Mary K Estes

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal
    Tyler M Sharp
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e13130. 2010
  2. ncbi request reprint Noroviruses everywhere: has something changed?
    Mary K Estes
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Infect Dis 19:467-74. 2006
  3. pmc The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans
    Sasirekha Ramani
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:7255-64. 2013
  4. ncbi request reprint Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs)
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Vaccine 24:1170-9. 2006
  5. pmc Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans
    Margarita K Lay
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 406:1-11. 2010
  6. pmc A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein
    Owen Kavanagh
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol Methods 189:228-31. 2013
  7. pmc A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly
    Jeanette M Criglar
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 88:786-98. 2014
  8. pmc Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses
    Tyler M Sharp
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virol J 9:181. 2012
  9. pmc Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication
    Xiaofang Jiang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 80:10829-35. 2006
  10. pmc Norwalk virus RNA is infectious in mammalian cells
    Susana Guix
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM 385, Houston, TX 77030, USA
    J Virol 81:12238-48. 2007

Detail Information

Publications87

  1. pmc Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal
    Tyler M Sharp
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e13130. 2010
    ..This unique and well-conserved human norovirus motif is therefore an appealing target for antiviral drug development...
  2. ncbi request reprint Noroviruses everywhere: has something changed?
    Mary K Estes
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Infect Dis 19:467-74. 2006
    ..This review summarizes new information about where and why these viruses are detected as well as new developments to prevent or treat these infections...
  3. pmc The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans
    Sasirekha Ramani
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:7255-64. 2013
    ..These studies provide the first molecular basis for understanding neonatal rotavirus infections, indicating that glycan modification during neonatal development may mediate the age-restricted infectivity of neonatal viruses...
  4. ncbi request reprint Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs)
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Vaccine 24:1170-9. 2006
    ..Combination oral/intranasal vaccination did not improve VLP protective efficacy. These studies indicate that host, viral, and vaccine factors determine the level of protective efficacy induced by VLPs...
  5. pmc Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans
    Margarita K Lay
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 406:1-11. 2010
    ..These results demonstrate that NV does not replicate in human CD11c(+) DCs, monocyte-derived DCs and MPhi, but abortive infection may occur in a few DCs. These results suggest that NV tropism is distinct from that of murine noroviruses...
  6. pmc A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein
    Owen Kavanagh
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol Methods 189:228-31. 2013
    ....
  7. pmc A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly
    Jeanette M Criglar
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 88:786-98. 2014
    ..Together, these data suggest that dNSP2 interacts with viral proteins, including hypophosphorylated NSP5, to initiate viroplasm formation, while viroplasm maturation includes phosphorylation of NSP5 and vNSP2. ..
  8. pmc Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses
    Tyler M Sharp
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virol J 9:181. 2012
    ..To explore conservation of function of this highly divergent calicivirus protein, we examined the effects of p22 homologues from four human and two murine noroviruses, and feline calicivirus on the secretory pathway...
  9. pmc Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication
    Xiaofang Jiang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 80:10829-35. 2006
    ....
  10. pmc Norwalk virus RNA is infectious in mammalian cells
    Susana Guix
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM 385, Houston, TX 77030, USA
    J Virol 81:12238-48. 2007
    ....
  11. pmc Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin
    Neung Seon Seo
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:8811-8. 2008
    ....
  12. pmc Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses
    Sreejesh Shanker
    Verna Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 88:6168-80. 2014
    ....
  13. pmc Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity
    Liya Hu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 86:10547-57. 2012
    ....
  14. pmc Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4
    Joseph M Hyser
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Virology 373:211-28. 2008
    ..The use of single epitope-specific antibodies to differentially block functions of NSP4 is a feasible approach to determine the functional domain structure of this important RV virulence factor...
  15. pmc Norwalk virus shedding after experimental human infection
    Robert L Atmar
    Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Emerg Infect Dis 14:1553-7. 2008
    ..Understanding of the relevance of prolonged fecal norovirus excretion must await the development of sensitive methods to measure virus infectivity...
  16. pmc The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 78:6974-81. 2004
    ..These findings indicate that the structure and conformation of the outer capsid protein, VP7, initiate intestinal B-cell activation during rotavirus infection...
  17. pmc Replication and packaging of Norwalk virus RNA in cultured mammalian cells
    Miyuki Asanaka
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:10327-32. 2005
    ..This work establishes a mammalian cell-based system for analysis of human norovirus replication and, thus, makes it feasible to investigate antiviral agents in mammalian cells...
  18. pmc Serological responses to experimental Norwalk virus infection measured using a quantitative duplex time-resolved fluorescence immunoassay
    Owen Kavanagh
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Clin Vaccine Immunol 18:1187-90. 2011
    ..The duplex assay showed superior performance by detecting seroconversion following experimental NV infection at an earlier time point than a reference total immunoglobulin enzyme-linked immunosorbent assay (ELISA)...
  19. ncbi request reprint Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice
    Andrea Bertolotti-Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, BCM 385, Houston, TX 77030, USA
    Vaccine 21:3885-900. 2003
    ..The use of 2/6-VLPs expressed from a single recombinant baculovirus simplifies production and would reduce the cost of a VLP-based vaccine...
  20. pmc Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity
    Joseph M Hyser
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:13579-88. 2013
    ..This is the first report of viroporin-mediated activation of SOCE, reinforcing NSP4 as a robust model to understand dysregulation of calcium homeostasis during virus infections. ..
  21. pmc Identification and characterization of a peptide affinity reagent for detection of noroviruses in clinical samples
    Jennifer D Rogers
    Departments of Pharmacology, aylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 51:1803-8. 2013
    ....
  22. pmc Structural basis of substrate specificity and protease inhibition in Norwalk virus
    Zana Muhaxhiri
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:4281-92. 2013
    ....
  23. pmc Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-β signaling is required for rotavirus replication
    Sue E Crawford
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:E3405-13. 2012
    ..These studies identify a unique mechanism of virus-mediated, calcium-activated signaling that initiates autophagy and hijacks this membrane trafficking pathway to transport viral proteins to sites of viral assembly...
  24. pmc Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies
    Joseph M Hyser
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 86:4921-34. 2012
    ..These data suggest that elevated cytosolic calcium is a common critical process for all rotavirus strains...
  25. pmc Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:3135-8. 2008
    ..Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered...
  26. pmc Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution
    Sreejesh Shanker
    Verna Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 85:8635-45. 2011
    ....
  27. pmc Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity
    Sugoto Chakravarty
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Virol 79:554-68. 2005
    ..The highly variable region of the capsid shows a distinct cluster whose residues may participate in norovirus-receptor interactions...
  28. pmc Serological correlate of protection against norovirus-induced gastroenteritis
    Amanda Reeck
    Departments of Molecular Virology, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 202:1212-8. 2010
    ..We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure...
  29. pmc Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid
    Tracy Dewese Parker
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM 385, Houston, TX 77030, USA
    J Virol 79:7402-9. 2005
    ..Identification of the epitopes for these monoclonal antibodies is of significance, as they are components in a commercially available norovirus-diagnostic enzyme-linked immunosorbent assay...
  30. pmc Structural basis of glycan interaction in gastroenteric viral pathogens
    B V Venkataram Prasad
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, United States Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States Electronic address
    Curr Opin Virol 7:119-27. 2014
    ..This chapter reviews the current status of the structural biology of such strain-dependent glycan specificities in these two families of viruses. ..
  31. pmc Vaccine-acquired rotavirus in infants with severe combined immunodeficiency
    Niraj C Patel
    Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
    N Engl J Med 362:314-9. 2010
    ..These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients...
  32. pmc Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions
    Pamela J Glass
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 77:3569-77. 2003
    ..These results indicate that the region of the ORF3 protein between amino acids 108 and 152 is responsible for interaction with the ORF2 protein...
  33. pmc Rotavirus enterotoxin NSP4 has mucosal adjuvant properties
    Owen V Kavanagh
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Vaccine 28:3106-11. 2010
    ..These studies suggest that the rotavirus enterotoxin NSP4 can function as an adjuvant to enhance immune responses for a co-administered antigen...
  34. pmc Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin
    Zuzana Berkova
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, 1200 Moursund Street, Houston, TX 77030 3404, USA
    J Virol 81:3545-53. 2007
    ....
  35. pmc Characterization of cross-reactive norovirus-specific monoclonal antibodies
    Baijun Kou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    Clin Vaccine Immunol 22:160-7. 2015
    ..Biochemical analyses of MAb reactivity, including SPR analysis, identified NV23 as a broadly reactive ligand for application in norovirus diagnostic assays. ..
  36. pmc Rotavirus viremia and extraintestinal viral infection in the neonatal rat model
    Sue E Crawford
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 80:4820-32. 2006
    ....
  37. pmc Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens
    Anne M Hutson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 77:405-15. 2003
    ..Overall, our results indicate that carbohydrate antigens in the gut are a previously unrecognized factor in NV pathogenesis...
  38. pmc Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:4087-95. 2002
    ....
  39. pmc Epidemiology of human noroviruses and updates on vaccine development
    Sasirekha Ramani
    aDepartment of Molecular Virology and Microbiology bDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Gastroenterol 30:25-33. 2014
    ..This review summarizes recent NoV disease burden estimates, epidemiology findings and provides an update on virus-like particle (VLP) vaccine studies...
  40. pmc Viroporin-mediated calcium-activated autophagy
    Sue E Crawford
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    Autophagy 9:797-8. 2013
    ..Thus, NSP4, a multifunctional viral protein known to regulate infectious particle assembly, also modulates membrane trafficking by orchestrating the activation of autophagy to benefit viral replication...
  41. pmc Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus
    Nadim J Ajami
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    Clin Vaccine Immunol 19:1980-3. 2012
    ..1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons...
  42. pmc Rotavirus non-structural proteins: structure and function
    Liya Hu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, United States
    Curr Opin Virol 2:380-8. 2012
    ..This brief review highlights our current knowledge of the structure-function relationships of the rotavirus non-structural proteins, as well as fascinating questions that remain to be understood...
  43. pmc Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus
    Rita Czakó
    Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA
    Clin Vaccine Immunol 19:284-7. 2012
    ..02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease...
  44. pmc Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system
    Shujuan Pan
    Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Biol Cell 22:2810-22. 2011
    ..Taken together, these data provide a potential mechanistic explanation for the spatial separation by which glycoprotein quality control components operate in mammalian cells...
  45. ncbi request reprint Norovirus disease: changing epidemiology and host susceptibility factors
    Anne M Hutson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM 385, Houston, TX 77030, USA
    Trends Microbiol 12:279-87. 2004
    ....
  46. pmc Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus
    Jae Mun Choi
    Verna Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:9175-80. 2008
    ....
  47. pmc X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity
    Rong Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:8048-53. 2006
    ..These observations suggest a mechanism for antigenic diversity and host specificity in caliciviruses and provide a structural framework for vaccine development...
  48. pmc The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein
    Andrea Bertolotti-Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 77:11603-15. 2003
    ..Furthermore, VP2 increased VP1 stability and protected VP1 from disassembly and protease degradation. The increase in VP1 expression levels caused by the presence of VP2 in cis was also observed in mammalian cells...
  49. pmc Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology
    Kapil Saxena
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 90:43-56. 2015
    ..These results demonstrate that HIEs are a novel pathophysiological model that will allow the study of HRV biology, including host restriction, cell type restriction, and virus-induced fluid secretion...
  50. pmc Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus
    Liya Hu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Commun 6:8346. 2015
    ....
  51. pmc Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia
    Paula M Hertel
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 417:281-92. 2011
    ..OPN-deficient mice, similar to WT mice, developed BA. Together, these data show that live but not inactivated rotavirus causes upregulation of hepatic OPN expression and BA but that OPN is not necessary for development of BA...
  52. pmc Norovirus vaccine against experimental human Norwalk Virus illness
    Robert L Atmar
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 365:2178-87. 2011
    ..Noroviruses cause epidemic and sporadic acute gastroenteritis. No vaccine is available to prevent norovirus illness or infection...
  53. ncbi request reprint Norwalk virus infection associates with secretor status genotyped from sera
    Anne M Hutson
    Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Med Virol 77:116-20. 2005
    ....
  54. pmc pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization
    Joseph B Pesavento
    Verna and McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    J Virol 79:8572-80. 2005
    ..This process involves sequential interactions with multiple receptors, and the mechanism by which the antibody neutralizes is by preventing this conformational change...
  55. pmc Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies
    Baijun Kou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 53:3916-8. 2015
    ..The detection of 25 different norovirus genotypes as recombinant virus-like particles or in clinical samples was dependent on virus or antigen concentration...
  56. pmc Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection
    Shayla Hesse
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Clin Vaccine Immunol 23:181-3. 2015
    ..1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge. ..
  57. pmc Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies
    Sue E Crawford
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    Clin Vaccine Immunol 22:168-77. 2015
    ....
  58. ncbi request reprint Rotavirus antigenaemia and viraemia: a common event?
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 362:1445-9. 2003
    ..We assessed whether rotavirus antigen, RNA, or both, were present in serum samples from immunocompetent rotavirus-infected children and animals...
  59. pmc B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans
    Zhannat Z Nurgalieva
    VAMC Rm 3A 320 111D, 2002 Holcombe Blvd, Houston, TX 77030, USA
    Infect Immun 73:2999-3006. 2005
    ..pylori antigens 2 to 4 weeks postchallenge. The majority of H. pylori proteins were those involved in motility and colonization and may represent targets for vaccine development...
  60. pmc Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity
    Rita Czakó
    Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    Clin Vaccine Immunol 22:221-8. 2015
    ..4 NoVs. These observations indicate that the development of a broadly cross-protective NoV vaccine containing a limited number of genotypes may be possible. ..
  61. pmc Inter- and intragenus structural variations in caliciviruses and their functional implications
    Rong Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Alkek Building N410, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 78:6469-79. 2004
    ....
  62. pmc Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
    Liya Hu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 485:256-9. 2012
    ..These results raise the possibility that host susceptibility to specific human rotavirus strains and pathogenesis are influenced by genetically controlled expression of different HBGAs among the world's population...
  63. pmc Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles
    Paula M Hertel
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA Electronic address
    Vaccine 31:5778-84. 2013
    ..Early reduction of viral load by clearance with RV-specific antibody is likely a critical determinant of disease in this model...
  64. pmc An inside job: subversion of the host secretory pathway by intestinal pathogens
    Tyler M Sharp
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Infect Dis 23:464-9. 2010
    ..This review focuses on our current understanding of the distinct mechanisms employed by enteric pathogens to antagonize the secretory pathway...
  65. ncbi request reprint Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virus Genes 24:107-18. 2002
    ..In addition, the VP6 and VP7 of BRV WC3 were very similar to the VP6 and VP7 of both SG I and G6 BRV NCDV and UK strains. However, the NSP4 of BRV WC3 was more closely related to that BRV NCDV, the P6 prototype, than to that of BRV UK...
  66. pmc Seroepidemiology of norovirus-associated travelers' diarrhea
    Nadim J Ajami
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA School of Public Health, Center for Infectious Diseases, Houston, TX, USA
    J Travel Med 21:6-11. 2014
    ....
  67. pmc Norwalk Virus Minor Capsid Protein VP2 Associates within the VP1 Shell Domain
    Sompong Vongpunsawad
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:4818-25. 2013
    ..The highly basic nature of VP2 and its location interior to the viral particle are consistent with its potential role in assisting capsid assembly and genome encapsidation...
  68. doi request reprint Rotavirus and biliary atresia: can causation be proven?
    Paula M Hertel
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Gastroenterol 28:10-7. 2012
    ....
  69. pmc Rotavirus vaccines and pathogenesis: 2008
    Joseph M Hyser
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Gastroenterol 25:36-43. 2009
    ..This review summarizes new data on these vaccines, their effectiveness, and remaining challenges including new data on the rotavirus enterotoxin, a potential antiviral target...
  70. pmc Rotavirus architecture at subnanometer resolution
    Zongli Li
    National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 83:1754-66. 2009
    ....
  71. pmc Stem cell-derived human intestinal organoids as an infection model for rotaviruses
    Stacy R Finkbeiner
    Department of Molecular Virology, Baylor College of Medicine, Houston, Texas, USA
    MBio 3:e00159-12. 2012
    ..This work demonstrates that iHIOs offer a promising new model to study rotaviruses and other gastrointestinal viruses...
  72. pmc Identification of human single-chain antibodies with broad reactivity for noroviruses
    Wanzhi Huang
    Department of Pharmacology, Baylor College of Medicine, Houston, TX, USA
    Protein Eng Des Sel 27:339-49. 2014
    ..Finally, phages displaying the HJT-R3-A9 scFv can be used directly to detect both GI.1 and GII.4 norovirus from stool samples, which has the potential to simplify and reduce the cost of diagnostics based on antibody-based ELISA methods. ..
  73. ncbi request reprint The epidemiologic and clinical importance of norovirus infection
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, MS BCM280, Houston, TX 77030, USA
    Gastroenterol Clin North Am 35:275-90, viii. 2006
    ..This article reviews the epidemiology, clinical manifestations and pathogenesis of norovirus infection, and it describes the diagnostic and therapeutic approaches to this disease...
  74. pmc X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolution
    Corinne E Zeitler
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 80:5050-8. 2006
    ..Since AEBSF was not apparent in the electron density map, it is possible that these conformational changes are due to subtle changes in pH caused by its addition during crystallization...
  75. pmc Reconciliation of rotavirus temperature-sensitive mutant collections and assignment of reassortment groups D, J, and K to genome segments
    Jeanette Criglar
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 85:5048-60. 2011
    ..Rotavirus ts mutation groups are now mapped to 9 of the 11 rotavirus genome segments. Possible segment locations of the two remaining unmapped ts mutant groups are discussed...
  76. ncbi request reprint Norwalk virus infection and disease is associated with ABO histo-blood group type
    Anne M Hutson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 185:1335-7. 2002
    ..096; 95% CI, 0.16-0.56) and symptomatic disease (OR, 0; 95% CI, 0-0.999). This is the first report demonstrating an association between a genetic factor and the risk of NV infection and symptomatic disease...
  77. pmc Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection
    Virginia L Scofield
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX, USA
    Immunol Lett 99:36-44. 2005
    ..These findings lend credence to the notion that TSH plays a role both in the development of intestinal T cells, and in the process of local immunity during enteric virus infection...
  78. pmc Adsorption and aggregation properties of norovirus GI and GII virus-like particles demonstrate differing responses to solution chemistry
    Allegra K da Silva
    Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut 06520 8286, United States
    Environ Sci Technol 45:520-6. 2011
    ..1 and GII.4 VLP attachment efficiencies in response to solution chemistry may be attributed to differential responses of the unique arrangement of exposed amino acid residues on the capsid surface of each VLP strain...
  79. ncbi request reprint Laboratory efforts to cultivate noroviruses
    Erwin Duizer
    National Institutes for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    J Gen Virol 85:79-87. 2004
    ..Thus, attempts to develop a method for the cultivation of NoV were unsuccessful...
  80. pmc Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP
    Noritoshi Kitamoto
    School of Humanities for Environmental Policy and Technology, Himeji Institute of Technology, Hyogo 670 0092, Japan
    J Clin Microbiol 40:2459-65. 2002
    ..These strain-, genogroup-, and genus-reactive MAbs will be useful tools for further study of the antigenic and structural topography of the HuCV virion and for diagnostic assays for HuCVs...
  81. ncbi request reprint Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Immunol 108:241-7. 2003
    ..Lymphoproliferative responses and IFN-gamma production were observed transiently among those who received 250 microg or 500 microg but not 2000 microg of VLP. Studies to increase immunogenicity using a mucosal adjuvant are planned...
  82. ncbi request reprint Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype
    Malin Modin Larsson
    Division of Molecular Virology, University of Linkoping, 581 85 Linkoping, Sweden
    J Infect Dis 194:1422-7. 2006
    ..Histo-blood group antigens and secretor status have been associated with susceptibility to Norovirus infections, which suggests that antibody prevalence and titer might correlate with these phenotypes...
  83. ncbi request reprint Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein
    Xiuren Zhang
    Department of Plant Biology, Cornell University, Ithaca, NY 18853 1801, USA
    Plant Biotechnol J 4:419-32. 2006
    ..These findings support the use of stabilized, dried tomato fruit for oral delivery of subunit vaccines...
  84. ncbi request reprint Oral immunization with a shiga toxin B subunit: rotavirus NSP4(90) fusion protein protects mice against gastroenteritis
    Nak Won Choi
    Center for Molecular Biology and Gene Therapy, Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    Vaccine 23:5168-76. 2005
    ....
  85. pmc Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen
    Christine L Moe
    Department of International Health, Rollins School of Public Health of Emory University, 1518 Clifton Rd NE, Room 716, Atlanta, GA 30322, USA
    Clin Diagn Lab Immunol 11:1028-34. 2004
    ..This is the first documented mucosal antibody response to NoV in children. This EIA provides a useful approach for diagnosing NoV outbreaks...
  86. pmc Norwalk virus-specific binding to oyster digestive tissues
    Françoise Le Guyader
    Laboratoire de Microbiologie, Institut Francais de Recherche pour l Exploitation de la Mer, Nantes, France
    Emerg Infect Dis 12:931-6. 2006
    ..These data show that the oyster can selectively concentrate a human pathogen and that conventional depuration will not eliminate noroviruses from oyster tissue...