Affiliation: Albert Einstein College of Medicine
- Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptorAntonia Patsialou
Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 69:9498-506. 2009..In particular, we show that the autocrine contribution to invasion is specifically amplified in vivo through a tumor microenvironment-induced upregulation of CSF-1R expression via the transforming growth factor-beta1...
- Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivoSumanta Goswami
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Clin Exp Metastasis 26:153-9. 2009..The Mena isoform switching pattern described here may provide a new biomarker for the presence of metastatic cancer cells and for prognosis...
- Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinaseHuan Pang
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 69:8868-76. 2009..Our observations suggest that, when compared with kinase domain mutations in a genetically identical background, expression of helical domain mutants of p110alpha produce a more severe metastatic phenotype...
- Chemotaxis in cancerEvanthia T Roussos
Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
Nat Rev Cancer 11:573-87. 2011..The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention...