Robert F Foronjy

Summary

Affiliation: Beth Israel Medical Center
Country: USA

Publications

  1. pmc Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation
    Anthony Brehm
    2Department of Medicine, St Luke s Roosevelt, Mt Sinai Health System, Antenucci Bldg, 432 West 58th St, Rm 311, New York, NY 10019, USA
    FASEB J 28:2318-31. 2014
  2. pmc A comparison of the inflammatory and proteolytic effects of dung biomass and cigarette smoke exposure in the lung
    Divya Mehra
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 7:e52889. 2012
  3. ncbi request reprint Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA
    Exp Lung Res 31:547-62. 2005
  4. pmc The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction
    Patrick Geraghty
    1 St Luke s Roosevelt Hospital Center, New York, New York
    Am J Respir Cell Mol Biol 49:721-30. 2013
  5. pmc Cigarette smoke activates the proto-oncogene c-src to promote airway inflammation and lung tissue destruction
    Patrick Geraghty
    1 St Luke s Roosevelt Hospital Center, New York, New York
    Am J Respir Cell Mol Biol 50:559-70. 2014
  6. pmc Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema
    JEANINE M D'ARMIENTO
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e56352. 2013
  7. ncbi request reprint The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure
    Stefan Klotz
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Am Coll Cardiol 49:1166-74. 2007
  8. doi request reprint Transgenic expression of matrix metalloproteinase-1 inhibits myocardial fibrosis and prevents the transition to heart failure in a pressure overload mouse model
    Robert F Foronjy
    Division of Pulmonary and Critical Care, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Hypertens Res 31:725-35. 2008
  9. pmc Role for cathepsin K in emphysema in smoke-exposed guinea pigs
    Polina Golovatch
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Exp Lung Res 35:631-45. 2009
  10. pmc Protein phosphatase 2A regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung
    Alison M Wallace
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, New York 10032, USA
    Toxicol Sci 126:589-99. 2012

Collaborators

Detail Information

Publications19

  1. pmc Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation
    Anthony Brehm
    2Department of Medicine, St Luke s Roosevelt, Mt Sinai Health System, Antenucci Bldg, 432 West 58th St, Rm 311, New York, NY 10019, USA
    FASEB J 28:2318-31. 2014
    ..Thus, these findings establish a novel anti-inflammatory function of PLTP in the lung and suggest that proteolytic cleavage of PLTP by cathepsin G may enhance the injurious inflammatory responses that occur in COPD...
  2. pmc A comparison of the inflammatory and proteolytic effects of dung biomass and cigarette smoke exposure in the lung
    Divya Mehra
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 7:e52889. 2012
    ..Despite their prevalent use and their potential impact on global health, the effects of these fuels on lung biology and function remain poorly understood...
  3. ncbi request reprint Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA
    Exp Lung Res 31:547-62. 2005
    ..This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil...
  4. pmc The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction
    Patrick Geraghty
    1 St Luke s Roosevelt Hospital Center, New York, New York
    Am J Respir Cell Mol Biol 49:721-30. 2013
    ..In conclusion, these findings establish that the GPx-1-PTP1B-PP2A axis plays a critical role in countering the inflammatory and proteolytic responses that result in lung-tissue destruction in response to cigarette smoke exposure...
  5. pmc Cigarette smoke activates the proto-oncogene c-src to promote airway inflammation and lung tissue destruction
    Patrick Geraghty
    1 St Luke s Roosevelt Hospital Center, New York, New York
    Am J Respir Cell Mol Biol 50:559-70. 2014
    ..These results indicate that activation of the proto-oncogene c-Src by cigarette smoke promotes processes linked to the development of COPD. ..
  6. pmc Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema
    JEANINE M D'ARMIENTO
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e56352. 2013
    ..This study aimed to determine whether bronchoalveolar lavage (BALF) or plasma MMP measurements correlated with disease severity or functional decline in emphysema...
  7. ncbi request reprint The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure
    Stefan Klotz
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Am Coll Cardiol 49:1166-74. 2007
    ..We hypothesized that angiotensin-converting enzyme inhibition (ACE-I) during left ventricular assist device (LVAD) support in patients with end-stage heart failure prevents potentially deleterious effects on the extracellular matrix...
  8. doi request reprint Transgenic expression of matrix metalloproteinase-1 inhibits myocardial fibrosis and prevents the transition to heart failure in a pressure overload mouse model
    Robert F Foronjy
    Division of Pulmonary and Critical Care, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Hypertens Res 31:725-35. 2008
    ..In conclusion, these results suggest that strategies aimed at improving the MMP-1/TIMP balance in the myocardium may help to prevent the onset and progression of hypertensive heart disease...
  9. pmc Role for cathepsin K in emphysema in smoke-exposed guinea pigs
    Polina Golovatch
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Exp Lung Res 35:631-45. 2009
    ..Elevation of cathepsin K in guinea pig lungs after smoke exposure likely constitutes a critical event leading to the disruption of lung extracellular matrix in this model...
  10. pmc Protein phosphatase 2A regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung
    Alison M Wallace
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, New York 10032, USA
    Toxicol Sci 126:589-99. 2012
    ..Together, these findings suggest that manipulation of PP2A activity may be a plausible means to treat COPD and other inflammatory diseases...
  11. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
    ..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
  12. pmc Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice
    Robert F Foronjy
    Department of Medicine, Columbia University, 630 West 168th Street, P and S 8 401, New York, NY 10032, USA
    Am J Respir Crit Care Med 173:623-31. 2006
    ..Oxidants are believed to play a major role in the development of emphysema...
  13. pmc Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study
    Alison M Wallace
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Respir Res 13:79. 2012
    ..Prior studies have demonstrated that the distal 1.5 kb of the MMP-1 promoter is fundamental in directing the induction of the MMP-1 gene by cigarette smoke...
  14. pmc α1-Antitrypsin activates protein phosphatase 2A to counter lung inflammatory responses
    Patrick Geraghty
    1 Division of Pulmonary and Critical Care Medicine, Mount Sinai Roosevelt Hospital, New York, New York
    Am J Respir Crit Care Med 190:1229-42. 2014
    ..Like A1AT, protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, regulates similar biologic processes and plays a key role in chronic obstructive pulmonary disease...
  15. ncbi request reprint Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, New York 10032, USA
    Am J Physiol Lung Cell Mol Physiol 284:L727-37. 2003
    ..This study provides evidence that MMP-1 induces progressive adult-onset emphysema by the selective degradation of type III collagen within the alveolar wall...
  16. pmc Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD
    Seungyeul Yoo
    Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Genet 11:e1004898. 2015
    ....
  17. pmc Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice
    Robert F Foronjy
    St Luke s Roosevelt Hospital, Mount Sinai Health System, Division of Pulmonary and Critical Care Medicine, New York, New York, United States of America
    PLoS ONE 9:e90567. 2014
    ..Indeed, these results indicate that preventing RSV transmission and infection has the potential to significantly impact on COPD severity and progression. ..
  18. ncbi request reprint Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness
    Stefan Klotz
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Circulation 112:364-74. 2005
    ....