Lars Kuepfer

Summary

Affiliation: Bayer HealthCare
Country: USA

Publications

  1. doi request reprint Multiscale mechanistic modeling in pharmaceutical research and development
    Lars Kuepfer
    Systems Biology and Computational Solutions, Bayer Technology Services GmbH, Building 9115, 51368 Leverkusen, Germany
    Adv Exp Med Biol 736:543-61. 2012
  2. pmc Integrating cellular metabolism into a multiscale whole-body model
    Markus Krauss
    Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany
    PLoS Comput Biol 8:e1002750. 2012
  3. doi request reprint A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation
    Christoph Thiel
    Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany Institute of Applied Microbiology, RWTH Aachen, Aachen, Germany
    J Pharm Sci 104:191-206. 2015
  4. pmc Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations
    Markus Krauss
    Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany
    PLoS ONE 10:e0139423. 2015
  5. doi request reprint Systems Medicine in Pharmaceutical Research and Development
    Lars Kuepfer
    Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany
    Methods Mol Biol 1386:87-104. 2016
  6. doi request reprint Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling
    Michaela Meyer
    Systems Biology and Computational Solutions, Bayer Technology Services GmbH, Building 9115, 51368 Leverkusen, Germany
    Drug Metab Dispos 40:892-901. 2012
  7. pmc Development of a physiologically based computational kidney model to describe the renal excretion of hydrophilic agents in rats
    Christoph Niederalt
    Computational Systems Biology, Bayer Technology Services GmbH Leverkusen, Germany
    Front Physiol 3:494. 2012

Collaborators

  • Stefan Willmann
  • Sebastian Zellmer
  • Markus Krauss
  • Christoph Thiel
  • Sebastian Schneckener
  • Joerg Lippert
  • Christoph Niederalt
  • Michaela Meyer
  • Kai Tappe
  • Linus Goerlitz
  • Tobias Kanacher
  • Ahmed Ghallab
  • Rolf Gebhardt
  • Jan G Hengstler
  • Ute Hofmann
  • Andreas Schuppert
  • Rolf Burghaus
  • Thomas Wendl
  • Philipp Lengsfeld
  • Stephan Schaller
  • Bernd Ludewig
  • Steffen Borchers
  • Jörg Lippert
  • Rolf Findeisen
  • Julia Winkler
  • Roland Loosen
  • Matthias Brautigam
  • Karina Claassen
  • Hubertus Pietsch
  • Marcus Schultze-Mosgau

Detail Information

Publications8

  1. doi request reprint Multiscale mechanistic modeling in pharmaceutical research and development
    Lars Kuepfer
    Systems Biology and Computational Solutions, Bayer Technology Services GmbH, Building 9115, 51368 Leverkusen, Germany
    Adv Exp Med Biol 736:543-61. 2012
    ....
  2. pmc Integrating cellular metabolism into a multiscale whole-body model
    Markus Krauss
    Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany
    PLoS Comput Biol 8:e1002750. 2012
    ..The approach presented may in future support a mechanistic understanding in diagnostics and drug development...
  3. doi request reprint A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation
    Christoph Thiel
    Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany Institute of Applied Microbiology, RWTH Aachen, Aachen, Germany
    J Pharm Sci 104:191-206. 2015
    ....
  4. pmc Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations
    Markus Krauss
    Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany
    PLoS ONE 10:e0139423. 2015
    ..This will facilitate decision making e.g. from preclinical to clinical development or extrapolation of PK behavior from healthy to clinically significant populations. ..
  5. doi request reprint Systems Medicine in Pharmaceutical Research and Development
    Lars Kuepfer
    Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany
    Methods Mol Biol 1386:87-104. 2016
    ..In this chapter, we sketch typical industrial application areas for both modeling techniques and derive the requirements for future technology development. ..
  6. doi request reprint Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling
    Michaela Meyer
    Systems Biology and Computational Solutions, Bayer Technology Services GmbH, Building 9115, 51368 Leverkusen, Germany
    Drug Metab Dispos 40:892-901. 2012
    ....
  7. pmc Development of a physiologically based computational kidney model to describe the renal excretion of hydrophilic agents in rats
    Christoph Niederalt
    Computational Systems Biology, Bayer Technology Services GmbH Leverkusen, Germany
    Front Physiol 3:494. 2012
    ....