Renren Wen

Summary

Affiliation: Blood Research Institute
Country: USA

Publications

  1. pmc Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis
    Renren Wen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Mol Cell Biol 26:9364-76. 2006
  2. ncbi request reprint Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation
    Subramaniam Malarkannan
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 179:3752-62. 2007
  3. ncbi request reprint B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 178:49-57. 2007
  4. pmc Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance
    Guoping Fu
    The Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:309-18. 2010
  5. pmc An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion
    Renren Wen
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    EMBO J 23:4007-17. 2004
  6. pmc B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia
    Yongwei Zheng
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
    Blood 123:931-4. 2014
  7. pmc A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation
    James Schuman
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee 53226, USA
    Blood 113:4566-74. 2009
  8. ncbi request reprint Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells
    Jeyarani Regunathan
    Blood Research Institute, Milwaukee, WI 53226, USA
    J Immunol 177:5365-76. 2006
  9. pmc Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing
    Li Bai
    Blood Research Institute, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Biol 27:5957-67. 2007
  10. pmc Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction
    Xuezhi Dai
    Blood Research Institute, 8727 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Mol Cell Biol 26:88-99. 2006

Collaborators

Detail Information

Publications30

  1. pmc Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis
    Renren Wen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Mol Cell Biol 26:9364-76. 2006
    ....
  2. ncbi request reprint Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation
    Subramaniam Malarkannan
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 179:3752-62. 2007
    ..These results indicate that Bcl10 represents an exclusive "molecular switch" that links the upstream receptor-mediated signaling to cytokine and chemokine generations...
  3. ncbi request reprint B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 178:49-57. 2007
    ..Thus, Bcl10 is essential for FcepsilonR-induced activation of AP-1, NF-kappaB, degranulation, and cytokine production in mast cells...
  4. pmc Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance
    Guoping Fu
    The Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:309-18. 2010
    ..Importantly, PLCgamma1 deficiency impairs the development and function of FoxP3(+) regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCgamma1 is essential for T cell development, activation, and tolerance...
  5. pmc An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion
    Renren Wen
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    EMBO J 23:4007-17. 2004
    ..These studies reveal an essential role of PLCgamma1, distinct from that of PLCgamma2, in B-cell development...
  6. pmc B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia
    Yongwei Zheng
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
    Blood 123:931-4. 2014
    ..Therefore, breakdown of tolerance can lead to PF4/heparin-specific antibody production, and B-cell tolerance may play an important role in HIT pathogenesis. ..
  7. pmc A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation
    James Schuman
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee 53226, USA
    Blood 113:4566-74. 2009
    ..Importantly, TAK1-deficient B cells failed to activate NF-kappaB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-kappaB activation...
  8. ncbi request reprint Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells
    Jeyarani Regunathan
    Blood Research Institute, Milwaukee, WI 53226, USA
    J Immunol 177:5365-76. 2006
    ..Our results strongly demonstrate that PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions...
  9. pmc Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing
    Li Bai
    Blood Research Institute, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Biol 27:5957-67. 2007
    ..Taken together, these data demonstrate that the PLCgamma2 signaling pathway plays a role in activation of light-chain loci and contributes to receptor editing...
  10. pmc Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction
    Xuezhi Dai
    Blood Research Institute, 8727 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Mol Cell Biol 26:88-99. 2006
    ..Taken together, these results demonstrate that whereas PI3K functions upstream of PLCgamma2, activation of PLCgamma2 can occur independently of PI3K and that PI3K and PLCgamma2 also have distinct functions in BCR signal transduction...
  11. pmc Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation
    Hu Zeng
    The Blood Research Institute, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Biol 27:5235-45. 2007
    ..Taken together, our findings demonstrate that phosphorylation of Bcl10 at S138 down-regulates Bcl10 protein levels and thus negatively regulates T-cell receptor-mediated NF-kappaB activation...
  12. pmc Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection
    Guoping Fu
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 189:2326-32. 2012
    ..Taken together, these data demonstrate that PLCγ2 participates in TCR signal transduction and plays a role in T cell selection...
  13. ncbi request reprint Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells
    Renren Wen
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 278:43654-62. 2003
    ..Therefore, the PLCgamma2 pathway provides a survival signal via regulation of Bcl-2 in all splenic B cell subpopulations and via additional induction of A1 in mature FO B cells...
  14. doi request reprint Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development
    Guoping Fu
    The Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Eur J Immunol . 2016
    ..Thus our studies demonstrate that PLCγ1 is important for pre-TCR mediated signal transduction and pre-T cell development. This article is protected by copyright. All rights reserved...
  15. pmc Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1
    Yongwei Zheng
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, Jiangsu, People s Republic of China
    PLoS ONE 10:e0119739. 2015
    ....
  16. pmc Critical role for mouse marginal zone B cells in PF4/heparin antibody production
    Yongwei Zheng
    Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Blood 121:3484-92. 2013
    ..Taken together, these data demonstrate that MZ B cells are critical for PF4/heparin-specific antibody production...
  17. pmc Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells
    Yuhong Chen
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 208:923-35. 2011
    ..Thus, Gimap5 is an important stabilizer of mouse hematopoietic progenitor cell survival...
  18. pmc Kras Is Critical for B Cell Lymphopoiesis
    Yuhong Chen
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226
    J Immunol 196:1678-85. 2016
    ..Thus, Kras is the unique Ras family member that plays a critical role in early B cell development and late B cell maturation through controlling the Raf-1/MEK/ERK pathway. ..
  19. doi request reprint The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression
    Srikanta Jana
    The Max McGee National Center for Juvenile Diabetes and Human Molecular Genetics Center, Medical College of Wisconsin and Children s Research Institute of Children s Hospital of Wisconsin, WI 53226, USA
    Eur J Immunol 39:2571-83. 2009
    ..A better understanding of Foxp3 regulation could be useful in dissecting the cause of Treg dysfunction in several autoimmune diseases and for generating more potent TGF-beta1-induced-Treg cells for therapeutic purposes...
  20. pmc A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 111:4627-36. 2008
    ..Thus, we have discovered a critical and distinct role of Rap1b in mature B-cell trafficking and development of MZ B cells...
  21. ncbi request reprint Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R
    Renren Wen
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 169:6743-52. 2002
    ..Moreover, PLCgamma2 plays a nonredundant role in Fc(gamma)R-mediated inflammatory skin reaction...
  22. ncbi request reprint Identification of Shp-2 as a Stat5A phosphatase
    Yuhong Chen
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 278:16520-7. 2003
    ..Therefore, we conclude that Shp-2 is a Stat5A phosphatase, which down-regulates the active Stat5A in vivo...
  23. pmc A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
    Gang Xin
    Blood Research Institute, BloodCenter of Wisconsin, 8727 West Watertown Plank Road, Milwaukee, WI 53213, USA
    Cell Rep 13:1118-24. 2015
    ..Collectively, these data suggest that CD4 T cells "help" the CD8 response during chronic infection via IL-21-induced BATF expression...
  24. pmc T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: an implication of differential NF-kappaB dependence of naïve and memory T cells during T cell receptor-mediated responses
    Hu Zeng
    Model Animal Research Center, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 225001, China
    J Biol Chem 283:24392-9. 2008
    ..Our studies suggest that antigen-experienced CD4+ T cells differ from their naïve counterparts and from CD8+ T cells in their ability to achieve activation independent of the Bcl10/NF-kappaB pathway...
  25. ncbi request reprint Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    Liquan Xue
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:857-65. 2003
    ..Thus, Bcl10 is essential for the development of all mature B cell subsets...
  26. ncbi request reprint Negative regulation of lymphocyte activation by the adaptor protein LAX
    Minghua Zhu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:5612-9. 2005
    ..Our data demonstrate that LAX functions as a negative regulator in lymphocyte signaling...
  27. pmc Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation
    Ravi S Misra
    Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    J Biol Chem 282:19365-74. 2007
    ..The current findings define a link among TCR, caspases, and the NF-kappaB pathway that occurs in a sequestered lipid raft environment in T cells...
  28. ncbi request reprint Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism
    Yuechun Zhu
    Department of Cell Biology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    J Immunol 173:2918-22. 2004
    ..Thus, our study demonstrates that IL-5 functions as a potent factor that drives bone marrow progenitor cells into IL-4-producing eosinophils...
  29. pmc Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors
    Donghai Wang
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 corrected USA
    Proc Natl Acad Sci U S A 104:145-50. 2007
    ..Together, our results provide genetic evidence showing that Bcl10 is a key signaling component mediating NF-kappaB activation induced by GPCRs in nonlymphoid cells...
  30. ncbi request reprint Stat5 is essential for early B cell development but not for B cell maturation and function
    Xuezhi Dai
    State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People s Republic of China
    J Immunol 179:1068-79. 2007
    ..Taken together, these data demonstrate that Stat5A/5B directly control IL-7-mediated early B cell development but are not required for B cell maturation and Ig production...