Marc E Lenburg

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
  2. pmc Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
    Sriram Sridhar
    Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
    BMC Genomics 9:259. 2008
  3. pmc Discovering biological connections between experimental conditions based on common patterns of differential gene expression
    Adam C Gower
    Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
    BMC Bioinformatics 12:381. 2011
  4. pmc Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data
    Marc E Lenburg
    Department of Genetics and Genomics, Boston University School of Medicine 715 Albany Street, E613 Boston, Massachusetts 02118, USA
    BMC Cancer 3:31. 2003
  5. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
  6. pmc Airway PI3K pathway activation is an early and reversible event in lung cancer development
    Adam M Gustafson
    Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Sci Transl Med 2:26ra25. 2010
  7. pmc Reliability and reproducibility of gene expression measurements using amplified RNA from laser-microdissected primary breast tissue with oligonucleotide arrays
    Chialin King
    Division of Graduate Medical Sciences, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    J Mol Diagn 7:57-64. 2005
  8. ncbi request reprint Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients
    Anusri Tripathi
    Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Int J Cancer 122:1557-66. 2008
  9. ncbi request reprint Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin
    Jonathan P Carson
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 64:2096-104. 2004
  10. pmc Airway gene expression in chronic obstructive pulmonary disease
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, 72 East Concord Street R 304, Boston, MA 02118
    Proc Am Thorac Soc 6:697-700. 2009

Collaborators

Detail Information

Publications26

  1. pmc Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
    ..The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk...
  2. pmc Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
    Sriram Sridhar
    Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
    BMC Genomics 9:259. 2008
    ..In this study, we explored relationships in whole-genome gene expression between extrathorcic (buccal and nasal) and intrathoracic (bronchial) epithelium in healthy current and never smokers...
  3. pmc Discovering biological connections between experimental conditions based on common patterns of differential gene expression
    Adam C Gower
    Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
    BMC Bioinformatics 12:381. 2011
    ..The second query, which used a signature of silencing of the transcription factor p63 (a key regulator of epidermal differentiation), identified datasets related to stratified squamous epithelia or epidermal diseases such as melanoma...
  4. pmc Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data
    Marc E Lenburg
    Department of Genetics and Genomics, Boston University School of Medicine 715 Albany Street, E613 Boston, Massachusetts 02118, USA
    BMC Cancer 3:31. 2003
    ..To better understand this lack of agreement we profiled renal cell tumor gene expression using genome-wide microarrays (45,000 probe sets) and compare our analysis to previous microarray studies...
  5. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  6. pmc Airway PI3K pathway activation is an early and reversible event in lung cancer development
    Adam M Gustafson
    Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Sci Transl Med 2:26ra25. 2010
    ..Our work further suggests that additional lung cancer chemoprevention trials either targeting the PI3K pathway or measuring airway PI3K activation as an intermediate endpoint are warranted...
  7. pmc Reliability and reproducibility of gene expression measurements using amplified RNA from laser-microdissected primary breast tissue with oligonucleotide arrays
    Chialin King
    Division of Graduate Medical Sciences, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    J Mol Diagn 7:57-64. 2005
    ..Future studies of in vivo gene expression using this approach will identify functionally important differences within or between specimens...
  8. ncbi request reprint Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients
    Anusri Tripathi
    Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Int J Cancer 122:1557-66. 2008
    ..Thus, cancer-related pathways may be perturbed in normal epithelium. These abnormalities could be markers of disease risk, occult disease, or the tissue's response to an existing tumor...
  9. ncbi request reprint Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin
    Jonathan P Carson
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 64:2096-104. 2004
    ....
  10. pmc Airway gene expression in chronic obstructive pulmonary disease
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, 72 East Concord Street R 304, Boston, MA 02118
    Proc Am Thorac Soc 6:697-700. 2009
    ....
  11. pmc Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5043. 2009
    ....
  12. pmc MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium
    Frank Schembri
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:2319-24. 2009
    ..These data indicate that mir-218 levels modulate the airway epithelial gene expression response to cigarette smoke and support a role for miRNAs in regulating host response to environmental toxins...
  13. pmc A prediction model for lung cancer diagnosis that integrates genomic and clinical features
    Jennifer Beane
    The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Cancer Prev Res (Phila) 1:56-64. 2008
    ..These findings suggest that use of the clinicogenomic model may expedite more invasive testing and definitive therapy for smokers with lung cancer and reduce invasive diagnostic procedures for individuals without lung cancer...
  14. pmc Clinical impact of high-throughput gene expression studies in lung cancer
    Jennifer Beane
    Bioinformatics Program, Boston University School of Engineering, Boston, Massachusetts, USA
    J Thorac Oncol 4:109-18. 2009
    ....
  15. ncbi request reprint Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays
    Xiaoling Zhang
    Boston University, Boston, Massachusetts 02215, USA
    Genome Inform 18:247-57. 2007
    ..These findings suggest that the all-Exon array is a more robust platform for measuring airway epithelial gene expression and can serve as an effective tool for exploring host response to and damage from cigarette smoke...
  16. pmc Transcriptomic studies of the airway field of injury associated with smoking-related lung disease
    Adam C Gower
    Boston University School of Medicine, Boston, MA 02118, USA
    Proc Am Thorac Soc 8:173-9. 2011
    ....
  17. doi request reprint Applying gene expression microarrays to pulmonary disease
    Joshua D Campbell
    Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston University, Boston, Massachusetts 02118, USA
    Respirology 16:407-18. 2011
    ....
  18. pmc Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal
    Teresa W Wang
    Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA, Bioinformatics Program, Boston University, Boston, MA 02215, USA
    Carcinogenesis 36:1494-501. 2015
    ....
  19. pmc Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model
    Kristy T Salisbury Palomares
    Boston University and Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 62:1108-18. 2010
    ..To characterize patterns of molecular expression that lead to cartilage formation in vivo in a postnatal setting, by profiling messenger RNA expression across the time course of mechanically induced chondrogenesis...
  20. pmc Aging, depot origin, and preadipocyte gene expression
    Mark J Cartwright
    Department of Medicine, Boston University, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 65:242-51. 2010
    ..Thus, age-related changes in preadipocyte gene expression differ among depots, potentially contributing to fat redistribution and dysfunction...
  21. pmc Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management
    Julie E Zeskind
    Bioinformatics Program, Boston University, Boston, MA 02118, USA
    Proc Am Thorac Soc 5:834-41. 2008
    ..Given these similarities, we argue that additional lung tissue and airway gene-expression studies are warranted, and present a roadmap for how such studies could lead to clinically relevant tools that would impact COPD management...
  22. pmc Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data
    Joshua D Campbell
    Bioinformatics Graduate Program, Boston University, Boston, Massachusetts 02215, USA Section of Computational Biomedicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    RNA 21:164-71. 2015
    ....
  23. ncbi request reprint Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    Avrum Spira
    The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 13:361-6. 2007
    ..These findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke...
  24. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  25. pmc Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia
    Mikhail P Panchenko
    Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Pathol 177:1562-72. 2010
    ..Our results indicate that the nuclear form of CK1alpha in humans, CK1alphaLS, plays a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction...
  26. ncbi request reprint Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study
    Alan Herbert
    Nat Genet 39:135-6. 2007