- Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley RatMark R Fielden
Comparative Biology and Safety Sciences, Amgen, Thousand Oaks, California, USA
Toxicol Pathol 43:581-92. 2015..These results suggest that AMG-8718 impairs phagolysosomal function in the rat RPE, which leads to photoreceptor dysfunction and ultimately loss of photoreceptors. ..
- Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the ratMark R Fielden
Comparative Biology and Safety Sciences, Amgen, South San Francisco, California 94080, USA
Toxicol Sci 124:54-74. 2011..These results support a potential early preclinical testing paradigm to catalyze broader understanding of putative NGHCs...