Christine Beeton

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function
    Chang Seok Lee
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA
    Skelet Muscle 5:4. 2015
  2. pmc Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases
    Christine Beeton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Inflamm Allergy Drug Targets 10:313-21. 2011
  3. pmc Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes
    Zolt n Pethő
    Department of Molecular Physiology and Biophysics, Mail Stop BCM335, Room S409A, Baylor College of Medicine, Houston, TX, 77030, USA
    Arthritis Res Ther 18:103. 2016
  4. pmc KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis
    Mark R Tanner
    Baylor College of Medicine, Houston, Texas
    Arthritis Rheumatol 67:96-106. 2015
  5. pmc KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis
    Xueyou Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:4014-22. 2012
  6. pmc Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin
    B Vijayalakshmi Ayyar
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Sci Rep 5:15776. 2015
  7. pmc Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes
    Shyny Koshy
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e76740. 2013

Collaborators

  • Gyorgy Panyi
  • Heike Wulff
  • Percio S Gulko
  • Frank T Horrigan
  • Raymond S Norton
  • Rajeev B Tajhya
  • Xueyou Hu
  • Mark R Tanner
  • Redwan Huq
  • Teresina Laragione
  • Shyny Koshy
  • Zolt n Pethő
  • Chang Seok Lee
  • B Vijayalakshmi Ayyar
  • Fatima S Khan
  • Iskander I Ismailov
  • Liang Sun
  • Patricia Yotnda
  • Keke Dong
  • M Zouhair Atassi
  • Mary E Dickinson
  • Ross A Poche
  • Viktor Yarotskyy
  • Mark Knoblauch
  • George G Rodney
  • Robert T Dirksen
  • Cheng Long
  • Adan Dagnino-Acosta
  • Susan L Hamilton
  • Alla Lyfenko
  • Pumin Zhang
  • Ted Tran
  • Amy Hanna
  • Johanna Lanner
  • Dimitra K Georgiou
  • Michael W Swank
  • DanLi Wu
  • Michael W Pennington
  • Karlie R Jones

Detail Information

Publications9

  1. pmc Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function
    Chang Seok Lee
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA
    Skelet Muscle 5:4. 2015
    ..1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca(2+) permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian skeletal muscle has not been assessed...
  2. pmc Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases
    Christine Beeton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Inflamm Allergy Drug Targets 10:313-21. 2011
    ..They are currently undergoing further evaluation as potential immunomodulators for the treatment of autoimmune diseases...
  3. pmc Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes
    Zolt n Pethő
    Department of Molecular Physiology and Biophysics, Mail Stop BCM335, Room S409A, Baylor College of Medicine, Houston, TX, 77030, USA
    Arthritis Res Ther 18:103. 2016
    ..Identification of the regulatory subunits of KCa1.1 expressed by RA-FLS may therefore provide the opportunity for generating a selective target for RA treatment...
  4. pmc KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis
    Mark R Tanner
    Baylor College of Medicine, Houston, Texas
    Arthritis Rheumatol 67:96-106. 2015
    ..The purpose of this study was to define the importance of KCa1.1 (BK, Maxi-K, Slo1, KCNMA1) channel expression and function in FLS and to establish these channels as potential new targets for RA therapy...
  5. pmc KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis
    Xueyou Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:4014-22. 2012
    ..Our findings indicate a regulatory role of KCa1.1 channels in RA-FLS function and suggest this channel as a potential target for the treatment of RA...
  6. pmc Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin
    B Vijayalakshmi Ayyar
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Sci Rep 5:15776. 2015
    ..These results are the first to describe and dissect the protective activity of the BoNT/A HN domain. ..
  7. pmc Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes
    Shyny Koshy
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e76740. 2013
    ..This results in a TRAM-34-induced increased ability of A-NK cells to reduce in vivo tumor growth. Taken together, our results suggest that targeting KCa3.1 on NK cells with selective blockers may be beneficial in cancer immunotherapy. ..