Ronald T Javier

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc The history of tumor virology
    Ronald T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:7693-706. 2008
  2. pmc Cell polarity proteins: common targets for tumorigenic human viruses
    R T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 27:7031-46. 2008
  3. pmc Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses
    Ronald T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 85:11544-56. 2011
  4. pmc The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions
    Lisa Golebiewski
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 85:10639-48. 2011
  5. pmc A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles
    Sang Hyuk Chung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 81:4787-97. 2007
  6. pmc Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor
    Kristopher K Frese
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 25:1406-17. 2006
  7. pmc The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble
    Hongbing Liu
    Department of Molecular Biology and Microbiology, Baylor College of Medicine, BCMD 824DB, Houston, TX 77030, USA
    J Virol 84:11164-74. 2010
  8. pmc Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression
    Kathleen Kong
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 89:10774-85. 2015
  9. pmc Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins
    Manish Kumar
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 88:14268-77. 2014
  10. pmc The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase
    Kathleen Kong
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Pathog 10:e1004102. 2014

Collaborators

Detail Information

Publications15

  1. pmc The history of tumor virology
    Ronald T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:7693-706. 2008
    ..This rich history promises that tumor virology will continue to contribute to our understanding of cancer and to the development of new therapeutic and preventive measures for this disease in the 21st century...
  2. pmc Cell polarity proteins: common targets for tumorigenic human viruses
    R T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 27:7031-46. 2008
    ..This review article discusses evidence supporting this hypothesis, with an emphasis on the human Ad E4-ORF1 oncoprotein...
  3. pmc Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses
    Ronald T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 85:11544-56. 2011
    ..The inhibition or perturbation of the function of cellular PDZ proteins appears to be a widely used strategy for viruses to enhance their replication, disseminate in the host, and transmit to new hosts...
  4. pmc The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions
    Lisa Golebiewski
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 85:10639-48. 2011
    ....
  5. pmc A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles
    Sang Hyuk Chung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 81:4787-97. 2007
    ....
  6. pmc Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor
    Kristopher K Frese
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 25:1406-17. 2006
    ..These findings establish the first known function for Dlg1 in virus-mediated cellular transformation and also surprisingly expose a previously unrecognized oncogenic activity encoded by this suspected cellular tumor suppressor gene...
  7. pmc The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble
    Hongbing Liu
    Department of Molecular Biology and Microbiology, Baylor College of Medicine, BCMD 824DB, Houston, TX 77030, USA
    J Virol 84:11164-74. 2010
    ..This study shows that one function of the avian ESEV PBM is to reduce apoptosis during infection through disruption of Scribble's proapoptotic function...
  8. pmc Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression
    Kathleen Kong
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 89:10774-85. 2015
    ..We postulate that E4-ORF1-induced constitutive Myc expression functions to ensure the formation of nuclear E4-ORF1:Myc complexes, which have been shown to activate Myc and to enhance adenovirus replication...
  9. pmc Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins
    Manish Kumar
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 88:14268-77. 2014
    ..Our findings indicate that most, if not all, human adenovirus E4-ORF1 proteins share a conserved molecular mechanism of PI3K activation, which confers a common capacity to promote oncogenic transformation in human epithelial cells...
  10. pmc The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase
    Kathleen Kong
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Pathog 10:e1004102. 2014
    ....
  11. pmc High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells
    Charletha V Irvin-Wilson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Viruses 3:2396-411. 2011
    ..This general approach represents a significant advancement over manual cell polarity scoring, which is subject to experimenter bias and requires more time and effort to evaluate large numbers of cells...
  12. pmc Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells
    Isabel J Latorre
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 118:4283-93. 2005
    ..These significant findings expose a direct link between the tumorigenic potential of E4-ORF1 and inactivation of cellular PDZ proteins involved in tight junction assembly and polarity establishment...
  13. pmc Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
    S S Lee
    Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 94:6670-5. 1997
    ....
  14. pmc Functionally distinct monomers and trimers produced by a viral oncoprotein
    S H Chung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 27:1412-20. 2008
    ..This work exposes a novel strategy wherein the oligomerization state of a protein not only determines the capacity to bind separate related targets but also couples the interactions to different functional consequences...
  15. pmc Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins
    S S Lee
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 74:9680-93. 2000
    ....