Affiliation: Blood Research Institute
- Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptorsSheldon R Garrison
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
Mol Pain 8:62. 2012..Yet, the hypersensitivity in these neural populations alone may not fully explain the mechanical allodynia phenotype in mouse and humans...
- Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell diseaseCheryl A Hillery
Department of Pediatrics and Children s Research Institute, Division of Hematology Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
Blood 118:3376-83. 2011..Therefore, TRPV1-targeted compounds that lack thermoregulatory side effects may provide relief from pain in patients with SCD...
- Erythrocyte adhesion is modified by alterations in cellular tonicity and volumeNancy J Wandersee
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Br J Haematol 131:366-77. 2005..In summary, these findings demonstrate that changes in hydration can significantly impact adhesion, causing normal erythrocytes to display adhesive properties similar to those of sickle cells and vice versa...
- Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosisPatrick G Gallagher
Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, CT 06520 8064
Blood 101:4625-7. 2003..Increased phosphatidylserine exposure accelerating thrombin-forming processes has been proposed as a mechanism for thrombosis in sickle cell disease and beta-thalassemia and may play a similar role in hereditary hydrocytosis...
- Pathophysiology of stroke in sickle cell diseaseCheryl A Hillery
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
Microcirculation 11:195-208. 2004..Increased red cell adhesion, oxidative injury of the vessel wall, inflammation, abnormal vasomotor tone regulation, and increased activity of the coagulation system all may contribute to cerebral vasopathology in SCD...
- Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesionNicholas A Watkins
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, USA
Blood 102:718-24. 2003..These scFvs will be useful reagents for investigating the role of the calcium and cell-binding domains of TSP in sickle RBC adhesion...
- Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell diseaseYogen Saunthararajah
University of Illinois at Chicago, Section of Hem Onc, MBRB Rm 3150 MC734, 900 S Ashland Ave, Chicago, IL 60607, USA
Blood 102:3865-70. 2003..Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated...
- Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosisNancy J Wandersee
Blood Research Institute, The Blood Center of Southeastern Wisconsin, 8727 Watertown Plank Rd, Milwaukee, WI 53226, USA
Blood 103:710-6. 2004..005). While the mechanism of infarction in these mice is unknown, we speculate that changes in RBC adhesive characteristics contribute to this pathology...
- Histopathology of experimentally induced asthma in a murine model of sickle cell diseaseSandhya D Nandedkar
Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Blood Research Institute, Children s Research Institute, Cardiovascular Center, Milwaukee, WI 53226, USA
Blood 112:2529-38. 2008..Our findings indicate SCD mice with experimentally induced asthma are more susceptible to death and pulmonary inflammation compared with control mice, suggesting that asthma contributes significantly to morbidity and mortality in SCD...
- Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertensionKenneth I Ataga
Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, CB 7305, 3009 Old Clinic Bldg Chapel Hill, NC 27599 7305, USA
Haematologica 93:20-6. 2008..Pulmonary hypertension (PHT) is common in sickle cell disease (SCD). The purpose of this study was to determine whether markers of coagulation activation and inflammation are associated with PHT in SCD...
- Genetic endothelial systems biology of sickle stroke riskLiming Chang Milbauer
Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, and Minneapolis Children s Hospital 55455, USA
Blood 111:3872-9. 2008....
- Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemiaJane S Hankins
Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Br J Haematol 140:80-5. 2008..KCl co-transporter activity declined after 3 months of magnesium pidolate (P = 0.02). A phase II study is needed to investigate the efficacy of this drug combination...
- L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell diseaseJingsong Ou
Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Circulation 107:2337-41. 2003..Here we hypothesize that L-4F, an apoA-1 mimetic, preserves vasodilation in hypercholesterolemia and SCD by decreasing mechanisms that increase O2*- generation...
- Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell diseaseElizabeth A Manci
Department of Pathology, Centralized Pathology Unit for Sickle Cell Disease, University of South Alabama, Mobile, AL 36604, USA
Blood 107:1651-8. 2006..While our study reinforces the fundamental strength of this model, the notable differences warrant careful consideration when drawing parallels to human sickle cell disease...
- Variation in hospitalizations and hospital length of stay in children with vaso-occlusive crises in sickle cell diseaseJulie A Panepinto
Department of Pediatrics, Section of Pediatric Hematology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Pediatr Blood Cancer 44:182-6. 2005....
- Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell diseaseJulie An M Talano
Medical College of Wisconsin, Department of Pediatric Hematology Oncology, MACC Fund Research Center, Milwaukee, WI 53226, USA
Pediatrics 111:e661-5. 2003..The objective of this study was to describe the clinical and laboratory findings of a case series in children who had SCD and experienced a DHTR/H syndrome at our institution...
- Patient-controlled analgesia for sickle cell pain crisis in a pediatric emergency departmentMarlene D Melzer-Lange
Department of Pediatrics, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
Pediatr Emerg Care 20:2-4. 2004..Also, to compare patient satisfaction and inpatient length of stay for the 2 groups...
- Hypoxia-induced acute lung injury in murine models of sickle cell diseaseKirkwood A Pritchard
Medical College of Wisconsin, Div of Pediatric Surgery, Cardiovascula Center M4060, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Lung Cell Mol Physiol 286:L705-14. 2004....
- The effect of magnesium on length of stay for pediatric sickle cell pain crisisDavid C Brousseau
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
Acad Emerg Med 11:968-72. 2004..To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis...
- Mechanisms of vaso-occlusion in sickle cell diseaseCHERYL HILLERY; Fiscal Year: 2005..Additionally, these studies will provide insights into the value of targeted anticoagulant/anti-inflammatory therapies for the treatment and prevention of SCD vascular pathology. ..
- Red Blood Cell Adhesion in Sickle Cell DiseaseCHERYL HILLERY; Fiscal Year: 2005..Thus, we expect that information derived from this proposal will lead to new therapeutic approaches for the treatment of vaso-occlusion in SS-D. ..