Ronald J Killiany

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Image processing: global and regional changes with age
    Ronald J Killiany
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Top Magn Reson Imaging 15:349-53. 2004
  2. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
  3. pmc A rhesus monkey reference label atlas for template driven segmentation
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    J Med Primatol 37:250-60. 2008
  4. doi request reprint Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    Somatosens Mot Res 30:185-96. 2013
  5. pmc Hippocampal network connections account for differences in memory performance in the middle-aged rhesus monkey
    Bang Bon Koo
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts
    Hippocampus 23:1179-88. 2013
  6. doi request reprint Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
  7. pmc Impairment in delayed nonmatching to sample following lesions of dorsal prefrontal cortex
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, W701, Boston, MA 02118, USA
    Behav Neurosci 126:772-80. 2012
  8. pmc Recovery from ischemia in the middle-aged brain: a nonhuman primate model
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:619.e9-619.e24. 2012
  9. ncbi request reprint Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Cereb Cortex 15:409-18. 2005
  10. doi request reprint Assessment of motor function of the hand in aged rhesus monkeys
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Somatosens Mot Res 27:121-30. 2010

Research Grants

Detail Information

Publications28

  1. ncbi request reprint Image processing: global and regional changes with age
    Ronald J Killiany
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Top Magn Reson Imaging 15:349-53. 2004
    ..It should not be surprising given the changes seen in studies of aging that our conventional wisdom of the aging process is being called into question...
  2. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
    ..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
  3. pmc A rhesus monkey reference label atlas for template driven segmentation
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    J Med Primatol 37:250-60. 2008
    ..To analyze these legacy data for regional volume changes, we have created a reference label atlas for the Template Driven Segmentation (TDS) algorithm...
  4. doi request reprint Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    Somatosens Mot Res 30:185-96. 2013
    ..Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity...
  5. pmc Hippocampal network connections account for differences in memory performance in the middle-aged rhesus monkey
    Bang Bon Koo
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts
    Hippocampus 23:1179-88. 2013
    ....
  6. doi request reprint Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
    ..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
  7. pmc Impairment in delayed nonmatching to sample following lesions of dorsal prefrontal cortex
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, W701, Boston, MA 02118, USA
    Behav Neurosci 126:772-80. 2012
    ..The presence and extent of the deficits that we observed were of some surprise and support the possibility that the dorsal prefrontal cortex plays a more direct role in learning and recognition memory than had been previously thought...
  8. pmc Recovery from ischemia in the middle-aged brain: a nonhuman primate model
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:619.e9-619.e24. 2012
    ..However, analysis of grasp patterns revealed that neither group recover preoperative finger thumb grasp patterns, rather they develop compensatory movements...
  9. ncbi request reprint Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Cereb Cortex 15:409-18. 2005
    ..These data indicate that an increase in AP firing rate may be responsible, in part, for age-related PFC dysfunction...
  10. doi request reprint Assessment of motor function of the hand in aged rhesus monkeys
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Somatosens Mot Res 27:121-30. 2010
    ..However, the magnitude and extent of impairment in the current study does differ from previous findings and is likely due to methodological differences in the degree of task complexity...
  11. doi request reprint Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    Restor Neurol Neurosci 34:827-48. 2016
    ..Inosine, a naturally occurring purine nucleoside, has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models...
  12. pmc An MRI study of age-related white and gray matter volume changes in the rhesus monkey
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, United States
    Neurobiol Aging 29:1563-75. 2008
    ..We found that none of the cognitive measures were related to ROI volume changes in our sample size of monkeys...
  13. doi request reprint Hippocampal subregions are differentially affected in the progression to Alzheimer's disease
    Sarah J Greene
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, 05405 0068, USA
    Anat Rec (Hoboken) 295:132-40. 2012
    ..Discriminant function analyses revealed that these regions, when combined with NP and CSF measures, were able to classify by diagnostic group, and classify MCI subjects who would and would not progress to AD within 12 months...
  14. doi request reprint Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta)
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Behav Neurosci 123:231-41. 2009
    ..Rhesus monkeys with lesions of the dorsolateral PFC were impaired in abstraction, establishing a response pattern to a specific category and maintaining and shifting that response pattern on the category set-shifting task...
  15. pmc Subregions of the inferior parietal lobule are affected in the progression to Alzheimer's disease
    Sarah J Greene
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 31:1304-11. 2010
    ....
  16. ncbi request reprint "Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta)": Correction to Moore et al (2009)
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine
    Behav Neurosci 123:712. 2009
    ..PsycINFO Database Record (c) 2009 APA, all rights reserved)...
  17. ncbi request reprint Executive system dysfunction occurs as early as middle-age in the rhesus monkey
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Neurobiol Aging 27:1484-93. 2006
    ....
  18. ncbi request reprint Impairment in abstraction and set shifting in aged rhesus monkeys
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Neurobiol Aging 24:125-34. 2003
    ..The pattern of performance displayed by the aged monkeys suggests an age-related decline in prefrontal cortex (PFC) functioning...
  19. ncbi request reprint Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
    Behav Brain Res 160:208-21. 2005
    ..Further analysis revealed a significant relationship between monoamine receptor binding and cognitive performance on three tasks: delayed non-matching to sample, delayed recognition span test and the conceptual set-shifting task...
  20. ncbi request reprint A non-human primate test of abstraction and set shifting: an automated adaptation of the Wisconsin Card Sorting Test
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701 Boston, MA 02118, USA
    J Neurosci Methods 146:165-73. 2005
    ....
  21. ncbi request reprint Impairment of executive function induced by hypertension in the rhesus monkey (Macaca mulatta)
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118, USA
    Behav Neurosci 116:387-96. 2002
    ..Although the neural basis of this impairment is unclear, evidence from studies with humans and monkeys suggests that the prefrontal cortex may be the locus for this effect of hypertension...
  22. pmc Age-related effects on cortical thickness patterns of the Rhesus monkey brain
    Bang Bon Koo
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    Neurobiol Aging 33:200.e23-31. 2012
    ..In contrast, results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions...
  23. ncbi request reprint An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    Rahul S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
    Neuroimage 31:968-80. 2006
    ....
  24. ncbi request reprint Quantitative magnetic resonance brain imaging in US army veterans of the 1991 Gulf War potentially exposed to sarin and cyclosarin
    Kristin J Heaton
    Boston Environmental Hazards Research Center, VA Boston Healthcare System, Boston, MA, USA
    Neurotoxicology 28:761-9. 2007
    ....
  25. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  26. ncbi request reprint Sex, age, and training modulate spatial memory in the rhesus monkey (Macaca mulatta)
    AGNES LACREUSE
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30322 USA
    Behav Neurosci 119:118-26. 2005
    ..The results confirm a male advantage in spatial working memory at a young age and confirm a greater decline with age in males than in females. It is important to note that prior training completely reverses the deficits of young females...
  27. pmc Medial temporal lobe function and structure in mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
    Ann Neurol 56:27-35. 2004
    ..We hypothesize that increased activation in MTL regions reflects a compensatory response to accumulating AD pathology and may serve as a marker for impending clinical decline...
  28. pmc Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils
    Richard G Boyes
    Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London, UK
    Neuroimage 39:1752-62. 2008
    ....

Research Grants1

  1. Primate Model of Hypertensive Cerebrovascular Disease
    Ronald Killiany; Fiscal Year: 2002
    ..Finally, as part of a preliminary effort to understand the mechanism by which neuropatholoigical processes are induced in the brain, we will survey the brain and aorta for signs of pathology. ..