Blood Research Institute

Summary

Organization: Blood Research Institute
Country: USA

Top Publications

  1. pmc Platelets as delivery systems for disease treatments
    Qizhen Shi
    Blood Research Institute, BloodCenter of Wisconsin, Departments of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, USA
    Adv Drug Deliv Rev 62:1196-203. 2010
  2. pmc Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:911-8. 2009
  3. doi Tracking blood products in blood centres using radio frequency identification: a comprehensive assessment
    Rodeina Davis
    BloodCenter of Wisconsin, Milwaukee, WI 53233, USA
    Vox Sang 97:50-60. 2009
  4. doi Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders
    Brian R Curtis
    BloodCenter of Wisconsin, Platelet and Neutrophil Immunology Laboratory, Milwaukee, Wisconsin 53201 2178, USA
    Semin Thromb Hemost 34:539-48. 2008
  5. doi Identification of four novel mutations in F5 associated with congenital factor V deficiency
    Sachiko Kanaji
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, 849 8501, Japan
    Int J Hematol 89:71-5. 2009
  6. pmc HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available
    Andrea Ferrante
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA
    PLoS ONE 3:e3722. 2008
  7. doi Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin-binding gamma' chain sequence
    M W Mosesson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:102-10. 2009
  8. pmc Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia
    Daniel W Bougie
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 113:1105-11. 2009
  9. doi Current status of thrombolytics-the need for better, especially safer, agents
    Gilbert C White
    BloodCenter of Wisconsin, Milwaukee, WI, USA
    Thromb Res 122:S1-2. 2008
  10. pmc Activated protein C in sepsis: the promise of nonanticoagulant activated protein C
    Hartmut Weiler
    aBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA
    Curr Opin Hematol 15:487-93. 2008

Research Grants

  1. HEMORRHAGIC DISEASES
    RICHARD HERBERT ASTER; Fiscal Year: 2010
  2. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2002
  3. RESEARCH TRAINING IN TRANSFUSION SCIENCE
    RICHARD ASTER; Fiscal Year: 2006
  4. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2007
  5. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 1980
  6. THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGY
    Hartmut Weiler; Fiscal Year: 2007
  7. Mechanism of Activated Protein C Action in Sepsis Therapy
    HARTMUT KARL HEINZ WEILER; Fiscal Year: 2010
  8. Mechanism of Activated Protein C Action in Sepsis Therapy
    Hartmut Weiler; Fiscal Year: 2009
  9. THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGY
    Hartmut Weiler; Fiscal Year: 2003
  10. INTEGRATIVE APPROACH TO CORONARY THROMBOSIS
    Robert Montgomery; Fiscal Year: 2001

Detail Information

Publications62

  1. pmc Platelets as delivery systems for disease treatments
    Qizhen Shi
    Blood Research Institute, BloodCenter of Wisconsin, Departments of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, USA
    Adv Drug Deliv Rev 62:1196-203. 2010
    ..This paper reviews the genetic therapy for inherited bleeding disorders utilizing platelets as delivery system, with a particular focus on platelet-derived FVIII for hemophilia A treatment...
  2. pmc Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:911-8. 2009
    ..Further studies to address these issues and characterize more completely the range of drugs and drug metabolites that can cause DITP are needed...
  3. doi Tracking blood products in blood centres using radio frequency identification: a comprehensive assessment
    Rodeina Davis
    BloodCenter of Wisconsin, Milwaukee, WI 53233, USA
    Vox Sang 97:50-60. 2009
    ..This article describes a systematic approach developed by the RFID Blood Consortium for a comprehensive feasibility and impact assessment of RFID application in blood centre operations...
  4. doi Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders
    Brian R Curtis
    BloodCenter of Wisconsin, Platelet and Neutrophil Immunology Laboratory, Milwaukee, Wisconsin 53201 2178, USA
    Semin Thromb Hemost 34:539-48. 2008
    ..Platelet genotyping may also someday prove important as an aid in determining the relative risk of patients for various thrombotic disorders...
  5. doi Identification of four novel mutations in F5 associated with congenital factor V deficiency
    Sachiko Kanaji
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, 849 8501, Japan
    Int J Hematol 89:71-5. 2009
    ..Although FV deficiency is a very rare disorder with a predicted incidence of one in 1 million, this study suggests that the numbers of F5 mutations, especially missense mutations, are higher than estimated...
  6. pmc HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available
    Andrea Ferrante
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA
    PLoS ONE 3:e3722. 2008
    ..Although DM has been shown to have two activities, peptide release and MHC class II refolding, a clear characterization of the mechanism by which DM facilitates peptide exchange has remained elusive...
  7. doi Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin-binding gamma' chain sequence
    M W Mosesson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:102-10. 2009
    ..This feature prompted us to produce a 'gain-of-function' transgenic mouse in which the wild-type (WT) C-terminal mu-gamma' chain fibrinogen sequence had been replaced with the C-terminal thrombin-binding human gamma' sequence...
  8. pmc Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia
    Daniel W Bougie
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 113:1105-11. 2009
    ..1 in the course of the immune response. These monoclonal reagents are the first of their kind and should facilitate studies to define the molecular basis for drug-dependent antibody binding and platelet destruction in DITP...
  9. doi Current status of thrombolytics-the need for better, especially safer, agents
    Gilbert C White
    BloodCenter of Wisconsin, Milwaukee, WI, USA
    Thromb Res 122:S1-2. 2008
    ..This supplement reviews the role of plasmin in fibrinolysis and locally administered plasmin as a safe and effective therapeutic...
  10. pmc Activated protein C in sepsis: the promise of nonanticoagulant activated protein C
    Hartmut Weiler
    aBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA
    Curr Opin Hematol 15:487-93. 2008
    ..To discuss the potential use of recombinant activated protein C (aPC) variants with altered bioactivity in sepsis therapy...
  11. doi Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors
    Alan E Mast
    Blood Research Institute, Blood Center of Wisconsin, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 3548, USA
    Transfusion 48:2197-204. 2008
    ..Individuals donating whole blood 13 times in a 2-year period without development of iron deficiency anemia (superdonors) are a self-selected population that is deferred for low hematocrit (Hct) level less frequently than other donors...
  12. doi Evidence that alpha2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation
    M W Mosesson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    J Thromb Haemost 6:1565-70. 2008
    ....
  13. pmc Syngeneic transplantation of hematopoietic stem cells that are genetically modified to express factor VIII in platelets restores hemostasis to hemophilia A mice with preexisting FVIII immunity
    Qizhen Shi
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, USA
    Blood 112:2713-21. 2008
    ....
  14. doi Immunodominant epitopes mapped by synthetic peptides on the capsid protein of avian hepatitis E virus are non-protective
    Hailong Guo
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA
    Viral Immunol 21:61-7. 2008
    ....
  15. pmc A clonotype nomenclature for T cell receptors
    Maryam B Yassai
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Immunogenetics 61:493-502. 2009
    ..The identifier includes the V and J region, the CDR3 length as well as its human or mouse origin. The framework of this naming system could also be expanded to the B cell receptor...
  16. doi Modulation of sepsis outcome with variants of activated protein C
    H Weiler
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 534226, USA
    J Thromb Haemost 7:127-31. 2009
    ..Animal studies suggest that aPC variants with near-normal signaling function, but with greatly diminished anticoagulant potential may exhibit a substantially improved risk-to-benefit ratio in sepsis therapy...
  17. doi The Y's that bind: negative regulators of Src family kinase activity in platelets
    D K Newman
    Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA
    J Thromb Haemost 7:195-9. 2009
    ....
  18. pmc Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A
    Qizhen Shi
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Blood 116:3049-57. 2010
    ....
  19. doi Unique strategies for therapeutic gene transfer in haemophilia A and haemophilia BWFH State-of-the-Art Session on Therapeutic Gene Transfer Buenos Aires, Argentina
    R R Montgomery
    Blood Research Institute, Milwaukee, WI, USA
    Haemophilia 16:29-34. 2010
    ..All of the three approaches have demonstrated efficacy in small animal models and are now the subject of larger animal studies. None has yet to progress to human trials...
  20. pmc Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia
    Daniel W Bougie
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Blood 116:3033-8. 2010
    ....
  21. pmc PECAM-1: conflicts of interest in inflammation
    Jamie R Privratsky
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Life Sci 87:69-82. 2010
    ..A better understanding of how inflammatory responses are regulated should enable the development of new therapeutics that can be used in the treatment of acute and chronic inflammatory disorders...
  22. doi Legal developments and practical implications of gene patenting on targeted drug discovery and development
    R D Klein
    Molecular Oncology, Blood Center of Wisconsin, Milwaukee, Wisconsin, USA
    Clin Pharmacol Ther 87:633-5. 2010
    ..The intellectual property rules by which these biological relationships are governed have profound implications for the growth of this field. Several cases currently before the courts may add reason and clarity to the law in this area...
  23. pmc Biospecimen repositories: are blood donors willing to participate?
    Erik A Scott
    BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA
    Transfusion 50:1943-50. 2010
    ..Some studies request additional permission to store biospecimens for future studies. The representativeness and applicability of studies performed using repositories may be reduced by low participation rates...
  24. doi Regulation of angiogenesis by a small GTPase Rap1
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Vascul Pharmacol 53:1-10. 2010
    ....
  25. doi Regulation of inflammation by the protein C system
    Hartmut Weiler
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA
    Crit Care Med 38:S18-25. 2010
    ..To review new findings about the function of the protein C system during inflammation and coagulation...
  26. pmc The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R>Q154 amino acid substitution
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Blood 115:2073-6. 2010
    ....
  27. doi Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond
    Andrea Ferrante
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    J Immunol 184:1153-8. 2010
    ..However, as expected of a cooperative model, this H-bond contributes to the overall energetics of the complex and its disruption impacts the ability of the exchange ligand to fold with the binding groove into a stable complex...
  28. doi The role of prophylaxis in the management of von Willebrand disease: today and tomorrow
    Thomas Abshire
    Emory University and Children s Hospital of Atlanta, Atlanta, Georgia, USA
    Thromb Res 124:S15-9. 2009
    ..The VWD International Prophylaxis (VIP) trial is an ongoing study that will help to identify which patients are most likely to benefit from long-term prophylaxis, and determine the optimal approach to prophylaxis in various settings...
  29. pmc New low-frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia
    Julie A Peterson
    Blood Research Institute and Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    Transfusion 50:324-33. 2010
    ..Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought...
  30. doi T-cell epitope mapping
    Laurent Malherbe
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    Ann Allergy Asthma Immunol 103:76-9. 2009
    ..To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology...
  31. pmc Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    Transfusion 48:358-64. 2008
    ..The implications of this trait for transfusion medicine are undefined...
  32. ncbi Reticulocyte hemoglobin content
    Alan E Mast
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    Am J Hematol 83:307-10. 2008
    ..Nephrol Dial Transplant 2003;18:370-377). Thus, reticulocyte hemoglobin content is a recent addition to an expanding list of biomarkers that can be used to differentiate iron deficiency from other causes of anemia...
  33. pmc Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis
    Renren Wen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Mol Cell Biol 26:9364-76. 2006
    ....
  34. ncbi When it comes to von Willebrand disease, does 1 + 1 = 3?
    R R Montgomery
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Thromb Haemost 4:2162-3. 2006
  35. pmc Patients with quinine-induced immune thrombocytopenia have both "drug-dependent" and "drug-specific" antibodies
    Daniel W Bougie
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, USA
    Blood 108:922-7. 2006
    ..In addition to having implications for pathogenesis, drug-specific antibodies may provide a surrogate measure of drug sensitivity in patients with drug-induced immune cytopenia...
  36. pmc The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions
    Subramaniam Malarkannan
    Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Semin Immunol 18:186-92. 2006
    ..These observations provide a firm basis of 'altered-balance' in NK signaling and describe an active interplay between inhibitory Ly49 and activating NKG2D receptors...
  37. ncbi Parachutes and prophylaxis: they both work!
    G C White
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:1226-7. 2006
  38. ncbi Urgent reversal of warfarin with prothrombin complex concentrate
    M W Lankiewicz
    The Southeastern BloodCenter of Wisconsin, 638 North 18th Street, Milwaukee, WI 53290 2178, USA
    J Thromb Haemost 4:967-70. 2006
    ..In the USA, warfarin effect is commonly reversed with fresh frozen plasma (FFP). The use of FFP is complicated by delays in correction, volume overload and often, inadequate correction...
  39. ncbi Heparin-induced immune thrombocytopenia - a clinical or laboratory diagnosis?
    R H Aster
    Medical College of Wisconsin and Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:757-8. 2006
  40. ncbi Hemostatic response to postprandial lipemia before and after exercise training
    Chad M Paton
    Department of Kinesiology, University of Maryland, College Park, USA
    J Appl Physiol (1985) 101:316-21. 2006
    ..We conclude that aerobic exercise training reduces the potential for coagulation, improves fibrinolytic potential, and reduces leukocyte TNF-alpha gene expression after the ingestion of a high-fat meal...
  41. ncbi Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, 53201 2178, USA
    Am J Hematol 81:193-8. 2006
    ....
  42. ncbi Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:678-9. 2006
  43. ncbi von Willebrand disease--the relevance of history
    R R Montgomery
    Department of Pediatrics, Section of Pediatric Hematology, Blood Research Institute of Blood Center of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA
    J Thromb Haemost 3:2617-8. 2005
  44. ncbi Erythrocyte adhesion is modified by alterations in cellular tonicity and volume
    Nancy J Wandersee
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Br J Haematol 131:366-77. 2005
    ..In summary, these findings demonstrate that changes in hydration can significantly impact adhesion, causing normal erythrocytes to display adhesive properties similar to those of sickle cells and vice versa...
  45. ncbi Heparin-independent activation of platelets by HIT antibodies: a clue to the etiology of delayed thrombocytopenia/thrombosis in patients given heparin?
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53201, USA
    J Thromb Haemost 3:2166-7. 2005
  46. ncbi Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome
    M W Mosesson
    The Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 5:62-9. 2007
    ..Together, the gamma'(423P) and gamma'(427L) chains comprise the total plasma fibrinogen gamma' chain content...
  47. ncbi Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A
    Q Shi
    Department of Pediatrics, Medical College of Wisconsin Milwaukee, WI 53226, USA
    J Thromb Haemost 5:352-61. 2007
    ....
  48. ncbi One center's experience: the serology and drugs associated with drug-induced immune hemolytic anemia--a new paradigm
    Susan T Johnson
    BloodCenter of Wisconsin, Inc, Immunohematology Reference Laboratory, Milwaukee, Wisconsin 53201 2178, USA
    Transfusion 47:697-702. 2007
    ..The full range of drugs causing DIIHA and the initial serologic presentation are not fully appreciated. This work identifies additional drugs associated with DIIHA and offers additional insights about diagnosis...
  49. pmc Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 111:2647-56. 2008
    ..These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells...
  50. pmc Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA
    Julie A Peterson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    Blood 111:1234-9. 2008
    ..The observations are consistent with a recently proposed model in which drug reacts noncovalently with both target protein and antibody to promote binding of an otherwise nonreactive immunoglobulin...
  51. ncbi The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis
    Reema Goel
    Blood Research Institute, BloodCenter of Wisconsin, P O Box 2178, Milwaukee, WI 53201, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1205-14. 2007
    ..Future examination of recently identified PECAM-1 allelic isoforms in humans as potential risk factors for developing NASH may be warranted...
  52. pmc Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
    B N Dittel
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, WI 53201 2178, USA
    Br J Pharmacol 153:271-6. 2008
    ..This review focuses on the function of the cannabinoid receptor 2 (CB2), primarily expressed in the immune system, in regulating T cell effector functions associated with autoimmune inflammation in the central nervous system (CNS)...
  53. ncbi Platelet secretion: indiscriminately spewed forth or highly orchestrated?
    G C White
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 5:2006-8. 2007
  54. ncbi Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation
    Subramaniam Malarkannan
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 179:3752-62. 2007
    ..These results indicate that Bcl10 represents an exclusive "molecular switch" that links the upstream receptor-mediated signaling to cytokine and chemokine generations...
  55. ncbi Drug-induced immune thrombocytopenia
    Richard H Aster
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 357:580-7. 2007
  56. ncbi Human platelets circulating in mice: applications for interrogating platelet function and survival, the efficacy of antiplatelet therapeutics, and the molecular basis of platelet immunological disorders
    P J Newman
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    J Thromb Haemost 5:305-9. 2007
    ....
  57. ncbi Update on antithrombin I (fibrin)
    Michael W Mosesson
    The Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Thromb Haemost 98:105-8. 2007
    ..g. fibrinogen Naples 1), or a reduced plasma gamma' chain content (reduced antithrombin I activity), predispose to intravascular thrombosis...
  58. ncbi Practice guidelines and proficiency testing for molecular assays
    Daniel B Bellissimo
    Molecular Diagnostics, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201, USA
    Transfusion 47:79S-84S. 2007
  59. ncbi Treatment of urgent bleeding in von Willebrand disease
    Joan Cox Gill
    Medical College of Wisconsin, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Thromb Res 120:S21-5. 2007
    ..In this article, specific approaches to the choice of treatment modalities, calculation of dosages, monitoring of therapy, possible side effects and complications of the treatment of the various types of VWD will be discussed...
  60. ncbi Endothelial protein C receptor: location...with a pool!
    H Weiler
    Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI, USA
    J Thromb Haemost 5:1391-3. 2007
  61. pmc Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
    Rashmi Sood
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 204:1049-56. 2007
    ..e., thrombosis or pregnancy loss), depending on the vascular bed in which this interaction occurs...
  62. ncbi Studies of thrombotic thrombocytopenic purpura: the role of the AABB Research Foundation grant
    Jerome Gottschall
    The BloodCenter of Southeastern Wisconsin and the Medical College of Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    Transfusion 45:60S-63S. 2005

Research Grants62

  1. HEMORRHAGIC DISEASES
    RICHARD HERBERT ASTER; Fiscal Year: 2010
    ..The proposed studies will lead to a better understanding of causation and to improved diagnosis and treatment. ..
  2. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2002
    ..Pathogenesis of other immune-mediated platelet disorders. Patients with other immune-mediated platelet disorders relevant to the objectives of this grant will be studied as they are encountered. ..
  3. RESEARCH TRAINING IN TRANSFUSION SCIENCE
    RICHARD ASTER; Fiscal Year: 2006
    ..Senior Investigators at the Blood Research Institute (BRI) of BCSEW will serve as mentors for trainees. Richard H Aster, M.D. and Peter J Newman, Ph.D...
  4. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2007
    ..Pathogenesis of other immune-mediated platelet disorders. Patients with other immune-mediated platelet disorders relevant to the objectives of this grant will be studies as time and resources permit. ..
  5. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 1980
    ..4. Short-term platelet preservation. Changes in membrane constituents of human platelets during short-term storage will be further characterized with special emphasis on major glycoproteins. ..
  6. THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGY
    Hartmut Weiler; Fiscal Year: 2007
    ..abstract_text> ..
  7. Mechanism of Activated Protein C Action in Sepsis Therapy
    HARTMUT KARL HEINZ WEILER; Fiscal Year: 2010
    ....
  8. Mechanism of Activated Protein C Action in Sepsis Therapy
    Hartmut Weiler; Fiscal Year: 2009
    ....
  9. THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGY
    Hartmut Weiler; Fiscal Year: 2003
    ..abstract_text> ..
  10. INTEGRATIVE APPROACH TO CORONARY THROMBOSIS
    Robert Montgomery; Fiscal Year: 2001
    ..This proposal offers a unique integrative approach to further our understanding of coronary pathophysiology and the role of the GPIba receptor, based on a detailed understanding of function both in vivo and in vitro. ..
  11. Molecular and Clinical Biology of VWD
    Robert Montgomery; Fiscal Year: 2007
    ..These 4 projects will be supported by Core A for administrative support and patient acquisition and Core B Clinical Laboratory and Sequencing Core. ..
  12. Role of Carboxyterminal Hypervariable Region in Rap1b Function
    Gilbert C White; Fiscal Year: 2010
    ..These findings will provide insight into how the body heals bleeding injuries, as well as the underlying cause of blood clotting conditions. ..
  13. Structure and Function of the VWF Propeptide
    Robert Montgomery; Fiscal Year: 2007
    ..the necessary components of the full proVWF molecule and initial studies will be undertaken using plasmid and viral vectors to induce VWF synthesis, multimerization, storage, and release in cells and animals deficit in VWF synthesis ..
  14. STRUCTURE/FUNCTION OF VWAGII
    Robert Montgomery; Fiscal Year: 2002
    ..Through these studies, we expect to increase our understanding of the cellular and molecular biology of this important regulatory protein and its role in both hemorrhagic and thrombotic disorders. ..
  15. Association of tissue factor pathway inhibitor with endothelium
    Alan E Mast; Fiscal Year: 2010
    ....
  16. Association of tissue factor pathway inhibitor with endothelium
    ALAN MAST; Fiscal Year: 2009
    ....
  17. Tissue Factor Pathway Inhibitor Binding Proteins on Endo
    ALAN MAST; Fiscal Year: 2005
    ..abstract_text> ..