G P Vigers
Affiliation: Array BioPharma
- X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1G P Vigers
Department of Inflammation Research, Amgen, Incorporated, Boulder, Colorado 80301, USA
J Biol Chem 275:36927-33. 2000..ligand structures. The structure shows an unexpected binding mode for the peptide and may contribute to the design of smaller IL-1R antagonists...
- Multiple active site corrections for docking and virtual screeningGuy P A Vigers
Array BioPharma Inc, 3200 Walnut St, Boulder, Colorado 80301, USA
J Med Chem 47:80-9. 2004..We have also tested the correction method against an extended set of 63 cocrystals and in a virtual screening experiment. In all cases, MASC significantly improves the results of the docking experiments...
- Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1betaG P Vigers
Amgen Inc, Boulder, Colorado 80301, USA
Nature 386:190-4. 1997..The two receptor-binding regions on IL-1beta identified by site-directed mutagenesis both contact the receptor: one binds to the first two domains of the receptor, while the other binds exclusively to the third domain...
- X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolutionG P Vigers
Synergen, Inc, Boulder, Colorado 80301
J Biol Chem 269:12874-9. 1994..However, there are a number of structural differences between the molecules, including significant differences at the open end of the beta-barrel, which has been identified in IL-1 beta as a receptor binding site...