L Rossetti

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Central leptin acutely reverses diet-induced hepatic insulin resistance
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Diabetes 54:3182-9. 2005
  2. pmc Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
    Hiraku Ono
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 118:2959-68. 2008
  3. pmc Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene
    L Rossetti
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 100:1831-9. 1997
  4. ncbi request reprint Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
    L Rossetti
    Diabetes Research and Training Center and Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:27758-63. 1997
  5. pmc Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, New York 10461, USA
    J Clin Invest 101:1353-61. 1998
  6. ncbi request reprint Surgical removal of visceral fat reverses hepatic insulin resistance
    N Barzilai
    Department of Medicine, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:94-8. 1999
  7. ncbi request reprint The effect of age-dependent increase in fat mass on peripheral insulin action is saturable
    N Barzilai
    Department of Medicine, the Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Gerontol A Biol Sci Med Sci 53:B141-6. 1998
  8. ncbi request reprint Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
    N Barzilai
    Division of Geriatrics, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:E291-8. 1999
  9. ncbi request reprint Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle
    T S Tsao
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:775-82. 1999
  10. ncbi request reprint Functional analysis of a conditionally transformed pancreatic beta-cell line
    N Fleischer
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 47:1419-25. 1998

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Central leptin acutely reverses diet-induced hepatic insulin resistance
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Diabetes 54:3182-9. 2005
    ..Thus central administration of leptin rescues the hepatic insulin resistance induced by short-term hyperphagia...
  2. pmc Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
    Hiraku Ono
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 118:2959-68. 2008
    ..These results suggest that activation of hypothalamic S6K contributes to hepatic insulin resistance in response to short-term nutrient excess...
  3. pmc Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene
    L Rossetti
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 100:1831-9. 1997
    ..Thus, varying levels of GLUT4 protein in striated muscle and adipose tissue can markedly alter whole body glucose disposal. These differences most likely account for the interindividual variations in peripheral insulin action...
  4. ncbi request reprint Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
    L Rossetti
    Diabetes Research and Training Center and Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:27758-63. 1997
    ....
  5. pmc Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
    N Barzilai
    Department of Medicine, Albert Einstein College of Medicine, New York 10461, USA
    J Clin Invest 101:1353-61. 1998
    ..Thus, interventions designed to prevent the accumulation of VF are likely to represent an effective mean to improve carbohydrate metabolism in aging...
  6. ncbi request reprint Surgical removal of visceral fat reverses hepatic insulin resistance
    N Barzilai
    Department of Medicine, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:94-8. 1999
    ..We conclude that visceral fat is a potent modulator of insulin action on hepatic glucose production and gene expression...
  7. ncbi request reprint The effect of age-dependent increase in fat mass on peripheral insulin action is saturable
    N Barzilai
    Department of Medicine, the Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Gerontol A Biol Sci Med Sci 53:B141-6. 1998
    ..We suggest that decreasing insulin responsiveness, in a heterogeneous group such as humans, will only occur within a specific accretion of visceral or total FM...
  8. ncbi request reprint Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
    N Barzilai
    Division of Geriatrics, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:E291-8. 1999
    ..We conclude that 1) a moderate decrease in VF uniformly leads to a marked increase in hepatic insulin action, but 2) the effects of leptin on peripheral insulin action are not due to the associated changes in VF or beta3 activation...
  9. ncbi request reprint Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle
    T S Tsao
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:775-82. 1999
    ..Based on these results, we propose that the onset of a diabetic phenotype in GLUT4+/- mice can be avoided by preventing decreases in muscle GLUT4 expression and glucose uptake...
  10. ncbi request reprint Functional analysis of a conditionally transformed pancreatic beta-cell line
    N Fleischer
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 47:1419-25. 1998
    ..These findings demonstrate that transformed beta-cells maintain function during long periods of growth arrest, suggesting that conditional transformation of beta-cells may be a useful approach for developing cell therapy for diabetes...
  11. ncbi request reprint Hyperglycemia modulates angiotensinogen gene expression
    I Gabriely
    Diabetes Research and Training Center, Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Regul Integr Comp Physiol 281:R795-802. 2001
    ..We propose that increased AGT gene expression and possibly its production may provide another link between obesity/insulin resistance and hypertension...
  12. ncbi request reprint Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele
    L Rossetti
    Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 273:E743-50. 1997
    ....
  13. ncbi request reprint Overfeeding rapidly induces leptin and insulin resistance
    J Wang
    Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 50:2786-91. 2001
    ..These findings demonstrate a paradoxical and rapid collapse of the leptin system in response to nutrient excess. This partial failure is tightly coupled with the onset of insulin resistance...
  14. pmc Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
    T P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:1875-81. 2001
    ..Thus, a moderate rise in circulating levels of the adipose-derived protein Acrp30 inhibits both the expression of hepatic gluconeogenic enzymes and the rate of endogenous glucose production...
  15. pmc Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production
    R A Ross
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Endocrinol Metab 299:E633-9. 2010
    ..It remains to be determined whether SFAs need to be converted to MUFAs to exert this effect or whether they activate a separate signaling pathway to inhibit GP...
  16. pmc Central melanocortin receptors regulate insulin action
    S Obici
    Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA 10461
    J Clin Invest 108:1079-85. 2001
    ..Our findings elucidate a neuroendocrine network that is likely to play a central role in the coupling of energy intake and insulin action...
  17. pmc Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    X L Du
    Albert Einstein College of Medicine, Diabetes Research Center, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 97:12222-6. 2000
    ..Thus, hyperglycemia-induced mitochondrial superoxide overproduction increases hexosamine synthesis and O-glycosylation of Sp1, which activates expression of genes that contribute to the pathogenesis of diabetic complications...
  18. ncbi request reprint Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance
    S VanPatten
    Department of Biochemistry, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Gastrointest Liver Physiol 281:G393-404. 2001
    ..Increased biliary cholesterol secretion in the setting of decreased cholesterol biosynthesis and increased catabolism to bile salts suggests that leptin promotes elimination of plasma cholesterol...
  19. pmc Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
    Alessandro Pocai
    Department of Medicine and Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 116:1081-91. 2006
    ....
  20. ncbi request reprint Regulation of blood glucose by hypothalamic pyruvate metabolism
    Tony K T Lam
    Departments of Medicine and Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 309:943-7. 2005
    ..Thus, interventions designed to enhance the hypothalamic sensing of glucose may improve glucose homeostasis in diabetes...
  21. ncbi request reprint A brain-liver circuit regulates glucose homeostasis
    Alessandro Pocai
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Metab 1:53-61. 2005
    ..This crosstalk between brain and liver couples central nutrient sensing to peripheral nutrient production and its disruption may lead to hyperglycemia...
  22. pmc Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
    Haruka Okamoto
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:1314-22. 2005
    ..Conversely, the rate of glucose production was increased approximately 2-fold in L1 mice. Thus, restoration of hepatic insulin signaling in Insr knockout mice fails to normalize the in vivo response to insulin...
  23. pmc Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice
    Christoph Buettner
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 115:1306-13. 2005
    ..Thus, near ablation of liver IR does not alter insulin action on glucose production...
  24. ncbi request reprint Hypothalamic K(ATP) channels control hepatic glucose production
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 434:1026-31. 2005
    ..These findings suggest that activation of hypothalamic K(ATP) channels normally restrains hepatic gluconeogenesis, and that any alteration within this central nervous system/liver circuit can contribute to diabetic hyperglycaemia...
  25. ncbi request reprint Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
    Tony K T Lam
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 701, Bronx, New York 10461, USA
    Nat Med 11:320-7. 2005
    ..These findings indicate that a physiological elevation in circulating lipids can be sensed within the hypothalamus and that a defect in hypothalamic lipid sensing disrupts glucose homeostasis...
  26. pmc Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    Roger Gutierrez-Juarez
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Invest 116:1686-95. 2006
    ..Thus, Scd1 is required for the onset of diet-induced hepatic insulin resistance...
  27. pmc Critical role of STAT3 in leptin's metabolic actions
    Christoph Buettner
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Metab 4:49-60. 2006
    ..Our results demonstrate that the activation of the hypothalamic STAT3 pathway is an absolute requirement for the effects of leptin on food intake and hepatic glucose metabolism...
  28. pmc Role of transcription factor NFAT in glucose and insulin homeostasis
    Teddy T C Yang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 26:7372-87. 2006
    ..Together, these results establish a role for NFAT in glucose/insulin homeostasis and expand the repertoire of NFAT function to metabolic pathogenesis and adipokine gene transcription...
  29. ncbi request reprint Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
    Andrea R Nawrocki
    Department of Cell Biology, Division of Endocrinology, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:2654-60. 2006
    ..In summary, adiponectin is an important contributor to PPARgamma-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway...
  30. pmc Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
    Christoph Buettner
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1005, New York, New York 10029, USA
    Nat Med 14:667-75. 2008
    ..These data suggest that the increased endocannabinoid tone observed in obesity is linked to a failure of central leptin signaling to restrain peripheral endocannabinoids...
  31. pmc Hypothalamic protein kinase C regulates glucose production
    Rachel Ross
    Departments of Molecular Pharmacology, Medicine, and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 57:2061-5. 2008
    ..2 ATP-sensitive K(+) (K(ATP)) channels inhibit hepatic glucose production. The mechanisms that link the ability of hypothalamic lipid metabolism to the activation of K(ATP) channels remain unknown...
  32. doi request reprint Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2
    Erez F Scapa
    Department of Medicine, Division of Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 22:2579-90. 2008
    ..Collectively, these data support a key biological role for PC-TP in the regulation of energy substrate utilization...
  33. ncbi request reprint Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    Michihiro Matsumoto
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 6:208-16. 2007
    ..The data provide a unifying mechanism for regulation of hepatic glucose production by cAMP and insulin...
  34. pmc Hypothalamic resistin induces hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    J Clin Invest 117:1670-8. 2007
    ..These results unveil what we believe to be a novel site of action of resistin on GP and inflammation and suggest that hypothalamic resistin action can contribute to hyperglycemia in type 2 diabetes mellitus...
  35. ncbi request reprint Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice
    Hua V Lin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Diabetes 56:1969-76. 2007
    ..Adiponectin increases insulin sensitivity and contributes to insulin's indirect effects on hepatic glucose production...
  36. ncbi request reprint Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
    Tony K T Lam
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Med 13:171-80. 2007
    ..These central effects of glucose (but not those of lactate) were rapidly lost in diet-induced obesity. These findings indicate that a defect in brain glucose sensing could play a critical role in the etiology of the metabolic syndrome...
  37. pmc Role of resistin in diet-induced hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 114:232-9. 2004
    ..These results provide strong support for a physiological role of resistin in the development of hepatic insulin resistance in this model...
  38. ncbi request reprint Abnormal glucose homeostasis due to chronic hyperresistinemia
    Shamina M Rangwala
    Department of Medicine, The Penn Diabetes Center, Philadelphia, Pennsylvania, USA
    Diabetes 53:1937-41. 2004
    ..This increase in glucose production may be partly explained by increased expression of hepatic phosphoenolpyruvate carboxykinase. Thus, chronic hyperresistinemia impairs normal glucose metabolism...
  39. ncbi request reprint Disulfide-dependent multimeric assembly of resistin family hormones
    Saurabh D Patel
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Science 304:1154-8. 2004
    ..This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation...
  40. ncbi request reprint Hypothalamic insulin signaling is required for inhibition of glucose production
    Silvana Obici
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1376-82. 2002
    ..These results reveal a new site of action of insulin on glucose production and suggest that hypothalamic insulin resistance can contribute to hyperglycemia in type 2 diabetes mellitus...
  41. ncbi request reprint Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo
    Richard E Goldstein
    Department of Surgery, Vanderbilt University, and the Nashville VA Medical Center, Nashville, TN, USA
    Am J Physiol Endocrinol Metab 283:E946-57. 2002
    ..This difference was most apparent in the steroid-treated group, where the combination of the two methods (GNG(flux)) detected a significant increase in gluconeogenic flux...
  42. ncbi request reprint Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
    Ilan Gabriely
    Diabetes Research and Training Center and Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 51:2951-8. 2002
    ..This study documents a cause-and-effect relationship between VF and major components of the metabolic syndrome...
  43. ncbi request reprint Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects
    Meredith Hawkins
    Division of Endocrinology and Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Diabetes 51:2179-89. 2002
    ..Short-term normalization of plasma glucose might break the vicious cycle of impaired glucose effectiveness in type 2 diabetes...
  44. ncbi request reprint Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    Silvana Obici
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Neurosci 5:566-72. 2002
    ..Thus, insulin receptors in discrete areas of the hypothalamus have a physiological role in the control of food intake, fat mass and hepatic action of insulin...
  45. ncbi request reprint Leptin resistance during aging is independent of fat mass
    Ilan Gabriely
    Department of Medicine, Division of Endocrinology, Diabetes Research and Training Center Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York
    Diabetes 51:1016-21. 2002
    ..Our results show that leptin's action is markedly diminished in aging rats, independently of their body fat pattern. Leptin's failure in this model suggests its causative role in the metabolic decline seen with aging...
  46. ncbi request reprint Fructose amplifies counterregulatory responses to hypoglycemia in humans
    Ilan Gabriely
    Department of Medicine, Division of Endocrinology and Metabolism, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 51:893-900. 2002
    ..We conclude that infusion of a catalytic dose of fructose amplifies the counterregulatory response to hypoglycemia by both increases in hormonal activation and augmentation of glucose counterregulation in humans...
  47. ncbi request reprint Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes
    Meredith Hawkins
    Division of Endocrinology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 51:606-14. 2002
    ..This suggests that the liver's inability to respond to hyperglycemia in type 2 diabetes, likely caused by impaired GK activity, contributes substantially to the increased GP in these individuals...
  48. ncbi request reprint Central administration of oleic acid inhibits glucose production and food intake
    Silvana Obici
    Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 51:271-5. 2002
    ..This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation...
  49. pmc Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production
    Michael W Rajala
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Invest 111:225-30. 2003
    ..These results support the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action...
  50. ncbi request reprint Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway
    Ilan Gabriely
    Institute for Aging Research, Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Belfer Bld 701 1300, Morris Park Avenue, Bronx, NY 10461, USA
    Atherosclerosis 160:115-22. 2002
    ..These findings may account for some of the fibrinolytic alterations seen in obese type 2 diabetic humans...
  51. ncbi request reprint Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
    Silvana Obici
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Med 9:756-61. 2003
    ....
  52. ncbi request reprint Hypothalamic responses to long-chain fatty acids are nutritionally regulated
    Kimyata Morgan
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:31139-48. 2004
    ..The lack of hypothalamic responses to oleic acid following short term overfeeding is likely to contribute to the rapid onset of weight gain and hepatic insulin resistance in this animal model...
  53. ncbi request reprint Einstein's Institute for Aging Research: collaborative and programmatic approaches in the search for successful aging
    Nir Barzilai
    Department of Medicine, Institute for Aging Research, Belfer Bldg 701, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Exp Gerontol 39:151-7. 2004
    ..We suggest that this Institute serve as a model that gerontologists at other institutions should consider as they evaluate opportunities for collaborative, multi-disciplinary approaches to enhance aging research...
  54. ncbi request reprint A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity
    Terry P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 145:367-83. 2004
    ....
  55. ncbi request reprint Regulation of fasted blood glucose by resistin
    Ronadip R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1195-8. 2004
    ..Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity...
  56. ncbi request reprint Melanocortin-independent effects of leptin on hepatic glucose fluxes
    Roger Gutierrez-Juarez
    Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:49704-15. 2004
    ..We conclude that leptin regulates hepatic glucose fluxes through a melanocortin-dependent pathway leading to stimulation of gluconeogenesis and a melanocortin-independent pathway causing inhibition of GP and glycogenolysis...
  57. ncbi request reprint A new piece in the diabetes puzzle
    Luciano Rossetti
    Nat Med 8:112-4. 2002
  58. ncbi request reprint Hypothalamic sensing of fatty acids
    Tony K T Lam
    Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 8:579-84. 2005
    ..There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals...
  59. pmc Intracerebroventricular leptin regulates hepatic cholesterol metabolism
    Sonya Vanpatten
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem J 379:229-33. 2004
    ..These results indicate that the hepatic response to leptin is transduced via the central nervous system...
  60. pmc Identification of a biochemical link between energy intake and energy expenditure
    Silvana Obici
    Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 109:1599-605. 2002
    ..Thus, the activation of the HBP by nutrients represents a biochemical link between nutrient availability, mitochondrial proteins, and energy expenditure, and it is likely to play an important role in the regulation of energy balance...
  61. pmc Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    Xueliang Du
    Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Invest 112:1049-57. 2003
    ..Elevated glucose increased poly(ADP-ribosyl)ation of GAPDH in WT aortae, but not in the aortae from PARP-1-deficient mice. Thus, inhibition of PARP blocks hyperglycemia-induced activation of multiple pathways of vascular damage...
  62. ncbi request reprint Minireview: nutrient sensing and the regulation of insulin action and energy balance
    Silvana Obici
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 701, Bronx, New York 10461, USA
    Endocrinology 144:5172-8. 2003
    ..The hypothalamus links the sensing of nutrients to the control of metabolism and feeding behavior. Here, we discuss how two central and peripheral nutrient-sensing mechanisms participate in this complex feedback system...
  63. ncbi request reprint Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    Tadahiro Kitamura
    Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nat Med 12:534-40. 2006
    ..Thus, FoxO1 represents a shared component of pathways integrating food intake and peripheral metabolism...
  64. ncbi request reprint Molecular disruption of hypothalamic nutrient sensing induces obesity
    Wu He
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Neurosci 9:227-33. 2006
    ....
  65. ncbi request reprint Did a muscle fuel gauge conquer the brain?
    Alessandro Pocai
    Nat Med 12:50-1; discussion 51. 2006