John F Parkinson

Summary

Affiliation: Berlex Biosciences
Country: USA

Publications

  1. ncbi Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University, WRB 10SH, 6125 Michael Street, Atlanta, GA 30322, USA
    J Immunol 168:5260-7. 2002
  2. pmc Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism
    Bruce D Levy
    Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    FASEB J 21:3877-84. 2007
  3. ncbi Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase
    Amy M Liang
    Molecular Pharmacology, Berlex Biosciences, Richmond, California 94804, USA
    J Biomol Screen 12:536-45. 2007
  4. ncbi Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation
    John F Parkinson
    Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA
    Inflamm Allergy Drug Targets 5:91-106. 2006
  5. ncbi Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs
    William J Guilford
    Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Prostaglandins Leukot Essent Fatty Acids 73:245-50. 2005
  6. ncbi The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase
    Marc Whitlow
    Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Bioorg Med Chem Lett 17:2505-8. 2007
  7. ncbi Mechanisms of intimal hyperplasia learned from a murine carotid artery ligation model
    Le Ning Zhang
    Department of Pharmacology and Immunology, Berlex Bioscience, Richmond, CA 94806, USA
    Curr Vasc Pharmacol 6:37-43. 2008
  8. ncbi Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo
    William J Guilford
    Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    J Med Chem 47:2157-65. 2004
  9. pmc A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica e Patologia, Universita di Perugia, 06122 Perugia, Italy
    Proc Natl Acad Sci U S A 101:15736-41. 2004
  10. pmc Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
    Gerard Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Br J Pharmacol 143:43-52. 2004

Collaborators

Detail Information

Publications11

  1. ncbi Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University, WRB 10SH, 6125 Michael Street, Atlanta, GA 30322, USA
    J Immunol 168:5260-7. 2002
    ..Thus, LXA(4) analog-mediated down-regulation of proinflammatory gene expression via inhibition of the NF-kappaB pathway can be therapeutic for diseases characterized by mucosal inflammation...
  2. pmc Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism
    Bruce D Levy
    Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    FASEB J 21:3877-84. 2007
    ..Moreover, these results demonstrate these analogs' therapeutic potential as new agonists for the resolution of inflammation...
  3. ncbi Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase
    Amy M Liang
    Molecular Pharmacology, Berlex Biosciences, Richmond, California 94804, USA
    J Biomol Screen 12:536-45. 2007
    ..84). The HTRF-based LTA4 hydrolase assay was shown to be an efficient and suitable assay for determining compound potency and library screening to guide the development of potent inhibitors of LTA4 hydrolase...
  4. ncbi Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation
    John F Parkinson
    Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA
    Inflamm Allergy Drug Targets 5:91-106. 2006
    ..These studies suggest roles for lipoxins as novel regulators of allergy and adaptive immunity and that lipoxins may have therapeutic potential in chronic immune disorders...
  5. ncbi Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs
    William J Guilford
    Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Prostaglandins Leukot Essent Fatty Acids 73:245-50. 2005
    ....
  6. ncbi The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase
    Marc Whitlow
    Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Bioorg Med Chem Lett 17:2505-8. 2007
    ..The resulting compounds were potent dimerization inhibitors that bound to the enzyme in a similar conformation as the fragments...
  7. ncbi Mechanisms of intimal hyperplasia learned from a murine carotid artery ligation model
    Le Ning Zhang
    Department of Pharmacology and Immunology, Berlex Bioscience, Richmond, CA 94806, USA
    Curr Vasc Pharmacol 6:37-43. 2008
    ....
  8. ncbi Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo
    William J Guilford
    Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    J Med Chem 47:2157-65. 2004
    ..The 3-oxatrien-11-yne analogue, 5, is equipotent to 2 in an animal model of inflammation but has enhanced metabolic and chemical stability and a greatly improved pharmacokinetic profile...
  9. pmc A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica e Patologia, Universita di Perugia, 06122 Perugia, Italy
    Proc Natl Acad Sci U S A 101:15736-41. 2004
    ..The combined antiinflammatory and immunomodulatory effects of ZK-192 in TNBS colitis suggest that ATL analogs may be an attractive oral treatment approach for inflammatory bowel diseases...
  10. pmc Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
    Gerard Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Br J Pharmacol 143:43-52. 2004
    ..The 3-oxa-ATL analogs, which have enhanced metabolic and chemical stability and a superior pharmacokinetic profile, provide new opportunities to explore the actions and therapeutic potential for LX and ATL...
  11. ncbi An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile
    Arndt J Schottelius
    Research Business Area Dermatology, Research Laboratories, Schering AG, Berlin, Germany
    J Immunol 169:7063-70. 2002
    ..Moreover, these results suggest that ATLa and related LXA(4) analogs may have broad therapeutic potential in inflammatory disorders and could provide an alternative to corticosteroids in certain clinical settings...