
- Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coalTeresa W Wang
Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA, Bioinformatics Program, Boston University, Boston, MA 02215, USA
Carcinogenesis 36:1494-501. 2015....
- Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat modelKristy T Salisbury Palomares
Boston University and Boston University School of Medicine, Boston, Massachusetts, USA
Arthritis Rheum 62:1108-18. 2010..To characterize patterns of molecular expression that lead to cartilage formation in vivo in a postnatal setting, by profiling messenger RNA expression across the time course of mechanically induced chondrogenesis...
- Aging, depot origin, and preadipocyte gene expressionMark J Cartwright
Department of Medicine, Boston University, Massachusetts, USA
J Gerontol A Biol Sci Med Sci 65:242-51. 2010..Thus, age-related changes in preadipocyte gene expression differ among depots, potentially contributing to fat redistribution and dysfunction...
- Translating the COPD transcriptome: insights into pathogenesis and tools for clinical managementJulie E Zeskind
Bioinformatics Program, Boston University, Boston, MA 02118, USA
Proc Am Thorac Soc 5:834-41. 2008..Given these similarities, we argue that additional lung tissue and airway gene-expression studies are warranted, and present a roadmap for how such studies could lead to clinically relevant tools that would impact COPD management...
- Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing dataJoshua D Campbell
Bioinformatics Graduate Program, Boston University, Boston, Massachusetts 02215, USA Section of Computational Biomedicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
RNA 21:164-71. 2015....
- Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancerAvrum Spira
The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
Nat Med 13:361-6. 2007..These findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke...
- A common genetic variant is associated with adult and childhood obesityAlan Herbert
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
Science 312:279-83. 2006..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
- Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasiaMikhail P Panchenko
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Pathol 177:1562-72. 2010..Our results indicate that the nuclear form of CK1alpha in humans, CK1alphaLS, plays a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction...
- Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart StudyAlan Herbert
Nat Genet 39:135-6. 2007