Qi Yan

Summary

Affiliation: Benaroya Research Institute
Country: USA

Publications

  1. ncbi request reprint Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, WA 98104 2046, USA
    J Cell Sci 115:2747-56. 2002
  2. ncbi request reprint Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    Invest Ophthalmol Vis Sci 46:4652-60. 2005
  3. ncbi request reprint Differential responses of human lens epithelial cells to intraocular lenses in vitro: hydrophobic acrylic versus PMMA or silicone discs
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101 2795, USA
    Graefes Arch Clin Exp Ophthalmol 243:1253-62. 2005
  4. ncbi request reprint An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium
    Norihito Gotoh
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    Invest Ophthalmol Vis Sci 48:4679-87. 2007
  5. ncbi request reprint Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro
    Matt S Weaver
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    J Cell Biochem 97:423-32. 2006
  6. ncbi request reprint Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Histochem Cytochem 51:503-11. 2003
  7. ncbi request reprint Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98104 2046, USA
    J Cell Physiol 203:286-94. 2005
  8. ncbi request reprint Caveolin-1 is up-regulated in transdifferentiated lens epithelial cells but minimal in normal human and murine lenses
    Nikole Perdue
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101 2795, USA
    Exp Eye Res 83:1154-61. 2006
  9. ncbi request reprint Peanut agglutinin high phenotype of activated CD8+ T cells results from de novo synthesis of CD45 glycans
    Margarida Amado
    Departments of Molecular Biology and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:36689-97. 2004
  10. ncbi request reprint Plasma surface modification of poly vinyl chloride for improvement of antibacterial properties
    Wei Zhang
    Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101, China
    Biomaterials 27:44-51. 2006

Research Grants

Collaborators

  • Thomas N Wight
  • E H Sage
  • Brian E Collins
  • Xuanyong Liu
  • Wei Zhang
  • Elena M Comelli
  • Margarida Amado
  • Qi Ru Wang
  • Norihito Gotoh
  • Matt S Weaver
  • Nikole Perdue
  • James C Paulson
  • Yan Hong Huang
  • Bao He Wang
  • Guo Dai
  • Wei Ming Li
  • John I Clark
  • Nikole R Perdue
  • Hiroyuki Matsushima
  • Mark Sutton-Smith
  • Steven R Head
  • Howard R Morris
  • Thomas Whisenant
  • David Goldberg
  • Caroline M Lanigan
  • Tim Gilmartin
  • Anne Dell
  • Maria Panico

Detail Information

Publications12

  1. ncbi request reprint Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, WA 98104 2046, USA
    J Cell Sci 115:2747-56. 2002
    ..These results underscore the importance of the capsular extracellular matrix in the maintenance of lens transparency and indicate that SPARC participates in the synthesis, assembly and/or stabilization of the lens basement membrane...
  2. ncbi request reprint Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    Invest Ophthalmol Vis Sci 46:4652-60. 2005
    ..To investigate the role of SPARC in the regulation of the expression and deposition of extracellular matrix (ECM) proteins in the lens capsule...
  3. ncbi request reprint Differential responses of human lens epithelial cells to intraocular lenses in vitro: hydrophobic acrylic versus PMMA or silicone discs
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101 2795, USA
    Graefes Arch Clin Exp Ophthalmol 243:1253-62. 2005
    ....
  4. ncbi request reprint An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium
    Norihito Gotoh
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    Invest Ophthalmol Vis Sci 48:4679-87. 2007
    ....
  5. ncbi request reprint Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro
    Matt S Weaver
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    J Cell Biochem 97:423-32. 2006
    ..We also identify SPARC as a modulator of LN-1 secretion and deposition by these cells, an activity important in epithelial cell-ECM interactions in the ocular lens...
  6. ncbi request reprint Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Histochem Cytochem 51:503-11. 2003
    ..The effects of SPARC in the lens appear to involve regulation of lens epithelial and fiber cell morphology and functions rather than deposition as a structural component of the lens capsule...
  7. ncbi request reprint Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98104 2046, USA
    J Cell Physiol 203:286-94. 2005
    ..SPARC therefore functions not only as an extracellular protein but also potentially as an intracellular protein to influence cellular activities and homeostasis...
  8. ncbi request reprint Caveolin-1 is up-regulated in transdifferentiated lens epithelial cells but minimal in normal human and murine lenses
    Nikole Perdue
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101 2795, USA
    Exp Eye Res 83:1154-61. 2006
    ..Caveolin-1 might have a role in the process of epithelial-mesenchymal transdifferentiation (EMT) in the lens, the most common cause of vision loss in human secondary cataracts...
  9. ncbi request reprint Peanut agglutinin high phenotype of activated CD8+ T cells results from de novo synthesis of CD45 glycans
    Margarida Amado
    Departments of Molecular Biology and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:36689-97. 2004
    ..Instead, our results indicate that the PNA(high) phenotype results from de novo synthesis of CD45 carrying reduced sialylated core 1 O-glycans...
  10. ncbi request reprint Plasma surface modification of poly vinyl chloride for improvement of antibacterial properties
    Wei Zhang
    Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101, China
    Biomaterials 27:44-51. 2006
    ..coli than bronopol. The change in the antibacterial effect on the modified PVC with time was also investigated and the antibacterial effect was observed to decrease with time...
  11. ncbi request reprint Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans
    Elena M Comelli
    Departments of Molecular Biology and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 177:2431-40. 2006
    ..The results have implications for differential recognition of activated and unactivated T cells by dendritic cells and B cells expressing glycan-binding proteins that recognize terminal sequences of N-linked glycans...
  12. ncbi request reprint Purification and growth of endothelial progenitor cells from murine bone marrow mononuclear cells
    Qi Ru Wang
    Experimental Hematology Laboratory, Xiang Ya Medical College, Central South University, Changsha 410078, China
    J Cell Biochem 103:21-9. 2008
    ..This approach is efficient for isolation/purification and outgrowth of bone marrow EPCs in vitro, a very important cell source in angiogenic therapies and regenerative medicine...

Research Grants1

  1. Lens Basement Membrane in SPARC-Null Cataractogenesis
    Qi Yan; Fiscal Year: 2005
    ..abstract_text> ..