Affiliation: Biogen Inc
- Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta)L Runkel
Biogen, Inc, Cambridge, Massachusetts 02142, USA
Pharm Res 15:641-9. 1998..The structural basis for activity differences between IFN-beta-1a and IFN-beta-1b, is determined...
- The structure of human interferon-beta: implications for activityM Karpusas
Biogen Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
Cell Mol Life Sci 54:1203-16. 1998..Finally, these structural implications are discussed in the context of the clinical use of HuIFN-beta...
- Mapping of IFN-beta epitopes important for receptor binding and biologic activation: comparison of results achieved using antibody-based methods and alanine substitution mutagenesisL Runkel
Biogen, Inc, Cambridge, MA 02142, USA
J Interferon Cytokine Res 21:931-41. 2001..Thus, neutralizing mAb may employ mechanisms other than steric blockade to inhibit directly the binding of receptor by cytokine, limiting their usefulness as tools to define precise receptor-ligand interaction sites...