Murali M Chintagumpala

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi request reprint Retinoblastoma: review of current management
    Murali Chintagumpala
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas, USA
    Oncologist 12:1237-46. 2007
  2. pmc Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Radiat Oncol 6:58. 2011
  3. ncbi request reprint A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group
    Murali M Chintagumpala
    Baylor College of Medicine, 6621 Fannin, CC 1510 00, Houston, TX, USA
    J Neurooncol 77:193-8. 2006
  4. pmc A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET
    Murali Chintagumpala
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neuro Oncol 11:33-40. 2009
  5. ncbi request reprint Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome
    Lisa L Wang
    Texas Children s Cancer Center and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Natl Cancer Inst 95:669-74. 2003
  6. pmc Results of treatment of patients with superficial facial rhabdomyosarcomas on protocols of the Intergroup Rhabdomyosarcoma Study Group (IRSG), 1984-1997
    R Beverly Raney
    Division of Pediatrics and Children s Cancer Hospital, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pediatr Blood Cancer 50:958-64. 2008
  7. ncbi request reprint Phase I and pharmacokinetic study of thalidomide with carboplatin in children with cancer
    Murali Chintagumpala
    Texas Children s Cancer Center, 6621 Fannin, MC 3 3320, Houston, TX 77030, USA
    J Clin Oncol 22:4394-400. 2004
  8. ncbi request reprint Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma
    Ching C Lau
    Department of Pediatrics, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Chromosomes Cancer 39:11-21. 2004
  9. doi request reprint Infantile fibrosarcoma: clinical and histologic responses to cytotoxic chemotherapy
    Heidi Russell
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatr Blood Cancer 53:23-7. 2009
  10. ncbi request reprint Expression profiles of osteosarcoma that can predict response to chemotherapy
    Tsz Kwong Man
    Department of Pediatrics, Texas Children s Cancer Center, Houston, Texas, USA
    Cancer Res 65:8142-50. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Retinoblastoma: review of current management
    Murali Chintagumpala
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas, USA
    Oncologist 12:1237-46. 2007
    ..Exciting discoveries using animal models are providing new insights into the development of this disease and opening new avenues for targeted therapies that may lead to high cure rates with minimal toxicities...
  2. pmc Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Radiat Oncol 6:58. 2011
    ..Compared to photons, proton radiotherapy reduces radiation dose to the cochlea for these patients. Here we examine whether this dosimetric advantage leads to a clinical benefit in audiometric outcomes...
  3. ncbi request reprint A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group
    Murali M Chintagumpala
    Baylor College of Medicine, 6621 Fannin, CC 1510 00, Houston, TX, USA
    J Neurooncol 77:193-8. 2006
    ..Future trials should consider strategies to overcome the resistance mechanisms in children with high-grade glioma...
  4. pmc A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET
    Murali Chintagumpala
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neuro Oncol 11:33-40. 2009
    ..Further, this chemotherapy allows for a reduction in the dose of CSI used to treat AR SPNET without compromising EFS...
  5. ncbi request reprint Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome
    Lisa L Wang
    Texas Children s Cancer Center and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Natl Cancer Inst 95:669-74. 2003
    ..We examined whether a predisposition to developing osteosarcoma among an international cohort of RTS patients was associated with a distinctive pattern of mutations in the RECQL4 gene...
  6. pmc Results of treatment of patients with superficial facial rhabdomyosarcomas on protocols of the Intergroup Rhabdomyosarcoma Study Group (IRSG), 1984-1997
    R Beverly Raney
    Division of Pediatrics and Children s Cancer Hospital, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pediatr Blood Cancer 50:958-64. 2008
    ..We analyzed the outcome of 47 patients with superficial facial rhabdomyosarcoma (RMS) treated on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-III, -IV-Pilot, and -IV...
  7. ncbi request reprint Phase I and pharmacokinetic study of thalidomide with carboplatin in children with cancer
    Murali Chintagumpala
    Texas Children s Cancer Center, 6621 Fannin, MC 3 3320, Houston, TX 77030, USA
    J Clin Oncol 22:4394-400. 2004
    ..Recent studies have indicated that thalidomide inhibits angiogenesis. We performed a phase I and pharmacokinetic study of thalidomide with carboplatin in children with refractory solid tumors...
  8. ncbi request reprint Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma
    Ching C Lau
    Department of Pediatrics, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Chromosomes Cancer 39:11-21. 2004
    ....
  9. doi request reprint Infantile fibrosarcoma: clinical and histologic responses to cytotoxic chemotherapy
    Heidi Russell
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatr Blood Cancer 53:23-7. 2009
    ..This report describes the histologic changes and outcomes in four patients with IF treated with chemotherapy and surgical resection...
  10. ncbi request reprint Expression profiles of osteosarcoma that can predict response to chemotherapy
    Tsz Kwong Man
    Department of Pediatrics, Texas Children s Cancer Center, Houston, Texas, USA
    Cancer Res 65:8142-50. 2005
    ..Many of the predictor genes are implicated in bone development, drug resistance, and tumorigenesis...
  11. doi request reprint Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma
    Arnold C Paulino
    Department of Radiation Oncology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:1445-50. 2010
    ....
  12. doi request reprint Neuropsychological outcome following intensity-modulated radiation therapy for pediatric medulloblastoma
    Neelam Jain
    Learning Support Center for Child Psychology, Texas Children s Hospital, Houston, Texas, USA
    Pediatr Blood Cancer 51:275-9. 2008
    ..This study compared the impact of the two treatments on measures of neurocognitive functioning...
  13. ncbi request reprint A homozygous mutation in MSH6 causes Turcot syndrome
    Madhuri R Hegde
    Diagnostic Sequencing Laboratory, Department of Molecular and Human Genetics and Texas Children s Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:4689-93. 2005
    ..Our findings support a role for MSH6 in Turcot syndrome and are consistent with an autosomal recessive mode of inheritance...
  14. ncbi request reprint Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir
    Patricia Chevez-Barrios
    Department of Pathology, Texas Children s Cancer Center, Houston, USA
    J Clin Oncol 23:7927-35. 2005
    ..To evaluate the feasibility and safety of adenovirus-mediated gene therapy as a treatment for tumor seeds in the vitreous of children with retinoblastoma...
  15. doi request reprint Low-level copy gain versus amplification of myc oncogenes in medulloblastoma: utility in predicting prognosis and survival. Laboratory investigation
    Hidehiro Takei
    Department of Pathology, The Methodist Hospital, Texas Children s Cancer Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosurg Pediatr 3:61-5. 2009
    ..The frequency of low-level copy gain of myc oncogenes and its relationship to prognosis of MB has not been explored...
  16. ncbi request reprint Extensively necrotic retinoblastoma is associated with high-risk prognostic factors
    Eva Marie Chong
    Department of Ophthalmology, Baylor College of Medicine, Houston, Tex, USA
    Arch Pathol Lab Med 130:1669-72. 2006
    ..This may alert the pathologist who makes the observation of extensive necrosis to carefully search for histologic features associated with adverse outcome...
  17. ncbi request reprint Intensity-modulated radiation therapy for pediatric medulloblastoma: early report on the reduction of ototoxicity
    Eugene Huang
    Department of Radiology Section of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 52:599-605. 2002
    ....
  18. pmc Intron-size constraint as a mutational mechanism in Rothmund-Thomson syndrome
    Lisa L Wang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 71:165-7. 2002
    ..Thus, monitoring of intron size may allow detection of mutations missed by exon-by-exon approaches...
  19. ncbi request reprint FOXG1 dysregulation is a frequent event in medulloblastoma
    Adekunle M Adesina
    Department of Pathology, Texas Children s Cancer Center, Baylor College of Medicine, One Baylor Plaza, Rm 286A, Houston, TX 77030, USA
    J Neurooncol 85:111-22. 2007
    ..Our findings are consistent with a role for FOXG1 in the inhibition of TGF-beta induced cytostasis in medulloblastoma...
  20. pmc Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma
    Nadia Barahmani
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Neuro Oncol 11:292-300. 2009
    ..GSTM1 and GSTT1 polymorphisms may predict adverse events, including cognitive impairment after therapy, in patients with medulloblastoma. A larger study to validate these findings is under way...
  21. pmc Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma
    Xin Yan Lu
    Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    Mol Cancer Res 6:937-46. 2008
    ..These results indicate that CDC5L, a cell cycle regulator important for the G2-M transition, is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma...
  22. doi request reprint Local control after intensity-modulated radiotherapy for head-and-neck rhabdomyosarcoma
    Amarinthia E Curtis
    Section of Radiation Oncology, Department of Radiology, Baylor College of Medicine, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:173-7. 2009
    ..To examine the patterns of failure in patients treated with intensity-modulated radiotherapy (IMRT) for head-and-neck rhabdomyosarcoma (RMS)...
  23. ncbi request reprint A single institution experience with pediatric nasopharyngeal carcinoma: high incidence of toxicity associated with platinum-based chemotherapy plus IMRT
    Chrystal U Louis
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Houston, TX, USA
    J Pediatr Hematol Oncol 29:500-5. 2007
    ..Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients...
  24. doi request reprint Radiation-induced malignant gliomas: is there a role for reirradiation?
    Arnold C Paulino
    Department of Radiology, Division of Radiation Oncology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:1381-7. 2008
    ..To review the literature regarding the role of radiotherapy (RT) in the treatment of patients with radiation-induced malignant gliomas (RIMGs)...
  25. doi request reprint Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma
    Qin Shu
    Laboratory of Molecular Neuro Oncology, Texas Children s Cancer Center, Texas Children s Hospital, 6621 Fannin St, MC 3 3320, Houston, Texas 77030, USA
    Stem Cells 26:1414-24. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  26. ncbi request reprint Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array
    Kwong Kwok Wong
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:11172-8. 2006
    ..Our results indicate that, in some pediatric glioblastoma multiforme, one allele each of EGFR and PDGFRalpha was lost but the remaining allele was amplified. This may represent a new molecular mechanism underlying tumor progression...
  27. doi request reprint Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report
    Andrew Jea
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas, USA
    J Neurosurg Pediatr 5:149-54. 2010
    ..They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development...
  28. ncbi request reprint Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival
    Hidehiro Takei
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Neurooncol 86:183-90. 2008
    ..In addition, we have shown the expression of 4 different ODMs in PAs, which may support the possibility that PAs arise from oligodendrocyte progenitor/precursor cells probably similar to the O2A progenitor cells in the mouse...
  29. ncbi request reprint Retinoblastoma: from bench to bedside
    Richard L Hurwitz
    Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Expert Rev Mol Med 5:1-14. 2003
    ..Each model has both strengths and weaknesses for exploring the mechanisms of disease development and progression and the efficacy of new treatment strategies...
  30. ncbi request reprint Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma
    Yiting Li
    Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    Proteomics 6:3426-35. 2006
    ..The classifier based on this plasma proteomic signature may be useful to differentiate malignant bone cancer from benign bone tumors and for early detection of OS in high-risk individuals...
  31. ncbi request reprint Prenatal presentation and outcome of children with pleuropulmonary blastoma
    Douglas N Miniati
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Pediatr Surg 41:66-71. 2006
    ..Treatment for this condition is primarily surgical resection; however, increasing experience suggests that adjuvant chemotherapy may decrease recurrence and improve outcome...
  32. ncbi request reprint Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups
    Kwong Kwok Wong
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 65:76-84. 2005
    ..Immunostaining of myelin basic protein on paraffin sections derived from 18 incompletely resected JPAs suggests that JPA without myelin basic protein-positively stained tumor cells may have a higher tendency to progress...
  33. pmc Changes mimicking new leptomeningeal disease after intensity-modulated radiotherapy for medulloblastoma
    Jodi A Muscal
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:214-21. 2009
    ..We report the post-RT neuroimaging changes in the posterior fossa after intensity-modulated RT (IMRT) in children with medulloblastoma and contrast them with those of leptomeningeal disease...
  34. pmc Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma
    Thomas E Merchant
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 70:782-7. 2008
    ..Conformal RT to less than the entire posterior fossa (PF) after craniospinal irradiation might reduce neurocognitive sequelae and requires evaluation...
  35. ncbi request reprint Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy
    Amar Gajjar
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2374-80. 2003
    ..The type and grade of toxicity did not differ between the two patient groups. Increasing the dosage of irinotecan increased the SN-38 AUC in some patients who received concomitant EIA therapy...
  36. ncbi request reprint Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy
    Kristine R Crews
    Departments of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 8:2202-9. 2002
    ..The purpose of this study was to determine the effect of enzyme-inducing anticonvulsants (EIAs) on the disposition of irinotecan and metabolites in pediatric patients with high-grade glioma...