Han Chen

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc A method of moments estimator for random effect multivariate meta-analysis
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Biometrics 68:1278-84. 2012
  2. pmc Sequence kernel association test for quantitative traits in family samples
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Genet Epidemiol 37:196-204. 2013
  3. pmc Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models
    Han Chen
    Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 98:653-66. 2016
  4. pmc Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
    Geoffrey A Walford
    Diabetes Research Center Diabetes Unit, Massachusetts General Hospital, Boston, MA Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA
    Diabetes 65:3200-11. 2016
  5. pmc Incorporating gene-environment interaction in testing for association with rare genetic variants
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, Mass, USA
    Hum Hered 78:81-90. 2014
  6. pmc Comparison of statistical approaches to rare variant analysis for quantitative traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Proc 5:S113. 2011
  7. pmc A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
    Alisa K Manning
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    Nat Genet 44:659-69. 2012
  8. pmc Sequence kernel association test for survival traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    Genet Epidemiol 38:191-7. 2014

Detail Information

Publications8

  1. pmc A method of moments estimator for random effect multivariate meta-analysis
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Biometrics 68:1278-84. 2012
    ..In the simulation study, our method performs well when compared to existing random effect model multivariate meta-analysis approaches. We also apply our method in the analysis of a real data example...
  2. pmc Sequence kernel association test for quantitative traits in family samples
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Genet Epidemiol 37:196-204. 2013
    ..We illustrate our approach to analyze the association of rare genetic variants using glycemic traits from the Framingham Heart Study...
  3. pmc Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models
    Han Chen
    Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 98:653-66. 2016
    ..We show in simulation studies and real data analysis that GMMAT effectively controls for population structure and relatedness when analyzing binary traits in a wide variety of study designs. ..
  4. pmc Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
    Geoffrey A Walford
    Diabetes Research Center Diabetes Unit, Massachusetts General Hospital, Boston, MA Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA
    Diabetes 65:3200-11. 2016
    ..In conclusion, we identified two novel loci and replicated known variants associated with insulin sensitivity. Further studies are needed to clarify the causal variant and function at the BCL2 and FAM19A2 loci. ..
  5. pmc Incorporating gene-environment interaction in testing for association with rare genetic variants
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, Mass, USA
    Hum Hered 78:81-90. 2014
    ..We aimed at developing powerful and computationally efficient tests for gene-environment interaction with rare variants...
  6. pmc Comparison of statistical approaches to rare variant analysis for quantitative traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Proc 5:S113. 2011
    ....
  7. pmc A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
    Alisa K Manning
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    Nat Genet 44:659-69. 2012
    ..The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology...
  8. pmc Sequence kernel association test for survival traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    Genet Epidemiol 38:191-7. 2014
    ..We also present results in an application to time-to-obesity using genotypes from Framingham Heart Study SNP Health Association Resource. ..