Cynthia A Afshari

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. pmc Integrating phenotypic and expression profiles to map arsenic-response networks
    Astrid C Haugen
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Genome Biol 5:R95. 2004
  2. pmc The evolution of bioinformatics in toxicology: advancing toxicogenomics
    Cynthia A Afshari
    Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 120:S225-37. 2011
  3. ncbi request reprint Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity
    Hisham K Hamadeh
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Mutat Res 549:169-83. 2004
  4. doi request reprint Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs
    Fan Fan
    Amgen Inc, Comparative Biology and Safety Sciences, Department of Discovery Toxicology, Thousand Oaks, California 91320 and Amgen Research GmbH, 93053 Regensburg, Germany
    Toxicol Sci 145:283-95. 2015
  5. doi request reprint Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors
    Hisham K Hamadeh
    Comparative Biology and Safety Sciences, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Chem Res Toxicol 23:1025-33. 2010
  6. doi request reprint Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat
    Mark R Fielden
    Comparative Biology and Safety Sciences, Amgen, Thousand Oaks, California, USA
    Toxicol Pathol 43:581-92. 2015
  7. doi request reprint Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development
    Ryan E Morgan
    Department of Comparative Biology and Safety Sciences Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 118:485-500. 2010
  8. pmc A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity
    M Ann Mongan
    Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California, United States of America
    PLoS ONE 5:e15595. 2010
  9. doi request reprint Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats
    Scott Taylor
    Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, CA, USA
    Bone 84:148-59. 2016
  10. ncbi request reprint Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers
    Sushil K Thukral
    Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Pathol 33:343-55. 2005

Collaborators

  • Hisham K Hamadeh
  • Yudong D He
  • Mark R Fielden
  • Dean Hickman
  • Yuan Chen
  • Guang Chen
  • Paul H Lee
  • Michael B Bass
  • Paul Nioi
  • Qihong Huang
  • P R Bushel
  • Michael Trauner
  • Rong Hu
  • Scott Taylor
  • Fan Fan
  • Robert T Dunn
  • M Ann Mongan
  • Ryan E Morgan
  • Sushil K Thukral
  • Astrid C Haugen
  • Sabina Buntich
  • Efrain Pacheco
  • Ian Pyrah
  • Michael S Ominsky
  • Danielle L Brown
  • Thomas J Wronski
  • J Ignacio Aguirre
  • Rogely Waite Boyce
  • Kerstin Weikl
  • Anke Munzli
  • Ralf Schwandner
  • Simone Strauch
  • Jeanine Bussiere
  • Carlo J van Staden
  • Toni L Williamson
  • Nancy Everds
  • Steven Vonderfecht
  • Suzanne Moss
  • Linda Carlock
  • Ruth Lightfoot-Dunn
  • Cheng Su
  • Christopher Dipalma
  • Charles Qualls
  • Michael Eschenberg
  • Bharath Ramachandran
  • Charles W Qualls
  • Marnie Higgins-Garn
  • Leah Sullivan
  • Mary E Cosenza
  • Laura Healy
  • Vincent D Fitzpatrick
  • Paul J Nordone
  • Eric Galambos
  • Jennifer B Collins
  • Changchun Deng
  • Trey Ideker
  • Ryan Kelley
  • J Martin Brown
  • Bennett Van Houten
  • Charles J Tucker

Detail Information

Publications10

  1. pmc Integrating phenotypic and expression profiles to map arsenic-response networks
    Astrid C Haugen
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Genome Biol 5:R95. 2004
    ..These data were then mapped to a metabolic network composed of all known biochemical reactions in yeast, as well as the yeast network of 20,985 protein-protein/protein-DNA interactions...
  2. pmc The evolution of bioinformatics in toxicology: advancing toxicogenomics
    Cynthia A Afshari
    Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 120:S225-37. 2011
    ..This review will cover the evolution of the field of toxicogenomics in the context of informatics integration its current promise, and limitations...
  3. ncbi request reprint Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity
    Hisham K Hamadeh
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Mutat Res 549:169-83. 2004
    ..Finally, to help determine the correlation between gene expression changes and liver pathology, we applied traditional microarray visualization tools to the assessment of clinical chemistry and pathology parameters...
  4. doi request reprint Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs
    Fan Fan
    Amgen Inc, Comparative Biology and Safety Sciences, Department of Discovery Toxicology, Thousand Oaks, California 91320 and Amgen Research GmbH, 93053 Regensburg, Germany
    Toxicol Sci 145:283-95. 2015
    ..These data highlight the merits of counter screening drug candidate against NHRs during drug discovery/development...
  5. doi request reprint Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors
    Hisham K Hamadeh
    Comparative Biology and Safety Sciences, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Chem Res Toxicol 23:1025-33. 2010
    ..Finally, we illustrate that in vivo gene expression profiles can serve as a complementary assessor of this activity and simultaneously help provide an assessment of on or off-target biological activity...
  6. doi request reprint Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat
    Mark R Fielden
    Comparative Biology and Safety Sciences, Amgen, Thousand Oaks, California, USA
    Toxicol Pathol 43:581-92. 2015
    ..These results suggest that AMG-8718 impairs phagolysosomal function in the rat RPE, which leads to photoreceptor dysfunction and ultimately loss of photoreceptors. ..
  7. doi request reprint Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development
    Ryan E Morgan
    Department of Comparative Biology and Safety Sciences Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 118:485-500. 2010
    ....
  8. pmc A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity
    M Ann Mongan
    Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California, United States of America
    PLoS ONE 5:e15595. 2010
    ..Comparison of concordant expression changes between PXR(+/+) and PXR(-/-) mice also suggested a PXR-independent association between CMP013 and perturbations to cellular stress, lipid metabolism, and biliary transport...
  9. doi request reprint Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats
    Scott Taylor
    Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, CA, USA
    Bone 84:148-59. 2016
    ..The interactions between Wnt and p53/c-Myc signaling may be key in limiting OP populations, thus contributing to self-regulation of bone formation with continued Scl-Ab administration. ..
  10. ncbi request reprint Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers
    Sushil K Thukral
    Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Pathol 33:343-55. 2005
    ..These include several transporters (Slc21a2, Slc15, Slc34a2), Kim 1, IGFbp-1, osteopontin, alpha-fibrinogen, and Gstalpha...