Cynthia A Afshari
Affiliation: Amgen Inc
- Integrating phenotypic and expression profiles to map arsenic-response networksAstrid C Haugen
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
Genome Biol 5:R95. 2004..These data were then mapped to a metabolic network composed of all known biochemical reactions in yeast, as well as the yeast network of 20,985 protein-protein/protein-DNA interactions...
- The evolution of bioinformatics in toxicology: advancing toxicogenomicsCynthia A Afshari
Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California 91320, USA
Toxicol Sci 120:S225-37. 2011..This review will cover the evolution of the field of toxicogenomics in the context of informatics integration its current promise, and limitations...
- Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicityHisham K Hamadeh
National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Mutat Res 549:169-83. 2004..Finally, to help determine the correlation between gene expression changes and liver pathology, we applied traditional microarray visualization tools to the assessment of clinical chemistry and pathology parameters...
- Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugsFan Fan
Amgen Inc, Comparative Biology and Safety Sciences, Department of Discovery Toxicology, Thousand Oaks, California 91320 and Amgen Research GmbH, 93053 Regensburg, Germany
Toxicol Sci 145:283-95. 2015..These data highlight the merits of counter screening drug candidate against NHRs during drug discovery/development...
- Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitorsHisham K Hamadeh
Comparative Biology and Safety Sciences, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
Chem Res Toxicol 23:1025-33. 2010..Finally, we illustrate that in vivo gene expression profiles can serve as a complementary assessor of this activity and simultaneously help provide an assessment of on or off-target biological activity...
- Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley RatMark R Fielden
Comparative Biology and Safety Sciences, Amgen, Thousand Oaks, California, USA
Toxicol Pathol 43:581-92. 2015..These results suggest that AMG-8718 impairs phagolysosomal function in the rat RPE, which leads to photoreceptor dysfunction and ultimately loss of photoreceptors. ..
- Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug developmentRyan E Morgan
Department of Comparative Biology and Safety Sciences Amgen Inc, Thousand Oaks, California 91320, USA
Toxicol Sci 118:485-500. 2010....
- A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicityM Ann Mongan
Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California, United States of America
PLoS ONE 5:e15595. 2010..Comparison of concordant expression changes between PXR(+/+) and PXR(-/-) mice also suggested a PXR-independent association between CMP013 and perturbations to cellular stress, lipid metabolism, and biliary transport...
- Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized ratsScott Taylor
Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, CA, USA
Bone 84:148-59. 2016..The interactions between Wnt and p53/c-Myc signaling may be key in limiting OP populations, thus contributing to self-regulation of bone formation with continued Scl-Ab administration. ..
- Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkersSushil K Thukral
Amgen Inc, Thousand Oaks, California 91320, USA
Toxicol Pathol 33:343-55. 2005..These include several transporters (Slc21a2, Slc15, Slc34a2), Kim 1, IGFbp-1, osteopontin, alpha-fibrinogen, and Gstalpha...