Michael Hasselmo

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Analysis of theta power in hippocampal EEG during bar pressing and running behavior in rats during distinct behavioral contexts
    Bradley P Wyble
    Computing Laboratory, University of Kent, Canterbury, Kent, United Kingdom
    Hippocampus 14:662-74. 2004
  2. pmc Coupled noisy spiking neurons as velocity-controlled oscillators in a model of grid cell spatial firing
    Eric A Zilli
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 30:13850-60. 2010
  3. pmc Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex
    James G Heys
    Center for Memory and Brain, Program in Neuroscience, and Psychology Department, Boston University, Boston, Massachusetts 02215, USA
    J Neurophysiol 104:258-70. 2010
  4. pmc Greater working memory load results in greater medial temporal activity at retrieval
    Karin Schon
    Department of Psychology and Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Cereb Cortex 19:2561-71. 2009
  5. pmc Coincidence detection of place and temporal context in a network model of spiking hippocampal neurons
    Yael Katz
    Interdepartmental Biological Sciences Program, Northwestern University, Evanston, Illinois, United States of America
    PLoS Comput Biol 3:e234. 2007
  6. doi request reprint If I had a million neurons: Potential tests of cortico-hippocampal theories
    Michael E Hasselmo
    Department of Psychological and Brain Sciences, Center for Memory and Brain, Center for Systems Neuroscience, Graduate Program for Neuroscience, Boston University, Boston, MA, USA Electronic address
    Prog Brain Res 219:1-19. 2015
  7. pmc A model combining oscillations and attractor dynamics for generation of grid cell firing
    Michael E Hasselmo
    Graduate Program for Neuroscience, Department of Psychology, Center for Memory and Brain, Boston University Boston, MA, USA
    Front Neural Circuits 6:30. 2012
  8. pmc Theta rhythm and the encoding and retrieval of space and time
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Graduate Program for Neuroscience, Boston University, 2 Cummington Mall, Boston, MA, 02215, USA Electronic address
    Neuroimage 85:656-66. 2014
  9. doi request reprint Location memory: separate cortical coding for distal and local cues
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Graduate Program for Neuroscience, Boston University, Boston, MA 02215, USA
    Curr Biol 23:R685-7. 2013
  10. pmc A model of prefrontal cortical mechanisms for goal-directed behavior
    Michael E Hasselmo
    Department of Psychology, Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    J Cogn Neurosci 17:1115-29. 2005

Research Grants

  1. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006

Detail Information

Publications81

  1. ncbi request reprint Analysis of theta power in hippocampal EEG during bar pressing and running behavior in rats during distinct behavioral contexts
    Bradley P Wyble
    Computing Laboratory, University of Kent, Canterbury, Kent, United Kingdom
    Hippocampus 14:662-74. 2004
    ..These data extend the current scope of theory in demonstrating that hippocampal theta activity can end abruptly 200-400 ms prior to the end of type 1 motor movement when approaching the end of a motor sequence...
  2. pmc Coupled noisy spiking neurons as velocity-controlled oscillators in a model of grid cell spatial firing
    Eric A Zilli
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 30:13850-60. 2010
    ..Nevertheless, a number of simplifications were still made and future work should examine increasingly realistic models...
  3. pmc Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex
    James G Heys
    Center for Memory and Brain, Program in Neuroscience, and Psychology Department, Boston University, Boston, Massachusetts 02215, USA
    J Neurophysiol 104:258-70. 2010
    ..Furthermore, our data suggest that these changes in resonance properties are mediated through modulation of h-current and m-current...
  4. pmc Greater working memory load results in greater medial temporal activity at retrieval
    Karin Schon
    Department of Psychology and Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Cereb Cortex 19:2561-71. 2009
    ..Bilateral dorsolateral prefrontal activity was present during maintenance, but not during encoding or retrieval. The results support models of WM predicting that activity in the MTL should be modulated by WM load...
  5. pmc Coincidence detection of place and temporal context in a network model of spiking hippocampal neurons
    Yael Katz
    Interdepartmental Biological Sciences Program, Northwestern University, Evanston, Illinois, United States of America
    PLoS Comput Biol 3:e234. 2007
    ..The model leads to a number of experimentally testable predictions that may lead to a better understanding of the biophysical basis of information processing in the hippocampus...
  6. doi request reprint If I had a million neurons: Potential tests of cortico-hippocampal theories
    Michael E Hasselmo
    Department of Psychological and Brain Sciences, Center for Memory and Brain, Center for Systems Neuroscience, Graduate Program for Neuroscience, Boston University, Boston, MA, USA Electronic address
    Prog Brain Res 219:1-19. 2015
    ....
  7. pmc A model combining oscillations and attractor dynamics for generation of grid cell firing
    Michael E Hasselmo
    Graduate Program for Neuroscience, Department of Psychology, Center for Memory and Brain, Boston University Boston, MA, USA
    Front Neural Circuits 6:30. 2012
    ..The pattern of interaction of oscillations requires use of separate populations that fire on alternate cycles of the net theta rhythmic input to grid cells...
  8. pmc Theta rhythm and the encoding and retrieval of space and time
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Graduate Program for Neuroscience, Boston University, 2 Cummington Mall, Boston, MA, 02215, USA Electronic address
    Neuroimage 85:656-66. 2014
    ..Here we discuss these models and relate them to current physiological and behavioral data. ..
  9. doi request reprint Location memory: separate cortical coding for distal and local cues
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Graduate Program for Neuroscience, Boston University, Boston, MA 02215, USA
    Curr Biol 23:R685-7. 2013
    ....
  10. pmc A model of prefrontal cortical mechanisms for goal-directed behavior
    Michael E Hasselmo
    Department of Psychology, Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    J Cogn Neurosci 17:1115-29. 2005
    ....
  11. pmc The role of acetylcholine in learning and memory
    Michael E Hasselmo
    Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Curr Opin Neurobiol 16:710-5. 2006
    ..These effects might enhance different types of encoding in different cortical structures. In particular, the effects in entorhinal and perirhinal cortex and hippocampus might be important for encoding new episodic memories...
  12. ncbi request reprint What is the function of hippocampal theta rhythm?--Linking behavioral data to phasic properties of field potential and unit recording data
    Michael E Hasselmo
    Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Hippocampus 15:936-49. 2005
    ..g., "splitter cells"), (3) the cholinergic regulation of sustained activity in entorhinal cortical neurons, and (4) the phasic timing of prefrontal cortical neurons relative to hippocampal theta rhythm...
  13. pmc Hippocampal mechanisms for the context-dependent retrieval of episodes
    Michael E Hasselmo
    Department of Psychology Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, USA
    Neural Netw 18:1172-90. 2005
    ..The model links data at the cellular level to behavior at the systems level, describing a physiologically plausible mechanism for the brain to recall a given episode which occurred at a specific place and time...
  14. pmc Mechanisms underlying working memory for novel information
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Trends Cogn Sci 10:487-93. 2006
    ..These intrinsic mechanisms in parahippocampal cortices provide an important alternative to theories of working memory based on recurrent synaptic excitation...
  15. ncbi request reprint Differences in time course of ACh and GABA modulation of excitatory synaptic potentials in slices of rat hippocampus
    M E Hasselmo
    Department of Psychology, Program in Neuroscience and Center for BioDynamics, Boston University, Boston, Massachusetts 02215, USA
    J Neurophysiol 86:1792-802. 2001
    ..The faster changes in synaptic potentials caused by GABA could cause changes within each cycle of the theta rhythm, rapidly switching between encoding and retrieval dynamics during exploration...
  16. ncbi request reprint Cholinergic modulation of cortical function
    M E Hasselmo
    Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    J Mol Neurosci 30:133-5. 2006
    ..Interference from prior memory is reduced by suppressing synapses modified by prior learning (Sevilla et al., 2002; Linster et al., 2003)...
  17. pmc Grid cell firing may arise from interference of theta frequency membrane potential oscillations in single neurons
    Michael E Hasselmo
    Center for Memory and Brain and Program in Neuroscience, Boston University, Boston, Massachusetts, USA
    Hippocampus 17:1252-71. 2007
    ..These same mechanisms of subthreshold oscillations may play a more general role in memory function, by providing a method for learning arbitrary time intervals in memory sequences...
  18. pmc Arc length coding by interference of theta frequency oscillations may underlie context-dependent hippocampal unit data and episodic memory function
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, Boston, Massachusetts 02215, USA
    Learn Mem 14:782-94. 2007
    ..Arc length coding could contribute to episodic encoding of trajectories as sequences of states and actions...
  19. pmc Modes and models of forebrain cholinergic neuromodulation of cognition
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
    Neuropsychopharmacology 36:52-73. 2011
    ..The available evidence and these models point to new principles governing the development of the next generation of cholinergic treatments for cognitive disorders...
  20. pmc Neuroscience. The scale of experience
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Science 321:46-7. 2008
  21. pmc Linking cellular mechanisms to behavior: entorhinal persistent spiking and membrane potential oscillations may underlie path integration, grid cell firing, and episodic memory
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Sreet, Boston, MA 02215, USA
    Neural Plast 2008:658323. 2008
    ..The interaction of oscillations and persistent firing could contribute to encoding and retrieval of trajectories through space and time as a mechanism relevant to episodic memory...
  22. pmc Temporally structured replay of neural activity in a model of entorhinal cortex, hippocampus and postsubiculum
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, USA
    Eur J Neurosci 28:1301-15. 2008
    ..These mechanisms could be important for episodic memory of trajectories...
  23. pmc Grid cell mechanisms and function: contributions of entorhinal persistent spiking and phase resetting
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, Boston, Massachusetts 02215, USA
    Hippocampus 18:1213-29. 2008
    ..Science, 2008), and a hairpin maze task...
  24. pmc A model of episodic memory: mental time travel along encoded trajectories using grid cells
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, United States
    Neurobiol Learn Mem 92:559-73. 2009
    ..These mechanisms allow retrieval of complex, self-crossing trajectories as continuous curves through space and time...
  25. pmc A phase code for memory could arise from circuit mechanisms in entorhinal cortex
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Neural Netw 22:1129-38. 2009
    ..Efforts to implement these abstract models in more detailed biophysical compartmental simulations raise specific issues that could be addressed in larger scale population models incorporating mechanisms of inhibition...
  26. pmc Cellular dynamical mechanisms for encoding the time and place of events along spatiotemporal trajectories in episodic memory
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Behav Brain Res 215:261-74. 2010
    ..The model also addresses how cellular dynamics could underlie unit firing data suggesting mechanisms for coding continuous dimensions of space, time, sensation and action...
  27. ncbi request reprint A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning
    Michael E Hasselmo
    Department of Psychology, Program in Neuroscience and Center for BioDynamics, Boston University, Boston, MA 02215, USA
    Neural Comput 14:793-817. 2002
    ..Consistent with these requirements, our recent data show that synaptic transmission in stratum radiatum is weakest at the positive peak of local theta, which is when previous data show that induction of LTP is strongest in this layer...
  28. ncbi request reprint Neuromodulation, theta rhythm and rat spatial navigation
    Michael E Hasselmo
    Department of Psychology, Center for BioDynamics, Boston University, MA 02215, USA
    Neural Netw 15:689-707. 2002
    ..We present analysis exploring how phasic changes in physiological variables during hippocampal theta rhythm could provide these different phases and enhance spatial navigation function...
  29. ncbi request reprint High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation
    Michael E Hasselmo
    Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, USA
    Prog Brain Res 145:207-31. 2004
  30. ncbi request reprint The role of hippocampal regions CA3 and CA1 in matching entorhinal input with retrieval of associations between objects and context: theoretical comment on Lee et al. (2005)
    Michael E Hasselmo
    Boston University, Boston, MA 02215, USA
    Behav Neurosci 119:342-5. 2005
    ..Along with recent electrophysiological data, this provides a framework for more specifically modeling the role of CA3 and CA1 in matching sensory input with context-dependent retrieval for memory-guided behavior in different tasks...
  31. ncbi request reprint Theta rhythmic stimulation of stratum lacunosum-moleculare in rat hippocampus contributes to associative LTP at a phase offset in stratum radiatum
    Sarah J Judge
    Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    J Neurophysiol 92:1615-24. 2004
    ..lacunosum-moleculare and the single pulse s. radiatum stimulation. The time of maximal LTP induction was found to be approximately 30 ms after the end of lacunosum-moleculare stimulation, consistent with the requirements of the model...
  32. ncbi request reprint First-in-first-out item replacement in a model of short-term memory based on persistent spiking
    Randal A Koene
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Cereb Cortex 17:1766-81. 2007
    ..As noise increases, the simulated buffer provides robust output that may underlie episodic encoding...
  33. pmc Time constants of h current in layer ii stellate cells differ along the dorsal to ventral axis of medial entorhinal cortex
    Lisa M Giocomo
    Center for Memory and Brain, Program in Neuroscience and Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:9414-25. 2008
    ..Differences in h current could underlie differences in membrane potential oscillation properties and contribute to grid cell periodicity along the dorsal-ventral axis of medial entorhinal cortex...
  34. ncbi request reprint Difference in time course of modulation of synaptic transmission by group II versus group III metabotropic glutamate receptors in region CA1 of the hippocampus
    Lisa M Giocomo
    Program in Neuroscience, Center for Memory and Brain, Boston University, Boston, MA 02214, USA
    Hippocampus 16:1004-16. 2006
    ..The difference in time course for group II vs. group III mGluRs suggests a different functional role, with group II playing a potential role in making synapses act as low pass filters...
  35. pmc Which way was I going? Contextual retrieval supports the disambiguation of well learned overlapping navigational routes
    Thackery I Brown
    Psychology Department, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 30:7414-22. 2010
    ....
  36. ncbi request reprint Hippocampal CA1 spiking during encoding and retrieval: relation to theta phase
    Joseph R Manns
    Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Neurobiol Learn Mem 87:9-20. 2007
    ..The modeling results obtained here demonstrated that the experimentally observed phase differences are consistent with different levels of CA3 synaptic input to CA1 during recognition of repeated items...
  37. ncbi request reprint An integrate-and-fire model of prefrontal cortex neuronal activity during performance of goal-directed decision making
    Randal A Koene
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Cereb Cortex 15:1964-81. 2005
    ..The spiking activity shows properties similar to recordings of orbitofrontal neurons during task performance...
  38. ncbi request reprint Neuromodulation by glutamate and acetylcholine can change circuit dynamics by regulating the relative influence of afferent input and excitatory feedback
    Lisa M Giocomo
    Program in Neuroscience, Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Mol Neurobiol 36:184-200. 2007
    ..Modulation of afferent versus intrinsic processing could contribute to the role of neuromodulators in regulating attention, learning, and memory effects in behavior...
  39. ncbi request reprint Persistence of parahippocampal representation in the absence of stimulus input enhances long-term encoding: a functional magnetic resonance imaging study of subsequent memory after a delayed match-to-sample task
    Karin Schon
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 24:11088-97. 2004
    ....
  40. ncbi request reprint Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans
    Karin Schon
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 25:9112-23. 2005
    ..The results are consistent with computational modeling data and behavioral pharmacological studies, suggesting that long-term encoding-related activity may be reduced if cholinergic receptors are blocked by scopolamine...
  41. ncbi request reprint Gradual translocation of spatial correlates of neuronal firing in the hippocampus toward prospective reward locations
    Inah Lee
    Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Neuron 51:639-50. 2006
    ..The within-session shifts in preferred firing locations in the absence of any changes in the environment suggest that certain cognitive factors can significantly alter the location-bound coding scheme of hippocampal neurons...
  42. pmc Knock-out of HCN1 subunit flattens dorsal-ventral frequency gradient of medial entorhinal neurons in adult mice
    Lisa M Giocomo
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 29:7625-30. 2009
    ..These findings have important implications for models of grid cells and generate predictions for future in vivo work on entorhinal grid cells...
  43. pmc Reversed and forward buffering of behavioral spike sequences enables retrospective and prospective retrieval in hippocampal regions CA3 and CA1
    Randal A Koene
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
    Neural Netw 21:276-88. 2008
    ..Associations are formed between buffered episodic cues, unique temporal context specific representations in dentate gyrus, and episodic memory in the CA3 recurrent network...
  44. pmc The temporal context model in spatial navigation and relational learning: toward a common explanation of medial temporal lobe function across domains
    Marc W Howard
    Department of Psychology, Syracuse University, Syracuse, NY 13244 2340, USA
    Psychol Rev 112:75-116. 2005
    ..These results constitute a first step toward a unified computational theory of MTL function that integrates neurophysiological, neuropsychological, and cognitive findings...
  45. pmc A model of behavioral treatments for self-mutilation behavior in Lesch-Nyhan syndrome
    Eric A Zilli
    Program in Neuroscience, Department of Psychology, Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Neuroreport 19:459-62. 2008
    ..Simulations of this model reproduce findings on the results of behavioral treatments for dealing with self-mutilation behaviors...
  46. ncbi request reprint Encoding and retrieval in the CA3 region of the hippocampus: a model of theta-phase separation
    Steve Kunec
    Center for BioDynamics, Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, Massachusetts 02215, USA
    J Neurophysiol 94:70-82. 2005
    ..Slow inhibitory neurons (O-LM cells) play a role in the disambiguation during retrieval. We compare and contrast our computational results with existing experimental data and other contemporary models...
  47. pmc The influence of Markov decision process structure on the possible strategic use of working memory and episodic memory
    Eric A Zilli
    Center for Memory and Brain, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2756. 2008
    ..This may provide a basis for a quantitative behavioral stoichiometry of memory tasks...
  48. pmc Evaluation of the oscillatory interference model of grid cell firing through analysis and measured period variance of some biological oscillators
    Eric A Zilli
    Department of Psychology, Boston University, Boston, Massachusetts, USA
    PLoS Comput Biol 5:e1000573. 2009
    ..However, oscillatory interference models can tolerate small amounts of noise, suggesting the utility of circuit level effects which might reduce oscillator variability. Further implications for grid cell models are discussed...
  49. pmc mGluR-dependent persistent firing in entorhinal cortex layer III neurons
    Motoharu Yoshida
    Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Eur J Neurosci 28:1116-26. 2008
    ....
  50. ncbi request reprint A model of STDP based on spatially and temporally local information: derivation and combination with gated decay
    Anatoli Gorchetchnikov
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon St, Boston, MA 02215, USA
    Neural Netw 18:458-66. 2005
    ..The results show that the advantages of using these gatings are transferred to the new rule without sacrificing its dependency on spike-timing...
  51. ncbi request reprint Modeling goal-directed spatial navigation in the rat based on physiological data from the hippocampal formation
    Randal A Koene
    Department of Pyschology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Neural Netw 16:577-84. 2003
    ..Together, input from ECIII and CA3 activated predictive spiking in cells in CA1 for the next desired place on a shortest path to a goal. Consistent with data, place cell activity in CA1 and CA3 showed smaller place fields than in ECIII...
  52. pmc Computation by oscillations: implications of experimental data for theoretical models of grid cells
    Lisa M Giocomo
    Center for Memory and Brain, Program in Neuroscience, and Psychology Department, Boston University, Boston, Massachusetts 02215, USA
    Hippocampus 18:1186-99. 2008
    ..Mechanisms of oscillatory interference and attractor dynamics may make complementary contributions to the properties of grid cell firing in entorhinal cortex...
  53. doi request reprint Decoding movement trajectories through a T-maze using point process filters applied to place field data from rat hippocampal region CA1
    Yifei Huang
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Neural Comput 21:3305-34. 2009
    ..Our computational framework provides a reliable approach for characterizing and extracting information from ensembles of neurons with spatially specific context or task-dependent firing activity...
  54. pmc Persistent firing supported by an intrinsic cellular mechanism in a component of the head direction system
    Motoharu Yoshida
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 29:4945-52. 2009
    ..These results suggest that persistent firing of head direction cells in the postsubiculum could be supported by an intrinsic mechanism...
  55. ncbi request reprint Medial prefrontal cortex cells show dynamic modulation with the hippocampal theta rhythm dependent on behavior
    James M Hyman
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
    Hippocampus 15:739-49. 2005
    ..mPFC neurons have the capability to respond to behaviorally relevant elements by dynamically alternating between hippocampal theta entrained and nonphasic firing...
  56. ncbi request reprint Stimulation in hippocampal region CA1 in behaving rats yields long-term potentiation when delivered to the peak of theta and long-term depression when delivered to the trough
    James M Hyman
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 23:11725-31. 2003
    ..The results are discussed within the framework of a recent theory that proposes that the theta rhythm sets the dynamics for alternating phases of encoding and retrieval (Hasselmo et al., 20021)...
  57. ncbi request reprint GABA(B) presynaptic inhibition has an in vivo time constant sufficiently rapid to allow modulation at theta frequency
    Bradley J Molyneaux
    Department of Psychology, Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    J Neurophysiol 87:1196-205. 2002
    ..This heterosynaptic depression was significantly reduced by local infusion of the GABA(B) receptor antagonist CGP55845A...
  58. pmc Modeling the role of working memory and episodic memory in behavioral tasks
    Eric A Zilli
    Program in Neuroscience, Departmentof Psychology, Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    Hippocampus 18:193-209. 2008
    ..When a delay is imposed, simulations with both episodic memory and WM can solve all of the tasks except a disambiguation of odor sequences task...
  59. ncbi request reprint Nicotinic modulation of glutamatergic synaptic transmission in region CA3 of the hippocampus
    Lisa M Giocomo
    Department of Psychology, Center for Memory and Brain, 2 Cummington Street, Boston University, Boston, MA, 02215, USA
    Eur J Neurosci 22:1349-56. 2005
    ....
  60. pmc Consequences of parameter differences in a model of short-term persistent spiking buffers provided by pyramidal cells in entorhinal cortex
    Randal A Koene
    Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Brain Res 1202:54-67. 2008
    ....
  61. pmc Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing
    Lisa M Giocomo
    Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Science 315:1719-22. 2007
    ....
  62. ncbi request reprint Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory task
    Amy L Griffin
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 27:2416-23. 2007
    ..Our results suggest that trial-phase-selective coding is common in tasks that require rapid alternation between encoding and retrieval processes...
  63. pmc An analysis of the mean theta phase of population activity in a model of hippocampal region CA1
    Eric A Zilli
    Program in Neuroscience, Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Network 17:277-97. 2006
    ..The analyses also reveal that the model's learning rule results in stability and normalization of synaptic weights and show how dysfunction of neuromodulatory systems might lead to epileptic or amnestic type conditions...
  64. ncbi request reprint Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
    Martin Sarter
    Department of Psychology, University of Michigan, 525 E University Ave, Ann Arbor, MI 48109 1109, USA
    Brain Res Brain Res Rev 48:98-111. 2005
    ....
  65. ncbi request reprint Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample task
    Jill McGaughy
    Department of Psychology Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 25:10273-81. 2005
    ..This indicates an important role for cholinergic innervation of the entorhinal cortex in working memory for novel stimuli...
  66. pmc A goal-directed spatial navigation model using forward trajectory planning based on grid cells
    Uğur M Erdem
    Center for Memory and Brain and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Eur J Neurosci 35:916-31. 2012
    ..The interaction of the forward linear look-ahead trajectory probes with the reward diffusion allows discovery of never-before experienced shortcuts towards a goal location...
  67. ncbi request reprint Less is more: how reduced activity reflects stronger recognition
    Chantal E Stern
    Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, Boston, Massachusetts 02215, USA
    Neuron 47:625-7. 2005
    ..This result provides an important test of theories of recognition memory function based on previous neuroimaging and unit recording data...
  68. ncbi request reprint Expecting the unexpected: modeling of neuromodulation
    Michael Hasselmo
    Department of Psychology, Center for Memory and Brain and Program in Neuroscience, Boston University, Massachusetts 02215, USA
    Neuron 46:526-8. 2005
    ..The model builds from data on physiological effects of modulators regulating the balance of cortical feedback and thalamic input...
  69. ncbi request reprint Is autism partly a consolidation disorder?
    Lisa A Femia
    Boston University, USA
    Behav Cogn Neurosci Rev 1:251-63. 2002
    ....
  70. ncbi request reprint Scopolamine impairs human recognition memory: data and modeling
    Seth J Sherman
    Department of Psychology, Boston University, 2 Cummington Street, Boston, Massachusetts 02215, USA
    Behav Neurosci 117:526-39. 2003
    ..In particular, scopolamine did not affect the frequency with which recollection took place, but rather, affected the amount of recollected information...
  71. ncbi request reprint Enhanced cholinergic suppression of previously strengthened synapses enables the formation of self-organized representations in olfactory cortex
    Christiane Linster
    Department of Psychology Center for Memory and Brain and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Neurobiol Learn Mem 80:302-14. 2003
    ..The results are consistent with the extensive evidence supporting a role for acetylcholine in encoding of new memories and enhancement of response to salient sensory stimuli...
  72. ncbi request reprint Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task
    Alireza Atri
    Boston University, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02215, USA
    Behav Neurosci 118:223-36. 2004
    ....
  73. ncbi request reprint Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia
    Peter J Siekmeier
    Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Res 89:177-90. 2007
    ..As such, it can shed light on the etiology of schizophrenia in a fundamental way, and also holds the promise of pointing the way to more effective treatments...
  74. ncbi request reprint Switching between "On" and "Off" states of persistent activity in lateral entorhinal layer III neurons
    Babak Tahvildari
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 17:257-63. 2007
    ..The neuronal ability to switch "On" and "Off" persistent activity may facilitate the concurrent representation of temporally segregated information arriving in the EC and being directed toward the hippocampus...
  75. ncbi request reprint Mechanism of graded persistent cellular activity of entorhinal cortex layer v neurons
    Erik Fransen
    School of Computer Science and Communication, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Neuron 49:735-46. 2006
    ..The model is consistent with detailed experimental observations and provides a mechanism for maintenance of memory-related activity in individual neurons...
  76. ncbi request reprint Ionic mechanisms in the generation of subthreshold oscillations and action potential clustering in entorhinal layer II stellate neurons
    Erik Fransen
    Department of Numerical Analysis and Computer Science, Royal Institute of Technology, Stockholm, Sweden
    Hippocampus 14:368-84. 2004
    ..The model also predicts that the fast component of Ih is responsible for the involvement in the generation of subthreshold oscillations, and the slow component dominates in the generation of spike clusters...
  77. ncbi request reprint From biophysics to behavior: Catacomb2 and the design of biologically-plausible models for spatial navigation
    Robert C Cannon
    Theoretical Neurobiology, Born Bunge Foundation, University of Antwerp, Universiteitsplein I, Antwerp, Belgium
    Neuroinformatics 1:3-42. 2003
    ....
  78. ncbi request reprint Graded persistent activity in entorhinal cortex neurons
    Alexei V Egorov
    Department of Neurology and Neurosurgery, Montreal Neurological Institute and McGill University, Montreal, Quebec H3A 2B4, Canada
    Nature 420:173-8. 2002
    ..Such an intrinsic neuronal ability to generate graded persistent activity constitutes an elementary mechanism for working memory...
  79. ncbi request reprint Simulations of the role of the muscarinic-activated calcium-sensitive nonspecific cation current INCM in entorhinal neuronal activity during delayed matching tasks
    Erik Fransen
    Department of Numerical Analysis and Computer Science, Royal Institute of Technology, S 100 44 Stockholm, Sweden
    J Neurosci 22:1081-97. 2002
    ....
  80. ncbi request reprint Using connectionist models to guide assessment of psychological disorder
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Psychol Assess 14:263-78. 2002
    ..Two extended examples are given based on the authors' research on cognitive aspects of depression and Alzheimer's disease...

Research Grants1

  1. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. [unreadable] [unreadable]..