Dirk E Smith

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
    Dirk E Smith
    Amgen Corporation, 51 University Street, Seattle, WA 98101, USA
    Immunity 18:87-96. 2003
  2. doi The biological paths of IL-1 family members IL-18 and IL-33
    Dirk E Smith
    Department of Inflammation Research, Amgen, Seattle, Washington 98119, USA
    J Leukoc Biol 89:383-92. 2011
  3. ncbi Genomic organization of the interleukin-1 locus
    Scott L Taylor
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Genomics 79:726-33. 2002
  4. ncbi A single amino acid difference between human and monkey interleukin (IL)-1beta dictates effective binding to soluble type II IL-1 receptor
    Dirk E Smith
    Amgen Corporation, Seattle, Washington 98101, USA
    J Biol Chem 277:47619-25. 2002
  5. doi IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma
    D E Smith
    Department of Inflammation Research, Amgen, Seattle, WA 98119, USA
    Clin Exp Allergy 40:200-8. 2010
  6. pmc A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1
    Dirk E Smith
    Department of Inflammation Research, Amgen, Seattle, WA 98119, USA
    Immunity 30:817-31. 2009
  7. pmc Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein
    Yangyang Huang
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 31:18048-59. 2011
  8. doi IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells
    Molly D Smithgall
    Department of Inflammation Research, Amgen Inc, 1201 Amgen Court West, Seattle, WA, USA
    Int Immunol 20:1019-30. 2008
  9. ncbi Regulation of interleukin-1 activity is enhanced by cooperation between the interleukin-1 receptor type II and interleukin-1 receptor accessory protein
    John E Sims
    Amgen, 51 University Street, Seattle, WA 98101, USA
    Eur Cytokine Netw 14:77-81. 2003
  10. doi The IL-1 family: regulators of immunity
    John E Sims
    Amgen, 1201 Amgen Court West, Seattle, Washington 98119, USA
    Nat Rev Immunol 10:89-102. 2010

Collaborators

Detail Information

Publications11

  1. ncbi The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
    Dirk E Smith
    Amgen Corporation, 51 University Street, Seattle, WA 98101, USA
    Immunity 18:87-96. 2003
    ..These findings suggest that the soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action...
  2. doi The biological paths of IL-1 family members IL-18 and IL-33
    Dirk E Smith
    Department of Inflammation Research, Amgen, Seattle, Washington 98119, USA
    J Leukoc Biol 89:383-92. 2011
    ..The purpose of this article is not to provide an exhaustive review of IL-18 and IL-33 but rather, to summarize what is known about their key functions and to provide perspective on their similarities and differences...
  3. ncbi Genomic organization of the interleukin-1 locus
    Scott L Taylor
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Genomics 79:726-33. 2002
    ..There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7...
  4. ncbi A single amino acid difference between human and monkey interleukin (IL)-1beta dictates effective binding to soluble type II IL-1 receptor
    Dirk E Smith
    Amgen Corporation, Seattle, Washington 98101, USA
    J Biol Chem 277:47619-25. 2002
    ..Structural and mutational analysis revealed that the unique sIL1R-II binding ability of human IL-1beta is due to a single amino acid difference compared with monkey IL-1beta...
  5. doi IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma
    D E Smith
    Department of Inflammation Research, Amgen, Seattle, WA 98119, USA
    Clin Exp Allergy 40:200-8. 2010
    ..Finally, there will be a discussion of still unanswered questions regarding the mechanisms by which cytokine activity is generated and IL-33's relationship with other Th2-associated cytokines...
  6. pmc A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1
    Dirk E Smith
    Department of Inflammation Research, Amgen, Seattle, WA 98119, USA
    Immunity 30:817-31. 2009
    ..These findings implicate AcPb as an additional component of the highly regulated IL-1 system and suggest that it may play a role in modulating CNS responses to IL-1 and the interplay between inflammation and neuronal survival...
  7. pmc Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein
    Yangyang Huang
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 31:18048-59. 2011
    ..AcPb also played a modulatory role in the activation of p38 MAPK, but had no effect on NF-κB signaling. The restricted expression of AcPb in CNS neurons, therefore, governs specific neuronal signaling and functional responses to IL-1β...
  8. doi IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells
    Molly D Smithgall
    Department of Inflammation Research, Amgen Inc, 1201 Amgen Court West, Seattle, WA, USA
    Int Immunol 20:1019-30. 2008
    ..Moreover, the nature of the responses elicited by IL-33 suggests that this axis may amplify both T(h)1- and T(h)2-oriented immune responses...
  9. ncbi Regulation of interleukin-1 activity is enhanced by cooperation between the interleukin-1 receptor type II and interleukin-1 receptor accessory protein
    John E Sims
    Amgen, 51 University Street, Seattle, WA 98101, USA
    Eur Cytokine Netw 14:77-81. 2003
  10. doi The IL-1 family: regulators of immunity
    John E Sims
    Amgen, 1201 Amgen Court West, Seattle, Washington 98119, USA
    Nat Rev Immunol 10:89-102. 2010
    ..This Review provides an overview of both the long-established and more recently characterized members of the IL-1 family. In addition to their effects on immune cells, their involvement in human disease and disease models is discussed...
  11. doi The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33
    Gaby Palmer
    Division of Rheumatology, University Hospital of Geneva, 26 Avenue Beau Sejour, 1211 Geneva 14, Switzerland
    Cytokine 42:358-64. 2008
    ..These observations identify AcP as a shared co-receptor within the IL-1 family that is essential for IL-33 signaling and suggest a novel role for sAcP in modulating the activity of IL-33...