K M Anderson

Summary

Country: USA

Publications

  1. ncbi request reprint Normoxic or hypoxic CD44/CD41 a₂ B₁ integrin-positive prostate PC3 cell side fractions and cancer stem cells
    K M Anderson
    Hektoen Research Institute, 627 S Wood Street, Chicago, IL, 60612, USA
    Med Oncol 31:779. 2014
  2. ncbi request reprint Review: description of the developmental patterns of epithelial cells and cancers originating from them will provide many sites for therapy
    Ken M Anderson
    Hektoen Institute, 627 S Wood Street, Chicago, IL 60612, USA
    In Vivo 27:159-63. 2013
  3. ncbi request reprint Order-of-magnitude estimates of latency (time to appearance) and refill time of a cancer from a single cancer 'stem' cell compared by an exponential and a logistic equation
    Ken M Anderson
    Division of Biology, Hektoen Institute, Chicago, IL 60612, USA
    In Vivo 26:183-9. 2012
  4. ncbi request reprint Do intra-tumor alkaline micro-regions represent additional therapeutically privileged sites?
    K M Anderson
    Hektoen Institute LLC, 627 S Wood Street, Chicago, IL 60612, United States
    Med Hypotheses 70:1193-6. 2008
  5. ncbi request reprint Are cancer stem cells concentrated in more alkaline hypoxic regions of tumors?
    K M Anderson
    Division of Cell Biology, Hektoen Institute for Medical Research, University of Illinois Medical Center, Chicago, IL 60612, USA
    Med Hypotheses 74:868-70. 2010
  6. ncbi request reprint In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells
    K M Anderson
    Hektoen Institute LLC, Chicago, IL, USA
    Anticancer Res 29:4579-88. 2009
  7. ncbi request reprint The effect of normoxia and hypoxia on a prostate (PC-3) CD44/CD41 cell side fraction
    K M Anderson
    Division of Cell Biology, Hekteon Institute, University of Illinois Medical School, Chicago, IL, 60612, USA
    Anticancer Res 31:487-94. 2011
  8. ncbi request reprint Reactive oxygen species and redox-induced programmed cell death due to MK 886: cells ("soil") "trump" agent ("seed")
    K M Anderson
    Division of Cell Biology, The Hektoen Institute for Medical Research, LLC, Chicago, IL 60612, USA
    In Vivo 19:109-18. 2005
  9. ncbi request reprint Acute changes in U937 nuclear Ca2+ preceding type 1 "apoptotic" programmed cell death due to MK 886
    K M Anderson
    Hektoen Institute, Department of Biochemistry, Rush University Medical Center, University of Illinois and West Side V A Chicago, IL 60612, USA
    Anticancer Res 24:2601-15. 2004
  10. ncbi request reprint NTBN, a free radical spin trap induces programmed cell death in human pancreatic cancer (PANC-1) cells
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Anticancer Res 18:3213-22. 1998

Detail Information

Publications24

  1. ncbi request reprint Normoxic or hypoxic CD44/CD41 a₂ B₁ integrin-positive prostate PC3 cell side fractions and cancer stem cells
    K M Anderson
    Hektoen Research Institute, 627 S Wood Street, Chicago, IL, 60612, USA
    Med Oncol 31:779. 2014
    ....
  2. ncbi request reprint Review: description of the developmental patterns of epithelial cells and cancers originating from them will provide many sites for therapy
    Ken M Anderson
    Hektoen Institute, 627 S Wood Street, Chicago, IL 60612, USA
    In Vivo 27:159-63. 2013
    ..This information should identify many new differentiation sites and their coupling with cellular proliferation as new potential targets susceptible to therapeutic manipulation...
  3. ncbi request reprint Order-of-magnitude estimates of latency (time to appearance) and refill time of a cancer from a single cancer 'stem' cell compared by an exponential and a logistic equation
    Ken M Anderson
    Division of Biology, Hektoen Institute, Chicago, IL 60612, USA
    In Vivo 26:183-9. 2012
    ..Applications might include determination of the time the cell mass reaches a size that can be detected by X-rays or physical examination or modeling growth rates in vitro in order to compare with other models or established data...
  4. ncbi request reprint Do intra-tumor alkaline micro-regions represent additional therapeutically privileged sites?
    K M Anderson
    Hektoen Institute LLC, 627 S Wood Street, Chicago, IL 60612, United States
    Med Hypotheses 70:1193-6. 2008
    ..The interplay between alkalinity and normoxia, hypoxia or anoxia may differentially advantage some cancer "stem" cells...
  5. ncbi request reprint Are cancer stem cells concentrated in more alkaline hypoxic regions of tumors?
    K M Anderson
    Division of Cell Biology, Hektoen Institute for Medical Research, University of Illinois Medical Center, Chicago, IL 60612, USA
    Med Hypotheses 74:868-70. 2010
    ....
  6. ncbi request reprint In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells
    K M Anderson
    Hektoen Institute LLC, Chicago, IL, USA
    Anticancer Res 29:4579-88. 2009
    ....
  7. ncbi request reprint The effect of normoxia and hypoxia on a prostate (PC-3) CD44/CD41 cell side fraction
    K M Anderson
    Division of Cell Biology, Hekteon Institute, University of Illinois Medical School, Chicago, IL, 60612, USA
    Anticancer Res 31:487-94. 2011
    ..At 24 h, 2-deoxy-L-glucose or sodium arsenate reduced normoxic DL cell numbers more than hypoxic ones. The interplay between hypoxia, increased medium pH and the effect of inhibitors as they might influence therapy are considered...
  8. ncbi request reprint Reactive oxygen species and redox-induced programmed cell death due to MK 886: cells ("soil") "trump" agent ("seed")
    K M Anderson
    Division of Cell Biology, The Hektoen Institute for Medical Research, LLC, Chicago, IL 60612, USA
    In Vivo 19:109-18. 2005
    ..Lastly, these results demonstrate that, as might be expected, "soil" (cell type) trumps "seed" (inciting agent)"...
  9. ncbi request reprint Acute changes in U937 nuclear Ca2+ preceding type 1 "apoptotic" programmed cell death due to MK 886
    K M Anderson
    Hektoen Institute, Department of Biochemistry, Rush University Medical Center, University of Illinois and West Side V A Chicago, IL 60612, USA
    Anticancer Res 24:2601-15. 2004
    ..In Ca2+-depleted, nonpermeabilized U937 cells studied with MK 886 in a Ca2+-free medium, an acute increase in Ca2+ occured within 10 to 20 seconds, detected with fura-2 measured with a spectrofluorimeter...
  10. ncbi request reprint NTBN, a free radical spin trap induces programmed cell death in human pancreatic cancer (PANC-1) cells
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Anticancer Res 18:3213-22. 1998
    ..In view of the spin-trap associated pinocytosis, augmented uptake of chemotherapy in affected cells might be anticipated, but additive, synergistic or antagonistic interactions between NTBN and 5-fluorouracil were not observed...
  11. ncbi request reprint Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Anticancer Res 18:791-800. 1998
    ..When gamma linolenic acid was combined with MK886, the more effective of the two 5-lipoxygenase inhibitors, a synergistic reduction in Panc-1 cell number and viability occurred...
  12. ncbi request reprint An interaction between type 1 and type 2 programmed cell death and clonogenic survival
    K M Anderson
    Department of Medicine, The University of Illinois and the West Side VA Hospital, Chicago, IL, USA
    Med Hypotheses 61:583-5. 2003
    ....
  13. ncbi request reprint Induction of type 1 programmed cell death in U937 cells by the antioxidant, butylated hydroxy-toluene or the free radical spin trap, NTBN
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Leuk Res 23:665-73. 1999
    ....
  14. ncbi request reprint Disparate forms of MK 886-induced programmed death in BCL-2 (+) blood and BCL-2 (-) solid cancer cells and a putative "nuclear" Ca2+ channel: "soil" trumps "seed"?
    K M Anderson
    The Hektoen Institute, and Cook County Hospital, 2100 W Harrison, Chicago, IL 60612, USA
    Med Hypotheses 64:307-11. 2005
    ..Lastly, these results demonstrate that "soil" trumps "seed"...
  15. ncbi request reprint The proliferative response of hela cells to 2-deoxy-D-glucose under hypoxic or anoxic conditions: an analogue for studying some properties of in vivo solid cancers
    K M Anderson
    Hektoen Medical Research Institute, The Cook County Hospital, Chicago, IL 60612, USA
    Anticancer Res 26:4155-62. 2006
    ..Due to the dependence of many malignantly transformed cells on glycolysis for metabolic energy, inhibiting this and other sources of energy should seriously reduce cell viability and proliferation, additively or even synergistically...
  16. ncbi request reprint To what extent are the "sets" of biologic properties expressed by hypoxic cancer cells and by cancer "stem" cells equivalent, intersecting, disjoint or complementary? Some implications for the design of cancer therapies
    K M Anderson
    Hektoen Medical Research Institute LLC, 627 South Wood Street, Chicago, IL 60612, United States
    Med Hypotheses 68:166-8. 2007
    ..Results from pre-clinical and clinical laboratory determination of the stem cell/hypoxic cell response may reflect the likely outcome of the proposed clinical treatment...
  17. ncbi request reprint Increased cytosol Ca(2+) and type 1 programmed cell death in Bcl-2-positive U937 but not in Bcl-2-negative PC-3 and Panc-1 cells induced by the 5-lipoxygenase inhibitor MK 886
    K M Anderson
    Department of Medicine, Section of Medical Oncology, Chicago, IL 60612, USA
    Prostaglandins Leukot Essent Fatty Acids 66:443-52. 2002
    ....
  18. ncbi request reprint Does homeobox-related "positional" genomic information contribute to implantation of metastatic cancer cells at non-random sites?
    K M Anderson
    Division of Cell Biology, Hektoen Medical Research Institute LLC, 627 S Wood Street, Chicago 60612, USA
    Anticancer Res 27:2141-53. 2007
    ..Furthermore, HOX or other homeobox genes or their products could provide novel intra- or extracellular targets for therapy...
  19. ncbi request reprint Is induction of type 2 programmed death in cancer cells from solid tumors directly related to mitochondrial mass?
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, USA
    Med Hypotheses 57:87-90. 2001
    ..The opportunity for successful therapy, considered to depend upon the ability to activate programmed cell death, therefore becomes progressively less probable...
  20. ncbi request reprint Selected features of nonendocrine pancreatic cancer
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, Illinois 60612, USA
    Exp Biol Med (Maywood) 226:521-37. 2001
    ..Difficulties in identifying those factors whose suppression or augmentation could result in inhibition of malignantly transformed cell properties are considered...
  21. ncbi request reprint Do lipoxygenases modulate normal or aberrant lympho-hematopoiesis?
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Leuk Res 23:51-6. 1999
    ..Recent evidence concerning these questions is reviewed and some reasons for these difficulties are considered...
  22. ncbi request reprint Comments on the unreasonable effectiveness of the biological and especially medical sciences
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, Illinois 60612, USA
    Med Hypotheses 56:431-3. 2001
    ..We consider some of the similarities and differences that distinguish these two modalities with which certain features of physical reality are apprehanded, analyzed and manipulated...
  23. ncbi request reprint A response of Panc-1 cells to cis-platinum, assessed with a cDNA array
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Anticancer Res 22:75-81. 2002
    ..The problem posed by the lack of response of cells in most solid cancers to current chemotherapy generally remains intractable...
  24. ncbi request reprint Addendum to a note regarding the success of biological and medical science
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Med Hypotheses 59:76-8. 2002
    ..Zeilinger, A foundational principle for quantum mechanics, Foundations of Physics 29 (1999) 631; H. C. Von Baeyer, In the beginning was the bit, New Scientist, 17 (2000) 26-30)...