Mi Jeong Lee

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc 25-hydroxyvitamin D₃ and 1,25-dihydroxyvitamin D₃ promote the differentiation of human subcutaneous preadipocytes
    Hataikarn Nimitphong
    Department of Medicine, Section of Endocrinology and Metabolism, Ramathibodi Hospital, Bangkok, Thailand
    PLoS ONE 7:e52171. 2012
  2. pmc Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA Electronic address
    Methods Enzymol 538:49-65. 2014
  3. pmc Glucocorticoids antagonize tumor necrosis factor-α-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes
    Mi Jeong Lee
    Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 303:E1126-33. 2012
  4. pmc Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study
    Mi Jeong Lee
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, 650 Albany St, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 300:E571-80. 2011
  5. ncbi request reprint Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase
    Maria E Trujillo
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Howard Hall 428, Baltimore, MD 21201, USA
    J Clin Endocrinol Metab 91:1484-90. 2006
  6. ncbi request reprint Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 290:E1253-61. 2006
  7. pmc Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes
    Tan Hooi Min Grahn
    From the Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118
    J Biol Chem 289:12029-39. 2014
  8. ncbi request reprint Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, School of Medicine, University of Maryland, 660 West Redwood St, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 292:E858-64. 2007
  9. pmc A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Boston University, School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2334-40. 2012
  10. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006

Collaborators

Detail Information

Publications24

  1. pmc 25-hydroxyvitamin D₃ and 1,25-dihydroxyvitamin D₃ promote the differentiation of human subcutaneous preadipocytes
    Hataikarn Nimitphong
    Department of Medicine, Section of Endocrinology and Metabolism, Ramathibodi Hospital, Bangkok, Thailand
    PLoS ONE 7:e52171. 2012
    ..1,25(OH)(2)D(3) also enhanced adipogenesis in primary mouse preadipocytes. We conclude that vitamin D status may regulate human adipose tissue growth and remodeling...
  2. pmc Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA Electronic address
    Methods Enzymol 538:49-65. 2014
    ..We also describe methods for assaying hormonal effects on glucose transport and lipolysis. ..
  3. pmc Glucocorticoids antagonize tumor necrosis factor-α-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes
    Mi Jeong Lee
    Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 303:E1126-33. 2012
    ..The extent to which GCs can restrain the lipolytic actions of TNF may both diminish the potentially deleterious effects of excess lipolysis and contribute to fat accumulation in obesity...
  4. pmc Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study
    Mi Jeong Lee
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, 650 Albany St, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 300:E571-80. 2011
    ..Overall, these studies reveal the powerful effects of GC on gene networks that regulate many key functions in human adipose tissue...
  5. ncbi request reprint Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase
    Maria E Trujillo
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Howard Hall 428, Baltimore, MD 21201, USA
    J Clin Endocrinol Metab 91:1484-90. 2006
    ..TNF increases plasma leptin in humans in vivo, but previous studies showed it decreases leptin in vitro...
  6. ncbi request reprint Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 290:E1253-61. 2006
    ..05) human adipocytes. Omentin increased Akt phosphorylation in the absence and presence of insulin. In conclusion, omentin is a new adipokine that is expressed in omental adipose tissue in humans and may regulate insulin action...
  7. pmc Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes
    Tan Hooi Min Grahn
    From the Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118
    J Biol Chem 289:12029-39. 2014
    ..Our results demonstrate a crucial role for FSP27-ATGL interactions in regulating lipolysis, triglyceride accumulation, and insulin signaling in human adipocytes. ..
  8. ncbi request reprint Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, School of Medicine, University of Maryland, 660 West Redwood St, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 292:E858-64. 2007
    ....
  9. pmc A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Boston University, School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2334-40. 2012
    ..This protocol permits functional analysis of metabolic phenotypes in valuable primary human adipocyte cultures through multiple passages...
  10. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006
    ..However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood...
  11. pmc Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity
    Mi Jeong Lee
    Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA
    Biochim Biophys Acta 1842:473-81. 2014
    ..This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. ..
  12. ncbi request reprint Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Maryland 21201, USA
    J Biol Chem 282:72-80. 2007
    ..Our data suggest that insulin derepresses leptin translation by a mechanism that requires both the 5'-UTR and the 3'-UTR and may contribute to the increase in leptin production with feeding...
  13. pmc Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway
    Partha Chakrabarti
    Boston University School of Medicine, Boston, Massachusetts, USA
    Mol Cell Biol 33:3659-66. 2013
    ..We suggest that the evolutionarily conserved mTORC1-Egr1-ATGL regulatory pathway represents an important component of the antilipolytic effect of insulin in the mammalian organism. ..
  14. pmc Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications
    Mi Jeong Lee
    Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University, School of Medicine, Boston, MA 02118, United States
    Mol Aspects Med 34:1-11. 2013
    ..In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women...
  15. pmc Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:1178-85. 2008
    ..Our main objective was to compare the regulation of cortisol production within omental (Om) and abdominal subcutaneous (Abd sc) human adipose tissue...
  16. pmc FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes
    Tan Hooi Min Grahn
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Biochem Biophys Res Commun 432:296-301. 2013
    ..Our data suggest that FSP27 interacts with PLIN1 to regulate lipid droplet size in human adipocytes in a concerted manner...
  17. pmc Adipose tissue remodeling in pathophysiology of obesity
    Mi Jeong Lee
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University, School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Clin Nutr Metab Care 13:371-6. 2010
    ..This review will summarize recent advances of our knowledge of the mechanisms that regulate adipose tissue remodeling and highlight the influences of obesity, depot, and sex, as well as the relevance of rodent models to humans...
  18. pmc Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes
    Mark P Jedrychowski
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA Department of Cell Biology, Harvard University School of Medicine, 240 Longwood Avenue Boston, MA 02115, USA
    Mol Metab 4:758-70. 2015
    ..To understand how such proteins are assembled for secretion we describe the function of a novel endoplasmic reticulum oxidoreductase, adiporedoxin (Adrx)...
  19. ncbi request reprint Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
    ..In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity...
  20. pmc Shaping fat distribution: New insights into the molecular determinants of depot- and sex-dependent adipose biology
    Susan K Fried
    Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
    Obesity (Silver Spring) 23:1345-52. 2015
    ..To review recent advances in understanding the cellular mechanisms that regulate fat distribution...
  21. pmc Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots
    Kalypso Karastergiou
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 98:362-71. 2013
    ..Differences in cellular characteristics and metabolic functions of these depots have been described, but the molecular mechanisms involved are not understood...
  22. pmc The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life
    Hyeran Jang
    Research Program in Men s Health Aging and Metabolism H J, S B, T G, C S, W G, K P, R J, Boston Claude D Pepper Older Americans Independence Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 and Boston Nutrition and Obesity Research Center M S, M J L, S K F, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118
    Endocrinology 156:3737-46. 2015
    ..Collectively, these data suggest that sustained reproductive and metabolic alterations may result in female mice from a transient exposure to T during a narrow postnatal developmental window. ..
  23. pmc Prolonged efficiency of siRNA-mediated gene silencing in primary cultures of human preadipocytes and adipocytes
    Mi Jeong Lee
    Section of Endocrinology Diabetes and Nutrition Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 22:1064-9. 2014
    ..To use these systems for mechanistic studies, siRNA-mediated knockdown of genes for its effectiveness was studied...
  24. pmc Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion
    Mi Jeong Lee
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA
    Am J Physiol Endocrinol Metab 296:E1230-8. 2009
    ....